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The map label for this gene is macA [H]

Identifier: 119386595

GI number: 119386595

Start: 1019578

End: 1020747

Strand: Direct

Name: macA [H]

Synonym: Pden_3888

Alternate gene names: 119386595

Gene position: 1019578-1020747 (Clockwise)

Preceding gene: 119386594

Following gene: 119386596

Centisome position: 58.93

GC content: 72.99

Gene sequence:

>1170_bases
ATGACGGCAACCTGCCGGATCACCCGGATCGCGATTCTGGCGCTTGCCTTGTCCCTGTCGGGATCGGGTCTGGCCGCCAT
GGCCGAGACGGCAGGCGCAGTCGAGCAAGCCGAATTGCCCGTGGTGACGCTGGCCGATGCCGAGCGCGGCTGGATCGAGG
CGCGCGTGCCGGTCTCGGGCTCTCTGGTCGCCCGGCAGGAGGTGCAGGTCCATGCCCTGGTCTCGGGTCACGAGATCACC
CGGCTCGAGGCCGAGGTCGGCGACCGCGTCGAGGCCGGCGCGGTGCTGGCGCGGCTGTCCGAGGATGTGTTGTCGGCGCA
ACTGGCTCAGGCCGAGGCCGAATATCAGCGCGCCGAGGCGGGAATCAGTCAGGCCGAAAGCCAGATCGCCAGCGCCGAGG
CCAGCCTGACGCAGGCGGTGGCGACGTTGGAGCGCACCCGCAGCCTGCGGCAAAGCGGCAATGCCAGCCAGGCGGTGCTG
GACCAGGCCATCGCGGCCGAGGCTTCGGCGCGGGCGGCGGCGGCCTCGGCCTCGGACGGGCTGGGGGTGGCGCGGGCCGC
GCTTGCGCAGGCTGCGGCGGCGCGGCGCATCGCGCAGCTGAACCTGGGCCATGCCAGCGTCACGGCGCCGGTCGACGGCG
TGGTCGTGGCGCGGACCGCCCGGCTGGGTGCCATTCCCGGCAGTGGCGGCGAGCCGCTGTTCACCCTGATTGCCGGCGGC
GAGGTCGAGCTTGAGGCCGATGTGATCGAAACCGCGCTGAGCCAGTTGAAAGCCGGCGATGCTGCCGAAATCCAGGTCGC
CGGCCTTGGTCGCGTCCAGGGCAAGCTGCGGCTGGTGCCGGCCGCCGTCGACCCGGTCACGCGGCTTGGCCCGGCGCGAA
TCGCGCTGGACCCCGACCCGCGCTTGCGTCCGGGGCTTTTCGCCAGCGGATGGATCATCACCGACCGCCGTGAGGCGGTG
ACCGTGCCCGCCTCGGCCATCCTTGCCGATGCCTCGGGCGAGCGGGTACAGGTGGTCAAGGACGGCCAGATCGAGACGCG
CGAGGTCCGCGGCGGGCTTGTCTGGCAGGGCCGCCGCGAGATCCTCGACGGGCTGGCCCCGGGCGAGACGGTCGTGGCCC
GCGCCGGTGCCTTCTTCCGCAGCGGCGACCAGGTGCGGGCGGCGCCATGA

Upstream 100 bases:

>100_bases
GAACCTACCCGGCGTCAGCGTTTCCTTCTGAAACCCGGCTGGCATTGTTGCCGGCGACTGGCGCCATTATGTTGCGCCGC
AGATTGGTTTGGAGGGGACG

Downstream 100 bases:

>100_bases
ACTTCTCGGCCTGGTCCATACGCCATCCGGTGCCGCCCATCGCGATCTTCCTCGTGCTGATGCTGATGGGGTTCTACAGC
TTCAGCCGGCTGGCGGTCAC

Product: Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MTATCRITRIAILALALSLSGSGLAAMAETAGAVEQAELPVVTLADAERGWIEARVPVSGSLVARQEVQVHALVSGHEIT
RLEAEVGDRVEAGAVLARLSEDVLSAQLAQAEAEYQRAEAGISQAESQIASAEASLTQAVATLERTRSLRQSGNASQAVL
DQAIAAEASARAAAASASDGLGVARAALAQAAAARRIAQLNLGHASVTAPVDGVVVARTARLGAIPGSGGEPLFTLIAGG
EVELEADVIETALSQLKAGDAAEIQVAGLGRVQGKLRLVPAAVDPVTRLGPARIALDPDPRLRPGLFASGWIITDRREAV
TVPASAILADASGERVQVVKDGQIETREVRGGLVWQGRREILDGLAPGETVVARAGAFFRSGDQVRAAP

Sequences:

>Translated_389_residues
MTATCRITRIAILALALSLSGSGLAAMAETAGAVEQAELPVVTLADAERGWIEARVPVSGSLVARQEVQVHALVSGHEIT
RLEAEVGDRVEAGAVLARLSEDVLSAQLAQAEAEYQRAEAGISQAESQIASAEASLTQAVATLERTRSLRQSGNASQAVL
DQAIAAEASARAAAASASDGLGVARAALAQAAAARRIAQLNLGHASVTAPVDGVVVARTARLGAIPGSGGEPLFTLIAGG
EVELEADVIETALSQLKAGDAAEIQVAGLGRVQGKLRLVPAAVDPVTRLGPARIALDPDPRLRPGLFASGWIITDRREAV
TVPASAILADASGERVQVVKDGQIETREVRGGLVWQGRREILDGLAPGETVVARAGAFFRSGDQVRAAP
>Mature_388_residues
TATCRITRIAILALALSLSGSGLAAMAETAGAVEQAELPVVTLADAERGWIEARVPVSGSLVARQEVQVHALVSGHEITR
LEAEVGDRVEAGAVLARLSEDVLSAQLAQAEAEYQRAEAGISQAESQIASAEASLTQAVATLERTRSLRQSGNASQAVLD
QAIAAEASARAAAASASDGLGVARAALAQAAAARRIAQLNLGHASVTAPVDGVVVARTARLGAIPGSGGEPLFTLIAGGE
VELEADVIETALSQLKAGDAAEIQVAGLGRVQGKLRLVPAAVDPVTRLGPARIALDPDPRLRPGLFASGWIITDRREAVT
VPASAILADASGERVQVVKDGQIETREVRGGLVWQGRREILDGLAPGETVVARAGAFFRSGDQVRAAP

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=342, Percent_Identity=29.2397660818713, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39862; Mature: 39730

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATCRITRIAILALALSLSGSGLAAMAETAGAVEQAELPVVTLADAERGWIEARVPVSG
CCCEEHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHCCCCEEEEECCCCCEEEEECCCCC
SLVARQEVQVHALVSGHEITRLEAEVGDRVEAGAVLARLSEDVLSAQLAQAEAEYQRAEA
CEEECCCEEEEEEECCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GISQAESQIASAEASLTQAVATLERTRSLRQSGNASQAVLDQAIAAEASARAAAASASDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
LGVARAALAQAAAARRIAQLNLGHASVTAPVDGVVVARTARLGAIPGSGGEPLFTLIAGG
HHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEEEEEHHHHCCCCCCCCCCEEEEEECC
EVELEADVIETALSQLKAGDAAEIQVAGLGRVQGKLRLVPAAVDPVTRLGPARIALDPDP
EEEEHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCHHHHCCCCEEEECCCC
RLRPGLFASGWIITDRREAVTVPASAILADASGERVQVVKDGQIETREVRGGLVWQGRRE
CCCCCCEECCEEEECCCCEEECCHHHEEECCCCCEEEEEECCCEEEHHHCCCCEECCHHH
ILDGLAPGETVVARAGAFFRSGDQVRAAP
HHCCCCCCCHHHHHCCHHHCCCCCEECCC
>Mature Secondary Structure 
TATCRITRIAILALALSLSGSGLAAMAETAGAVEQAELPVVTLADAERGWIEARVPVSG
CCEEHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHCCCCEEEEECCCCCEEEEECCCCC
SLVARQEVQVHALVSGHEITRLEAEVGDRVEAGAVLARLSEDVLSAQLAQAEAEYQRAEA
CEEECCCEEEEEEECCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GISQAESQIASAEASLTQAVATLERTRSLRQSGNASQAVLDQAIAAEASARAAAASASDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
LGVARAALAQAAAARRIAQLNLGHASVTAPVDGVVVARTARLGAIPGSGGEPLFTLIAGG
HHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEEEEEHHHHCCCCCCCCCCEEEEEECC
EVELEADVIETALSQLKAGDAAEIQVAGLGRVQGKLRLVPAAVDPVTRLGPARIALDPDP
EEEEHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCHHHHCCCCEEEECCCC
RLRPGLFASGWIITDRREAVTVPASAILADASGERVQVVKDGQIETREVRGGLVWQGRRE
CCCCCCEECCEEEECCCCEEECCHHHEEECCCCCEEEEEECCCEEEHHHCCCCEECCHHH
ILDGLAPGETVVARAGAFFRSGDQVRAAP
HHCCCCCCCHHHHHCCHHHCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]