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The map label for this gene is hemL

Identifier: 119358325

GI number: 119358325

Start: 2932812

End: 2934107

Strand: Direct

Name: hemL

Synonym: Cpha266_2557

Alternate gene names: 119358325

Gene position: 2932812-2934107 (Clockwise)

Preceding gene: 119358324

Following gene: 119358329

Centisome position: 93.58

GC content: 54.86

Gene sequence:

>1296_bases
ATGCTTCAACACACCAAATCAGCAGAACTCTTTGAAAAAGCAAAGCAGTTTATTCCCGGCGGCGTAAACTCTCCGGTTCG
CGCATTTAAATCCGTCGGCGGCACGCCGATTTACATGGCTAAAGGCAGAGGCGCCTACCTTACCGATGTTGATGGCAACA
GCTACCTTGACTATGTCGGTTCATGGGGCCCGTTTATCCTCGGCAGCATGCACCCCAGAATCACGGCGGCGCTTGAGTAT
ACCCTCAAAAATATCGGCACAAGCTTCGGCACCCCGATCGAGATGGAAATCGAAATCGCTGAACTGCTCTGTAAAATCGT
ACCCTCTCTTGAAATGGTCCGCATGGTCAACAGCGGCACCGAAGCGACCATGTCGGCGGTACGCCTTGCCCGAGGATACA
CCGGACGCGATAAAATCATCAAATTCGAAGGGTGCTATCATGGCCACGGCGACAGCTTCCTCATCAAAGCCGGCTCGGGC
GCGCTCACGCTCGGAGCCCCCGACAGCCCCGGCGTCACCAAAGGAACAGCCCTCGACACCCTCAACGCCACCTACAACGA
CATCGAATCGGTAAAACTCCTCGTCGAGGAAAACAAGAACAACATTGCCGCAATCATCATCGAACCGGTTGCCGGCAACA
CCGGGGTCATACCCGCAAAACCGGGATTCCTTGCAGACCTACGCAACCTTTGCGACCAGAACGGCATTGTCCTGATTTTT
GATGAAGTCATGTGTGGCTTCCGCGTTGCGCTCGGCGGAGCACAAAGCCTCTACGGAGTAACGCCCGACCTGACCACCAT
GGGTAAAATCATCGGCGGCGGCCTTCCTGTCGGAGCATTCGGCGGAAAACGCAAAATCATGGAACGCGTAGCCCCGCTTG
GCGACGTCTATCAGGCAGGCACCCTGTCCGGCAACCCGCTGGCGCTCACCGCCGGTCTCGAGACCCTCAAAATCCTCATG
GACGAAAATCCATATCCGGAACTTGAAAGAAAGGCGGCAATACTTGAAGCCGGCTTCCGCGACAACATGCAGAAACTCGG
ACTCAACTTCGTACAGAACCGCGTCGGCTCCATGGCCTGCCTCTTCTTCACCGAAACACCGGTCGAAAGCTATGCCAGCG
CCATCACCGCCGACATCAGGAAATACGGAAAATATTTCCACTCCATGCTCGAACAAGGAATCTATCTCGCCCCGTCGCAA
TTCGAGGCCATGTTCACCAGCAGCATGCATACCGATGAAGATCTCGATAAAACCATCAAAGCAAACTTCAACGCGCTGCA
GATTGCATGCAGTTGA

Upstream 100 bases:

>100_bases
AGGATTTCTGTTTTCTATCTTCAGGAGTATTTCTATCTTGACGGGATATTTTCTTACACTCTTCATGCGTCTTTTTCAAT
CCAAAACCGTATAGCCTGAA

Downstream 100 bases:

>100_bases
CCGTTTTATTACCGTACAAAAAAAAAGGGAAGCCTCACCGCTTCCCTTTTTTTTCTCATTCCGCATAAGCACGAAAAACT
ACTCGATAATACCCGAGCGA

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLQHTKSAELFEKAKQFIPGGVNSPVRAFKSVGGTPIYMAKGRGAYLTDVDGNSYLDYVGSWGPFILGSMHPRITAALEY
TLKNIGTSFGTPIEMEIEIAELLCKIVPSLEMVRMVNSGTEATMSAVRLARGYTGRDKIIKFEGCYHGHGDSFLIKAGSG
ALTLGAPDSPGVTKGTALDTLNATYNDIESVKLLVEENKNNIAAIIIEPVAGNTGVIPAKPGFLADLRNLCDQNGIVLIF
DEVMCGFRVALGGAQSLYGVTPDLTTMGKIIGGGLPVGAFGGKRKIMERVAPLGDVYQAGTLSGNPLALTAGLETLKILM
DENPYPELERKAAILEAGFRDNMQKLGLNFVQNRVGSMACLFFTETPVESYASAITADIRKYGKYFHSMLEQGIYLAPSQ
FEAMFTSSMHTDEDLDKTIKANFNALQIACS

Sequences:

>Translated_431_residues
MLQHTKSAELFEKAKQFIPGGVNSPVRAFKSVGGTPIYMAKGRGAYLTDVDGNSYLDYVGSWGPFILGSMHPRITAALEY
TLKNIGTSFGTPIEMEIEIAELLCKIVPSLEMVRMVNSGTEATMSAVRLARGYTGRDKIIKFEGCYHGHGDSFLIKAGSG
ALTLGAPDSPGVTKGTALDTLNATYNDIESVKLLVEENKNNIAAIIIEPVAGNTGVIPAKPGFLADLRNLCDQNGIVLIF
DEVMCGFRVALGGAQSLYGVTPDLTTMGKIIGGGLPVGAFGGKRKIMERVAPLGDVYQAGTLSGNPLALTAGLETLKILM
DENPYPELERKAAILEAGFRDNMQKLGLNFVQNRVGSMACLFFTETPVESYASAITADIRKYGKYFHSMLEQGIYLAPSQ
FEAMFTSSMHTDEDLDKTIKANFNALQIACS
>Mature_431_residues
MLQHTKSAELFEKAKQFIPGGVNSPVRAFKSVGGTPIYMAKGRGAYLTDVDGNSYLDYVGSWGPFILGSMHPRITAALEY
TLKNIGTSFGTPIEMEIEIAELLCKIVPSLEMVRMVNSGTEATMSAVRLARGYTGRDKIIKFEGCYHGHGDSFLIKAGSG
ALTLGAPDSPGVTKGTALDTLNATYNDIESVKLLVEENKNNIAAIIIEPVAGNTGVIPAKPGFLADLRNLCDQNGIVLIF
DEVMCGFRVALGGAQSLYGVTPDLTTMGKIIGGGLPVGAFGGKRKIMERVAPLGDVYQAGTLSGNPLALTAGLETLKILM
DENPYPELERKAAILEAGFRDNMQKLGLNFVQNRVGSMACLFFTETPVESYASAITADIRKYGKYFHSMLEQGIYLAPSQ
FEAMFTSSMHTDEDLDKTIKANFNALQIACS

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=328, Percent_Identity=29.8780487804878, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI13994255, Length=324, Percent_Identity=29.6296296296296, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI37574042, Length=307, Percent_Identity=29.3159609120521, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI24119277, Length=304, Percent_Identity=26.6447368421053, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI226442705, Length=308, Percent_Identity=29.8701298701299, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI226442709, Length=276, Percent_Identity=29.7101449275362, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI284507298, Length=247, Percent_Identity=29.9595141700405, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786349, Length=418, Percent_Identity=55.5023923444976, Blast_Score=475, Evalue=1e-135,
Organism=Escherichia coli, GI1789016, Length=346, Percent_Identity=34.1040462427746, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1789759, Length=331, Percent_Identity=31.4199395770393, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788044, Length=292, Percent_Identity=33.9041095890411, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1787560, Length=373, Percent_Identity=29.7587131367292, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI145693181, Length=334, Percent_Identity=28.4431137724551, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1786991, Length=335, Percent_Identity=28.0597014925373, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71992977, Length=338, Percent_Identity=29.8816568047337, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=322, Percent_Identity=27.639751552795, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=340, Percent_Identity=29.7058823529412, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI25144274, Length=140, Percent_Identity=32.8571428571429, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=329, Percent_Identity=27.355623100304, Blast_Score=103, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6324432, Length=363, Percent_Identity=26.4462809917355, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357415, Length=300, Percent_Identity=27.3333333333333, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_CHLPD (A1BJG8)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912969.1
- ProteinModelPortal:   A1BJG8
- SMR:   A1BJG8
- STRING:   A1BJG8
- GeneID:   4569013
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_2557
- NMPDR:   fig|290317.7.peg.2674
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   VGCFGGK
- ProtClustDB:   PRK00062
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46316; Mature: 46316

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQHTKSAELFEKAKQFIPGGVNSPVRAFKSVGGTPIYMAKGRGAYLTDVDGNSYLDYVG
CCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCCCCHHHHHC
SWGPFILGSMHPRITAALEYTLKNIGTSFGTPIEMEIEIAELLCKIVPSLEMVRMVNSGT
CCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHCCHHHHHHHCCCH
EATMSAVRLARGYTGRDKIIKFEGCYHGHGDSFLIKAGSGALTLGAPDSPGVTKGTALDT
HHHHHHHHHHCCCCCCCCEEEEECEECCCCCEEEEEECCCEEEECCCCCCCCCCCCCHHC
LNATYNDIESVKLLVEENKNNIAAIIIEPVAGNTGVIPAKPGFLADLRNLCDQNGIVLIF
CCCCHHHHHHEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEE
DEVMCGFRVALGGAQSLYGVTPDLTTMGKIIGGGLPVGAFGGKRKIMERVAPLGDVYQAG
HHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHCC
TLSGNPLALTAGLETLKILMDENPYPELERKAAILEAGFRDNMQKLGLNFVQNRVGSMAC
CCCCCCEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
LFFTETPVESYASAITADIRKYGKYFHSMLEQGIYLAPSQFEAMFTSSMHTDEDLDKTIK
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHCCCCCHHHHHHHH
ANFNALQIACS
CCCCEEEEEEC
>Mature Secondary Structure
MLQHTKSAELFEKAKQFIPGGVNSPVRAFKSVGGTPIYMAKGRGAYLTDVDGNSYLDYVG
CCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCEEEECCCCCHHHHHC
SWGPFILGSMHPRITAALEYTLKNIGTSFGTPIEMEIEIAELLCKIVPSLEMVRMVNSGT
CCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHCCHHHHHHHCCCH
EATMSAVRLARGYTGRDKIIKFEGCYHGHGDSFLIKAGSGALTLGAPDSPGVTKGTALDT
HHHHHHHHHHCCCCCCCCEEEEECEECCCCCEEEEEECCCEEEECCCCCCCCCCCCCHHC
LNATYNDIESVKLLVEENKNNIAAIIIEPVAGNTGVIPAKPGFLADLRNLCDQNGIVLIF
CCCCHHHHHHEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEE
DEVMCGFRVALGGAQSLYGVTPDLTTMGKIIGGGLPVGAFGGKRKIMERVAPLGDVYQAG
HHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHCC
TLSGNPLALTAGLETLKILMDENPYPELERKAAILEAGFRDNMQKLGLNFVQNRVGSMAC
CCCCCCEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
LFFTETPVESYASAITADIRKYGKYFHSMLEQGIYLAPSQFEAMFTSSMHTDEDLDKTIK
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHCCCCCHHHHHHHH
ANFNALQIACS
CCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA