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The map label for this gene is thrS [H]

Identifier: 119358269

GI number: 119358269

Start: 2868951

End: 2870978

Strand: Direct

Name: thrS [H]

Synonym: Cpha266_2501

Alternate gene names: 119358269

Gene position: 2868951-2870978 (Clockwise)

Preceding gene: 119358268

Following gene: 119358270

Centisome position: 91.55

GC content: 51.78

Gene sequence:

>2028_bases
ATGCAGCCTTTGCTGCGGCAGCGGATAGAAACGACAAGTTATAAAATGTCAGACAATCAGGAACAAAAGGCTTTCATAGC
TATTACCCTGCCCGACGGGAGCATACGCTCTTTCCCTTACGGCAGCACGGGATTGGATATTGCCCTTTCAATCGGGCGCA
AGCTGGCACAGGACGCACTTGCGATTACCTTTGAAGGCAAAGCGCTCGAACTCGACACGCCCCTGACCGAAAGCGGGCAC
ATGGAAATACTCACATTCGACAGCCCTGAAGGCAAAGAGATTTTCTGGCACAGTTCGAGCCACCTCATGGCCCAGGCCAT
CGAAGAGCTCTTTGCAGGCACCAGATTCGGTGCCGGACCGGCCATTGAACAGGGCTTTTACTACGACATCGCTTCCGATC
ACCGGTTTCGTGAAGAAGATCTTCGCGCCATTGAGCTGCGCATGATCGAAATAAGCAAACGAGAGAGCCAAATCAACCGC
CGGGAGATGAGTCGCGAAGAGGCCATCGAGTTTTTCAAAACCGTCAGGAATGATCCCTATAAGGTCGAAATTCTTGAAGA
TACCCTCAAAAACACTCCGGTTGTCTCTCTGTACGAGCAAGAGAACTTCACCGATCTCTGCAGCGGCCCGCATCTGCATT
CGACCTCTAAAATAAAAGCCGTACAACTGACCAATATCTCCACATCGTACTGGCGCGGAGACTCCTCGCGCGAGAGCATG
CAGAGGATTTACGGCATCACGTTTCCCTCCGAAAAACTTCTCAAAGAGCATACAGCAAGAGTTGAAGAGGCAAAACGCAG
AGACCACCGCAAACTCGGCGCCGAACTTGAGCTATTCATGCTTTCGCCGGAGATAGGCAGCGGACTGCCAGTCTGGCTAC
CGAAAGGAGCCATCATCCGCAACGAGCTCGAAACCTTTTTGAAAGAAGAGCAGCGCAAACGCGGCTATCTTCCGGTCTAT
ACGCCGCATATCGGCAATATAGAACTCTATAAACGCTCGGGGCATTACCCGTACTACAGTGATTCGCAGTTTCCGCCGCT
CACCTATCATGATGAGAATGGAAAACAGGAGCAGTACCTCCTCAAACCCATGAACTGCCCGCATCACCATCTGATATACA
ACGTCAAACTCCGCAGTTACAGAGACCTGCCCATTCGGCTTGCGGAATTCGGAACGGTCTACCGTCACGAACAGTCGGGC
GAGCTGAACGGCCTTGTACGAGCTCGGGGATTTACACAGGACGATTCACATATCTACTGCCGGCCAGACCAGCTTGTTGA
CGAAATCTGCAATGCCATCGACCTGACACAGCATGTTTTTGCCACACTGGGATTCTCTGACGTGCAGACGCGCCTCTCCA
TGCATGACCCTCTGAACCAGGAAAAATATGGCGGAACTCCGGAGGTCTGGGAGCAGGCGGAAAAGGATGTAACCGAAGCG
GCCAACCGTATGGGAATCAACTATGTTATCGGCATAGGCGAAGCGAGTTTCTACGGCCCTAAAATCGACTTTATTGTCCG
TGATGCCATCGGAAGAAAGTGGCAACTCGGCACCGTGCAGGTCGACTACGTCATGCCGGAACGATTCGACCTTTCCTATA
TTGGCAGTGACAGTCAGAAACACAGGCCGATCGTGATCCACCGGGCGCCATTCGGATCCATGGAACGATTTATCGGCGTC
CTCATTGAACATACAGCAGGGAACTTCCCGCTCTGGCTTGCACCTGTTCAGGCCATTATCATGCCGCTTGGTGAAGAGAT
TCATGCGTATGCAAAAAGCATCCACGAAAAACTTCTGCATTCGGGCATCCGGGCCGAACTTGATCTGAGAAATGAAAAAA
TCGGCAAAAAAATCAGGGAAGCCGAAATCGGAAAGCTTCCCTACATGATTATTATCGGCCAGAAAGAGCTCGAGAGCGGT
CAACTATCGCTCCGGCGCCACCGCACCGGTGACGAAGGTCTTTTCACCACAGACTCGCTGATAGACAAGCTCAAAAAGGA
AATAGCGGCAAAAACCCTGATCCTCTAA

Upstream 100 bases:

>100_bases
TCGGGGATAGCAGTGTAAACTGATCAGCCCTCCCGACCGGGCGATACCAACAATAAGCGGCTGATTACACCTCTCATTAT
AAAAAGAGAGAACCTCTGCA

Downstream 100 bases:

>100_bases
ACAAACCTTGATCGCATGAAGAAACAGAAGACCACGACTCAGAAACCGAAACTTTCCTACAGGATCAATGAACAGATCCG
TGTTCCGGAAGTCAGGATTA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 675; Mature: 675

Protein sequence:

>675_residues
MQPLLRQRIETTSYKMSDNQEQKAFIAITLPDGSIRSFPYGSTGLDIALSIGRKLAQDALAITFEGKALELDTPLTESGH
MEILTFDSPEGKEIFWHSSSHLMAQAIEELFAGTRFGAGPAIEQGFYYDIASDHRFREEDLRAIELRMIEISKRESQINR
REMSREEAIEFFKTVRNDPYKVEILEDTLKNTPVVSLYEQENFTDLCSGPHLHSTSKIKAVQLTNISTSYWRGDSSRESM
QRIYGITFPSEKLLKEHTARVEEAKRRDHRKLGAELELFMLSPEIGSGLPVWLPKGAIIRNELETFLKEEQRKRGYLPVY
TPHIGNIELYKRSGHYPYYSDSQFPPLTYHDENGKQEQYLLKPMNCPHHHLIYNVKLRSYRDLPIRLAEFGTVYRHEQSG
ELNGLVRARGFTQDDSHIYCRPDQLVDEICNAIDLTQHVFATLGFSDVQTRLSMHDPLNQEKYGGTPEVWEQAEKDVTEA
ANRMGINYVIGIGEASFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLSYIGSDSQKHRPIVIHRAPFGSMERFIGV
LIEHTAGNFPLWLAPVQAIIMPLGEEIHAYAKSIHEKLLHSGIRAELDLRNEKIGKKIREAEIGKLPYMIIIGQKELESG
QLSLRRHRTGDEGLFTTDSLIDKLKKEIAAKTLIL

Sequences:

>Translated_675_residues
MQPLLRQRIETTSYKMSDNQEQKAFIAITLPDGSIRSFPYGSTGLDIALSIGRKLAQDALAITFEGKALELDTPLTESGH
MEILTFDSPEGKEIFWHSSSHLMAQAIEELFAGTRFGAGPAIEQGFYYDIASDHRFREEDLRAIELRMIEISKRESQINR
REMSREEAIEFFKTVRNDPYKVEILEDTLKNTPVVSLYEQENFTDLCSGPHLHSTSKIKAVQLTNISTSYWRGDSSRESM
QRIYGITFPSEKLLKEHTARVEEAKRRDHRKLGAELELFMLSPEIGSGLPVWLPKGAIIRNELETFLKEEQRKRGYLPVY
TPHIGNIELYKRSGHYPYYSDSQFPPLTYHDENGKQEQYLLKPMNCPHHHLIYNVKLRSYRDLPIRLAEFGTVYRHEQSG
ELNGLVRARGFTQDDSHIYCRPDQLVDEICNAIDLTQHVFATLGFSDVQTRLSMHDPLNQEKYGGTPEVWEQAEKDVTEA
ANRMGINYVIGIGEASFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLSYIGSDSQKHRPIVIHRAPFGSMERFIGV
LIEHTAGNFPLWLAPVQAIIMPLGEEIHAYAKSIHEKLLHSGIRAELDLRNEKIGKKIREAEIGKLPYMIIIGQKELESG
QLSLRRHRTGDEGLFTTDSLIDKLKKEIAAKTLIL
>Mature_675_residues
MQPLLRQRIETTSYKMSDNQEQKAFIAITLPDGSIRSFPYGSTGLDIALSIGRKLAQDALAITFEGKALELDTPLTESGH
MEILTFDSPEGKEIFWHSSSHLMAQAIEELFAGTRFGAGPAIEQGFYYDIASDHRFREEDLRAIELRMIEISKRESQINR
REMSREEAIEFFKTVRNDPYKVEILEDTLKNTPVVSLYEQENFTDLCSGPHLHSTSKIKAVQLTNISTSYWRGDSSRESM
QRIYGITFPSEKLLKEHTARVEEAKRRDHRKLGAELELFMLSPEIGSGLPVWLPKGAIIRNELETFLKEEQRKRGYLPVY
TPHIGNIELYKRSGHYPYYSDSQFPPLTYHDENGKQEQYLLKPMNCPHHHLIYNVKLRSYRDLPIRLAEFGTVYRHEQSG
ELNGLVRARGFTQDDSHIYCRPDQLVDEICNAIDLTQHVFATLGFSDVQTRLSMHDPLNQEKYGGTPEVWEQAEKDVTEA
ANRMGINYVIGIGEASFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLSYIGSDSQKHRPIVIHRAPFGSMERFIGV
LIEHTAGNFPLWLAPVQAIIMPLGEEIHAYAKSIHEKLLHSGIRAELDLRNEKIGKKIREAEIGKLPYMIIIGQKELESG
QLSLRRHRTGDEGLFTTDSLIDKLKKEIAAKTLIL

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=645, Percent_Identity=37.984496124031, Blast_Score=471, Evalue=1e-132,
Organism=Homo sapiens, GI38570111, Length=652, Percent_Identity=37.1165644171779, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI20070344, Length=644, Percent_Identity=37.111801242236, Blast_Score=431, Evalue=1e-120,
Organism=Escherichia coli, GI1788013, Length=647, Percent_Identity=40.3400309119011, Blast_Score=525, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI71984192, Length=645, Percent_Identity=37.0542635658915, Blast_Score=472, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI71984184, Length=645, Percent_Identity=37.0542635658915, Blast_Score=471, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322112, Length=661, Percent_Identity=35.5521936459909, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322654, Length=392, Percent_Identity=36.4795918367347, Blast_Score=261, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24583839, Length=644, Percent_Identity=38.3540372670807, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24583842, Length=644, Percent_Identity=38.6645962732919, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI28574141, Length=644, Percent_Identity=38.6645962732919, Blast_Score=476, Evalue=1e-134,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 77284; Mature: 77284

Theoretical pI: Translated: 6.49; Mature: 6.49

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPLLRQRIETTSYKMSDNQEQKAFIAITLPDGSIRSFPYGSTGLDIALSIGRKLAQDAL
CCHHHHHHHHHCCEECCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCE
AITFEGKALELDTPLTESGHMEILTFDSPEGKEIFWHSSSHLMAQAIEELFAGTRFGAGP
EEEECCCEEEECCCCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCC
AIEQGFYYDIASDHRFREEDLRAIELRMIEISKRESQINRREMSREEAIEFFKTVRNDPY
CCCCCEEEECCCCCCCCHHHHHEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
KVEILEDTLKNTPVVSLYEQENFTDLCSGPHLHSTSKIKAVQLTNISTSYWRGDSSRESM
EEEEEHHHHCCCCEEEEEECCCCHHHHCCCCCCCCCCEEEEEEECCCHHHCCCCCHHHHH
QRIYGITFPSEKLLKEHTARVEEAKRRDHRKLGAELELFMLSPEIGSGLPVWLPKGAIIR
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEECCCCHHHH
NELETFLKEEQRKRGYLPVYTPHIGNIELYKRSGHYPYYSDSQFPPLTYHDENGKQEQYL
HHHHHHHHHHHHHCCCCCEECCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCHHHE
LKPMNCPHHHLIYNVKLRSYRDLPIRLAEFGTVYRHEQSGELNGLVRARGFTQDDSHIYC
ECCCCCCCCEEEEEEEECCCCCCCEEHHHHHHHHEECCCCCCCCEEEECCCCCCCCEEEE
RPDQLVDEICNAIDLTQHVFATLGFSDVQTRLSMHDPLNQEKYGGTPEVWEQAEKDVTEA
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
ANRMGINYVIGIGEASFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLSYIGSDSQK
HHHCCCEEEEECCCCCCCCCCEEEEEEHHCCCEEEECEEEEEEECCCCCCEEECCCCCCC
HRPIVIHRAPFGSMERFIGVLIEHTAGNFPLWLAPVQAIIMPLGEEIHAYAKSIHEKLLH
CCCEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
SGIRAELDLRNEKIGKKIREAEIGKLPYMIIIGQKELESGQLSLRRHRTGDEGLFTTDSL
CCCCEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCEEHHHH
IDKLKKEIAAKTLIL
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MQPLLRQRIETTSYKMSDNQEQKAFIAITLPDGSIRSFPYGSTGLDIALSIGRKLAQDAL
CCHHHHHHHHHCCEECCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCE
AITFEGKALELDTPLTESGHMEILTFDSPEGKEIFWHSSSHLMAQAIEELFAGTRFGAGP
EEEECCCEEEECCCCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCC
AIEQGFYYDIASDHRFREEDLRAIELRMIEISKRESQINRREMSREEAIEFFKTVRNDPY
CCCCCEEEECCCCCCCCHHHHHEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
KVEILEDTLKNTPVVSLYEQENFTDLCSGPHLHSTSKIKAVQLTNISTSYWRGDSSRESM
EEEEEHHHHCCCCEEEEEECCCCHHHHCCCCCCCCCCEEEEEEECCCHHHCCCCCHHHHH
QRIYGITFPSEKLLKEHTARVEEAKRRDHRKLGAELELFMLSPEIGSGLPVWLPKGAIIR
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEECCCCHHHH
NELETFLKEEQRKRGYLPVYTPHIGNIELYKRSGHYPYYSDSQFPPLTYHDENGKQEQYL
HHHHHHHHHHHHHCCCCCEECCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCHHHE
LKPMNCPHHHLIYNVKLRSYRDLPIRLAEFGTVYRHEQSGELNGLVRARGFTQDDSHIYC
ECCCCCCCCEEEEEEEECCCCCCCEEHHHHHHHHEECCCCCCCCEEEECCCCCCCCEEEE
RPDQLVDEICNAIDLTQHVFATLGFSDVQTRLSMHDPLNQEKYGGTPEVWEQAEKDVTEA
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
ANRMGINYVIGIGEASFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLSYIGSDSQK
HHHCCCEEEEECCCCCCCCCCEEEEEEHHCCCEEEECEEEEEEECCCCCCEEECCCCCCC
HRPIVIHRAPFGSMERFIGVLIEHTAGNFPLWLAPVQAIIMPLGEEIHAYAKSIHEKLLH
CCCEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
SGIRAELDLRNEKIGKKIREAEIGKLPYMIIIGQKELESGQLSLRRHRTGDEGLFTTDSL
CCCCEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCEEHHHH
IDKLKKEIAAKTLIL
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA