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The map label for this gene is atpA [H]

Identifier: 119358312

GI number: 119358312

Start: 2921353

End: 2922933

Strand: Reverse

Name: atpA [H]

Synonym: Cpha266_2544

Alternate gene names: 119358312

Gene position: 2922933-2921353 (Counterclockwise)

Preceding gene: 119358316

Following gene: 119358311

Centisome position: 93.27

GC content: 51.68

Gene sequence:

>1581_bases
ATGTCTACAACAGTCAGGCCTGATGAGGTTTCATCCATACTTCGCAAGCAGCTTGCCGGTTTTGAGTCCGAGGCTGATGT
CTACGATGTGGGAACAGTTTTGCAGGTTGGTGACGGTATCGCCCGTGTGTATGGATTATCCAAGGCGGCTGCCGGTGAAC
TTCTTGAGTTTCCCAACAAGGTGATGGGTATGGCGCTTAACCTTGAAGAAGACAATGTCGGCGCGGTATTGTTCGGAGAA
TCCAATCTGGTTAAAGAGGGCGATACGGTTAAACGAACCGGTATTCTTGCCTCTATCCCGGTTGGCGAGGCTATGCTTGG
AAGGGTCATCAATCCTCTGGGAGAGCCGATTGACGGAAAAGGGCCGATCGAAACACAGATCAGGCTTCCGCTCGAGCGCA
GGGCACCTGGCGTTATCTACCGTAAATCAGTGCATGAACCGCTTCAGACCGGACTCAAGGCGATCGACTCGATGATTCCT
ATCGGCCGCGGACAGCGCGAGCTTATTATTGGCGATCGTCAGACCGGAAAGACGGCGGTTGCAATCGATACCATTATCAA
CCAGAAGGGCAAGGGCGTTTTCTGTATCTATGTCGCTATCGGTCTGAAAGGGTCAACGGTGGCTCAGGTGGTCAATACGC
TTGAGAAATTCGGCGCCATGGAGTATACCACGGTTATTACGGCTACGGCTTCCGATCCGGCGCCTCTTCAGTTTATCGCT
CCGTTCGCAGGCGCTACTCTTGGCGAGTATTTCCGCGATACCGGCCGCCACGCGCTGGTTGTTTATGACGATCTTTCAAA
GCAGGCTGTTGCCTATCGCCAGCTCTCCCTGCTCCTTCGCCGTCCGCCGGGACGCGAAGCATATCCCGGCGATGTATTCT
ATTTACATTCCCGTCTTCTCGAAAGGGCTGCAAAGATTACTGATGATATTGAGGTTGCAAGGAAGATGAACGATCTTCCC
GATGCGCTCAAATCGATGGTTAAAGGCGGCGGCAGTCTTACTGCGCTTCCTGTTATTGAAACCCAGGCGGGTGACGTTTC
CGCGTATATTCCGACCAACGTTATTTCGATTACCGATGGTCAGATTTTTCTTGAGTCGAACCTTTTCAATTCGGGTCAGC
GGCCTGCAATCAACGTTGGTATTTCGGTATCCCGCGTTGGTGGTTCTGCACAGATCAAGGCAATGAAAAAGGTTGCCGGT
ACCCTGCGACTCGATCTTGCGCAGTTCCGTGAACTTGAGGCTTTCTCGAAATTCGGTTCGGATCTTGATAAAACCACGAA
AGCGCAGCTTGACAGAGGCGCAAGACTGGTCGAGATTCTCAAGCAGGGCCAGTATATTCCAATGGCTGTTGAAAAACAGG
TTGCCATCATCTTCCTTGGTACTCAGGGTTTGCTTGATGCTGTCGATGTAACGCGTATTCGCAAGTTTGAAGAGGAGTTC
CTTGGGTTGCTTGAGCACAAGCATCCGGAAGTGCTCAAGGCGATTGCCGAAACGGGCACTCTTGAAACCGATACCGCTAA
CAAGATCAAGGAGGCAGCGCAGAAGTTTATCGCTTCCTTCAACCAGAAAGCAAAGGCGTAA

Upstream 100 bases:

>100_bases
CTTTCATTTTTTGGAAAAGTAACAGACCGCTTTGATTTTCAAAAGAAGGTAAGCAGAATCTTGCTCTTTTCTTACAAACA
AATAACCAAGCGAATAAGAT

Downstream 100 bases:

>100_bases
GAGAGGCATAAGGGCGCCTCTGAATATGGCCGCTGTTGTTGACGTTGTCGCGTCAATGCGCGGAACTGCTCAGGGGTGTC
TGCAAGGTTTATCAAGCAAT

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MSTTVRPDEVSSILRKQLAGFESEADVYDVGTVLQVGDGIARVYGLSKAAAGELLEFPNKVMGMALNLEEDNVGAVLFGE
SNLVKEGDTVKRTGILASIPVGEAMLGRVINPLGEPIDGKGPIETQIRLPLERRAPGVIYRKSVHEPLQTGLKAIDSMIP
IGRGQRELIIGDRQTGKTAVAIDTIINQKGKGVFCIYVAIGLKGSTVAQVVNTLEKFGAMEYTTVITATASDPAPLQFIA
PFAGATLGEYFRDTGRHALVVYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAAKITDDIEVARKMNDLP
DALKSMVKGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLESNLFNSGQRPAINVGISVSRVGGSAQIKAMKKVAG
TLRLDLAQFRELEAFSKFGSDLDKTTKAQLDRGARLVEILKQGQYIPMAVEKQVAIIFLGTQGLLDAVDVTRIRKFEEEF
LGLLEHKHPEVLKAIAETGTLETDTANKIKEAAQKFIASFNQKAKA

Sequences:

>Translated_526_residues
MSTTVRPDEVSSILRKQLAGFESEADVYDVGTVLQVGDGIARVYGLSKAAAGELLEFPNKVMGMALNLEEDNVGAVLFGE
SNLVKEGDTVKRTGILASIPVGEAMLGRVINPLGEPIDGKGPIETQIRLPLERRAPGVIYRKSVHEPLQTGLKAIDSMIP
IGRGQRELIIGDRQTGKTAVAIDTIINQKGKGVFCIYVAIGLKGSTVAQVVNTLEKFGAMEYTTVITATASDPAPLQFIA
PFAGATLGEYFRDTGRHALVVYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAAKITDDIEVARKMNDLP
DALKSMVKGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLESNLFNSGQRPAINVGISVSRVGGSAQIKAMKKVAG
TLRLDLAQFRELEAFSKFGSDLDKTTKAQLDRGARLVEILKQGQYIPMAVEKQVAIIFLGTQGLLDAVDVTRIRKFEEEF
LGLLEHKHPEVLKAIAETGTLETDTANKIKEAAQKFIASFNQKAKA
>Mature_525_residues
STTVRPDEVSSILRKQLAGFESEADVYDVGTVLQVGDGIARVYGLSKAAAGELLEFPNKVMGMALNLEEDNVGAVLFGES
NLVKEGDTVKRTGILASIPVGEAMLGRVINPLGEPIDGKGPIETQIRLPLERRAPGVIYRKSVHEPLQTGLKAIDSMIPI
GRGQRELIIGDRQTGKTAVAIDTIINQKGKGVFCIYVAIGLKGSTVAQVVNTLEKFGAMEYTTVITATASDPAPLQFIAP
FAGATLGEYFRDTGRHALVVYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAAKITDDIEVARKMNDLPD
ALKSMVKGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLESNLFNSGQRPAINVGISVSRVGGSAQIKAMKKVAGT
LRLDLAQFRELEAFSKFGSDLDKTTKAQLDRGARLVEILKQGQYIPMAVEKQVAIIFLGTQGLLDAVDVTRIRKFEEEFL
GLLEHKHPEVLKAIAETGTLETDTANKIKEAAQKFIASFNQKAKA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=520, Percent_Identity=60, Blast_Score=632, Evalue=0.0,
Organism=Homo sapiens, GI4757810, Length=520, Percent_Identity=60, Blast_Score=632, Evalue=0.0,
Organism=Homo sapiens, GI19913428, Length=416, Percent_Identity=26.2019230769231, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI19913426, Length=424, Percent_Identity=27.122641509434, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI32189394, Length=440, Percent_Identity=24.7727272727273, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI19913424, Length=275, Percent_Identity=25.8181818181818, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790172, Length=512, Percent_Identity=55.2734375, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1790170, Length=356, Percent_Identity=24.7191011235955, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788251, Length=290, Percent_Identity=27.5862068965517, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71988063, Length=520, Percent_Identity=60, Blast_Score=638, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988080, Length=520, Percent_Identity=60, Blast_Score=636, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988074, Length=520, Percent_Identity=56.7307692307692, Blast_Score=580, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI17570191, Length=430, Percent_Identity=26.046511627907, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17510931, Length=460, Percent_Identity=25.4347826086956, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI25144756, Length=445, Percent_Identity=23.8202247191011, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=60, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71988068, Length=75, Percent_Identity=48, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17565854, Length=266, Percent_Identity=26.6917293233083, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=527, Percent_Identity=59.7722960151803, Blast_Score=639, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319603, Length=411, Percent_Identity=28.2238442822384, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6322581, Length=442, Percent_Identity=25.5656108597285, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24658560, Length=529, Percent_Identity=59.5463137996219, Blast_Score=641, Evalue=0.0,
Organism=Drosophila melanogaster, GI281361666, Length=414, Percent_Identity=26.5700483091787, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646341, Length=414, Percent_Identity=26.5700483091787, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17136796, Length=414, Percent_Identity=26.5700483091787, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24638766, Length=470, Percent_Identity=25.7446808510638, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI28574560, Length=424, Percent_Identity=24.2924528301887, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583992, Length=332, Percent_Identity=25.9036144578313, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583988, Length=283, Percent_Identity=25.0883392226148, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583986, Length=283, Percent_Identity=25.0883392226148, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583984, Length=283, Percent_Identity=25.0883392226148, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20129479, Length=267, Percent_Identity=26.9662921348315, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 56820; Mature: 56689

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTVRPDEVSSILRKQLAGFESEADVYDVGTVLQVGDGIARVYGLSKAAAGELLEFPNK
CCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHCCHH
VMGMALNLEEDNVGAVLFGESNLVKEGDTVKRTGILASIPVGEAMLGRVINPLGEPIDGK
HHCEEEEECCCCCCEEEECCCCCCCCCCCCHHCCCEEECCCCHHHHHHHHHHHCCCCCCC
GPIETQIRLPLERRAPGVIYRKSVHEPLQTGLKAIDSMIPIGRGQRELIIGDRQTGKTAV
CCCCEEEECCHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEE
AIDTIINQKGKGVFCIYVAIGLKGSTVAQVVNTLEKFGAMEYTTVITATASDPAPLQFIA
EHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEC
PFAGATLGEYFRDTGRHALVVYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLL
CHHCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ERAAKITDDIEVARKMNDLPDALKSMVKGGGSLTALPVIETQAGDVSAYIPTNVISITDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCEEEEECC
QIFLESNLFNSGQRPAINVGISVSRVGGSAQIKAMKKVAGTLRLDLAQFRELEAFSKFGS
EEEEECCCCCCCCCCEEEECEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DLDKTTKAQLDRGARLVEILKQGQYIPMAVEKQVAIIFLGTQGLLDAVDVTRIRKFEEEF
CHHHHHHHHHHCCHHHHHHHHCCCCCCEEECCEEEEEEECCCCHHHHHHHHHHHHHHHHH
LGLLEHKHPEVLKAIAETGTLETDTANKIKEAAQKFIASFNQKAKA
HHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STTVRPDEVSSILRKQLAGFESEADVYDVGTVLQVGDGIARVYGLSKAAAGELLEFPNK
CCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHCCHH
VMGMALNLEEDNVGAVLFGESNLVKEGDTVKRTGILASIPVGEAMLGRVINPLGEPIDGK
HHCEEEEECCCCCCEEEECCCCCCCCCCCCHHCCCEEECCCCHHHHHHHHHHHCCCCCCC
GPIETQIRLPLERRAPGVIYRKSVHEPLQTGLKAIDSMIPIGRGQRELIIGDRQTGKTAV
CCCCEEEECCHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEE
AIDTIINQKGKGVFCIYVAIGLKGSTVAQVVNTLEKFGAMEYTTVITATASDPAPLQFIA
EHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEC
PFAGATLGEYFRDTGRHALVVYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLL
CHHCCHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ERAAKITDDIEVARKMNDLPDALKSMVKGGGSLTALPVIETQAGDVSAYIPTNVISITDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCEEEEECC
QIFLESNLFNSGQRPAINVGISVSRVGGSAQIKAMKKVAGTLRLDLAQFRELEAFSKFGS
EEEEECCCCCCCCCCEEEECEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DLDKTTKAQLDRGARLVEILKQGQYIPMAVEKQVAIIFLGTQGLLDAVDVTRIRKFEEEF
CHHHHHHHHHHCCHHHHHHHHCCCCCCEEECCEEEEEEECCCCHHHHHHHHHHHHHHHHH
LGLLEHKHPEVLKAIAETGTLETDTANKIKEAAQKFIASFNQKAKA
HHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]