Click here to switch to the map view.

The map label for this gene is clpP

Identifier: 119357822

GI number: 119357822

Start: 2347987

End: 2348670

Strand: Reverse

Name: clpP

Synonym: Cpha266_2030

Alternate gene names: 119357822

Gene position: 2348670-2347987 (Counterclockwise)

Preceding gene: 119357824

Following gene: 119357821

Centisome position: 74.94

GC content: 50.29

Gene sequence:

>684_bases
ATGGCAAATATCAACTTCGGTTTTGAGCATCATGCACGCAAACTCTATTCAGGCGCCATAGAGCAGGGAATCACCGGTTC
GCTTGTGCCTATGGTTATTGAAACATCGGGTCGCGGCGAACGCGCTTTCGATATTTTTTCGAGATTGCTCAGAGAGCGGA
TTATTTTTCTTGGCAGCGGCATCGATGAGCATGTTGCCGGCCTTATTATGGCGCAGCTTATTTTTCTTGAGTCGGAAGAT
CCTGAGCGCGATATCTATATTTATGTCAACTCTCCAGGCGGCAGCGTGTCGGCGGGTCTGGGAATTTATGATACCATGCA
GTATATCCGTCCGGATGTTTCGACGGTCTGCGTAGGCATGGCTGCAAGCATGGGCGCTTTTCTGCTCGCCAGCGGAACAA
AGGGTAAACGGGCTTCGCTGCCTCATTCAAGAATCATGATTCATCAGCCGTCCGGCGGGGCTCAGGGACAGGAGAGCGAT
ATCATTATCCAGGCGCGTGAAATAGAAAAGATCAGGAGGCTTCTTGAAGAGATTCTTGCCAGTCATACCGGCAAGGATGT
TCAGCAGGTCAGGGAGGATTCCGAAAGAGATCGCTGGATGAATGCCCAGGAGGCGCTTGAGTACGGCATTATCGATCAGA
TATTTGAAAAACGTCCGAAACCGGATAAGGAAAAGGAGTCCTGA

Upstream 100 bases:

>100_bases
TGAGTGTTTATTTTGTCAGCTCAAGTTATGAGCGGGTGCATCCTGATGGGTTCATCTGCTTGCGCGAAAGCTCGTTAACC
AATTCAAACGAAAATTTTTC

Downstream 100 bases:

>100_bases
ACCGGACCGTTTTCAGGGCACATCGTCGTTATTGCCGGTGATCGGATCGTGCCGGATGCGACAGCGTTCCGGCATGTGGT
CCGTTTTCGCTGTGATCGAA

Product: ATP-dependent Clp protease proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MANINFGFEHHARKLYSGAIEQGITGSLVPMVIETSGRGERAFDIFSRLLRERIIFLGSGIDEHVAGLIMAQLIFLESED
PERDIYIYVNSPGGSVSAGLGIYDTMQYIRPDVSTVCVGMAASMGAFLLASGTKGKRASLPHSRIMIHQPSGGAQGQESD
IIIQAREIEKIRRLLEEILASHTGKDVQQVREDSERDRWMNAQEALEYGIIDQIFEKRPKPDKEKES

Sequences:

>Translated_227_residues
MANINFGFEHHARKLYSGAIEQGITGSLVPMVIETSGRGERAFDIFSRLLRERIIFLGSGIDEHVAGLIMAQLIFLESED
PERDIYIYVNSPGGSVSAGLGIYDTMQYIRPDVSTVCVGMAASMGAFLLASGTKGKRASLPHSRIMIHQPSGGAQGQESD
IIIQAREIEKIRRLLEEILASHTGKDVQQVREDSERDRWMNAQEALEYGIIDQIFEKRPKPDKEKES
>Mature_226_residues
ANINFGFEHHARKLYSGAIEQGITGSLVPMVIETSGRGERAFDIFSRLLRERIIFLGSGIDEHVAGLIMAQLIFLESEDP
ERDIYIYVNSPGGSVSAGLGIYDTMQYIRPDVSTVCVGMAASMGAFLLASGTKGKRASLPHSRIMIHQPSGGAQGQESDI
IIQAREIEKIRRLLEEILASHTGKDVQQVREDSERDRWMNAQEALEYGIIDQIFEKRPKPDKEKES

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=199, Percent_Identity=56.78391959799, Blast_Score=235, Evalue=3e-62,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=60.4166666666667, Blast_Score=266, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=53.2258064516129, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI20129427, Length=198, Percent_Identity=53.5353535353535, Blast_Score=227, Evalue=4e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_CHLPD (A1BI15)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912466.1
- ProteinModelPortal:   A1BI15
- SMR:   A1BI15
- STRING:   A1BI15
- MEROPS:   S14.001
- GeneID:   4569150
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_2030
- NMPDR:   fig|290317.7.peg.2144
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   KFGLVDN
- ProtClustDB:   CLSK637818
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 25236; Mature: 25105

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 123-123 ACT_SITE 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANINFGFEHHARKLYSGAIEQGITGSLVPMVIETSGRGERAFDIFSRLLRERIIFLGSG
CCCCCCCHHHHHHHHHHHHHHCCCCCCEEHEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
IDEHVAGLIMAQLIFLESEDPERDIYIYVNSPGGSVSAGLGIYDTMQYIRPDVSTVCVGM
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHH
AASMGAFLLASGTKGKRASLPHSRIMIHQPSGGAQGQESDIIIQAREIEKIRRLLEEILA
HHHHHHHEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHH
SHTGKDVQQVREDSERDRWMNAQEALEYGIIDQIFEKRPKPDKEKES
HCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ANINFGFEHHARKLYSGAIEQGITGSLVPMVIETSGRGERAFDIFSRLLRERIIFLGSG
CCCCCCHHHHHHHHHHHHHHCCCCCCEEHEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
IDEHVAGLIMAQLIFLESEDPERDIYIYVNSPGGSVSAGLGIYDTMQYIRPDVSTVCVGM
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHH
AASMGAFLLASGTKGKRASLPHSRIMIHQPSGGAQGQESDIIIQAREIEKIRRLLEEILA
HHHHHHHEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHH
SHTGKDVQQVREDSERDRWMNAQEALEYGIIDQIFEKRPKPDKEKES
HCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA