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The map label for this gene is pyrH

Identifier: 119357800

GI number: 119357800

Start: 2321729

End: 2322439

Strand: Reverse

Name: pyrH

Synonym: Cpha266_2008

Alternate gene names: 119357800

Gene position: 2322439-2321729 (Counterclockwise)

Preceding gene: 119357801

Following gene: 119357798

Centisome position: 74.11

GC content: 49.79

Gene sequence:

>711_bases
ATGTTACGATACAAGCGTATACTGCTCAAGCTGAGCGGTGAGGCCCTTGCGGGTGAAGATGGTTATGGAATTAATGCACA
GATGCTTGAGCGGTATGCCGAGGAGATTCGCGAGGTTCGTAATCTTGGCGCTGAGGTTGCGCTTGTCATTGGCGGCGGAA
ACATATTTCGCGGTGTTTCAGAGGCGGCAGCCAATATGGACAGGGTGCAGGCGGACTATATGGGTATGCTTGCGACTGTG
ATCAATGCCATAGCTTTTCAGGATGCCCTTGAGAGAAAAGGGGTTTTTACCAGACTGCAGACCGCTATCAAGATGGAGCA
GATGGCCGAGCCTTTTATCAGGCGACGGGCTATTCGCCATCTGGAGAAAGGGCGCGTCGTCATTTTCGGTGCCGGAACCG
GTAATCCATATTTTACAACTGATACGGCGGCCTCATTGCGTGCAATAGAAATTGAAGCCGAGCTTATTGTTAAAGGAACC
AGGGTCAATGGTGTGTATGATTCCGATCCTGAGAAAAATCCTGACGCTGTGTTTTATCCGAAAATATCCTATCAGGATGT
GATTCGGAAAAATCTGCGGGTTATGGATATGACTGCCATTACGCTGTGCCGTGAAAACCTGCTTCCGATTGTCGTCATGA
ACATGAACGAAAGCGGTAATTTTTCGCGGTTGCTGTGCGGCGAAGAGATCGGCACGCTCGTTCATGCCTGA

Upstream 100 bases:

>100_bases
GGTGAGTAAAAAAAAAGCCTCGTTGTACGAGGCTTTTTTTTTAGGCATATTTTCGTGTCGATGTCCTTCGTAAAAACTTT
CATGAGTGGAGGTGGTGCCA

Downstream 100 bases:

>100_bases
GTCAGACTAATCCATCTCATCTTCTGAAGAGGTGGATAGCGAAAGAAGTCGTTTGACGGTCTGCTCAATGGCATGCCACT
CAAATCCCCTGTTATAAAGA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MLRYKRILLKLSGEALAGEDGYGINAQMLERYAEEIREVRNLGAEVALVIGGGNIFRGVSEAAANMDRVQADYMGMLATV
INAIAFQDALERKGVFTRLQTAIKMEQMAEPFIRRRAIRHLEKGRVVIFGAGTGNPYFTTDTAASLRAIEIEAELIVKGT
RVNGVYDSDPEKNPDAVFYPKISYQDVIRKNLRVMDMTAITLCRENLLPIVVMNMNESGNFSRLLCGEEIGTLVHA

Sequences:

>Translated_236_residues
MLRYKRILLKLSGEALAGEDGYGINAQMLERYAEEIREVRNLGAEVALVIGGGNIFRGVSEAAANMDRVQADYMGMLATV
INAIAFQDALERKGVFTRLQTAIKMEQMAEPFIRRRAIRHLEKGRVVIFGAGTGNPYFTTDTAASLRAIEIEAELIVKGT
RVNGVYDSDPEKNPDAVFYPKISYQDVIRKNLRVMDMTAITLCRENLLPIVVMNMNESGNFSRLLCGEEIGTLVHA
>Mature_236_residues
MLRYKRILLKLSGEALAGEDGYGINAQMLERYAEEIREVRNLGAEVALVIGGGNIFRGVSEAAANMDRVQADYMGMLATV
INAIAFQDALERKGVFTRLQTAIKMEQMAEPFIRRRAIRHLEKGRVVIFGAGTGNPYFTTDTAASLRAIEIEAELIVKGT
RVNGVYDSDPEKNPDAVFYPKISYQDVIRKNLRVMDMTAITLCRENLLPIVVMNMNESGNFSRLLCGEEIGTLVHA

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=231, Percent_Identity=52.8138528138528, Blast_Score=251, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_CHLPD (A1BHZ3)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912444.1
- ProteinModelPortal:   A1BHZ3
- SMR:   A1BHZ3
- STRING:   A1BHZ3
- GeneID:   4569535
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_2008
- NMPDR:   fig|290317.7.peg.2120
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26221; Mature: 26221

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: BINDING 52-52 BINDING 53-53 BINDING 57-57 BINDING 72-72 BINDING 160-160 BINDING 166-166 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRYKRILLKLSGEALAGEDGYGINAQMLERYAEEIREVRNLGAEVALVIGGGNIFRGVS
CCHHHEEHHEECCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHH
EAAANMDRVQADYMGMLATVINAIAFQDALERKGVFTRLQTAIKMEQMAEPFIRRRAIRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRVVIFGAGTGNPYFTTDTAASLRAIEIEAELIVKGTRVNGVYDSDPEKNPDAVFYP
HHCCCEEEEECCCCCCEEECCCCCCEEEEEEEEEEEEEECEECCCCCCCCCCCCCEEEEC
KISYQDVIRKNLRVMDMTAITLCRENLLPIVVMNMNESGNFSRLLCGEEIGTLVHA
CCCHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEHHHHHHHHHCC
>Mature Secondary Structure
MLRYKRILLKLSGEALAGEDGYGINAQMLERYAEEIREVRNLGAEVALVIGGGNIFRGVS
CCHHHEEHHEECCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHH
EAAANMDRVQADYMGMLATVINAIAFQDALERKGVFTRLQTAIKMEQMAEPFIRRRAIRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRVVIFGAGTGNPYFTTDTAASLRAIEIEAELIVKGTRVNGVYDSDPEKNPDAVFYP
HHCCCEEEEECCCCCCEEECCCCCCEEEEEEEEEEEEEECEECCCCCCCCCCCCCEEEEC
KISYQDVIRKNLRVMDMTAITLCRENLLPIVVMNMNESGNFSRLLCGEEIGTLVHA
CCCHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA