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The map label for this gene is pyrG

Identifier: 119358425

GI number: 119358425

Start: 3053818

End: 3055515

Strand: Reverse

Name: pyrG

Synonym: Cpha266_2661

Alternate gene names: 119358425

Gene position: 3055515-3053818 (Counterclockwise)

Preceding gene: 119358426

Following gene: 119358420

Centisome position: 97.5

GC content: 54.18

Gene sequence:

>1698_bases
ATGGCACGCCCTAAAAATGTAAAGCATATTTTTGTTACCGGAGGGGTCATCTCCTCTCTTGGCAAAGGTATACTGTCGGC
GTCGCTCGGCATGCTGCTGAAATCAAGAGGGCTCAAAGTAGCCATACAGAAATACGACCCCTATATCAACGTCGATCCCG
GCACCATGTCCCCCTACCAGCACGGAGAGGTCTATGTAACCGACGACGGCGCTGAAACCGACCTTGATCTCGGCCACTAC
GAGCGATTCCTCGACGAAGCCACCTCCCAGGCATCGAACCTCACTATGGGAAGAGTCTACAAATCCGTCATCGACAAAGA
ACGGAGCGGCGAATATCTCGGCGGAACCGTGCAGGTCGTACCGCACGTCATCGACGAGATCAAAGACAGAATGGCCGAAC
TCGCCAAAAACGGCAACCTCGACGTACTCATCACCGAAATAGGCGGAACCATCGGCGACATCGAGTCCCTTCCCTTCCTC
GAAGCGATGCGGCAGATGAAGCTTGAAATGGGAGAGCGCAACCTGCTCAACATCCACCTCACCTTCGTGCCCTATATCAA
GGCCGCCTGCGAGCTCAAAACCAAGCCGACGCAGCACAGCGTCAAAATGCTCCTTGAAACCGGCATACAGCCCGATATTC
TCGTCTGCCGCAGCGAAAAACCGCTCTCCAGAGAGATCAAAAACAAGGTCGGCCACTTCTGCAACGTCAACGAACTCGAC
GTCATCGGGCTCAACGACTGCGACACCATCTACGAAGTGCCGCTCATGCTGCTCAAGGAGAAGCTCGACCTGCGCGTCAT
GAAAAAGCTCGGTCTCAAAAAATTCAGGGAACCGAACCTCGAATACTGGAGAGACTTCTGCAACAAGGTACTGCACCCCA
CAGAGGGCGAAGTAACCATCGGCGTCTGCGGCAAATACACCGAATACCCCGACGCCTACAAATCCATTCTCGAAGCATTT
ATCCATGCCGGCGCAAGCAACAACGTACGCGTCACCATCAAGCTGCTCCGGGCCGAAGACGCCGAAGCGGGATCGTTCGA
CTTCAAAAAAGAGATGCAGGGGGTCAGCGGAGTACTTGTAGCGCCCGGATTCGGCGATCGCGGCATCGAAGGTAAAATAA
GCTTCATCCGGTACGCCAGGGAGCAGAACATCCCCTTTTTCGGAATCTGTCTCGGCATGCAGTGCGCCACCATCGAGTTT
GCCCGCAACGTCTGCGGCCTGCATGACGCCAACTCCACCGAATTCAACAAACGAACCCGCTTTCCCGTTATCGACCTCAT
GGAACAGCAGAAAAAGGTCAAGGAAAAAGGCGGAACCATGCGGCTCGGCAGCTACCCCTGCATCATCAAAGAGGGCTCCA
AAGCCTACGACATCTACAAAAAATTTCTTATCAACGAACGGCACCGCCACCGCTTCGAATTCAACAACACCTATCGTAGC
GCGCTTGAAGAGCAGGGGATGGTCTTTTCCGGAACCTCGCCCAACGGCGAACTTGTCGAAATCATTGAACTCAAGGATCA
CCGCTGGTTTGTAGGGGTGCAGTTCCATCCCGAACTCAAATCGAGAGTGCAGCAGGTACACCCTCTCTTTCACGGCTTCG
TTGCCGCGGCAAAAGAGTACGAGAAAGGTTCCCGCCAGATGGAACTCACCGTCGACATGCCATCCTTCATGCCTGTTGAA
AACGAACCGGCGCAATAA

Upstream 100 bases:

>100_bases
GCTCGGCTGAGTGCCGCGCGCTCATCATGGTGCATGACCAGGAACCGCATCAGAGAGCGCAAAAGCCGATAATTATTAAT
ACTAAACGACGAATGACGTT

Downstream 100 bases:

>100_bases
CGCGCCGAATCCACAAAAAGCAGCCATACGGCCACGCTCACGCAGGAATCCCGACCCCCGTCGGGATTCCTCTGTTTCCG
CCCATTCCAGCCTGAATTCC

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MARPKNVKHIFVTGGVISSLGKGILSASLGMLLKSRGLKVAIQKYDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHY
ERFLDEATSQASNLTMGRVYKSVIDKERSGEYLGGTVQVVPHVIDEIKDRMAELAKNGNLDVLITEIGGTIGDIESLPFL
EAMRQMKLEMGERNLLNIHLTFVPYIKAACELKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNVNELD
VIGLNDCDTIYEVPLMLLKEKLDLRVMKKLGLKKFREPNLEYWRDFCNKVLHPTEGEVTIGVCGKYTEYPDAYKSILEAF
IHAGASNNVRVTIKLLRAEDAEAGSFDFKKEMQGVSGVLVAPGFGDRGIEGKISFIRYAREQNIPFFGICLGMQCATIEF
ARNVCGLHDANSTEFNKRTRFPVIDLMEQQKKVKEKGGTMRLGSYPCIIKEGSKAYDIYKKFLINERHRHRFEFNNTYRS
ALEEQGMVFSGTSPNGELVEIIELKDHRWFVGVQFHPELKSRVQQVHPLFHGFVAAAKEYEKGSRQMELTVDMPSFMPVE
NEPAQ

Sequences:

>Translated_565_residues
MARPKNVKHIFVTGGVISSLGKGILSASLGMLLKSRGLKVAIQKYDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHY
ERFLDEATSQASNLTMGRVYKSVIDKERSGEYLGGTVQVVPHVIDEIKDRMAELAKNGNLDVLITEIGGTIGDIESLPFL
EAMRQMKLEMGERNLLNIHLTFVPYIKAACELKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNVNELD
VIGLNDCDTIYEVPLMLLKEKLDLRVMKKLGLKKFREPNLEYWRDFCNKVLHPTEGEVTIGVCGKYTEYPDAYKSILEAF
IHAGASNNVRVTIKLLRAEDAEAGSFDFKKEMQGVSGVLVAPGFGDRGIEGKISFIRYAREQNIPFFGICLGMQCATIEF
ARNVCGLHDANSTEFNKRTRFPVIDLMEQQKKVKEKGGTMRLGSYPCIIKEGSKAYDIYKKFLINERHRHRFEFNNTYRS
ALEEQGMVFSGTSPNGELVEIIELKDHRWFVGVQFHPELKSRVQQVHPLFHGFVAAAKEYEKGSRQMELTVDMPSFMPVE
NEPAQ
>Mature_564_residues
ARPKNVKHIFVTGGVISSLGKGILSASLGMLLKSRGLKVAIQKYDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHYE
RFLDEATSQASNLTMGRVYKSVIDKERSGEYLGGTVQVVPHVIDEIKDRMAELAKNGNLDVLITEIGGTIGDIESLPFLE
AMRQMKLEMGERNLLNIHLTFVPYIKAACELKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNVNELDV
IGLNDCDTIYEVPLMLLKEKLDLRVMKKLGLKKFREPNLEYWRDFCNKVLHPTEGEVTIGVCGKYTEYPDAYKSILEAFI
HAGASNNVRVTIKLLRAEDAEAGSFDFKKEMQGVSGVLVAPGFGDRGIEGKISFIRYAREQNIPFFGICLGMQCATIEFA
RNVCGLHDANSTEFNKRTRFPVIDLMEQQKKVKEKGGTMRLGSYPCIIKEGSKAYDIYKKFLINERHRHRFEFNNTYRSA
LEEQGMVFSGTSPNGELVEIIELKDHRWFVGVQFHPELKSRVQQVHPLFHGFVAAAKEYEKGSRQMELTVDMPSFMPVEN
EPAQ

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=549, Percent_Identity=44.2622950819672, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI28559085, Length=556, Percent_Identity=42.9856115107914, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI28559083, Length=556, Percent_Identity=42.9856115107914, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI221316689, Length=556, Percent_Identity=42.9856115107914, Blast_Score=432, Evalue=1e-121,
Organism=Escherichia coli, GI1789142, Length=544, Percent_Identity=51.2867647058823, Blast_Score=540, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI25148299, Length=626, Percent_Identity=36.9009584664537, Blast_Score=389, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322563, Length=565, Percent_Identity=41.4159292035398, Blast_Score=419, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319432, Length=565, Percent_Identity=40.353982300885, Blast_Score=409, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24664469, Length=551, Percent_Identity=46.4609800362976, Blast_Score=458, Evalue=1e-129,
Organism=Drosophila melanogaster, GI21357815, Length=495, Percent_Identity=44.2424242424242, Blast_Score=385, Evalue=1e-107,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_CHLPD (A1BJR8)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_913069.1
- ProteinModelPortal:   A1BJR8
- SMR:   A1BJR8
- STRING:   A1BJR8
- GeneID:   4568765
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_2661
- NMPDR:   fig|290317.7.peg.2780
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 63732; Mature: 63601

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 390-390 ACT_SITE 516-516 ACT_SITE 518-518

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARPKNVKHIFVTGGVISSLGKGILSASLGMLLKSRGLKVAIQKYDPYINVDPGTMSPYQ
CCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCC
HGEVYVTDDGAETDLDLGHYERFLDEATSQASNLTMGRVYKSVIDKERSGEYLGGTVQVV
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHH
PHVIDEIKDRMAELAKNGNLDVLITEIGGTIGDIESLPFLEAMRQMKLEMGERNLLNIHL
HHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEE
TFVPYIKAACELKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNVNELD
EHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCEE
VIGLNDCDTIYEVPLMLLKEKLDLRVMKKLGLKKFREPNLEYWRDFCNKVLHPTEGEVTI
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHCCCCCCCEEE
GVCGKYTEYPDAYKSILEAFIHAGASNNVRVTIKLLRAEDAEAGSFDFKKEMQGVSGVLV
EECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCHHHHHCCCCEEEE
APGFGDRGIEGKISFIRYAREQNIPFFGICLGMQCATIEFARNVCGLHDANSTEFNKRTR
ECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
FPVIDLMEQQKKVKEKGGTMRLGSYPCIIKEGSKAYDIYKKFLINERHRHRFEFNNTYRS
CCHHHHHHHHHHHHHCCCEEEECCCCEEEECCCHHHHHHHHHHHCHHHHHCCCCCHHHHH
ALEEQGMVFSGTSPNGELVEIIELKDHRWFVGVQFHPELKSRVQQVHPLFHGFVAAAKEY
HHHHCCEEEECCCCCCCEEEEEEECCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
EKGSRQMELTVDMPSFMPVENEPAQ
HCCCCEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
ARPKNVKHIFVTGGVISSLGKGILSASLGMLLKSRGLKVAIQKYDPYINVDPGTMSPYQ
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCC
HGEVYVTDDGAETDLDLGHYERFLDEATSQASNLTMGRVYKSVIDKERSGEYLGGTVQVV
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHH
PHVIDEIKDRMAELAKNGNLDVLITEIGGTIGDIESLPFLEAMRQMKLEMGERNLLNIHL
HHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEE
TFVPYIKAACELKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNVNELD
EHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCEE
VIGLNDCDTIYEVPLMLLKEKLDLRVMKKLGLKKFREPNLEYWRDFCNKVLHPTEGEVTI
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHCCCCCCCEEE
GVCGKYTEYPDAYKSILEAFIHAGASNNVRVTIKLLRAEDAEAGSFDFKKEMQGVSGVLV
EECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCHHHHHCCCCEEEE
APGFGDRGIEGKISFIRYAREQNIPFFGICLGMQCATIEFARNVCGLHDANSTEFNKRTR
ECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
FPVIDLMEQQKKVKEKGGTMRLGSYPCIIKEGSKAYDIYKKFLINERHRHRFEFNNTYRS
CCHHHHHHHHHHHHHCCCEEEECCCCEEEECCCHHHHHHHHHHHCHHHHHCCCCCHHHHH
ALEEQGMVFSGTSPNGELVEIIELKDHRWFVGVQFHPELKSRVQQVHPLFHGFVAAAKEY
HHHHCCEEEECCCCCCCEEEEEEECCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
EKGSRQMELTVDMPSFMPVENEPAQ
HCCCCEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA