Click here to switch to the map view.

The map label for this gene is gyrA [H]

Identifier: 119358427

GI number: 119358427

Start: 3055926

End: 3058409

Strand: Reverse

Name: gyrA [H]

Synonym: Cpha266_2663

Alternate gene names: 119358427

Gene position: 3058409-3055926 (Counterclockwise)

Preceding gene: 119358428

Following gene: 119358426

Centisome position: 97.59

GC content: 56.08

Gene sequence:

>2484_bases
ATGCAGCGCGAAAGAATATTGCCGATCAGTATCGAAGAGGAGATGCGGGATTCCTATCTCGACTATTCCATGTCGGTTAT
TGTCAGTCGTGCGCTGCCCGATGTCCGCGACGGGCTCAAACCGGTCCATCGCAGGGTACTCTACGGTATGCACGAACTCG
GGCTGCAGGCAGGCAAGCCCCATAAAAAATCTGCCCGTATCGTCGGTGAAGTGCTTGGCAAGTTTCACCCCCACGGCGAC
ACGGCCGTCTACGACAGTCTTGTCCGACTTGTGCAGGACTTTTCAATGCGCTACCCGCTGATCGACGGACAGGGCAACTT
CGGTTCGATTGACGGCGACTCGCCGGCGGCCATGAGGTACACCGAGGTCCGCATGAAAGCCATTGCCGGCGAAATGCTCA
AAGACCTCGACAAGGAGACCGTCGATTTCTCGCTCAACTTCGACGACTCCCTCGAAGAACCGACCGTTCTGCCCTCGGCA
ATTCCCAATCTCCTGGTCAACGGCTCCTCCGGCATTGCCGTAGGCATGGCCACCAACATCCCTCCCCAGAACCTCAGGGA
GGTTGTCGACGGCATCATAGCGCTCATAGAAAACCCCGACATCGAAATAGCCGATCTCATGAAACATGTGATCGCCCCTG
ATTTTCCTACCGCAGGCATCATATACGGCTACGAAGGGGTCAAGCAGGCATACCTCACCGGAAGAGGCAAGGTGGTTATC
CGCGCGCGAGCGCTCGTGGAGGTCACCCAGAAAAACGGACGCGAATCGATTATCGTAACCGAATTGCCCTATCAGGTCAA
CAAAGTCAGGCTGATCGAAAAAATCGTTGAACTCGTCCACGACAAAAAGCTCGAAGGCATAGCGGATATCCGCGACGAAT
CCGATCGGGACGGCATGAGGCTGGTTATCGAACTCAAAAGAGACGCCGTAGCCAAAGTCGTACTGAACAATCTCTACAAG
CACACCCCGATGCAGGACACCTTCGGGGTCATCATGCTTGCGCTGGTCGACGGCATGCCGAGGGTACTCAATCTCAAGCA
GATGATGGAGTACTACATCAGGCACCGCAACGAGATCGTGCTTCGCCGGACGCAATATGACCTCACCGCGGCAGAAAAAC
GGGCGCATATTCTCGAAGGGCTCAAAATCTGTCTCGACAACCTCGACGAAGTCATCACCACCATCCGCCAGTCCCCCGAC
GCTCCGACGGCCCAGAGCAGCCTCATGGAAAAGTTCGGACTCACGGAAATCCAGTCGAAAGCCATACTCGAAATGCGTCT
GCAGCGCCTCACCGGCATGGAGCGCAAAAAAATCGACATGGAGTACCAGGAAACCCTGCTCCTCATTGACGAGCTTCGCT
CCATTCTTGCCAACCCCCAGAAGCAGATGCAGATCATCCGCGAAGAGCTGCTTAAAGTCAAGGATGTATACGGCGACGCC
CGCCGCACAGAAATTGTGCCGCAGGAAGGAGACTTTTCCATCGAAGACATGATCGCCCAGGAAGACGTGGTGATCACCAT
CACCCACGACGGCTTTATCAAGCGCTTTCCCGTATCGGGCTACCGACGCCAGGCAAGGGGAGGAAAAGGGGTAGCCGGAG
CCCAGGCAAAGCACGACGACTTTGTCGAGCACATGTTTATTGCCTCAACGCACAACTACATCCTCTTCTTCACCACCAGA
GGACGCTGCTACTGGCTCAAGGTCTACGAAATACCCGAAGCCGGTCGTACCGCTCGGGGCCGCTCCCTTGCGAACATCAT
GGAGCTGCAGCCGGCAGAAAAAATCAGGGCATACATCAACATCCGGAACTTTGACGAACCGGGCTTCATCGTTATGGCAA
CAGGAAACGGAACCGTCAAGAAAACCGGGCTCGACGAATTCTCCCGCCCGAGACGAAACGGCATAGCCGCCATCACCATC
GAGGAAAACGACGAACTGATCGACGCTCGGCTTACCGACGGCGACCACCAGATCATTCTTGCCAAAAGCTCGGGTTATGT
CGTGCGATTCCCCGAAAGCGAAATCCGCTCCATGGGGCGCACCGCGATGGGGGTCAGGGGCATTACGCTCGACGCCGACG
AAAAGTGCATCTCCATGGTCACCACCAAACGCTTTGACACTACGCTTCTGGCCGTAACCGACAACGGATTCGGCAAAAGA
AGCCGGGTCGAAGACTACCGCCTCACCAAAAGAGGAGCTCGCGGGGTCATAACGCTCAAGGCGCACGAAAAAACCGGCGC
GATGGTCGGTCTGCTCGACGTCAACGACGAAGACGATCTGATCATCATCACCAACAACGGCATCGTCAACCGCCAGCACG
TATCCGATATCAGGCTCACCGGAAGAAACACCTCCGGCGTCAGACTCATCAGACTCATGGCGGGAGACATCATCTCCGCG
CTTGCGCGTGTGCCGAAAAGCGACGAAGAGATCGATCCGGACTCTCTTCCCGAAAACCCGGACGGCCAGATCGATCTCTT
TTAG

Upstream 100 bases:

>100_bases
GTCGCCAACCCCCCGAAGCAGGGGAGGCGAGGCGGACAAAACGCTCTGATGCTTGTAAGTCATTGGGCTATTTCAGTTAA
TTATTATATGGATTTTATTT

Downstream 100 bases:

>100_bases
GCCGACGGAGAGCTAAAGAGCCCTCGCTGAAAAAGCGGGGGCAGAGAAGAACCGGCAAAAAACCGGCAGAACAGAACCGA
AAAGGAAGGCGACCCATGGA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 827; Mature: 827

Protein sequence:

>827_residues
MQRERILPISIEEEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLYGMHELGLQAGKPHKKSARIVGEVLGKFHPHGD
TAVYDSLVRLVQDFSMRYPLIDGQGNFGSIDGDSPAAMRYTEVRMKAIAGEMLKDLDKETVDFSLNFDDSLEEPTVLPSA
IPNLLVNGSSGIAVGMATNIPPQNLREVVDGIIALIENPDIEIADLMKHVIAPDFPTAGIIYGYEGVKQAYLTGRGKVVI
RARALVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELVHDKKLEGIADIRDESDRDGMRLVIELKRDAVAKVVLNNLYK
HTPMQDTFGVIMLALVDGMPRVLNLKQMMEYYIRHRNEIVLRRTQYDLTAAEKRAHILEGLKICLDNLDEVITTIRQSPD
APTAQSSLMEKFGLTEIQSKAILEMRLQRLTGMERKKIDMEYQETLLLIDELRSILANPQKQMQIIREELLKVKDVYGDA
RRTEIVPQEGDFSIEDMIAQEDVVITITHDGFIKRFPVSGYRRQARGGKGVAGAQAKHDDFVEHMFIASTHNYILFFTTR
GRCYWLKVYEIPEAGRTARGRSLANIMELQPAEKIRAYINIRNFDEPGFIVMATGNGTVKKTGLDEFSRPRRNGIAAITI
EENDELIDARLTDGDHQIILAKSSGYVVRFPESEIRSMGRTAMGVRGITLDADEKCISMVTTKRFDTTLLAVTDNGFGKR
SRVEDYRLTKRGARGVITLKAHEKTGAMVGLLDVNDEDDLIIITNNGIVNRQHVSDIRLTGRNTSGVRLIRLMAGDIISA
LARVPKSDEEIDPDSLPENPDGQIDLF

Sequences:

>Translated_827_residues
MQRERILPISIEEEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLYGMHELGLQAGKPHKKSARIVGEVLGKFHPHGD
TAVYDSLVRLVQDFSMRYPLIDGQGNFGSIDGDSPAAMRYTEVRMKAIAGEMLKDLDKETVDFSLNFDDSLEEPTVLPSA
IPNLLVNGSSGIAVGMATNIPPQNLREVVDGIIALIENPDIEIADLMKHVIAPDFPTAGIIYGYEGVKQAYLTGRGKVVI
RARALVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELVHDKKLEGIADIRDESDRDGMRLVIELKRDAVAKVVLNNLYK
HTPMQDTFGVIMLALVDGMPRVLNLKQMMEYYIRHRNEIVLRRTQYDLTAAEKRAHILEGLKICLDNLDEVITTIRQSPD
APTAQSSLMEKFGLTEIQSKAILEMRLQRLTGMERKKIDMEYQETLLLIDELRSILANPQKQMQIIREELLKVKDVYGDA
RRTEIVPQEGDFSIEDMIAQEDVVITITHDGFIKRFPVSGYRRQARGGKGVAGAQAKHDDFVEHMFIASTHNYILFFTTR
GRCYWLKVYEIPEAGRTARGRSLANIMELQPAEKIRAYINIRNFDEPGFIVMATGNGTVKKTGLDEFSRPRRNGIAAITI
EENDELIDARLTDGDHQIILAKSSGYVVRFPESEIRSMGRTAMGVRGITLDADEKCISMVTTKRFDTTLLAVTDNGFGKR
SRVEDYRLTKRGARGVITLKAHEKTGAMVGLLDVNDEDDLIIITNNGIVNRQHVSDIRLTGRNTSGVRLIRLMAGDIISA
LARVPKSDEEIDPDSLPENPDGQIDLF
>Mature_827_residues
MQRERILPISIEEEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLYGMHELGLQAGKPHKKSARIVGEVLGKFHPHGD
TAVYDSLVRLVQDFSMRYPLIDGQGNFGSIDGDSPAAMRYTEVRMKAIAGEMLKDLDKETVDFSLNFDDSLEEPTVLPSA
IPNLLVNGSSGIAVGMATNIPPQNLREVVDGIIALIENPDIEIADLMKHVIAPDFPTAGIIYGYEGVKQAYLTGRGKVVI
RARALVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELVHDKKLEGIADIRDESDRDGMRLVIELKRDAVAKVVLNNLYK
HTPMQDTFGVIMLALVDGMPRVLNLKQMMEYYIRHRNEIVLRRTQYDLTAAEKRAHILEGLKICLDNLDEVITTIRQSPD
APTAQSSLMEKFGLTEIQSKAILEMRLQRLTGMERKKIDMEYQETLLLIDELRSILANPQKQMQIIREELLKVKDVYGDA
RRTEIVPQEGDFSIEDMIAQEDVVITITHDGFIKRFPVSGYRRQARGGKGVAGAQAKHDDFVEHMFIASTHNYILFFTTR
GRCYWLKVYEIPEAGRTARGRSLANIMELQPAEKIRAYINIRNFDEPGFIVMATGNGTVKKTGLDEFSRPRRNGIAAITI
EENDELIDARLTDGDHQIILAKSSGYVVRFPESEIRSMGRTAMGVRGITLDADEKCISMVTTKRFDTTLLAVTDNGFGKR
SRVEDYRLTKRGARGVITLKAHEKTGAMVGLLDVNDEDDLIIITNNGIVNRQHVSDIRLTGRNTSGVRLIRLMAGDIISA
LARVPKSDEEIDPDSLPENPDGQIDLF

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=320, Percent_Identity=25, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI19913406, Length=174, Percent_Identity=30.4597701149425, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788562, Length=845, Percent_Identity=51.5976331360947, Blast_Score=860, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=681, Percent_Identity=36.8575624082232, Blast_Score=405, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17535065, Length=356, Percent_Identity=24.7191011235955, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=357, Percent_Identity=24.3697478991597, Blast_Score=74, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=190, Percent_Identity=26.8421052631579, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=336, Percent_Identity=24.1071428571429, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17136538, Length=173, Percent_Identity=29.4797687861272, Blast_Score=70, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 92919; Mature: 92919

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRERILPISIEEEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLYGMHELGLQAGKP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
HKKSARIVGEVLGKFHPHGDTAVYDSLVRLVQDFSMRYPLIDGQGNFGSIDGDSPAAMRY
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHH
TEVRMKAIAGEMLKDLDKETVDFSLNFDDSLEEPTVLPSAIPNLLVNGSSGIAVGMATNI
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHEEECCCCEEEEEECCC
PPQNLREVVDGIIALIENPDIEIADLMKHVIAPDFPTAGIIYGYEGVKQAYLTGRGKVVI
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEECCHHHHHHHHCCCCEEEE
RARALVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELVHDKKLEGIADIRDESDRDGMR
EEHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCE
LVIELKRDAVAKVVLNNLYKHTPMQDTFGVIMLALVDGMPRVLNLKQMMEYYIRHRNEIV
EEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEE
LRRTQYDLTAAEKRAHILEGLKICLDNLDEVITTIRQSPDAPTAQSSLMEKFGLTEIQSK
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHH
AILEMRLQRLTGMERKKIDMEYQETLLLIDELRSILANPQKQMQIIREELLKVKDVYGDA
HHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
RRTEIVPQEGDFSIEDMIAQEDVVITITHDGFIKRFPVSGYRRQARGGKGVAGAQAKHDD
HHCCCCCCCCCCCHHHHHCCCCEEEEEECCCCEEECCCCCHHHHCCCCCCCCCCCCCHHH
FVEHMFIASTHNYILFFTTRGRCYWLKVYEIPEAGRTARGRSLANIMELQPAEKIRAYIN
HHHHHHHEECCCEEEEEEECCEEEEEEEEECCCCCCCCCCCHHHHHHHCCCHHHHEEEEE
IRNFDEPGFIVMATGNGTVKKTGLDEFSRPRRNGIAAITIEENDELIDARLTDGDHQIIL
EECCCCCCEEEEECCCCCEEECCCHHHCCHHHCCEEEEEECCCCCEEEEEECCCCCEEEE
AKSSGYVVRFPESEIRSMGRTAMGVRGITLDADEKCISMVTTKRFDTTLLAVTDNGFGKR
EECCCCEEECCHHHHHHCCCHHHCEEEEEECCCHHHHHHHHHCCCCEEEEEEECCCCCCC
SRVEDYRLTKRGARGVITLKAHEKTGAMVGLLDVNDEDDLIIITNNGIVNRQHVSDIRLT
CCCHHHHHHHCCCCEEEEEEECCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCEEEEE
GRNTSGVRLIRLMAGDIISALARVPKSDEEIDPDSLPENPDGQIDLF
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECC
>Mature Secondary Structure
MQRERILPISIEEEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLYGMHELGLQAGKP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
HKKSARIVGEVLGKFHPHGDTAVYDSLVRLVQDFSMRYPLIDGQGNFGSIDGDSPAAMRY
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHH
TEVRMKAIAGEMLKDLDKETVDFSLNFDDSLEEPTVLPSAIPNLLVNGSSGIAVGMATNI
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHEEECCCCEEEEEECCC
PPQNLREVVDGIIALIENPDIEIADLMKHVIAPDFPTAGIIYGYEGVKQAYLTGRGKVVI
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEECCHHHHHHHHCCCCEEEE
RARALVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELVHDKKLEGIADIRDESDRDGMR
EEHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCE
LVIELKRDAVAKVVLNNLYKHTPMQDTFGVIMLALVDGMPRVLNLKQMMEYYIRHRNEIV
EEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEE
LRRTQYDLTAAEKRAHILEGLKICLDNLDEVITTIRQSPDAPTAQSSLMEKFGLTEIQSK
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHH
AILEMRLQRLTGMERKKIDMEYQETLLLIDELRSILANPQKQMQIIREELLKVKDVYGDA
HHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
RRTEIVPQEGDFSIEDMIAQEDVVITITHDGFIKRFPVSGYRRQARGGKGVAGAQAKHDD
HHCCCCCCCCCCCHHHHHCCCCEEEEEECCCCEEECCCCCHHHHCCCCCCCCCCCCCHHH
FVEHMFIASTHNYILFFTTRGRCYWLKVYEIPEAGRTARGRSLANIMELQPAEKIRAYIN
HHHHHHHEECCCEEEEEEECCEEEEEEEEECCCCCCCCCCCHHHHHHHCCCHHHHEEEEE
IRNFDEPGFIVMATGNGTVKKTGLDEFSRPRRNGIAAITIEENDELIDARLTDGDHQIIL
EECCCCCCEEEEECCCCCEEECCCHHHCCHHHCCEEEEEECCCCCEEEEEECCCCCEEEE
AKSSGYVVRFPESEIRSMGRTAMGVRGITLDADEKCISMVTTKRFDTTLLAVTDNGFGKR
EECCCCEEECCHHHHHHCCCHHHCEEEEEECCCHHHHHHHHHCCCCEEEEEEECCCCCCC
SRVEDYRLTKRGARGVITLKAHEKTGAMVGLLDVNDEDDLIIITNNGIVNRQHVSDIRLT
CCCHHHHHHHCCCCEEEEEEECCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCEEEEE
GRNTSGVRLIRLMAGDIISALARVPKSDEEIDPDSLPENPDGQIDLF
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]