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The map label for this gene is dxr

Identifier: 119358444

GI number: 119358444

Start: 3074413

End: 3075567

Strand: Direct

Name: dxr

Synonym: Cpha266_2680

Alternate gene names: 119358444

Gene position: 3074413-3075567 (Clockwise)

Preceding gene: 119358443

Following gene: 119358445

Centisome position: 98.1

GC content: 56.8

Gene sequence:

>1155_bases
ATGAGATCACTATCCATCCTCGGCAGTACCGGTTCGATCGGGCTCAGCACTCTCGATGTTGTTCGTCAGCACCCTGAGCA
GTTCACCATTACCGGCCTTGCTGAAGGCCATGATGTGGGAATGCTTGTAAAACAGATCCGGGAGTTCAACCCTCGCCTTG
TTTCGGTACGAAATGCCGATGCCGCAGCCGAACTTGCTTCGCTCCTCGGCAATGAGAAGCCGGAGATTTTTTACGGTATC
GAGGGAGCCGCCACCGTCGCCGCGGCGGATGGAGCTGATATGGTCGTTTCCGCTATTGTGGGAGCTGCCGGACTTGTGCC
GACCATCAGCGCCATCAAAGCCGGTAAAAACATCGCGCTTGCCAACAAGGAGACCATGGTCGTAGCGGGCAGGCTTGTTA
CCGATCTTGCCCGGCAGCACAAGGTGACCATCATTCCCGTCGACAGCGAACATTCCGCTATTTATCAGTCGCTTCTCGGC
CATCGGCACGAGGATGTTCTGCGCCTTATTCTGACCGCATCGGGAGGACCGTTCCTGAACACCTCTGCTGAAGAGCTTCG
CGAGGTTACTCTCGAGCAGGCTCTGAAACATCCGAAATGGACGATGGGGGCAAAAATCACGATCGATTCGGCGACGCTGA
TGAACAAGGGGCTTGAGGTCATCGAGGCTCACTGGCTGTTCGACATGCCCGCACATAAAATAGGCGTTGTGGTGCATCCG
CAAAGCATCATTCACTCCATGGTGGAGTATATCGACGGTTGCGTCATGGCGCAGCTCGGCATGCCGGACATGAGGGCTCC
CATCGCTTACGCCATCGCCTATCCGGAACGTTGCCCGAGCGGCATCGAGCGGCTTGATCTGCCGAAAATCGGTTCCCTGA
GCTTCCAGGAACCTGATCCGGGCAGATTCCCCTGTCTGCGACTGGCCTATGAATCGCTTGAGGCGGGAAGAACCTGTCCG
GCCGTGCTGAATGCCGCCAATGAAATCGCCGTTGCCGCGTTTCTCGACAAACGGATCGGGTTTACCGATATTGCCGATAC
CGTCGACAAGACCATGCAGGCTCATGAGGCGTATACTCCGGTATCGCTCGAGGAGTACCTGGAGGCAGACCGGTGGGCGC
GAGAGATGGCAAAAGGTCTCGTTGAACGGGCATAA

Upstream 100 bases:

>100_bases
AGAGAAGCGGCGGGCGGAATTTGTAACCCTTTGCGAAAAAGCATAAATTCATGCCGGTAGATTCAATACGAAACCCCGGC
AACTTTTTTTACTATACGTT

Downstream 100 bases:

>100_bases
AATAGCGTATCCGCTGCTGTAACCTATATCCCGGGCTCTGTAACAGGATGTCCGGGCAGTTTTTTTTCTGAAACGAACGA
GGAATCCATGGATTTTCTGA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MRSLSILGSTGSIGLSTLDVVRQHPEQFTITGLAEGHDVGMLVKQIREFNPRLVSVRNADAAAELASLLGNEKPEIFYGI
EGAATVAAADGADMVVSAIVGAAGLVPTISAIKAGKNIALANKETMVVAGRLVTDLARQHKVTIIPVDSEHSAIYQSLLG
HRHEDVLRLILTASGGPFLNTSAEELREVTLEQALKHPKWTMGAKITIDSATLMNKGLEVIEAHWLFDMPAHKIGVVVHP
QSIIHSMVEYIDGCVMAQLGMPDMRAPIAYAIAYPERCPSGIERLDLPKIGSLSFQEPDPGRFPCLRLAYESLEAGRTCP
AVLNAANEIAVAAFLDKRIGFTDIADTVDKTMQAHEAYTPVSLEEYLEADRWAREMAKGLVERA

Sequences:

>Translated_384_residues
MRSLSILGSTGSIGLSTLDVVRQHPEQFTITGLAEGHDVGMLVKQIREFNPRLVSVRNADAAAELASLLGNEKPEIFYGI
EGAATVAAADGADMVVSAIVGAAGLVPTISAIKAGKNIALANKETMVVAGRLVTDLARQHKVTIIPVDSEHSAIYQSLLG
HRHEDVLRLILTASGGPFLNTSAEELREVTLEQALKHPKWTMGAKITIDSATLMNKGLEVIEAHWLFDMPAHKIGVVVHP
QSIIHSMVEYIDGCVMAQLGMPDMRAPIAYAIAYPERCPSGIERLDLPKIGSLSFQEPDPGRFPCLRLAYESLEAGRTCP
AVLNAANEIAVAAFLDKRIGFTDIADTVDKTMQAHEAYTPVSLEEYLEADRWAREMAKGLVERA
>Mature_384_residues
MRSLSILGSTGSIGLSTLDVVRQHPEQFTITGLAEGHDVGMLVKQIREFNPRLVSVRNADAAAELASLLGNEKPEIFYGI
EGAATVAAADGADMVVSAIVGAAGLVPTISAIKAGKNIALANKETMVVAGRLVTDLARQHKVTIIPVDSEHSAIYQSLLG
HRHEDVLRLILTASGGPFLNTSAEELREVTLEQALKHPKWTMGAKITIDSATLMNKGLEVIEAHWLFDMPAHKIGVVVHP
QSIIHSMVEYIDGCVMAQLGMPDMRAPIAYAIAYPERCPSGIERLDLPKIGSLSFQEPDPGRFPCLRLAYESLEAGRTCP
AVLNAANEIAVAAFLDKRIGFTDIADTVDKTMQAHEAYTPVSLEEYLEADRWAREMAKGLVERA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=395, Percent_Identity=48.3544303797468, Blast_Score=364, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_CHLPD (A1BJT7)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_913088.1
- ProteinModelPortal:   A1BJT7
- SMR:   A1BJT7
- STRING:   A1BJT7
- GeneID:   4568859
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_2680
- NMPDR:   fig|290317.7.peg.2801
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 41463; Mature: 41463

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: BINDING 123-123 BINDING 150-150 BINDING 174-174 BINDING 197-197 BINDING 219-219

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSLSILGSTGSIGLSTLDVVRQHPEQFTITGLAEGHDVGMLVKQIREFNPRLVSVRNAD
CCCCEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCH
AAAELASLLGNEKPEIFYGIEGAATVAAADGADMVVSAIVGAAGLVPTISAIKAGKNIAL
HHHHHHHHHCCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ANKETMVVAGRLVTDLARQHKVTIIPVDSEHSAIYQSLLGHRHEDVLRLILTASGGPFLN
ECCCEEEEHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
TSAEELREVTLEQALKHPKWTMGAKITIDSATLMNKGLEVIEAHWLFDMPAHKIGVVVHP
CCHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHCHHHHHHHHHCCCCCCCEEEEECC
QSIIHSMVEYIDGCVMAQLGMPDMRAPIAYAIAYPERCPSGIERLDLPKIGSLSFQEPDP
HHHHHHHHHHHHHHHHHHCCCCCHHCCHHHEEECHHHCCCHHHHCCCCCCCCCCCCCCCC
GRFPCLRLAYESLEAGRTCPAVLNAANEIAVAAFLDKRIGFTDIADTVDKTMQAHEAYTP
CCCHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
VSLEEYLEADRWAREMAKGLVERA
CCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRSLSILGSTGSIGLSTLDVVRQHPEQFTITGLAEGHDVGMLVKQIREFNPRLVSVRNAD
CCCCEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCH
AAAELASLLGNEKPEIFYGIEGAATVAAADGADMVVSAIVGAAGLVPTISAIKAGKNIAL
HHHHHHHHHCCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ANKETMVVAGRLVTDLARQHKVTIIPVDSEHSAIYQSLLGHRHEDVLRLILTASGGPFLN
ECCCEEEEHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
TSAEELREVTLEQALKHPKWTMGAKITIDSATLMNKGLEVIEAHWLFDMPAHKIGVVVHP
CCHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHCHHHHHHHHHCCCCCCCEEEEECC
QSIIHSMVEYIDGCVMAQLGMPDMRAPIAYAIAYPERCPSGIERLDLPKIGSLSFQEPDP
HHHHHHHHHHHHHHHHHHCCCCCHHCCHHHEEECHHHCCCHHHHCCCCCCCCCCCCCCCC
GRFPCLRLAYESLEAGRTCPAVLNAANEIAVAAFLDKRIGFTDIADTVDKTMQAHEAYTP
CCCHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
VSLEEYLEADRWAREMAKGLVERA
CCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA