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The map label for this gene is serS

Identifier: 119357562

GI number: 119357562

Start: 2006131

End: 2007426

Strand: Direct

Name: serS

Synonym: Cpha266_1765

Alternate gene names: 119357562

Gene position: 2006131-2007426 (Clockwise)

Preceding gene: 119357561

Following gene: 119357565

Centisome position: 64.01

GC content: 49.0

Gene sequence:

>1296_bases
ATGCTTGACATTACCTATGTCCGACAGAACCTGGCTGAAATAGAATCCATGTTGCAGAATCGCCAGCTTGCGTCTGAAAA
ACCCCGGCTCCGTCAGCTCCTTGAATACGATAAAAACCGCAGAGAGCTTGTTCAGCGATCCGATGAGATGAAAGCTCAAC
GCAATAAGGTATCGAAGGAAATTGCCGACATTAAAAGAACCGGCCAGGGATCGGGCGAGGAACTTATCCGACAGATGAAA
GAGGTTTCCGATGAGATCACCATGATGGACGCAACCCTCTCAAAGCTTGCATCAGACATTGAAGAGATACTGCTCTCCCT
GCCAAACAGACTGCATGAATCCGTGCCGACAGGCAAATGCGCAGAGGACAATGTAATCTGCAAAGCACCCGTTCCCTATC
TGCATCTGCTTGATTTCCCGATAAAAAACCATCTTGAACTGGGCAGATCACTCGGCATTCTCGATTTTGAACGAGGCGCG
AAAATCAGCGGTGCCGGCTTCCCTGTCTATATCGGAAAAGGCGCGCGACTTGAACGTGCGCTGATTAACTTCATGCTCGA
TTACCATACCGACCATCACGGCTTCACCGAAGTGTTTCCCCCGTTTTTTGTCAATCAGGAATCACTGCGAGGTACTGGCC
AATGGCCTAAATTCGCTGACCAGGTCTACCATATCGAAGAAGACAATCTCTATGCCATTCCTACGGCTGAAGTACCGGTC
ACAAACCTCCATCGCAATGAAATGATTGATGCTGAACGGCTTCCCGTCTCCTATGTTGCATATTCCGCATGTTTCAGACG
GGAAGCGGGAAGCTACGGCAAGGATACCCGAGGATTTTTACGGGTACACCAGTTTAACAAGGTTGAAATGGTAAAATTCA
CCCGTCCTGAAGAGTCCTATCAAGAGCTTGAAAAGATTCTCATGAGCGCCGAAGCAATTCTGCAGGCACTTATGATCCCT
TATCGGGTACTCCTGCTCTGCAGCGGCGACATCAGTGCCAATGCCACAAAATGCTATGATATCGAAGTGTGGTCACCAGC
AGAAGAGAAATATCTTGAAGCTTCGAGCTGTTCGAATTTCGAGGATTACCAGGCAAGACGCATGAACATCCGATTCAAGG
CCGACAGTCGCTCAAAGCCGGAGTTTGTACATACGCTTAACGGATCAGGCCTTGCAACATCCAGACTGATGGTATCCCTG
CTTGAACACTATCAGAACCGGGACGGCTCGATAACCATTCCGGAGGCCTTGCGACCCTATACAGGATTCACATCGATCGA
TCAGCTAACATCCTGA

Upstream 100 bases:

>100_bases
GAAGCCATGAAAACCCTCAAAGGAAAGGCTGACGGCACCAAAGTACAGCTCATTGTAAAATCGCAGCTCTCTCTCTAAAC
CCCATTGTTGTTGATAGACT

Downstream 100 bases:

>100_bases
TCTCCGCCCGACGCCCGATCATTCATAAATTCCCTTACCATGCGGCTGACCTTTTCGGTATCAATAAGAAAAGCGTCATG
TCCGTATGGCTCTTCAAGGT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLDITYVRQNLAEIESMLQNRQLASEKPRLRQLLEYDKNRRELVQRSDEMKAQRNKVSKEIADIKRTGQGSGEELIRQMK
EVSDEITMMDATLSKLASDIEEILLSLPNRLHESVPTGKCAEDNVICKAPVPYLHLLDFPIKNHLELGRSLGILDFERGA
KISGAGFPVYIGKGARLERALINFMLDYHTDHHGFTEVFPPFFVNQESLRGTGQWPKFADQVYHIEEDNLYAIPTAEVPV
TNLHRNEMIDAERLPVSYVAYSACFRREAGSYGKDTRGFLRVHQFNKVEMVKFTRPEESYQELEKILMSAEAILQALMIP
YRVLLLCSGDISANATKCYDIEVWSPAEEKYLEASSCSNFEDYQARRMNIRFKADSRSKPEFVHTLNGSGLATSRLMVSL
LEHYQNRDGSITIPEALRPYTGFTSIDQLTS

Sequences:

>Translated_431_residues
MLDITYVRQNLAEIESMLQNRQLASEKPRLRQLLEYDKNRRELVQRSDEMKAQRNKVSKEIADIKRTGQGSGEELIRQMK
EVSDEITMMDATLSKLASDIEEILLSLPNRLHESVPTGKCAEDNVICKAPVPYLHLLDFPIKNHLELGRSLGILDFERGA
KISGAGFPVYIGKGARLERALINFMLDYHTDHHGFTEVFPPFFVNQESLRGTGQWPKFADQVYHIEEDNLYAIPTAEVPV
TNLHRNEMIDAERLPVSYVAYSACFRREAGSYGKDTRGFLRVHQFNKVEMVKFTRPEESYQELEKILMSAEAILQALMIP
YRVLLLCSGDISANATKCYDIEVWSPAEEKYLEASSCSNFEDYQARRMNIRFKADSRSKPEFVHTLNGSGLATSRLMVSL
LEHYQNRDGSITIPEALRPYTGFTSIDQLTS
>Mature_431_residues
MLDITYVRQNLAEIESMLQNRQLASEKPRLRQLLEYDKNRRELVQRSDEMKAQRNKVSKEIADIKRTGQGSGEELIRQMK
EVSDEITMMDATLSKLASDIEEILLSLPNRLHESVPTGKCAEDNVICKAPVPYLHLLDFPIKNHLELGRSLGILDFERGA
KISGAGFPVYIGKGARLERALINFMLDYHTDHHGFTEVFPPFFVNQESLRGTGQWPKFADQVYHIEEDNLYAIPTAEVPV
TNLHRNEMIDAERLPVSYVAYSACFRREAGSYGKDTRGFLRVHQFNKVEMVKFTRPEESYQELEKILMSAEAILQALMIP
YRVLLLCSGDISANATKCYDIEVWSPAEEKYLEASSCSNFEDYQARRMNIRFKADSRSKPEFVHTLNGSGLATSRLMVSL
LEHYQNRDGSITIPEALRPYTGFTSIDQLTS

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=429, Percent_Identity=31.2354312354312, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI8923421, Length=360, Percent_Identity=32.2222222222222, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI225579074, Length=335, Percent_Identity=33.7313432835821, Blast_Score=171, Evalue=2e-42,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=44.0559440559441, Blast_Score=357, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI17539260, Length=463, Percent_Identity=29.8056155507559, Blast_Score=200, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI17542084, Length=261, Percent_Identity=33.3333333333333, Blast_Score=138, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=408, Percent_Identity=34.5588235294118, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6321799, Length=436, Percent_Identity=30.5045871559633, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24581334, Length=369, Percent_Identity=32.7913279132791, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI17737985, Length=281, Percent_Identity=33.4519572953737, Blast_Score=143, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_CHLPD (A1BHA5)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912206.1
- ProteinModelPortal:   A1BHA5
- SMR:   A1BHA5
- STRING:   A1BHA5
- GeneID:   4570109
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_1765
- NMPDR:   fig|290317.7.peg.1848
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 49246; Mature: 49246

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS50862 AA_TRNA_LIGASE_II; PS00037 MYB_1

Important sites: BINDING 282-282 BINDING 289-289 BINDING 389-389

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDITYVRQNLAEIESMLQNRQLASEKPRLRQLLEYDKNRRELVQRSDEMKAQRNKVSKE
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
IADIKRTGQGSGEELIRQMKEVSDEITMMDATLSKLASDIEEILLSLPNRLHESVPTGKC
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AEDNVICKAPVPYLHLLDFPIKNHLELGRSLGILDFERGAKISGAGFPVYIGKGARLERA
CCCCEEEECCCCCHHHHCCCHHHHHHHHHHCCCEECCCCCEECCCCCEEEECCCCHHHHH
LINFMLDYHTDHHGFTEVFPPFFVNQESLRGTGQWPKFADQVYHIEEDNLYAIPTAEVPV
HHHHHHHHCCCCCCHHHHCCCHHCCHHHCCCCCCCCHHHHHEEEECCCCEEEECCCCCCC
TNLHRNEMIDAERLPVSYVAYSACFRREAGSYGKDTRGFLRVHQFNKVEMVKFTRPEESY
CCCCHHHCCCHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEEECCCHHHH
QELEKILMSAEAILQALMIPYRVLLLCSGDISANATKCYDIEVWSPAEEKYLEASSCSNF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCHHHHHHCHHCCCCC
EDYQARRMNIRFKADSRSKPEFVHTLNGSGLATSRLMVSLLEHYQNRDGSITIPEALRPY
HHHHHHEEEEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCEECHHHHCCC
TGFTSIDQLTS
CCCCCHHHHCC
>Mature Secondary Structure
MLDITYVRQNLAEIESMLQNRQLASEKPRLRQLLEYDKNRRELVQRSDEMKAQRNKVSKE
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
IADIKRTGQGSGEELIRQMKEVSDEITMMDATLSKLASDIEEILLSLPNRLHESVPTGKC
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AEDNVICKAPVPYLHLLDFPIKNHLELGRSLGILDFERGAKISGAGFPVYIGKGARLERA
CCCCEEEECCCCCHHHHCCCHHHHHHHHHHCCCEECCCCCEECCCCCEEEECCCCHHHHH
LINFMLDYHTDHHGFTEVFPPFFVNQESLRGTGQWPKFADQVYHIEEDNLYAIPTAEVPV
HHHHHHHHCCCCCCHHHHCCCHHCCHHHCCCCCCCCHHHHHEEEECCCCEEEECCCCCCC
TNLHRNEMIDAERLPVSYVAYSACFRREAGSYGKDTRGFLRVHQFNKVEMVKFTRPEESY
CCCCHHHCCCHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEEECCCHHHH
QELEKILMSAEAILQALMIPYRVLLLCSGDISANATKCYDIEVWSPAEEKYLEASSCSNF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCHHHHHHCHHCCCCC
EDYQARRMNIRFKADSRSKPEFVHTLNGSGLATSRLMVSLLEHYQNRDGSITIPEALRPY
HHHHHHEEEEEEECCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCEECHHHHCCC
TGFTSIDQLTS
CCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA