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The map label for this gene is pepD [H]

Identifier: 119357481

GI number: 119357481

Start: 1907430

End: 1908884

Strand: Reverse

Name: pepD [H]

Synonym: Cpha266_1680

Alternate gene names: 119357481

Gene position: 1908884-1907430 (Counterclockwise)

Preceding gene: 119357487

Following gene: 119357474

Centisome position: 60.91

GC content: 52.03

Gene sequence:

>1455_bases
ATGAGTACTGATATTCTCCGACTGGAACCACATGCTGTGTGGAGAAATTTTTATAGTCTGACCAGGGTTCCACGTCCTTC
GGGCCATGAGGAAAAAATCAGGGAGTTCGTTTCGGGTTTTGGCAGAAAGCTTGGTTTGGAAACTATTGTCGACGAAGTCG
GGAACGTCATCATCCGCAAGCCCGCGACATCCGGCATGGAAAAACGCAAGGGGGTGATCCTGCAGGCTCACCTCGACATG
GTTCCAGAGAAGAATGGCGATAAGCTTCATGATTTTGCCCGGGATCCGATTGACGCCTTTGTTGACGGCGATTGGGTACG
TGCCAGAGGCACTACGCTCGGCGCCGATAACGGTATGGGTGTGGCGGCAGCTATGGCAGTGCTTGAATCGACCACGCTGC
GGCATGGTTTCATTGAAGCGCTGTTCACCTGCGAAGAGGAGGCTGGTATGACCGGAGCTATCGGACTGAAACCTGATCTG
CTCAAGGGAGAAATTCTTCTGAACATGGATTCGGAAGATGAGGGAGAACTGTTTATCGGCTGTGCCGGCGGCCTTGACGG
AACGATGACCTTCAGCTATAGCGAAGAGCGGATTTCTGCCGATTATACAGGGTTCGTTATCAGGGTAAGCGGCTTGAAGG
GTGGACACAGCGGCATGGATATTCATCTGGGACGTGGCAATGCCAACAAAATCATGAACCGTATCCTTTACGAAGGACAT
GCTCGATATGGTATGCGTCTGGCATCAATCGACGGCGGGACGCTTCGCAATGCCATACCGCGTGAAGCGACGGCTACGGT
GGCTGTTCCGACAGCAAATACCGGGACCTTTTATGAAGGTCTTTCCATACTTGCCGGAAAGATAAAGCATGAGCTTTCGA
CTGCTGATCCGGAGCTCTGCATAGAGGTGGTTCCAGCCGGGACACCGGAGATGGTAATTGAAGCGGGTGTTGTCGTCAGG
TTGCTCAATGCGCTCTATGCCTGTCCTGATGGCGTTATGCGAATGAGCAGTGATATGGCTGGCCTTGTTGAAACATCGAG
TAACCTTGCCATGGTAACGTCAGTGCACGGTGTTGTTACCATCAAGTGTCTGCTCAGAAGTTCTGTGGATTCTGCCATGG
AAGATCTCAAGGCAATGATCGGCTCTCTTTTCGATCTGGCGGGAGCGGGAGCGGTATTTGACGGGGGCTATCCCGGCTGG
AAACCGAATCCGGATTCACCGATTCTCAAGAGGATGCAGGAGGTCTATACATCGAAATTCGGTAAAACTCCCGAGATAAA
GGCTGTTCATGCTGGTCTCGAATGCGGGATTATTGGCGGCACCTCTCCTTCACTCGATATGATCTCTTTTGGTCCGACCA
TTCGCTATCCTCACTCTCCGGATGAAAAGGTCAATATCGCATCCGTCGGAAAATTCTGGGATTTTCTTGTGGAGACGCTC
AGGATGGCCCCTTGA

Upstream 100 bases:

>100_bases
AGTGACGAGAGGTGCCTTTTACTGTGTATGATCTTGTATATTTTGAACATAGAGGGATAAAAACATTTTTTTTTGACATT
CAACGGCAGTGCATTGATAT

Downstream 100 bases:

>100_bases
TTGTCAAGCTGTTTTTTTTGCCAGCTCGCGGTAAAAATCCATAAGGTGATTCGTGCCGGTGGCAGGAGCGACGTTGTCGA
TCTTGTTTACCGTGACGGCA

Product: Pep581 peptidase. metallo peptidase. MEROPS family M20C

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSTDILRLEPHAVWRNFYSLTRVPRPSGHEEKIREFVSGFGRKLGLETIVDEVGNVIIRKPATSGMEKRKGVILQAHLDM
VPEKNGDKLHDFARDPIDAFVDGDWVRARGTTLGADNGMGVAAAMAVLESTTLRHGFIEALFTCEEEAGMTGAIGLKPDL
LKGEILLNMDSEDEGELFIGCAGGLDGTMTFSYSEERISADYTGFVIRVSGLKGGHSGMDIHLGRGNANKIMNRILYEGH
ARYGMRLASIDGGTLRNAIPREATATVAVPTANTGTFYEGLSILAGKIKHELSTADPELCIEVVPAGTPEMVIEAGVVVR
LLNALYACPDGVMRMSSDMAGLVETSSNLAMVTSVHGVVTIKCLLRSSVDSAMEDLKAMIGSLFDLAGAGAVFDGGYPGW
KPNPDSPILKRMQEVYTSKFGKTPEIKAVHAGLECGIIGGTSPSLDMISFGPTIRYPHSPDEKVNIASVGKFWDFLVETL
RMAP

Sequences:

>Translated_484_residues
MSTDILRLEPHAVWRNFYSLTRVPRPSGHEEKIREFVSGFGRKLGLETIVDEVGNVIIRKPATSGMEKRKGVILQAHLDM
VPEKNGDKLHDFARDPIDAFVDGDWVRARGTTLGADNGMGVAAAMAVLESTTLRHGFIEALFTCEEEAGMTGAIGLKPDL
LKGEILLNMDSEDEGELFIGCAGGLDGTMTFSYSEERISADYTGFVIRVSGLKGGHSGMDIHLGRGNANKIMNRILYEGH
ARYGMRLASIDGGTLRNAIPREATATVAVPTANTGTFYEGLSILAGKIKHELSTADPELCIEVVPAGTPEMVIEAGVVVR
LLNALYACPDGVMRMSSDMAGLVETSSNLAMVTSVHGVVTIKCLLRSSVDSAMEDLKAMIGSLFDLAGAGAVFDGGYPGW
KPNPDSPILKRMQEVYTSKFGKTPEIKAVHAGLECGIIGGTSPSLDMISFGPTIRYPHSPDEKVNIASVGKFWDFLVETL
RMAP
>Mature_483_residues
STDILRLEPHAVWRNFYSLTRVPRPSGHEEKIREFVSGFGRKLGLETIVDEVGNVIIRKPATSGMEKRKGVILQAHLDMV
PEKNGDKLHDFARDPIDAFVDGDWVRARGTTLGADNGMGVAAAMAVLESTTLRHGFIEALFTCEEEAGMTGAIGLKPDLL
KGEILLNMDSEDEGELFIGCAGGLDGTMTFSYSEERISADYTGFVIRVSGLKGGHSGMDIHLGRGNANKIMNRILYEGHA
RYGMRLASIDGGTLRNAIPREATATVAVPTANTGTFYEGLSILAGKIKHELSTADPELCIEVVPAGTPEMVIEAGVVVRL
LNALYACPDGVMRMSSDMAGLVETSSNLAMVTSVHGVVTIKCLLRSSVDSAMEDLKAMIGSLFDLAGAGAVFDGGYPGWK
PNPDSPILKRMQEVYTSKFGKTPEIKAVHAGLECGIIGGTSPSLDMISFGPTIRYPHSPDEKVNIASVGKFWDFLVETLR
MAP

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=486, Percent_Identity=46.2962962962963, Blast_Score=453, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 52024; Mature: 51893

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDILRLEPHAVWRNFYSLTRVPRPSGHEEKIREFVSGFGRKLGLETIVDEVGNVIIRK
CCCCEEEECHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEC
PATSGMEKRKGVILQAHLDMVPEKNGDKLHDFARDPIDAFVDGDWVRARGTTLGADNGMG
CCCCCHHHHCCEEEEEEECCCCCCCCCHHHHHHCCCHHHHCCCCEEEECCCEECCCCCCH
VAAAMAVLESTTLRHGFIEALFTCEEEAGMTGAIGLKPDLLKGEILLNMDSEDEGELFIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCCCCCCEEEE
CAGGLDGTMTFSYSEERISADYTGFVIRVSGLKGGHSGMDIHLGRGNANKIMNRILYEGH
EECCCCCEEEEEECHHHHCCCCCEEEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHCC
ARYGMRLASIDGGTLRNAIPREATATVAVPTANTGTFYEGLSILAGKIKHELSTADPELC
HHHCEEEEECCCCHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCE
IEVVPAGTPEMVIEAGVVVRLLNALYACPDGVMRMSSDMAGLVETSSNLAMVTSVHGVVT
EEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHH
IKCLLRSSVDSAMEDLKAMIGSLFDLAGAGAVFDGGYPGWKPNPDSPILKRMQEVYTSKF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHC
GKTPEIKAVHAGLECGIIGGTSPSLDMISFGPTIRYPHSPDEKVNIASVGKFWDFLVETL
CCCCCCEEEECCCEEEEECCCCCCCCEEECCCEECCCCCCCCCEEHHHHHHHHHHHHHHH
RMAP
HCCC
>Mature Secondary Structure 
STDILRLEPHAVWRNFYSLTRVPRPSGHEEKIREFVSGFGRKLGLETIVDEVGNVIIRK
CCCEEEECHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEC
PATSGMEKRKGVILQAHLDMVPEKNGDKLHDFARDPIDAFVDGDWVRARGTTLGADNGMG
CCCCCHHHHCCEEEEEEECCCCCCCCCHHHHHHCCCHHHHCCCCEEEECCCEECCCCCCH
VAAAMAVLESTTLRHGFIEALFTCEEEAGMTGAIGLKPDLLKGEILLNMDSEDEGELFIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCCCCCCEEEE
CAGGLDGTMTFSYSEERISADYTGFVIRVSGLKGGHSGMDIHLGRGNANKIMNRILYEGH
EECCCCCEEEEEECHHHHCCCCCEEEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHCC
ARYGMRLASIDGGTLRNAIPREATATVAVPTANTGTFYEGLSILAGKIKHELSTADPELC
HHHCEEEEECCCCHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCE
IEVVPAGTPEMVIEAGVVVRLLNALYACPDGVMRMSSDMAGLVETSSNLAMVTSVHGVVT
EEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHH
IKCLLRSSVDSAMEDLKAMIGSLFDLAGAGAVFDGGYPGWKPNPDSPILKRMQEVYTSKF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHC
GKTPEIKAVHAGLECGIIGGTSPSLDMISFGPTIRYPHSPDEKVNIASVGKFWDFLVETL
CCCCCCEEEECCCEEEEECCCCCCCCEEECCCEECCCCCCCCCEEHHHHHHHHHHHHHHH
RMAP
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]