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The map label for this gene is pyrE

Identifier: 119358339

GI number: 119358339

Start: 2946470

End: 2947051

Strand: Direct

Name: pyrE

Synonym: Cpha266_2571

Alternate gene names: 119358339

Gene position: 2946470-2947051 (Clockwise)

Preceding gene: 119358338

Following gene: 119358340

Centisome position: 94.02

GC content: 57.22

Gene sequence:

>582_bases
ATGAATCAACCGCCAATGCTCGACATTTTCAGATCGACGGGAGCCCTGCTTGAGGGCCATTTCAAACTGACCTCAGGACG
TCACAGCAACACCTATTTCCAGTGTGCCAAAGTGCTGCAACACCCGGAACACCTCAGCGCTGTCTGTCATAAAATTGCCG
CGCACTTCAGTCAGAAAGGTGTCGACACCGTCATCTCGCCCGCTATCGGCGGCATAGTTGCAGGAACGGAAACAGGCCGT
CAGCTCGGCGTTAAAACCATCTTTGCCGAACGCAAGGATGGCCGTATGACCATCCGTCGCGGATTCAGCGTTGCCCCGGG
CGAAAAAGTGCTTGTCATCGAAGATGTCATTACCACCGGCGGCTCCGTTCAGGAAGTGATCGAACTGCTCAAAAACGCCG
GCGCCCTCATTATCGGAGTCGGTTGCGTCGTAGACCGCAGCAACGGAAAAGTCCGGCTGACCGACGACCAGTACGCCGTC
CTTTCGATGGAGGTCGTCAGCTACGCCCCCGAAGAGTGCCCACTCTGCAAGGAAGGCATGCCGATCGATGCCCCCGGAAG
CCGGGCAAATCAGCAGCCGTGA

Upstream 100 bases:

>100_bases
GAAAGCACCCCCGCAGAGACTTTTTCTCGCAACGATTGTGGAAAACCGGTTCTTTATCTTTAGCTTATATGACTTGTATG
TATCTTCATCTTTTTATGTC

Downstream 100 bases:

>100_bases
TCCGTATGAGCCCTAACCCGCCAATACGAAGCATCTCCTTTATCGGTCTCGGACTGATAGGAGTCTCCCTTTTGCGAGCC
TTTCGGAACGCCCCCATCAT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MNQPPMLDIFRSTGALLEGHFKLTSGRHSNTYFQCAKVLQHPEHLSAVCHKIAAHFSQKGVDTVISPAIGGIVAGTETGR
QLGVKTIFAERKDGRMTIRRGFSVAPGEKVLVIEDVITTGGSVQEVIELLKNAGALIIGVGCVVDRSNGKVRLTDDQYAV
LSMEVVSYAPEECPLCKEGMPIDAPGSRANQQP

Sequences:

>Translated_193_residues
MNQPPMLDIFRSTGALLEGHFKLTSGRHSNTYFQCAKVLQHPEHLSAVCHKIAAHFSQKGVDTVISPAIGGIVAGTETGR
QLGVKTIFAERKDGRMTIRRGFSVAPGEKVLVIEDVITTGGSVQEVIELLKNAGALIIGVGCVVDRSNGKVRLTDDQYAV
LSMEVVSYAPEECPLCKEGMPIDAPGSRANQQP
>Mature_193_residues
MNQPPMLDIFRSTGALLEGHFKLTSGRHSNTYFQCAKVLQHPEHLSAVCHKIAAHFSQKGVDTVISPAIGGIVAGTETGR
QLGVKTIFAERKDGRMTIRRGFSVAPGEKVLVIEDVITTGGSVQEVIELLKNAGALIIGVGCVVDRSNGKVRLTDDQYAV
LSMEVVSYAPEECPLCKEGMPIDAPGSRANQQP

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_CHLPD (A1BJI2)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912983.1
- ProteinModelPortal:   A1BJI2
- SMR:   A1BJI2
- STRING:   A1BJI2
- GeneID:   4569086
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_2571
- NMPDR:   fig|290317.7.peg.2690
- eggNOG:   COG0461
- HOGENOM:   HBG404341
- OMA:   FYLQSAK
- ProtClustDB:   PRK00455
- HAMAP:   MF_01208
- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01367

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 20697; Mature: 20697

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 118-118 BINDING 146-146

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQPPMLDIFRSTGALLEGHFKLTSGRHSNTYFQCAKVLQHPEHLSAVCHKIAAHFSQKG
CCCCCHHHHHHHCCCCEECEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
VDTVISPAIGGIVAGTETGRQLGVKTIFAERKDGRMTIRRGFSVAPGEKVLVIEDVITTG
HHHHHHHHHCCEEECCCCCHHHHHHHHEECCCCCCEEEECCCCCCCCCEEEEEEEHHHCC
GSVQEVIELLKNAGALIIGVGCVVDRSNGKVRLTDDQYAVLSMEVVSYAPEECPLCKEGM
CCHHHHHHHHHCCCEEEEEEEEEEECCCCEEEEECCCEEEEEHHHHHHCCCCCCCCCCCC
PIDAPGSRANQQP
CCCCCCCCCCCCC
>Mature Secondary Structure
MNQPPMLDIFRSTGALLEGHFKLTSGRHSNTYFQCAKVLQHPEHLSAVCHKIAAHFSQKG
CCCCCHHHHHHHCCCCEECEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
VDTVISPAIGGIVAGTETGRQLGVKTIFAERKDGRMTIRRGFSVAPGEKVLVIEDVITTG
HHHHHHHHHCCEEECCCCCHHHHHHHHEECCCCCCEEEECCCCCCCCCEEEEEEEHHHCC
GSVQEVIELLKNAGALIIGVGCVVDRSNGKVRLTDDQYAVLSMEVVSYAPEECPLCKEGM
CCHHHHHHHHHCCCEEEEEEEEEEECCCCEEEEECCCEEEEEHHHHHHCCCCCCCCCCCC
PIDAPGSRANQQP
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA