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The map label for this gene is cqsS [H]

Identifier: 119357598

GI number: 119357598

Start: 2053271

End: 2055370

Strand: Reverse

Name: cqsS [H]

Synonym: Cpha266_1801

Alternate gene names: 119357598

Gene position: 2055370-2053271 (Counterclockwise)

Preceding gene: 119357599

Following gene: 119357597

Centisome position: 65.59

GC content: 45.38

Gene sequence:

>2100_bases
GTGTTGGCCTACATTCGACAGTGTGTAATTGACGGTACTCAGGTATCACGTTTCAATACGCTTGCAGCCGGGCTTCTTGG
CGCTCCAGCCCATTTCTTTTTTTATTTTATTTTCAAATATGGTTTTGATCTTCCTTATGAAAACCTGTTCCTTCGTCTGA
CGGCAACGCTCTTGTGTCTTGCCGTGCTTTTCAAGAGCAGACTTCCCGGTTTTATTCAGACCCGGTTCACTTTTTTCTGG
CATTTCACCATAATTTTTGTTCTTCCCTTTGTTTTTACGGTCAATCTTATCATGAACAACTTTCATGAGCTGTGGCTGTA
CTGGGAAATTTTTATGCTGTTTGTGCTTATTGCCTTTGTTCCCAACTGGCTGATGTTTCTTTTTGATCTGCTTCTGGGTT
TTGCCGGGGCGGTTGTATTTTATTTTCTTTCAACTCCACGCGTCGAACTCCATCCCGAATTCAATATTCCACTCTATCTT
CTGGTGCTGGTGTTTACCATTGTTGCCGGTTATGTCTTCAGCTACAGCAATAAAAGGGGGATTATGGCCATGGAGAGAAA
CAATGCCCTTAAGGCTCTTGCGGCCGGCATTGCCCATGAGATGCGTAATCCTCTGGGTCAGATACGCTATAATCTTGAAT
CCATTCAGGAAGAACTCCCGCTCTATCATGCAGAAAGGCTCTATCCTTCGATCAGCGCAGGAGGAGTCGAACGAATCTAT
GAAAAAGTTGCCCGAGGTCAGATAGCAGTCAACAGGGGCATTCAGGTCATTGAGATGATTCTTGAAGAGGTCAGGGAAGA
TGCTTCAGAGGATGCCGGATTAACCTATCTGTCCGCTGCGGCAATAACTCGCAAGGCTATTGATGAATATGGCTACGAAT
CGCAAGAAGAGCGTCAACGCGTTCATTTTTTTGAAGACGATGATTTTGTTTTCAAGGGTGTAGAGACCATGTATGTTTTT
GTGCTTTTCAATCTTGTCATGAATGCGCTCTATTTTCTCCGCTCTTTTCCCGACGGTCGCATCGATATCCGTCTCAAAAG
AGGGGAGATCTTAAACAGTGTTACAGTAAGAGATACTGGCCCTGGCGTTGCTAAAGAGAATCTTGCAAAGTTGTTTGACC
CTTTTTATACTTCCGGCAGAAAAGGCGGGACTGGTCTTGGTCTTGCCTACTGCAAGCGGGTTATGCGTTTTTTCGGGGGA
GATATTGTCTGTCGTTCTGTTCGGTATGAATTCACTGAATTTATACTGACATTTCCTCCGGTGAGTGATGGCGATATTGC
CGATTTTGAGGCAGATCTTTATGCTCAATATCATGAACTCTTTTCGGCAAAGCGGATTCTTCATGTTGGTGCTGATCCGG
CAAATCTTGTATTGATTGCCCGGTATCTTTTGCCGCTCAGTGTTGAGCTCGATCAGGTTCAGAGCGGAGCAGAGGCAATG
GAGATGATAGCATCAAGACAATATGACCTTGTTCTTCTGGATCTTGAACTGCCGATTATTGACGGCTATGAGCTTGCTTT
CAGAATGCAGGAAAACGGCGTCGTTCTGTCGATCGTCGCCTATACCCGAATGTCCTCGACGTTGTTGAAGGGACGTGCGG
AAAAGTTAGGTATACAGGCACTGCTTTCCATGCCCATAGTTCTGGCGGAGCTTCTTTCGGTGCTTGCGGAAGCGATCGAG
ACAAAACCGGATACCCTGAAAAACTCTCTGGCCGGAAAAACGGTGCTTGTCGCAGATGATTCTGCCCTTAATCGTATGGT
CGTCAAAAACATACTGCAACGGGGCGGTTTAACGGTTCTTGATGCGAAAAACGGTCAGGAGGCCATTGATATCCTTGAAC
ATTATCCATGCGATCTTTTGCTTATCGATATTCAAATGCCTGTTCTTGACGGGCTTGAAGCGGCAAAGCGCATTCGTGCA
ACAAAGAGTGGTTACCGCGGCATTCCGATTATCTGTCTGAGTGGTGATGGTGACAAGGAAACCGTTCGTCGTGCTATGGA
GAGCGGTATGAATGATTATCTTATAAAACCTGTCGACAGTAAAAATCTTTTGCAGAAGGTCTCCCGTTTGCTGTTATTGA
CTGAAAAAACACAGAAATAA

Upstream 100 bases:

>100_bases
CCGCAACGGGTGATTATCGTCGTGGCGCATCCATAGAGGCGTGCTTCAGGGCAGCGGGGGAGTGTGTGCATAAATTACTT
GACGGGGGTAAGGATTGAAG

Downstream 100 bases:

>100_bases
ACCACTGTTTTTTGTTGTGTTTCAATTTTTTTTAAACTCTGAAGGAGGTTCGGCATGGGTATTTTTGACCGTTTCTTTAA
GAAGGAGTCGAATGCACCAG

Product: integral membrane sensor hybrid histidine kinase

Products: NA

Alternate protein names: Cholerae quorum-sensing sensor [H]

Number of amino acids: Translated: 699; Mature: 699

Protein sequence:

>699_residues
MLAYIRQCVIDGTQVSRFNTLAAGLLGAPAHFFFYFIFKYGFDLPYENLFLRLTATLLCLAVLFKSRLPGFIQTRFTFFW
HFTIIFVLPFVFTVNLIMNNFHELWLYWEIFMLFVLIAFVPNWLMFLFDLLLGFAGAVVFYFLSTPRVELHPEFNIPLYL
LVLVFTIVAGYVFSYSNKRGIMAMERNNALKALAAGIAHEMRNPLGQIRYNLESIQEELPLYHAERLYPSISAGGVERIY
EKVARGQIAVNRGIQVIEMILEEVREDASEDAGLTYLSAAAITRKAIDEYGYESQEERQRVHFFEDDDFVFKGVETMYVF
VLFNLVMNALYFLRSFPDGRIDIRLKRGEILNSVTVRDTGPGVAKENLAKLFDPFYTSGRKGGTGLGLAYCKRVMRFFGG
DIVCRSVRYEFTEFILTFPPVSDGDIADFEADLYAQYHELFSAKRILHVGADPANLVLIARYLLPLSVELDQVQSGAEAM
EMIASRQYDLVLLDLELPIIDGYELAFRMQENGVVLSIVAYTRMSSTLLKGRAEKLGIQALLSMPIVLAELLSVLAEAIE
TKPDTLKNSLAGKTVLVADDSALNRMVVKNILQRGGLTVLDAKNGQEAIDILEHYPCDLLLIDIQMPVLDGLEAAKRIRA
TKSGYRGIPIICLSGDGDKETVRRAMESGMNDYLIKPVDSKNLLQKVSRLLLLTEKTQK

Sequences:

>Translated_699_residues
MLAYIRQCVIDGTQVSRFNTLAAGLLGAPAHFFFYFIFKYGFDLPYENLFLRLTATLLCLAVLFKSRLPGFIQTRFTFFW
HFTIIFVLPFVFTVNLIMNNFHELWLYWEIFMLFVLIAFVPNWLMFLFDLLLGFAGAVVFYFLSTPRVELHPEFNIPLYL
LVLVFTIVAGYVFSYSNKRGIMAMERNNALKALAAGIAHEMRNPLGQIRYNLESIQEELPLYHAERLYPSISAGGVERIY
EKVARGQIAVNRGIQVIEMILEEVREDASEDAGLTYLSAAAITRKAIDEYGYESQEERQRVHFFEDDDFVFKGVETMYVF
VLFNLVMNALYFLRSFPDGRIDIRLKRGEILNSVTVRDTGPGVAKENLAKLFDPFYTSGRKGGTGLGLAYCKRVMRFFGG
DIVCRSVRYEFTEFILTFPPVSDGDIADFEADLYAQYHELFSAKRILHVGADPANLVLIARYLLPLSVELDQVQSGAEAM
EMIASRQYDLVLLDLELPIIDGYELAFRMQENGVVLSIVAYTRMSSTLLKGRAEKLGIQALLSMPIVLAELLSVLAEAIE
TKPDTLKNSLAGKTVLVADDSALNRMVVKNILQRGGLTVLDAKNGQEAIDILEHYPCDLLLIDIQMPVLDGLEAAKRIRA
TKSGYRGIPIICLSGDGDKETVRRAMESGMNDYLIKPVDSKNLLQKVSRLLLLTEKTQK
>Mature_699_residues
MLAYIRQCVIDGTQVSRFNTLAAGLLGAPAHFFFYFIFKYGFDLPYENLFLRLTATLLCLAVLFKSRLPGFIQTRFTFFW
HFTIIFVLPFVFTVNLIMNNFHELWLYWEIFMLFVLIAFVPNWLMFLFDLLLGFAGAVVFYFLSTPRVELHPEFNIPLYL
LVLVFTIVAGYVFSYSNKRGIMAMERNNALKALAAGIAHEMRNPLGQIRYNLESIQEELPLYHAERLYPSISAGGVERIY
EKVARGQIAVNRGIQVIEMILEEVREDASEDAGLTYLSAAAITRKAIDEYGYESQEERQRVHFFEDDDFVFKGVETMYVF
VLFNLVMNALYFLRSFPDGRIDIRLKRGEILNSVTVRDTGPGVAKENLAKLFDPFYTSGRKGGTGLGLAYCKRVMRFFGG
DIVCRSVRYEFTEFILTFPPVSDGDIADFEADLYAQYHELFSAKRILHVGADPANLVLIARYLLPLSVELDQVQSGAEAM
EMIASRQYDLVLLDLELPIIDGYELAFRMQENGVVLSIVAYTRMSSTLLKGRAEKLGIQALLSMPIVLAELLSVLAEAIE
TKPDTLKNSLAGKTVLVADDSALNRMVVKNILQRGGLTVLDAKNGQEAIDILEHYPCDLLLIDIQMPVLDGLEAAKRIRA
TKSGYRGIPIICLSGDGDKETVRRAMESGMNDYLIKPVDSKNLLQKVSRLLLLTEKTQK

Specific function: Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to luxU and luxO [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=383, Percent_Identity=25.3263707571802, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI48994928, Length=254, Percent_Identity=27.5590551181102, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1788713, Length=277, Percent_Identity=28.158844765343, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI1790436, Length=237, Percent_Identity=27.8481012658228, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788549, Length=253, Percent_Identity=25.6916996047431, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=228, Percent_Identity=25.4385964912281, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI87081816, Length=211, Percent_Identity=27.4881516587678, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1786599, Length=120, Percent_Identity=28.3333333333333, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=355, Percent_Identity=26.1971830985915, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323034, Length=164, Percent_Identity=29.2682926829268, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 79107; Mature: 79107

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAYIRQCVIDGTQVSRFNTLAAGLLGAPAHFFFYFIFKYGFDLPYENLFLRLTATLLCL
CHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AVLFKSRLPGFIQTRFTFFWHFTIIFVLPFVFTVNLIMNNFHELWLYWEIFMLFVLIAFV
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PNWLMFLFDLLLGFAGAVVFYFLSTPRVELHPEFNIPLYLLVLVFTIVAGYVFSYSNKRG
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
IMAMERNNALKALAAGIAHEMRNPLGQIRYNLESIQEELPLYHAERLYPSISAGGVERIY
EEEEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHH
EKVARGQIAVNRGIQVIEMILEEVREDASEDAGLTYLSAAAITRKAIDEYGYESQEERQR
HHHHCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
VHFFEDDDFVFKGVETMYVFVLFNLVMNALYFLRSFPDGRIDIRLKRGEILNSVTVRDTG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHCCEEEECCC
PGVAKENLAKLFDPFYTSGRKGGTGLGLAYCKRVMRFFGGDIVCRSVRYEFTEFILTFPP
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEECCC
VSDGDIADFEADLYAQYHELFSAKRILHVGADPANLVLIARYLLPLSVELDQVQSGAEAM
CCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHCCCCCHHHHHCCHHHH
EMIASRQYDLVLLDLELPIIDGYELAFRMQENGVVLSIVAYTRMSSTLLKGRAEKLGIQA
HHHHCCCCCEEEEEEECCEECCCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
LLSMPIVLAELLSVLAEAIETKPDTLKNSLAGKTVLVADDSALNRMVVKNILQRGGLTVL
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCEEEE
DAKNGQEAIDILEHYPCDLLLIDIQMPVLDGLEAAKRIRATKSGYRGIPIICLSGDGDKE
ECCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHH
TVRRAMESGMNDYLIKPVDSKNLLQKVSRLLLLTEKTQK
HHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLAYIRQCVIDGTQVSRFNTLAAGLLGAPAHFFFYFIFKYGFDLPYENLFLRLTATLLCL
CHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AVLFKSRLPGFIQTRFTFFWHFTIIFVLPFVFTVNLIMNNFHELWLYWEIFMLFVLIAFV
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PNWLMFLFDLLLGFAGAVVFYFLSTPRVELHPEFNIPLYLLVLVFTIVAGYVFSYSNKRG
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
IMAMERNNALKALAAGIAHEMRNPLGQIRYNLESIQEELPLYHAERLYPSISAGGVERIY
EEEEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHH
EKVARGQIAVNRGIQVIEMILEEVREDASEDAGLTYLSAAAITRKAIDEYGYESQEERQR
HHHHCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
VHFFEDDDFVFKGVETMYVFVLFNLVMNALYFLRSFPDGRIDIRLKRGEILNSVTVRDTG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHCCEEEECCC
PGVAKENLAKLFDPFYTSGRKGGTGLGLAYCKRVMRFFGGDIVCRSVRYEFTEFILTFPP
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEECCC
VSDGDIADFEADLYAQYHELFSAKRILHVGADPANLVLIARYLLPLSVELDQVQSGAEAM
CCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHCCCCCHHHHHCCHHHH
EMIASRQYDLVLLDLELPIIDGYELAFRMQENGVVLSIVAYTRMSSTLLKGRAEKLGIQA
HHHHCCCCCEEEEEEECCEECCCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
LLSMPIVLAELLSVLAEAIETKPDTLKNSLAGKTVLVADDSALNRMVVKNILQRGGLTVL
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCEEEE
DAKNGQEAIDILEHYPCDLLLIDIQMPVLDGLEAAKRIRATKSGYRGIPIICLSGDGDKE
ECCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHH
TVRRAMESGMNDYLIKPVDSKNLLQKVSRLLLLTEKTQK
HHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA