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The map label for this gene is ada [H]

Identifier: 119385599

GI number: 119385599

Start: 41122

End: 41718

Strand: Direct

Name: ada [H]

Synonym: Pden_2874

Alternate gene names: 119385599

Gene position: 41122-41718 (Clockwise)

Preceding gene: 119385596

Following gene: 119385600

Centisome position: 2.38

GC content: 71.69

Gene sequence:

>597_bases
ATGACACAGACGTTCTTTACCTTTGCCCAGCCCCAACCCGGGCTGCGGGTCTCGATCACCACGCAGCCGGCGCAGGATCT
GGGCGCGGTGCTTTGTCGCGGCAGGTTTGCCACGCCGCTCGGCACGGTGGTCGCCATGGGTGCGGGCGGGGCGCTCTGGG
GCCTGGGCTTCGCCGGCGCGATGTCCGAGGACCAGGTCGAGGCCGATCTGGCCGCGCGCTGGCCCCGCGCCCGCCTGGTC
GAGGCGTCCGAGGCGCTGGCCCCCTCCATCCAGGCATTGCTGGCCGGTGAGGGCGTCATCACGGTTCACCTGACCGGCAC
CGAGTTCCAGTTGCAGGTCTGGCGTGCCCTGGTCACGGTGCCGCCGGGCCAGGTCATCAGCTATGCCACGCTGGCCGAAC
GCATCGGGCGCCCGAACGCCCTGCGCGCGGTGGGCACCGCGGTCGGGCAGAACCCGGTCTCGTGGGCGATCCCCTGCCAT
CGCGTAACCCGCACCGGCGGACGCATCGGCGGCTATCATTGGGGCGAGGCCGTGAAGCGCGCCTTGCTGGTGCGCGAAGG
CGCCAGCATCGCGCCCCGCACCATCGCCGCTTTGTGA

Upstream 100 bases:

>100_bases
GGGCTCCAGATGCCCTGCCCCGCTGCCATGCGCAAGCTTTCGTGCATGGATTTGGCCGGCCGCTGCGCTACTCTGCCACG
GCAACAGTCGCGAGGCCGGG

Downstream 100 bases:

>100_bases
GCCGCCCCGGGGCGATTTCCCGTCTATTCCTGTGGAGTTGGCCCGGAACCCATGCCAATGTGACCGCGTTTGGGCATCAG
CCGCCGGCCCCGGAAGCAAG

Product: methylated-DNA--protein-cysteine methyltransferase

Products: NA

Alternate protein names: Regulatory protein of adaptative response; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MTQTFFTFAQPQPGLRVSITTQPAQDLGAVLCRGRFATPLGTVVAMGAGGALWGLGFAGAMSEDQVEADLAARWPRARLV
EASEALAPSIQALLAGEGVITVHLTGTEFQLQVWRALVTVPPGQVISYATLAERIGRPNALRAVGTAVGQNPVSWAIPCH
RVTRTGGRIGGYHWGEAVKRALLVREGASIAPRTIAAL

Sequences:

>Translated_198_residues
MTQTFFTFAQPQPGLRVSITTQPAQDLGAVLCRGRFATPLGTVVAMGAGGALWGLGFAGAMSEDQVEADLAARWPRARLV
EASEALAPSIQALLAGEGVITVHLTGTEFQLQVWRALVTVPPGQVISYATLAERIGRPNALRAVGTAVGQNPVSWAIPCH
RVTRTGGRIGGYHWGEAVKRALLVREGASIAPRTIAAL
>Mature_197_residues
TQTFFTFAQPQPGLRVSITTQPAQDLGAVLCRGRFATPLGTVVAMGAGGALWGLGFAGAMSEDQVEADLAARWPRARLVE
ASEALAPSIQALLAGEGVITVHLTGTEFQLQVWRALVTVPPGQVISYATLAERIGRPNALRAVGTAVGQNPVSWAIPCHR
VTRTGGRIGGYHWGEAVKRALLVREGASIAPRTIAAL

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus. It activates the transcription of alkA, alkB and aidB [H]

COG id: COG0350

COG function: function code L; Methylated DNA-protein cysteine methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI197304670, Length=75, Percent_Identity=50.6666666666667, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1788542, Length=91, Percent_Identity=46.1538461538462, Blast_Score=90, Evalue=8e-20,
Organism=Escherichia coli, GI1787596, Length=82, Percent_Identity=52.4390243902439, Blast_Score=84, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI115533070, Length=108, Percent_Identity=38.8888888888889, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI115533068, Length=108, Percent_Identity=38.8888888888889, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320001, Length=86, Percent_Identity=40.6976744186046, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137554, Length=125, Percent_Identity=40, Blast_Score=88, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR016221
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR001497
- InterPro:   IPR014048
- InterPro:   IPR008332
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF01035 DNA_binding_1; PF00165 HTH_AraC; PF02870 Methyltransf_1N [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 20803; Mature: 20672

Theoretical pI: Translated: 10.56; Mature: 10.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTFFTFAQPQPGLRVSITTQPAQDLGAVLCRGRFATPLGTVVAMGAGGALWGLGFAGA
CCCCEEEECCCCCCCEEEEECCCHHHHHHHHHCCCCCCCHHHHEEECCCCHHHHHCCCCC
MSEDQVEADLAARWPRARLVEASEALAPSIQALLAGEGVITVHLTGTEFQLQVWRALVTV
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHCC
PPGQVISYATLAERIGRPNALRAVGTAVGQNPVSWAIPCHRVTRTGGRIGGYHWGEAVKR
CCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCHHHHHHCCCCCCCCHHHHHHHH
ALLVREGASIAPRTIAAL
HHHHHCCCCCCCHHHHCC
>Mature Secondary Structure 
TQTFFTFAQPQPGLRVSITTQPAQDLGAVLCRGRFATPLGTVVAMGAGGALWGLGFAGA
CCCEEEECCCCCCCEEEEECCCHHHHHHHHHCCCCCCCHHHHEEECCCCHHHHHCCCCC
MSEDQVEADLAARWPRARLVEASEALAPSIQALLAGEGVITVHLTGTEFQLQVWRALVTV
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHCC
PPGQVISYATLAERIGRPNALRAVGTAVGQNPVSWAIPCHRVTRTGGRIGGYHWGEAVKR
CCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCHHHHHHCCCCCCCCHHHHHHHH
ALLVREGASIAPRTIAAL
HHHHHCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1904855; 11677609 [H]