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The map label for this gene is groEL [H]

Identifier: 119357732

GI number: 119357732

Start: 2243329

End: 2244972

Strand: Reverse

Name: groEL [H]

Synonym: Cpha266_1936

Alternate gene names: 119357732

Gene position: 2244972-2243329 (Counterclockwise)

Preceding gene: 119357733

Following gene: 119357731

Centisome position: 71.64

GC content: 49.88

Gene sequence:

>1644_bases
ATGACTGCTAAAGATATTATTTTTGATTCTGACGCGAGAGCGAAACTGAAAGTTGGCGTTGACAAACTGGCCAACGCGGT
TAAAGTTACTCTTGGACCTGCCGGACGCAATGTCCTGATCGACAAAAAATTCGGTGCTCCAACTTCCACCAAAGATGGCG
TGACTGTTGCCAAAGAGATCGAACTTGCTGATGCTGTTGAGAACATGGGCGCGCAGATGGTTCGTGAAGTTGCTTCGAAA
ACCAGTGATGTTGCCGGTGACGGTACCACTACGGCAACCGTTCTTGCACAGGCTATCTATCGTGAAGGTCTGAAGAACGT
TGCAGCCGGTGCCCGCCCGATTGATTTGAAAAGAGGCATCGACCGTGCTGTCAAAGAGGTTGTGCTTGAGCTGAGAAATA
TCAGCCGCAGCATCTCCGGTAAAAAAGAGATTGCCCAGGTCGGCACTATTTCTGCCAACAACGATCCTGAAATCGGCGAA
CTGATTGCCGAAGCCATGGATAAGGTCGGCAAGGACGGCGTTATTACCGTTGAAGAGGCAAAAGGCATGGATACCGAGCT
GAAGGTTGTTGAGGGTATGCAGTTTGATCGTGGCTACCTTTCGCCGTACTTCGTGACCAATCCTGAAAACATGGAGGCAG
AGCTCGAAGATCCGCTTATCCTTATTCATGACAAAAAGATCAGCAACATGAAAGAGCTGTTGCCGATTCTTGAAAAATCA
GCACAGTCCGGTCGTCCCCTCCTCATCATTTCCGAGGATATCGAAGGCGAGGCACTTGCTACGCTTGTTGTCAACAGGCT
CAGGGGTACCCTGAAAGTCTGCGCCGTCAAAGCTCCGGGCTTCGGCGATCGTCGCAAAGCAATGCTTGAAGATATCGCTA
TTCTTACCGGCGGTACCGTTATTTCTGAAGAGAAAGGCTACAAACTTGAAAACGCGACGCTTACCTATCTTGGTCAGGCC
GGTCGTATTACGGTTGACAAGGACAATACCACTGTTGTTGAGGGTAAGGGCAAGCCGGAAGAGATCAAGGCTCGCATCAA
CGAAATCAAAGGCCAGATTGAAAAATCAACCTCTGATTATGATACCGAAAAATTGCAGGAGCGGCTTGCAAAACTTTCCG
GCGGCGTAGCCGTACTCAATATCGGTGCATCTACCGAAGTTGAGATGAAAGAGAAAAAAGCCCGCGTTGAAGATGCGCTG
CATGCAACCCGCGCTGCTGTTCAGGAAGGTATTGTTGTTGGTGGCGGTGTTGCGCTTATTCGTGCTATCAAAGGCCTCGA
TAATGCGGTTGCCGACAATGAAGATCAGAAAACCGGCATCGAAATTATCCGTCGCGCGCTTGAAGAGCCGCTTCGCCAGA
TCGTTGCGAACACCGGCACTACCGATGGTGCAGTTGTTCTTGAAAAGGTGAAGAATGGCGAAGGCGACTTTGGTTTCAAT
GCCAGAACCGAACAGTACGAAAACCTGGTTGAAGCAGGTGTTGTCGATCCTACCAAGGTGACCAGAAGCGCTCTTGAGAA
CGCTGCATCAGTTGCCAGTATTCTTTTGACAACCGAAGCTGCAATTACAGACATCAAGGAAGAAAAATCCGACATGCCTG
CAATGCCTCCGGGCGGAATGGGTGGTATGGGCGGTATGTACTGA

Upstream 100 bases:

>100_bases
GGTGAAGATTACCTCATCATGCGCGAGTCGGACATTTTTGCTATTCTTGATTAAGTGATTGTTAAAACAATAAAAAAATC
CTACAGGAGGAACGCTTTAC

Downstream 100 bases:

>100_bases
TCCCTGTTCACCGATATGGATACGAAAGCCATCCCGAATTTTAATTCGGGATGGCTTTTTTTTTGCCCCAGCCGGATGAA
TCCAAAAGAATTGCATACCT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MTAKDIIFDSDARAKLKVGVDKLANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIELADAVENMGAQMVREVASK
TSDVAGDGTTTATVLAQAIYREGLKNVAAGARPIDLKRGIDRAVKEVVLELRNISRSISGKKEIAQVGTISANNDPEIGE
LIAEAMDKVGKDGVITVEEAKGMDTELKVVEGMQFDRGYLSPYFVTNPENMEAELEDPLILIHDKKISNMKELLPILEKS
AQSGRPLLIISEDIEGEALATLVVNRLRGTLKVCAVKAPGFGDRRKAMLEDIAILTGGTVISEEKGYKLENATLTYLGQA
GRITVDKDNTTVVEGKGKPEEIKARINEIKGQIEKSTSDYDTEKLQERLAKLSGGVAVLNIGASTEVEMKEKKARVEDAL
HATRAAVQEGIVVGGGVALIRAIKGLDNAVADNEDQKTGIEIIRRALEEPLRQIVANTGTTDGAVVLEKVKNGEGDFGFN
ARTEQYENLVEAGVVDPTKVTRSALENAASVASILLTTEAAITDIKEEKSDMPAMPPGGMGGMGGMY

Sequences:

>Translated_547_residues
MTAKDIIFDSDARAKLKVGVDKLANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIELADAVENMGAQMVREVASK
TSDVAGDGTTTATVLAQAIYREGLKNVAAGARPIDLKRGIDRAVKEVVLELRNISRSISGKKEIAQVGTISANNDPEIGE
LIAEAMDKVGKDGVITVEEAKGMDTELKVVEGMQFDRGYLSPYFVTNPENMEAELEDPLILIHDKKISNMKELLPILEKS
AQSGRPLLIISEDIEGEALATLVVNRLRGTLKVCAVKAPGFGDRRKAMLEDIAILTGGTVISEEKGYKLENATLTYLGQA
GRITVDKDNTTVVEGKGKPEEIKARINEIKGQIEKSTSDYDTEKLQERLAKLSGGVAVLNIGASTEVEMKEKKARVEDAL
HATRAAVQEGIVVGGGVALIRAIKGLDNAVADNEDQKTGIEIIRRALEEPLRQIVANTGTTDGAVVLEKVKNGEGDFGFN
ARTEQYENLVEAGVVDPTKVTRSALENAASVASILLTTEAAITDIKEEKSDMPAMPPGGMGGMGGMY
>Mature_546_residues
TAKDIIFDSDARAKLKVGVDKLANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIELADAVENMGAQMVREVASKT
SDVAGDGTTTATVLAQAIYREGLKNVAAGARPIDLKRGIDRAVKEVVLELRNISRSISGKKEIAQVGTISANNDPEIGEL
IAEAMDKVGKDGVITVEEAKGMDTELKVVEGMQFDRGYLSPYFVTNPENMEAELEDPLILIHDKKISNMKELLPILEKSA
QSGRPLLIISEDIEGEALATLVVNRLRGTLKVCAVKAPGFGDRRKAMLEDIAILTGGTVISEEKGYKLENATLTYLGQAG
RITVDKDNTTVVEGKGKPEEIKARINEIKGQIEKSTSDYDTEKLQERLAKLSGGVAVLNIGASTEVEMKEKKARVEDALH
ATRAAVQEGIVVGGGVALIRAIKGLDNAVADNEDQKTGIEIIRRALEEPLRQIVANTGTTDGAVVLEKVKNGEGDFGFNA
RTEQYENLVEAGVVDPTKVTRSALENAASVASILLTTEAAITDIKEEKSDMPAMPPGGMGGMGGMY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=50.7547169811321, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=50.7547169811321, Blast_Score=525, Evalue=1e-149,
Organism=Escherichia coli, GI1790586, Length=533, Percent_Identity=65.2908067542214, Blast_Score=683, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=49.7164461247637, Blast_Score=520, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI193210679, Length=209, Percent_Identity=50.2392344497608, Blast_Score=206, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6323288, Length=527, Percent_Identity=54.0796963946869, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=53.5104364326376, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=53.5104364326376, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=50.9469696969697, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=50.9469696969697, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=50.9469696969697, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI17864606, Length=545, Percent_Identity=45.5045871559633, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24584129, Length=524, Percent_Identity=38.1679389312977, Blast_Score=322, Evalue=4e-88,
Organism=Drosophila melanogaster, GI19921262, Length=524, Percent_Identity=38.1679389312977, Blast_Score=322, Evalue=4e-88,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58322; Mature: 58191

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKDIIFDSDARAKLKVGVDKLANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEI
CCCCCCEECCCCCCEEEECHHHHCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHH
ELADAVENMGAQMVREVASKTSDVAGDGTTTATVLAQAIYREGLKNVAAGARPIDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
DRAVKEVVLELRNISRSISGKKEIAQVGTISANNDPEIGELIAEAMDKVGKDGVITVEEA
HHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KGMDTELKVVEGMQFDRGYLSPYFVTNPENMEAELEDPLILIHDKKISNMKELLPILEKS
CCCCCHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHH
AQSGRPLLIISEDIEGEALATLVVNRLRGTLKVCAVKAPGFGDRRKAMLEDIAILTGGTV
HCCCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEEKGYKLENATLTYLGQAGRITVDKDNTTVVEGKGKPEEIKARINEIKGQIEKSTSDY
EECCCCCEECCCEEEEECCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
DTEKLQERLAKLSGGVAVLNIGASTEVEMKEKKARVEDALHATRAAVQEGIVVGGGVALI
CHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHH
RAIKGLDNAVADNEDQKTGIEIIRRALEEPLRQIVANTGTTDGAVVLEKVKNGEGDFGFN
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCC
ARTEQYENLVEAGVVDPTKVTRSALENAASVASILLTTEAAITDIKEEKSDMPAMPPGGM
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GGMGGMY
CCCCCCC
>Mature Secondary Structure 
TAKDIIFDSDARAKLKVGVDKLANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEI
CCCCCEECCCCCCEEEECHHHHCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHH
ELADAVENMGAQMVREVASKTSDVAGDGTTTATVLAQAIYREGLKNVAAGARPIDLKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
DRAVKEVVLELRNISRSISGKKEIAQVGTISANNDPEIGELIAEAMDKVGKDGVITVEEA
HHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KGMDTELKVVEGMQFDRGYLSPYFVTNPENMEAELEDPLILIHDKKISNMKELLPILEKS
CCCCCHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHH
AQSGRPLLIISEDIEGEALATLVVNRLRGTLKVCAVKAPGFGDRRKAMLEDIAILTGGTV
HCCCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEEKGYKLENATLTYLGQAGRITVDKDNTTVVEGKGKPEEIKARINEIKGQIEKSTSDY
EECCCCCEECCCEEEEECCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
DTEKLQERLAKLSGGVAVLNIGASTEVEMKEKKARVEDALHATRAAVQEGIVVGGGVALI
CHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHH
RAIKGLDNAVADNEDQKTGIEIIRRALEEPLRQIVANTGTTDGAVVLEKVKNGEGDFGFN
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCC
ARTEQYENLVEAGVVDPTKVTRSALENAASVASILLTTEAAITDIKEEKSDMPAMPPGGM
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GGMGGMY
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA