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The map label for this gene is gcvT

Identifier: 119357809

GI number: 119357809

Start: 2330690

End: 2331787

Strand: Reverse

Name: gcvT

Synonym: Cpha266_2017

Alternate gene names: 119357809

Gene position: 2331787-2330690 (Counterclockwise)

Preceding gene: 119357810

Following gene: 119357808

Centisome position: 74.41

GC content: 49.54

Gene sequence:

>1098_bases
ATGAAAAAAACAGCGCTCTATCATTGGCATGAACAAGCAGGTGCCAGAATTATTGATTTCGGCGGCTATCTCATGCCTGT
TCAGTACTCTGGAATTATTGCTGAACATCGGGCAGTACGGAGTGCCGCGGGGCTTTTTGACGTTTCTCATATGGGTAATT
TTTACGTTACCGGTGAGCGTTCCGAAGCCTTTCTTCAGTATATGGTTACCAATGATCTTTCGAAGGTCAGGGATGGCGAG
GCGCAGTATAATCTTATGCTCTATCCTAACGGCGGGGTTGTCGATGATCTCATTATCTATCGACTCGACAGTAAAACGTT
TTTTCTCATTGTCAATGCGAGCAATACAGAAAAAGATTATGCATGGCTTCAGCAGCATATCGGCGCATTTGATGGCGTCT
GTCTTGAGGATCATACCGACCGGCTTTCGCTTATTGCGCTGCAGGGGCCGGTTGCGATCGATATTGTAAAGACGGTCTTT
CCTTCGGTTGATTTTGACGCTCTTCTACAGTTTCAGTTTTGTCGCACGTTGTATGGCGATGCTCCGGTGATGATCGCCCG
TACCGGTTATACCGGCGAAAAAGGGGTTGAAATCTGTCTTCCCAATGAAGCAGCACTGCCTTTATGGGAGGCTCTTTATG
ATGCCGGCAGAGCGTGCGGTATCTCTCCTGTCGGTCTCGGAGCGCGTGATACGCTCAGGCTTGAAATGGGTTACTCCCTT
TATGGGCATGAGATAGATCAGGATATAAATCCGCTCGAAGCAAGGCTTAAATGGGCGGTTAAAATGGACAAGGGGAGTTT
TATCGGCAGGGAGGCCTGTCAGCAGGTGGAGTTGCATCTCACTCGTGGCGTTGCCGGTTTCAGCATCGAAAGCCGGGTAC
TGCCCCGTCAGCACTGCAAGGTTTACAATACGGACAGGCAGGAGATCGGGTGGGTGTGCAGCGGTACGCTTTCGCCAACA
CTTCAGGAGCCGATTGGAACCTGCAATATTGTCAGGAAGTACATTACCTCAGGCGACTCTGTTTTTGTTGATGTTCGAGG
GACATTGCATAAGGGGGAGATCCGGCGCTTGCCGTTTGTGAAAACATCGCTTGGTTAA

Upstream 100 bases:

>100_bases
AAAAAGAGTCGATTTCGGCAGAAAAGGCTTTGAACTTCATGGTAAAATGCTTTTTTACAGTCAATTGTCATCAGGGTCAA
TAACTCAGTAAAAGGTGGTT

Downstream 100 bases:

>100_bases
TGTGCGGGAAAAGAGAACAGCAGGAGGGAGACAAAGAGACGTGAAAACAAAAAGAGAAAACAAGAGCAGTGCGACGAATG
TGAGGAGCAGGGACAAGCTG

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MKKTALYHWHEQAGARIIDFGGYLMPVQYSGIIAEHRAVRSAAGLFDVSHMGNFYVTGERSEAFLQYMVTNDLSKVRDGE
AQYNLMLYPNGGVVDDLIIYRLDSKTFFLIVNASNTEKDYAWLQQHIGAFDGVCLEDHTDRLSLIALQGPVAIDIVKTVF
PSVDFDALLQFQFCRTLYGDAPVMIARTGYTGEKGVEICLPNEAALPLWEALYDAGRACGISPVGLGARDTLRLEMGYSL
YGHEIDQDINPLEARLKWAVKMDKGSFIGREACQQVELHLTRGVAGFSIESRVLPRQHCKVYNTDRQEIGWVCSGTLSPT
LQEPIGTCNIVRKYITSGDSVFVDVRGTLHKGEIRRLPFVKTSLG

Sequences:

>Translated_365_residues
MKKTALYHWHEQAGARIIDFGGYLMPVQYSGIIAEHRAVRSAAGLFDVSHMGNFYVTGERSEAFLQYMVTNDLSKVRDGE
AQYNLMLYPNGGVVDDLIIYRLDSKTFFLIVNASNTEKDYAWLQQHIGAFDGVCLEDHTDRLSLIALQGPVAIDIVKTVF
PSVDFDALLQFQFCRTLYGDAPVMIARTGYTGEKGVEICLPNEAALPLWEALYDAGRACGISPVGLGARDTLRLEMGYSL
YGHEIDQDINPLEARLKWAVKMDKGSFIGREACQQVELHLTRGVAGFSIESRVLPRQHCKVYNTDRQEIGWVCSGTLSPT
LQEPIGTCNIVRKYITSGDSVFVDVRGTLHKGEIRRLPFVKTSLG
>Mature_365_residues
MKKTALYHWHEQAGARIIDFGGYLMPVQYSGIIAEHRAVRSAAGLFDVSHMGNFYVTGERSEAFLQYMVTNDLSKVRDGE
AQYNLMLYPNGGVVDDLIIYRLDSKTFFLIVNASNTEKDYAWLQQHIGAFDGVCLEDHTDRLSLIALQGPVAIDIVKTVF
PSVDFDALLQFQFCRTLYGDAPVMIARTGYTGEKGVEICLPNEAALPLWEALYDAGRACGISPVGLGARDTLRLEMGYSL
YGHEIDQDINPLEARLKWAVKMDKGSFIGREACQQVELHLTRGVAGFSIESRVLPRQHCKVYNTDRQEIGWVCSGTLSPT
LQEPIGTCNIVRKYITSGDSVFVDVRGTLHKGEIRRLPFVKTSLG

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=378, Percent_Identity=29.6296296296296, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI257796258, Length=360, Percent_Identity=29.4444444444444, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI257796254, Length=372, Percent_Identity=27.4193548387097, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI257796256, Length=322, Percent_Identity=28.5714285714286, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI24797151, Length=360, Percent_Identity=25.8333333333333, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI194306651, Length=268, Percent_Identity=29.1044776119403, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI197927446, Length=288, Percent_Identity=26.7361111111111, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI21361378, Length=288, Percent_Identity=26.7361111111111, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1789272, Length=368, Percent_Identity=39.945652173913, Blast_Score=244, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI17560118, Length=377, Percent_Identity=32.8912466843501, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71994045, Length=311, Percent_Identity=27.0096463022508, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71994052, Length=311, Percent_Identity=27.0096463022508, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI32563613, Length=266, Percent_Identity=27.4436090225564, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320222, Length=385, Percent_Identity=34.2857142857143, Blast_Score=190, Evalue=2e-49,
Organism=Drosophila melanogaster, GI20129441, Length=376, Percent_Identity=33.5106382978723, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI28571104, Length=271, Percent_Identity=27.6752767527675, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20130091, Length=259, Percent_Identity=22.3938223938224, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_CHLPD (A1BI02)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912453.1
- ProteinModelPortal:   A1BI02
- SMR:   A1BI02
- STRING:   A1BI02
- GeneID:   4569544
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_2017
- NMPDR:   fig|290317.7.peg.2129
- eggNOG:   COG0404
- HOGENOM:   HBG299834
- OMA:   KALYGGM
- ProtClustDB:   PRK00389
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 40686; Mature: 40686

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTALYHWHEQAGARIIDFGGYLMPVQYSGIIAEHRAVRSAAGLFDVSHMGNFYVTGER
CCCCEEEEEHHHCCCEEEECCCEEEEEEECCCHHHHHHHHHHHCCEEHHHCCCEEEECCC
SEAFLQYMVTNDLSKVRDGEAQYNLMLYPNGGVVDDLIIYRLDSKTFFLIVNASNTEKDY
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEECCCEEEEEEECCCCCHHH
AWLQQHIGAFDGVCLEDHTDRLSLIALQGPVAIDIVKTVFPSVDFDALLQFQFCRTLYGD
HHHHHHCCCCCCEEECCCCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
APVMIARTGYTGEKGVEICLPNEAALPLWEALYDAGRACGISPVGLGARDTLRLEMGYSL
CCEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCEE
YGHEIDQDINPLEARLKWAVKMDKGSFIGREACQQVELHLTRGVAGFSIESRVLPRQHCK
ECCCCCCCCCHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHCCCCCHHHCE
VYNTDRQEIGWVCSGTLSPTLQEPIGTCNIVRKYITSGDSVFVDVRGTLHKGEIRRLPFV
EECCCHHHCCEEEECCCCCHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEE
KTSLG
CCCCC
>Mature Secondary Structure
MKKTALYHWHEQAGARIIDFGGYLMPVQYSGIIAEHRAVRSAAGLFDVSHMGNFYVTGER
CCCCEEEEEHHHCCCEEEECCCEEEEEEECCCHHHHHHHHHHHCCEEHHHCCCEEEECCC
SEAFLQYMVTNDLSKVRDGEAQYNLMLYPNGGVVDDLIIYRLDSKTFFLIVNASNTEKDY
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEECCCEEEEEEECCCCCHHH
AWLQQHIGAFDGVCLEDHTDRLSLIALQGPVAIDIVKTVFPSVDFDALLQFQFCRTLYGD
HHHHHHCCCCCCEEECCCCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
APVMIARTGYTGEKGVEICLPNEAALPLWEALYDAGRACGISPVGLGARDTLRLEMGYSL
CCEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCEE
YGHEIDQDINPLEARLKWAVKMDKGSFIGREACQQVELHLTRGVAGFSIESRVLPRQHCK
ECCCCCCCCCHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHCCCCCHHHCE
VYNTDRQEIGWVCSGTLSPTLQEPIGTCNIVRKYITSGDSVFVDVRGTLHKGEIRRLPFV
EECCCHHHCCEEEECCCCCHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEE
KTSLG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA