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The map label for this gene is tetA [H]

Identifier: 119356932

GI number: 119356932

Start: 1255528

End: 1256862

Strand: Reverse

Name: tetA [H]

Synonym: Cpha266_1111

Alternate gene names: 119356932

Gene position: 1256862-1255528 (Counterclockwise)

Preceding gene: 119356933

Following gene: 119356931

Centisome position: 40.11

GC content: 47.27

Gene sequence:

>1335_bases
ATGTTTTGTTATCTTGGGAGCTTTAGCGCAATAATAGAATCTGCTTGCATGAAGAAGTCCCCACTGGTCATCCTTCTCTT
AACGGTACTGCTTGATTTGATCGGCTTTGGCATTGTACTGCCGCTTCTTCCGACTTATGCAAAAGACCTTGGTGCAAGCC
CCCTGATGATTGGGCTGATTGCTGCGATTTTCTCCATCATGCAGTTCATCTTCTCCCCGCTCTGGGGCAAACTGAGCGAT
AAAATCGGTCGCAGACCGGTTATGCTCATCAGTATTTTCATTACCGCCGTCTCCTATTTTGTTTTTTCACAGGCCGTTAC
CATCCCTCTTCTTATTTTTGCCAGAGGTCTTTCCGGAATAGGATCAGCCAATATTGCCGCTGCCCAGGCATACATCACCG
ATGTCACCGACAATCAAAACCGGTCCAAAGCCATGGGAATGATAGGTGCGGCTTTCGGCATCGGATTTATTATCGGCCCA
TTGATCGGTGGCCTGCTCAAGCATAACTACGGCATTGCTATGGTAGGTTATGTCGCATCAGCTCTGATTACTCTTGACTT
TATTCTGGCGATTTTCCTCTTGCCGGAATCCAATAAACATGCGATAAAATTCAATTTCGGGTTTCTGAAAGAGAAGTCAG
GAGCCGGTGCTTCAAATGAAAAGCCAACGAGCTCGTCTGGCAATAAAATGCAAGCCTACATTGACGGCCTTAAACTTGCT
TTCACCTCCCGACCACTTGCCCTCCTGATGATTGCCAACTATGTCTTCACCTTTGCCATCGTCAATATGCAGGTAGCCTC
GATTCTACTTTGGAAAGAGTATTTTCATGCTTCCGATCAGGCTATCGGCTATCTCTTCGCTTATGTGGGATTCTTTTCTG
TCGTTGTCCAGGGCGGCCTGATAAGCAAACTGATCAAGGCGCTTGGCGAACACAAGCTGTTTTTCTGGGGTCATCTTTTT
ACCTTTGTAGGGGTCTTTTTTATCCCTTTTCTGCCTTCAGATACCCTCTTTTCGTTCGGACTGTTCATTCTGTTTTTCTT
CGCAATCGGAACAAGCCTGGTGGCGCCCATAAACATCTCGCTCATCTCGCTCTATACTTACAAACAGAAGCAGGGGGAAA
TCCTCGGACTGTCGCAATCCATCAACTCGTTTGCACGCATTATGGGCCCTTTCAGCGGCAGCGTTCTCTATGGCCTGAAC
GTCCACGCGCCTTATATCCTTGCCGGCGTGCTGACGTTGTTTGGCGCAGTGATTTCTCTCATGCTGTTCAAGTATAAAAT
AGATGCTCTGGATCCCGATCTGGACACACAGCCATCTTGGTCAAACAAGGATTAA

Upstream 100 bases:

>100_bases
TCCGAGGGTACTCGAAGGAATAGAAGAGCTCAAAAAAATCATGCGCTCCGAATAGTTGCGCGATTACGGGTTTTTTGAAC
CCTTGATATCAAAAAAGTCT

Downstream 100 bases:

>100_bases
CAGGAATGAACAGCATGCGGATCGGCGTTATCGGAACAGGAAAACTCGGCGAATTTCATACCAAGCTGCTCGGAGAAATC
GCGCAAAACAGACATGATAC

Product: major facilitator transporter

Products: NA

Alternate protein names: TetA(A) [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MFCYLGSFSAIIESACMKKSPLVILLLTVLLDLIGFGIVLPLLPTYAKDLGASPLMIGLIAAIFSIMQFIFSPLWGKLSD
KIGRRPVMLISIFITAVSYFVFSQAVTIPLLIFARGLSGIGSANIAAAQAYITDVTDNQNRSKAMGMIGAAFGIGFIIGP
LIGGLLKHNYGIAMVGYVASALITLDFILAIFLLPESNKHAIKFNFGFLKEKSGAGASNEKPTSSSGNKMQAYIDGLKLA
FTSRPLALLMIANYVFTFAIVNMQVASILLWKEYFHASDQAIGYLFAYVGFFSVVVQGGLISKLIKALGEHKLFFWGHLF
TFVGVFFIPFLPSDTLFSFGLFILFFFAIGTSLVAPINISLISLYTYKQKQGEILGLSQSINSFARIMGPFSGSVLYGLN
VHAPYILAGVLTLFGAVISLMLFKYKIDALDPDLDTQPSWSNKD

Sequences:

>Translated_444_residues
MFCYLGSFSAIIESACMKKSPLVILLLTVLLDLIGFGIVLPLLPTYAKDLGASPLMIGLIAAIFSIMQFIFSPLWGKLSD
KIGRRPVMLISIFITAVSYFVFSQAVTIPLLIFARGLSGIGSANIAAAQAYITDVTDNQNRSKAMGMIGAAFGIGFIIGP
LIGGLLKHNYGIAMVGYVASALITLDFILAIFLLPESNKHAIKFNFGFLKEKSGAGASNEKPTSSSGNKMQAYIDGLKLA
FTSRPLALLMIANYVFTFAIVNMQVASILLWKEYFHASDQAIGYLFAYVGFFSVVVQGGLISKLIKALGEHKLFFWGHLF
TFVGVFFIPFLPSDTLFSFGLFILFFFAIGTSLVAPINISLISLYTYKQKQGEILGLSQSINSFARIMGPFSGSVLYGLN
VHAPYILAGVLTLFGAVISLMLFKYKIDALDPDLDTQPSWSNKD
>Mature_444_residues
MFCYLGSFSAIIESACMKKSPLVILLLTVLLDLIGFGIVLPLLPTYAKDLGASPLMIGLIAAIFSIMQFIFSPLWGKLSD
KIGRRPVMLISIFITAVSYFVFSQAVTIPLLIFARGLSGIGSANIAAAQAYITDVTDNQNRSKAMGMIGAAFGIGFIIGP
LIGGLLKHNYGIAMVGYVASALITLDFILAIFLLPESNKHAIKFNFGFLKEKSGAGASNEKPTSSSGNKMQAYIDGLKLA
FTSRPLALLMIANYVFTFAIVNMQVASILLWKEYFHASDQAIGYLFAYVGFFSVVVQGGLISKLIKALGEHKLFFWGHLF
TFVGVFFIPFLPSDTLFSFGLFILFFFAIGTSLVAPINISLISLYTYKQKQGEILGLSQSINSFARIMGPFSGSVLYGLN
VHAPYILAGVLTLFGAVISLMLFKYKIDALDPDLDTQPSWSNKD

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI217416366, Length=417, Percent_Identity=25.1798561151079, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI225703104, Length=355, Percent_Identity=24.7887323943662, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI225703102, Length=355, Percent_Identity=24.7887323943662, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI166064062, Length=366, Percent_Identity=25.6830601092896, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI166064060, Length=366, Percent_Identity=25.6830601092896, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI39753965, Length=351, Percent_Identity=24.2165242165242, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI94721311, Length=378, Percent_Identity=26.7195767195767, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI22749525, Length=146, Percent_Identity=30.8219178082192, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI87081738, Length=181, Percent_Identity=34.8066298342541, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1787291, Length=432, Percent_Identity=21.7592592592593, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71996331, Length=387, Percent_Identity=23.2558139534884, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17551570, Length=420, Percent_Identity=22.8571428571429, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17738085, Length=380, Percent_Identity=26.8421052631579, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI221513297, Length=188, Percent_Identity=27.1276595744681, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21357569, Length=187, Percent_Identity=29.4117647058824, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24667557, Length=202, Percent_Identity=28.2178217821782, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161080926, Length=187, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161080924, Length=187, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24656463, Length=187, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24656468, Length=187, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24667561, Length=207, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45550550, Length=471, Percent_Identity=25.0530785562633, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48237; Mature: 48237

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFCYLGSFSAIIESACMKKSPLVILLLTVLLDLIGFGIVLPLLPTYAKDLGASPLMIGLI
CEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AAIFSIMQFIFSPLWGKLSDKIGRRPVMLISIFITAVSYFVFSQAVTIPLLIFARGLSGI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GSANIAAAQAYITDVTDNQNRSKAMGMIGAAFGIGFIIGPLIGGLLKHNYGIAMVGYVAS
CCCCHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ALITLDFILAIFLLPESNKHAIKFNFGFLKEKSGAGASNEKPTSSSGNKMQAYIDGLKLA
HHHHHHHHHHHHHCCCCCCCEEEEECCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FTSRPLALLMIANYVFTFAIVNMQVASILLWKEYFHASDQAIGYLFAYVGFFSVVVQGGL
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHH
ISKLIKALGEHKLFFWGHLFTFVGVFFIPFLPSDTLFSFGLFILFFFAIGTSLVAPINIS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
LISLYTYKQKQGEILGLSQSINSFARIMGPFSGSVLYGLNVHAPYILAGVLTLFGAVISL
EEEEEHHHHHCCCEEEHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
MLFKYKIDALDPDLDTQPSWSNKD
HHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFCYLGSFSAIIESACMKKSPLVILLLTVLLDLIGFGIVLPLLPTYAKDLGASPLMIGLI
CEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AAIFSIMQFIFSPLWGKLSDKIGRRPVMLISIFITAVSYFVFSQAVTIPLLIFARGLSGI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GSANIAAAQAYITDVTDNQNRSKAMGMIGAAFGIGFIIGPLIGGLLKHNYGIAMVGYVAS
CCCCHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ALITLDFILAIFLLPESNKHAIKFNFGFLKEKSGAGASNEKPTSSSGNKMQAYIDGLKLA
HHHHHHHHHHHHHCCCCCCCEEEEECCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FTSRPLALLMIANYVFTFAIVNMQVASILLWKEYFHASDQAIGYLFAYVGFFSVVVQGGL
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHH
ISKLIKALGEHKLFFWGHLFTFVGVFFIPFLPSDTLFSFGLFILFFFAIGTSLVAPINIS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
LISLYTYKQKQGEILGLSQSINSFARIMGPFSGSVLYGLNVHAPYILAGVLTLFGAVISL
EEEEEHHHHHCCCEEEHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
MLFKYKIDALDPDLDTQPSWSNKD
HHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312499; 6310527 [H]