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The map label for this gene is uvrB

Identifier: 119357816

GI number: 119357816

Start: 2336639

End: 2338696

Strand: Reverse

Name: uvrB

Synonym: Cpha266_2024

Alternate gene names: 119357816

Gene position: 2338696-2336639 (Counterclockwise)

Preceding gene: 119357820

Following gene: 119357815

Centisome position: 74.63

GC content: 51.26

Gene sequence:

>2058_bases
ATGCATGGCATAACAGACGGAACATACAGGCTGGTGAGCGAATACGATCCTAAAGGTGATCAGCCCAAAGCTATTATGGC
CTTGACCGACGGCGTTTTACGCGGCGATCGCTGGCAGACGCTTCTCGGGGTTACAGGATCGGGAAAAACCTTTACCGTTT
CCAATGTCATAGCGCAGGTTGATAAACCGGTTCTGGTGATGAGCCATAACAAAACTCTTGCAGCTCAGCTTTACGGTGAA
CTCAGGCAGTTTTTTCCTGATAATGCCGTTGAATATTTTGTGAGCTATTACGATTTCTATCAGCCGGAGGCATACCTTCC
CGCTCTTGACAAGTATATCGCAAAGGATCTGCGTATCAATGATGAAATCGAGCGGTTGCGTCTCAAGACTACCAGTTCGC
TGCTCAGCGGACGCAGGGACGTTATTGTCGTCAGTTCGGTAAGCTGTATCTATGGTCTTGGTTCTCCGGACGACTGGAAG
GCACAGATAGTTGAACTGCGTTCAGGCATGGAAAAAGATCGGGATCTTTTTCTGCAGGAGCTTGTTTCGCTTCATTATAT
CAGGGATGATGTTGACCCTGGTCCGGGTAAGTTCAGGGTCAGAGGGGATATCATCGATCTGGTTCCGGCTCATGAGGAGC
TTGCCCTGAGGGTGGAGTTTTTCGGTTCGGAAATAGAAAGTCTGCAGACGTTCAATATTCAGAGCGGCGAACTGCTCGGC
AAGGATACGTATGCGTTTATCTATCCTGCGCGACAGTTTATTGCTGAAGCAGAAACGCTCAAGCAGGCTATGGTCGCAAT
TGAAAACGAGCTTGCTGGGAGGCTTAATGAGCTGCGCAGGGATGATCGACTCGTTGAAGCCAGACGGCTTGAGGAGAGAA
CCCGGTACGATCTTGAAATGATGAAAGAGCTGGGTTACTGTTCAGGGATTGAAAATTATTCAAGGCATCTTGCCGGTCGC
AGTGAAGGGGAGCGTCCCTACTGTCTGCTTGATTATTTTCCCGAGGATTTTCTTGTGATTGTGGATGAATCGCACGTTAC
GCTACCTCAGATACGAGGGATGTATGGCGGAGATCGTTCACGCAAGGCGATTCTTGTCGAACATGGTTTCAGATTGCCTT
CCGCGCTTGATAACCGTCCGCTTCGGTTTGAGGAGTTCACTGAAATTGTTCCCCAGGTGATCTGTGTCAGCGCGACGCCG
GGGGATCTGGAACTTGAACGATGCGGCGGGGTTGTTGTTGAGCAGCTTGTTCGTCCGACGGGTCTGCTTGATCCTCCCGT
TGAGGTTCGTCCGGTGAAAGGGCAGATTGACGATCTTCTGGCGGAGATCCGGCGGCATACGGCAAAAGGGCATAAGGCGC
TCGTTATGACGCTTACCAAAAGGATGTCGGAGGATCTTGACGATTATTTTAAAAAAGTCGGAATTCGGTCGCGTTATCTT
CATTCGGAAATAAAGAGTCTCGAACGCATACAGATTCTCAGAGAGCTCAGGGCAGGAGATGTTGAGGTTCTCGTCGGGGT
TAATCTGCTTCGCGAAGGGCTTGATCTTCCGGAGGTTTCGCTGGTTGCCATCCTTGATGCTGACAAGGAGGGTTTTTTGC
GTAACACCCGCTCCCTGATGCAGATTGCCGGTCGCGCCGCGCGAAACGTTGATGGTTTTGTGGTGTTCTATGCCGACGTT
CTTACCCGTTCCATCATGGAGGTGCTTGATGAAACCGCACGTCGCCGAACCGTTCAGCAACTCTATAATGAGACGCACGG
TATTACTCCCCGGTCGATCAGGAAGTCTCTGGACCAGGTTCTCAATACGACCAGCGTGGCCGATGCCGAGGAGAGATATC
GCAGAAAACGGTTTGGTCTGGGAGCGAAATCGGGGGTCCAGTCGGCGGCTCTTCTGCACTCCTTTACCCCGGAGGAAAGC
TATGCCATGGTTGCAGAGCTCCGACTGGAGATGAACGAGGCAGCGATTCAGATGGAATATGAAAAAGCGGCCTACCTTCG
CGATGAGATAGCGCGGCTCATGCATGGCCTTGAAGCTCAGTCCGACAGCAAGGAATAA

Upstream 100 bases:

>100_bases
ATACTGTTTACAAGGATTTTCGAATCCTTTGCGGGTAGTGTGATCCGCAAAGGGGTATTAATCTTGGCGAGTTGATCATA
AGAAGGAGATTATCAGGACG

Downstream 100 bases:

>100_bases
AGGATTTTTCGCGACGGGCGGTTTTGTTATGCAGAAATAAAATTATATAAAGAAAGAGAGTGTATTCATACGTCACAACC
ATGTAGTTGAGGGAGTTTGC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 685; Mature: 685

Protein sequence:

>685_residues
MHGITDGTYRLVSEYDPKGDQPKAIMALTDGVLRGDRWQTLLGVTGSGKTFTVSNVIAQVDKPVLVMSHNKTLAAQLYGE
LRQFFPDNAVEYFVSYYDFYQPEAYLPALDKYIAKDLRINDEIERLRLKTTSSLLSGRRDVIVVSSVSCIYGLGSPDDWK
AQIVELRSGMEKDRDLFLQELVSLHYIRDDVDPGPGKFRVRGDIIDLVPAHEELALRVEFFGSEIESLQTFNIQSGELLG
KDTYAFIYPARQFIAEAETLKQAMVAIENELAGRLNELRRDDRLVEARRLEERTRYDLEMMKELGYCSGIENYSRHLAGR
SEGERPYCLLDYFPEDFLVIVDESHVTLPQIRGMYGGDRSRKAILVEHGFRLPSALDNRPLRFEEFTEIVPQVICVSATP
GDLELERCGGVVVEQLVRPTGLLDPPVEVRPVKGQIDDLLAEIRRHTAKGHKALVMTLTKRMSEDLDDYFKKVGIRSRYL
HSEIKSLERIQILRELRAGDVEVLVGVNLLREGLDLPEVSLVAILDADKEGFLRNTRSLMQIAGRAARNVDGFVVFYADV
LTRSIMEVLDETARRRTVQQLYNETHGITPRSIRKSLDQVLNTTSVADAEERYRRKRFGLGAKSGVQSAALLHSFTPEES
YAMVAELRLEMNEAAIQMEYEKAAYLRDEIARLMHGLEAQSDSKE

Sequences:

>Translated_685_residues
MHGITDGTYRLVSEYDPKGDQPKAIMALTDGVLRGDRWQTLLGVTGSGKTFTVSNVIAQVDKPVLVMSHNKTLAAQLYGE
LRQFFPDNAVEYFVSYYDFYQPEAYLPALDKYIAKDLRINDEIERLRLKTTSSLLSGRRDVIVVSSVSCIYGLGSPDDWK
AQIVELRSGMEKDRDLFLQELVSLHYIRDDVDPGPGKFRVRGDIIDLVPAHEELALRVEFFGSEIESLQTFNIQSGELLG
KDTYAFIYPARQFIAEAETLKQAMVAIENELAGRLNELRRDDRLVEARRLEERTRYDLEMMKELGYCSGIENYSRHLAGR
SEGERPYCLLDYFPEDFLVIVDESHVTLPQIRGMYGGDRSRKAILVEHGFRLPSALDNRPLRFEEFTEIVPQVICVSATP
GDLELERCGGVVVEQLVRPTGLLDPPVEVRPVKGQIDDLLAEIRRHTAKGHKALVMTLTKRMSEDLDDYFKKVGIRSRYL
HSEIKSLERIQILRELRAGDVEVLVGVNLLREGLDLPEVSLVAILDADKEGFLRNTRSLMQIAGRAARNVDGFVVFYADV
LTRSIMEVLDETARRRTVQQLYNETHGITPRSIRKSLDQVLNTTSVADAEERYRRKRFGLGAKSGVQSAALLHSFTPEES
YAMVAELRLEMNEAAIQMEYEKAAYLRDEIARLMHGLEAQSDSKE
>Mature_685_residues
MHGITDGTYRLVSEYDPKGDQPKAIMALTDGVLRGDRWQTLLGVTGSGKTFTVSNVIAQVDKPVLVMSHNKTLAAQLYGE
LRQFFPDNAVEYFVSYYDFYQPEAYLPALDKYIAKDLRINDEIERLRLKTTSSLLSGRRDVIVVSSVSCIYGLGSPDDWK
AQIVELRSGMEKDRDLFLQELVSLHYIRDDVDPGPGKFRVRGDIIDLVPAHEELALRVEFFGSEIESLQTFNIQSGELLG
KDTYAFIYPARQFIAEAETLKQAMVAIENELAGRLNELRRDDRLVEARRLEERTRYDLEMMKELGYCSGIENYSRHLAGR
SEGERPYCLLDYFPEDFLVIVDESHVTLPQIRGMYGGDRSRKAILVEHGFRLPSALDNRPLRFEEFTEIVPQVICVSATP
GDLELERCGGVVVEQLVRPTGLLDPPVEVRPVKGQIDDLLAEIRRHTAKGHKALVMTLTKRMSEDLDDYFKKVGIRSRYL
HSEIKSLERIQILRELRAGDVEVLVGVNLLREGLDLPEVSLVAILDADKEGFLRNTRSLMQIAGRAARNVDGFVVFYADV
LTRSIMEVLDETARRRTVQQLYNETHGITPRSIRKSLDQVLNTTSVADAEERYRRKRFGLGAKSGVQSAALLHSFTPEES
YAMVAELRLEMNEAAIQMEYEKAAYLRDEIARLMHGLEAQSDSKE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=667, Percent_Identity=53.2233883058471, Blast_Score=682, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_CHLPD (A1BI09)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912460.1
- ProteinModelPortal:   A1BI09
- SMR:   A1BI09
- STRING:   A1BI09
- GeneID:   4569144
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_2024
- NMPDR:   fig|290317.7.peg.2136
- eggNOG:   COG0556
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 77742; Mature: 77742

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGITDGTYRLVSEYDPKGDQPKAIMALTDGVLRGDRWQTLLGVTGSGKTFTVSNVIAQV
CCCCCCCHHHHHHCCCCCCCCCCEEHEEHHHHHCCCCHHEEEEECCCCCEEEHHHHHHHC
DKPVLVMSHNKTLAAQLYGELRQFFPDNAVEYFVSYYDFYQPEAYLPALDKYIAKDLRIN
CCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
DEIERLRLKTTSSLLSGRRDVIVVSSVSCIYGLGSPDDWKAQIVELRSGMEKDRDLFLQE
CHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
LVSLHYIRDDVDPGPGKFRVRGDIIDLVPAHEELALRVEFFGSEIESLQTFNIQSGELLG
HHHHHHHHCCCCCCCCCEEEECCEEEECCCCHHHEEEHHHHHHHHHHHHCCCCCCCCEEC
KDTYAFIYPARQFIAEAETLKQAMVAIENELAGRLNELRRDDRLVEARRLEERTRYDLEM
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKELGYCSGIENYSRHLAGRSEGERPYCLLDYFPEDFLVIVDESHVTLPQIRGMYGGDRS
HHHCHHHCCHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHCCCCCCCC
RKAILVEHGFRLPSALDNRPLRFEEFTEIVPQVICVSATPGDLELERCGGVVVEQLVRPT
CCEEEEECCCCCCHHCCCCCCCHHHHHHHHHHHEEEECCCCCCCHHHHCCHHHHHHHCCC
GLLDPPVEVRPVKGQIDDLLAEIRRHTAKGHKALVMTLTKRMSEDLDDYFKKVGIRSRYL
CCCCCCCCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
HSEIKSLERIQILRELRAGDVEVLVGVNLLREGLDLPEVSLVAILDADKEGFLRNTRSLM
HHHHHHHHHHHHHHHHCCCCEEEHCCHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHH
QIAGRAARNVDGFVVFYADVLTRSIMEVLDETARRRTVQQLYNETHGITPRSIRKSLDQV
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LNTTSVADAEERYRRKRFGLGAKSGVQSAALLHSFTPEESYAMVAELRLEMNEAAIQMEY
HHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEHH
EKAAYLRDEIARLMHGLEAQSDSKE
HHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MHGITDGTYRLVSEYDPKGDQPKAIMALTDGVLRGDRWQTLLGVTGSGKTFTVSNVIAQV
CCCCCCCHHHHHHCCCCCCCCCCEEHEEHHHHHCCCCHHEEEEECCCCCEEEHHHHHHHC
DKPVLVMSHNKTLAAQLYGELRQFFPDNAVEYFVSYYDFYQPEAYLPALDKYIAKDLRIN
CCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
DEIERLRLKTTSSLLSGRRDVIVVSSVSCIYGLGSPDDWKAQIVELRSGMEKDRDLFLQE
CHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
LVSLHYIRDDVDPGPGKFRVRGDIIDLVPAHEELALRVEFFGSEIESLQTFNIQSGELLG
HHHHHHHHCCCCCCCCCEEEECCEEEECCCCHHHEEEHHHHHHHHHHHHCCCCCCCCEEC
KDTYAFIYPARQFIAEAETLKQAMVAIENELAGRLNELRRDDRLVEARRLEERTRYDLEM
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKELGYCSGIENYSRHLAGRSEGERPYCLLDYFPEDFLVIVDESHVTLPQIRGMYGGDRS
HHHCHHHCCHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCHHHHHCCCCCCCC
RKAILVEHGFRLPSALDNRPLRFEEFTEIVPQVICVSATPGDLELERCGGVVVEQLVRPT
CCEEEEECCCCCCHHCCCCCCCHHHHHHHHHHHEEEECCCCCCCHHHHCCHHHHHHHCCC
GLLDPPVEVRPVKGQIDDLLAEIRRHTAKGHKALVMTLTKRMSEDLDDYFKKVGIRSRYL
CCCCCCCCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
HSEIKSLERIQILRELRAGDVEVLVGVNLLREGLDLPEVSLVAILDADKEGFLRNTRSLM
HHHHHHHHHHHHHHHHCCCCEEEHCCHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHH
QIAGRAARNVDGFVVFYADVLTRSIMEVLDETARRRTVQQLYNETHGITPRSIRKSLDQV
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LNTTSVADAEERYRRKRFGLGAKSGVQSAALLHSFTPEESYAMVAELRLEMNEAAIQMEY
HHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEHH
EKAAYLRDEIARLMHGLEAQSDSKE
HHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA