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The map label for this gene is nifL [H]

Identifier: 119357630

GI number: 119357630

Start: 2092158

End: 2094203

Strand: Reverse

Name: nifL [H]

Synonym: Cpha266_1834

Alternate gene names: 119357630

Gene position: 2094203-2092158 (Counterclockwise)

Preceding gene: 119357631

Following gene: 119357629

Centisome position: 66.82

GC content: 46.24

Gene sequence:

>2046_bases
ATGTCAGCCGTTGAAAAGAAAGCGACAGTTCTTATTGTTGATGACAGTGCGCTGATACGGGCATCAACCTCACATATTAT
CAGAGAGCTTGGCTTCAATCCGGTAACGGCAGAGTGTGGGGATGACTGTATTGAGCTTCTCAATACGAGCAAGATCGATC
TTGTACTTCTCGATATCAACATGCCCGGAAAAAACGGAATGGAGGTGCTTTCCGATATCCGGAATCATCACTTCATGGTT
CCGGTGATCATGATTTCCGGTTCGAATGACATTGAGCAGGCAGTTCAGTCCGTCAAGATGGGCGCATACCAGTACCTGAT
AAAACCGGTCAATCCTGACAAGCTTGAGGTTACGGTAAAAAACGCGCTTTCCGAATCGAAGCTCCGACAGAAGGTTAAAC
TTTTTTCGGCTGTGATTACCCGGAGTCCGATAACGATCGCTATAACCGATAATCATGGCGATCTTGAATACGTCAACCCG
GCATTCAGCAGAACGACCGGTTATTCCTACAAGGAGGCTATAGGCAAGAACCCCCGGATATTGAAATCCGGTGATCAGCC
CGATGAATACTATAAGGCACTCTGGGATACCATTACTGCAGGAAAGGTCTGGCATGGCGAGTTTCATAACAGGAAAAAAA
ACGGGGAAATGTATTGGGAGGAGGCGATTATCAGCCCGATTACCGATCACACGGGAAAGATTTCGCATTATATCAGTCTC
AAACAGGATATTTCTCAGCGCAAAAAGGAACAGGAAGCTCTCGCTGAAAGCGAAAGCCGTTTTCAGGAACTTGCCGATCT
TTTGCCCCAGCCTGTTTTCGAACTCGATATGAAGGGAAACATCATCTATACCAACAGTCTTGGTTTTCAAGCATTCGGAT
ATACAAAGGATGATCTTGAAAAGGGCGTTTCAAGTCTTGCGCTTTTTGTTCCTGAAGACCGCGAAACTGTTCTGCAAAAT
ATTGAAAACCGGTTGAAAAATATTCCGTTTGAGAATCATGAATATACCGCGTTGAGAAAAGACGGCACTACCTTTCCAAT
CCTGATCTACACCGCTCGTATTAATCGGGGTGGCGTGCCTGTCGGTATTCGGGGTATTGTGCTTGATATTACGGATCGCA
AACAGGCCGAGGAAAATCTCGTGCAGCTTAACCAGAATCTTGAGCTGCGGGTTGAGGAACGCACAAGAGAGCTTGAAGTG
ACGCATCAGCAGATGATTTTGCAGGAGAAACTTGCTTCAATCGGTCAGCTTGCGGCAGGTATTGCTCACGAACTGAACAA
CCCTATCAATTTTGTCAGAATCAATTTCGCAACCCTGCAGGAGGATGTTTCCGATCTCCATACGCTTCTCAAAGAGTATC
GCCTTGTGACGGAAAAACTGGAAGATCGTCCGCTTTCGTCTGAAGAGCTTAAAAAGTTGCGATTGGCTGAGGAATCTCTT
GCTGTTGATTCACTGCTCGAGAGCATTCCTGAAATTTTTGCCGAATCCCAGCGCGGGTTCGAACGCATTACAACTATCAT
CGGAAGCATGCGGAACTTCTCGTTTCGTCATGCAATTGATGAACGGGTTCAGTTCAATATCAACAAGGGTATTTGTGATA
CGCTCATTATCGCCAGAAATGAATATCGATATCTTGCTGATGTGACGACAAAACTTGAAGATCTGCCTTCAGTTCCCTGT
AATCCCGAGCAGGTTAACCAGGTTTTTCTCAATCTTGTGGTTAACAGCGCTCATGCTATTGAGTCACAGCATCGGCTGGA
AAAAGGAAAGATCACCATTCGCACCTGGTACGACAGCAGCAATGTTTTCTGTTCCGTAACCGATGACGGTCCAGGTATTC
CTCCTGAAGTCAGACGCCGTATTTTTGAGCCGTTTTTCACCACCAAACAACCGGGAAAAGGTACCGGTCTCGGTCTGAGC
ATCTCCTATGATATCGTTGTTCATAAACATGGAGGAACTCTTGATGTTCATTGCCCGCCCGAGGGAGGTACCGTTATTAC
TCTTTCGCTTCCCCTGAGACAAATGACCGAAACGACAAACCCATGA

Upstream 100 bases:

>100_bases
TCTTCTCTGCACATCTTCCTCATAAATGCATATATTTGGTATAATGAGGTTATGATTTGCCTTTTGTGCGGGTCGATGAC
AACATAAACAAACGTGATAG

Downstream 100 bases:

>100_bases
AAAATATTGCTGATATAACGGTGCTTTTTGTTGATGATGAGGCTGATATTCTCAGCTCATTAAACAGGTTTCTGCGCAGG
GAGCCCTATAAAAAACTGTT

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 681; Mature: 680

Protein sequence:

>681_residues
MSAVEKKATVLIVDDSALIRASTSHIIRELGFNPVTAECGDDCIELLNTSKIDLVLLDINMPGKNGMEVLSDIRNHHFMV
PVIMISGSNDIEQAVQSVKMGAYQYLIKPVNPDKLEVTVKNALSESKLRQKVKLFSAVITRSPITIAITDNHGDLEYVNP
AFSRTTGYSYKEAIGKNPRILKSGDQPDEYYKALWDTITAGKVWHGEFHNRKKNGEMYWEEAIISPITDHTGKISHYISL
KQDISQRKKEQEALAESESRFQELADLLPQPVFELDMKGNIIYTNSLGFQAFGYTKDDLEKGVSSLALFVPEDRETVLQN
IENRLKNIPFENHEYTALRKDGTTFPILIYTARINRGGVPVGIRGIVLDITDRKQAEENLVQLNQNLELRVEERTRELEV
THQQMILQEKLASIGQLAAGIAHELNNPINFVRINFATLQEDVSDLHTLLKEYRLVTEKLEDRPLSSEELKKLRLAEESL
AVDSLLESIPEIFAESQRGFERITTIIGSMRNFSFRHAIDERVQFNINKGICDTLIIARNEYRYLADVTTKLEDLPSVPC
NPEQVNQVFLNLVVNSAHAIESQHRLEKGKITIRTWYDSSNVFCSVTDDGPGIPPEVRRRIFEPFFTTKQPGKGTGLGLS
ISYDIVVHKHGGTLDVHCPPEGGTVITLSLPLRQMTETTNP

Sequences:

>Translated_681_residues
MSAVEKKATVLIVDDSALIRASTSHIIRELGFNPVTAECGDDCIELLNTSKIDLVLLDINMPGKNGMEVLSDIRNHHFMV
PVIMISGSNDIEQAVQSVKMGAYQYLIKPVNPDKLEVTVKNALSESKLRQKVKLFSAVITRSPITIAITDNHGDLEYVNP
AFSRTTGYSYKEAIGKNPRILKSGDQPDEYYKALWDTITAGKVWHGEFHNRKKNGEMYWEEAIISPITDHTGKISHYISL
KQDISQRKKEQEALAESESRFQELADLLPQPVFELDMKGNIIYTNSLGFQAFGYTKDDLEKGVSSLALFVPEDRETVLQN
IENRLKNIPFENHEYTALRKDGTTFPILIYTARINRGGVPVGIRGIVLDITDRKQAEENLVQLNQNLELRVEERTRELEV
THQQMILQEKLASIGQLAAGIAHELNNPINFVRINFATLQEDVSDLHTLLKEYRLVTEKLEDRPLSSEELKKLRLAEESL
AVDSLLESIPEIFAESQRGFERITTIIGSMRNFSFRHAIDERVQFNINKGICDTLIIARNEYRYLADVTTKLEDLPSVPC
NPEQVNQVFLNLVVNSAHAIESQHRLEKGKITIRTWYDSSNVFCSVTDDGPGIPPEVRRRIFEPFFTTKQPGKGTGLGLS
ISYDIVVHKHGGTLDVHCPPEGGTVITLSLPLRQMTETTNP
>Mature_680_residues
SAVEKKATVLIVDDSALIRASTSHIIRELGFNPVTAECGDDCIELLNTSKIDLVLLDINMPGKNGMEVLSDIRNHHFMVP
VIMISGSNDIEQAVQSVKMGAYQYLIKPVNPDKLEVTVKNALSESKLRQKVKLFSAVITRSPITIAITDNHGDLEYVNPA
FSRTTGYSYKEAIGKNPRILKSGDQPDEYYKALWDTITAGKVWHGEFHNRKKNGEMYWEEAIISPITDHTGKISHYISLK
QDISQRKKEQEALAESESRFQELADLLPQPVFELDMKGNIIYTNSLGFQAFGYTKDDLEKGVSSLALFVPEDRETVLQNI
ENRLKNIPFENHEYTALRKDGTTFPILIYTARINRGGVPVGIRGIVLDITDRKQAEENLVQLNQNLELRVEERTRELEVT
HQQMILQEKLASIGQLAAGIAHELNNPINFVRINFATLQEDVSDLHTLLKEYRLVTEKLEDRPLSSEELKKLRLAEESLA
VDSLLESIPEIFAESQRGFERITTIIGSMRNFSFRHAIDERVQFNINKGICDTLIIARNEYRYLADVTTKLEDLPSVPCN
PEQVNQVFLNLVVNSAHAIESQHRLEKGKITIRTWYDSSNVFCSVTDDGPGIPPEVRRRIFEPFFTTKQPGKGTGLGLSI
SYDIVVHKHGGTLDVHCPPEGGTVITLSLPLRQMTETTNP

Specific function: Required for the inhibition of nifA activity in response to oxygen and low level of fixed nitrogen [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Homo sapiens, GI26006851, Length=123, Percent_Identity=34.9593495934959, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI71164873, Length=123, Percent_Identity=34.9593495934959, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI71164869, Length=123, Percent_Identity=34.9593495934959, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI27734721, Length=131, Percent_Identity=35.8778625954198, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1788549, Length=465, Percent_Identity=25.8064516129032, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790436, Length=283, Percent_Identity=28.6219081272085, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788905, Length=141, Percent_Identity=31.2056737588652, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790299, Length=126, Percent_Identity=32.5396825396825, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1788550, Length=142, Percent_Identity=30.2816901408451, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790437, Length=117, Percent_Identity=31.6239316239316, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786599, Length=116, Percent_Identity=31.0344827586207, Blast_Score=74, Evalue=5e-14,
Organism=Escherichia coli, GI87081816, Length=143, Percent_Identity=32.1678321678322, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1790863, Length=117, Percent_Identity=29.9145299145299, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788191, Length=115, Percent_Identity=33.9130434782609, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1787487, Length=125, Percent_Identity=32, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1789453, Length=96, Percent_Identity=31.25, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788222, Length=117, Percent_Identity=29.9145299145299, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR014285
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 76778; Mature: 76647

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVEKKATVLIVDDSALIRASTSHIIRELGFNPVTAECGDDCIELLNTSKIDLVLLDIN
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEEEC
MPGKNGMEVLSDIRNHHFMVPVIMISGSNDIEQAVQSVKMGAYQYLIKPVNPDKLEVTVK
CCCCCHHHHHHHHHCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHEEECCCCCEEEEEHH
NALSESKLRQKVKLFSAVITRSPITIAITDNHGDLEYVNPAFSRTTGYSYKEAIGKNPRI
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEECCCHHHHCCCCCHHHHHCCCCCE
LKSGDQPDEYYKALWDTITAGKVWHGEFHNRKKNGEMYWEEAIISPITDHTGKISHYISL
ECCCCCHHHHHHHHHHHHHCCCEEECHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
KQDISQRKKEQEALAESESRFQELADLLPQPVFELDMKGNIIYTNSLGFQAFGYTKDDLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEECCCCEECCCCHHHHH
KGVSSLALFVPEDRETVLQNIENRLKNIPFENHEYTALRKDGTTFPILIYTARINRGGVP
HHHHHEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEEEEEECCCCCC
VGIRGIVLDITDRKQAEENLVQLNQNLELRVEERTRELEVTHQQMILQEKLASIGQLAAG
EEEEEEEEEECCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAHELNNPINFVRINFATLQEDVSDLHTLLKEYRLVTEKLEDRPLSSEELKKLRLAEESL
HHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AVDSLLESIPEIFAESQRGFERITTIIGSMRNFSFRHAIDERVQFNINKGICDTLIIARN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCCHHHEEEECC
EYRYLADVTTKLEDLPSVPCNPEQVNQVFLNLVVNSAHAIESQHRLEKGKITIRTWYDSS
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
NVFCSVTDDGPGIPPEVRRRIFEPFFTTKQPGKGTGLGLSISYDIVVHKHGGTLDVHCPP
CEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCCEEEEEECC
EGGTVITLSLPLRQMTETTNP
CCCEEEEEECCHHHHHCCCCC
>Mature Secondary Structure 
SAVEKKATVLIVDDSALIRASTSHIIRELGFNPVTAECGDDCIELLNTSKIDLVLLDIN
CCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEEEC
MPGKNGMEVLSDIRNHHFMVPVIMISGSNDIEQAVQSVKMGAYQYLIKPVNPDKLEVTVK
CCCCCHHHHHHHHHCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHEEECCCCCEEEEEHH
NALSESKLRQKVKLFSAVITRSPITIAITDNHGDLEYVNPAFSRTTGYSYKEAIGKNPRI
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEECCCHHHHCCCCCHHHHHCCCCCE
LKSGDQPDEYYKALWDTITAGKVWHGEFHNRKKNGEMYWEEAIISPITDHTGKISHYISL
ECCCCCHHHHHHHHHHHHHCCCEEECHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
KQDISQRKKEQEALAESESRFQELADLLPQPVFELDMKGNIIYTNSLGFQAFGYTKDDLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEECCCCEECCCCHHHHH
KGVSSLALFVPEDRETVLQNIENRLKNIPFENHEYTALRKDGTTFPILIYTARINRGGVP
HHHHHEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEEEEEECCCCCC
VGIRGIVLDITDRKQAEENLVQLNQNLELRVEERTRELEVTHQQMILQEKLASIGQLAAG
EEEEEEEEEECCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAHELNNPINFVRINFATLQEDVSDLHTLLKEYRLVTEKLEDRPLSSEELKKLRLAEESL
HHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AVDSLLESIPEIFAESQRGFERITTIIGSMRNFSFRHAIDERVQFNINKGICDTLIIARN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCCHHHEEEECC
EYRYLADVTTKLEDLPSVPCNPEQVNQVFLNLVVNSAHAIESQHRLEKGKITIRTWYDSS
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
NVFCSVTDDGPGIPPEVRRRIFEPFFTTKQPGKGTGLGLSISYDIVVHKHGGTLDVHCPP
CEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEEECCCEEEEEECC
EGGTVITLSLPLRQMTETTNP
CCCEEEEEECCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8231815; 2840552; 9601070; 9593306 [H]