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The map label for this gene is thyX [H]

Identifier: 119357823

GI number: 119357823

Start: 2348987

End: 2349562

Strand: Direct

Name: thyX [H]

Synonym: Cpha266_2031

Alternate gene names: 119357823

Gene position: 2348987-2349562 (Clockwise)

Preceding gene: 119357819

Following gene: 119357825

Centisome position: 74.95

GC content: 48.96

Gene sequence:

>576_bases
ATGGCTTACTGCGCGCGAGTATCCAGCCCGCACCAGGAAAACGACAGTTACGAAAAGCTGCTCGCATACTGCCTGGAACA
TAAACACTGGAGCGTTTTCGAAATGGCTGATATGACCGTTGAAATCGTCACATCAAGGGCAATATCTCCCCAGATTCTCC
GACACAGAAGCTTTCAGTTTCAGGAATTCTCACAACGATACGCAAAAGCCCAGGCGATAGAAACATACCGGCCACGCCGC
CAGGACAATAAAAACCGGCAAAACTCCCTCGACGACCTCGACCCTTCCACCTGCGCCTGGTTTGACGAAACGCAAAAAAA
CATAGCCGGTCTGGCGATGGAAAAATATAACGAGGCATTGGAAAGAGGTATTGCCAAAGAGTGCGCAAGAGTCCTTTTAC
CGCTTGCCACGCAGACAAAGCTGTACATGAAGGGATCGGTACGCAGCTGGATACACTATCTGGAAATCAGAACCCTTGAA
AGCACGCAGAAAGAACACCGGGAAATAGCGATCGAAATAAAACACATATTTTCAGAACGATTCCCCGCTGTATCGAAAGC
GCTTGGCTGGAGTTAA

Upstream 100 bases:

>100_bases
CTTTACAATCAAAAAACCGGTAACCATGCAGGTACGCCTGATTTCGGCCACTTCCCCGCTGATCAGTATCGACAACAAAC
CACTTTCGGCAGAGGGCCTC

Downstream 100 bases:

>100_bases
GGCGCAAGCATGGTCATGAGACGCACGATCTGCGTTTTCAACTCCCTGCGATGAACAATGAGATCGAGAAACCCGTGCTC
AAGAAGAAACTCGGCACGCT

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 191; Mature: 190

Protein sequence:

>191_residues
MAYCARVSSPHQENDSYEKLLAYCLEHKHWSVFEMADMTVEIVTSRAISPQILRHRSFQFQEFSQRYAKAQAIETYRPRR
QDNKNRQNSLDDLDPSTCAWFDETQKNIAGLAMEKYNEALERGIAKECARVLLPLATQTKLYMKGSVRSWIHYLEIRTLE
STQKEHREIAIEIKHIFSERFPAVSKALGWS

Sequences:

>Translated_191_residues
MAYCARVSSPHQENDSYEKLLAYCLEHKHWSVFEMADMTVEIVTSRAISPQILRHRSFQFQEFSQRYAKAQAIETYRPRR
QDNKNRQNSLDDLDPSTCAWFDETQKNIAGLAMEKYNEALERGIAKECARVLLPLATQTKLYMKGSVRSWIHYLEIRTLE
STQKEHREIAIEIKHIFSERFPAVSKALGWS
>Mature_190_residues
AYCARVSSPHQENDSYEKLLAYCLEHKHWSVFEMADMTVEIVTSRAISPQILRHRSFQFQEFSQRYAKAQAIETYRPRRQ
DNKNRQNSLDDLDPSTCAWFDETQKNIAGLAMEKYNEALERGIAKECARVLLPLATQTKLYMKGSVRSWIHYLEIRTLES
TQKEHREIAIEIKHIFSERFPAVSKALGWS

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 22375; Mature: 22243

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYCARVSSPHQENDSYEKLLAYCLEHKHWSVFEMADMTVEIVTSRAISPQILRHRSFQF
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCHH
QEFSQRYAKAQAIETYRPRRQDNKNRQNSLDDLDPSTCAWFDETQKNIAGLAMEKYNEAL
HHHHHHHHHHHHHHHHCCCHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ERGIAKECARVLLPLATQTKLYMKGSVRSWIHYLEIRTLESTQKEHREIAIEIKHIFSER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPAVSKALGWS
CHHHHHHCCCC
>Mature Secondary Structure 
AYCARVSSPHQENDSYEKLLAYCLEHKHWSVFEMADMTVEIVTSRAISPQILRHRSFQF
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCHH
QEFSQRYAKAQAIETYRPRRQDNKNRQNSLDDLDPSTCAWFDETQKNIAGLAMEKYNEAL
HHHHHHHHHHHHHHHHCCCHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ERGIAKECARVLLPLATQTKLYMKGSVRSWIHYLEIRTLESTQKEHREIAIEIKHIFSER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPAVSKALGWS
CHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]