Click here to switch to the map view.

The map label for this gene is nuoD

Identifier: 119356792

GI number: 119356792

Start: 1104309

End: 1105511

Strand: Direct

Name: nuoD

Synonym: Cpha266_0964

Alternate gene names: 119356792

Gene position: 1104309-1105511 (Clockwise)

Preceding gene: 119356791

Following gene: 119356793

Centisome position: 35.24

GC content: 48.46

Gene sequence:

>1203_bases
ATGCAGGAATTAGGGATAACTGGACAGGGCTCAGTAAGGGTTACCCGCAAGGAGGGTAATGTTGTAGTTCTTGAAAAGGA
CCTCGCAACAGAGCAGATGGTTCTTGCCATGGGTCCGCAGCACCCTTCGACACATGGCGTTCTGAAGCTTGAATGTTTTA
CTGACGGAGAGGTTGTTACACATGCGGAGCCCTATCTCGGCTATCTTCATCGCTGTTTTGAAAAACATTGCGAAGTTGTT
GATTACCCCGGGATTGTTCCATATACCGACAGAATGGACTATCTTGCCGGGATGAACAGCGAGTGGGCTTACTGTCTTGC
TGTTGAAAAACTGCTTGATCTTGAACTTCCCCGGCGTGTAGAGTTTATTCGCGTTATTGTTTCCGAGCTTAACAGGATCG
CATCCCACCTTGTGGCTATAGGTACCTATGCGATTGATCTTGGCGCCTTTACCCCGTTTTTATTTTGTTTTCGCGACAGG
GAGCATATACTCAGTCTCCTTGAGTGGGCTTCAGGCGCCAGAATGCTCTATAATTATATATGGATTGGGGGTCTGGCTTA
TGACGTTCCAGCCGATTTCAACAAGCGTGTCAAGGAGTTTGTTGACTATTTCCGACCCAAGGCTGTTGAGCTCTACCAGC
TGCTCACCGAAAACGAGATTTTTGTGAAGCGCACAAAGGGAATAGGGATCATGCCGGCTGATGTGGCTATCAATTACGGC
TGGTCCGGGCCAATGCTTCGCGGTTCGGGTGTACAGTGGGATCTTCGCAGAAACGATCCCTACTCTGTCTATCCGGAACT
TGATTTCAAGGTGCCGATTCCTGACGGAAAGTTTTCTGATGTTGGCGATTGCCTTTCACGCCACCTTGTTCGTGCTCTTG
AAATGGATGAAAGTCTCAGTATTATTGAGCAGTGTATTGACAAAATGCCCGGTTCAGAGGGTTTCAACCCAAGGGCCGCC
GTACCAAAAAGAGTGCGTGCAAAAGCGGGCGAGGTCTATTGCCGCGCTGAAAATCCTCGAGGCGAACTTGGTTTCTATAT
CCAGAGTGATGGCAAGTCAACCAAACCGCTTCGCTGCAAGGCTCGATCTTCCTGTTTTGTTAATCTTTCGGCAATGAAAG
ATCTTTCCAAAGGTCAGTTGATCCCTGATCTCGTTGCAATAATCGGCAGTATCGATATTGTACTCGGGGAGGTTGACCGA
TGA

Upstream 100 bases:

>100_bases
GAAGGGTTTCCGCTTCGCAAGGATTACAAGGTACAGGAGACCTATCATGGAATCAAGGTTCCATACTGAAAGAGTTTAAC
TTGAATAAAGCAGTTCACGT

Downstream 100 bases:

>100_bases
GTGTAATGGCTTTATCGCAAATCCGTATTCCTCTGCTTATGGGTAACAGTCTCAATGCCTGGTCGGAAGCCCTTACCGGT
TTTTCGATCTGGGGATTTCC

Product: NADH dehydrogenase (ubiquinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MQELGITGQGSVRVTRKEGNVVVLEKDLATEQMVLAMGPQHPSTHGVLKLECFTDGEVVTHAEPYLGYLHRCFEKHCEVV
DYPGIVPYTDRMDYLAGMNSEWAYCLAVEKLLDLELPRRVEFIRVIVSELNRIASHLVAIGTYAIDLGAFTPFLFCFRDR
EHILSLLEWASGARMLYNYIWIGGLAYDVPADFNKRVKEFVDYFRPKAVELYQLLTENEIFVKRTKGIGIMPADVAINYG
WSGPMLRGSGVQWDLRRNDPYSVYPELDFKVPIPDGKFSDVGDCLSRHLVRALEMDESLSIIEQCIDKMPGSEGFNPRAA
VPKRVRAKAGEVYCRAENPRGELGFYIQSDGKSTKPLRCKARSSCFVNLSAMKDLSKGQLIPDLVAIIGSIDIVLGEVDR

Sequences:

>Translated_400_residues
MQELGITGQGSVRVTRKEGNVVVLEKDLATEQMVLAMGPQHPSTHGVLKLECFTDGEVVTHAEPYLGYLHRCFEKHCEVV
DYPGIVPYTDRMDYLAGMNSEWAYCLAVEKLLDLELPRRVEFIRVIVSELNRIASHLVAIGTYAIDLGAFTPFLFCFRDR
EHILSLLEWASGARMLYNYIWIGGLAYDVPADFNKRVKEFVDYFRPKAVELYQLLTENEIFVKRTKGIGIMPADVAINYG
WSGPMLRGSGVQWDLRRNDPYSVYPELDFKVPIPDGKFSDVGDCLSRHLVRALEMDESLSIIEQCIDKMPGSEGFNPRAA
VPKRVRAKAGEVYCRAENPRGELGFYIQSDGKSTKPLRCKARSSCFVNLSAMKDLSKGQLIPDLVAIIGSIDIVLGEVDR
>Mature_400_residues
MQELGITGQGSVRVTRKEGNVVVLEKDLATEQMVLAMGPQHPSTHGVLKLECFTDGEVVTHAEPYLGYLHRCFEKHCEVV
DYPGIVPYTDRMDYLAGMNSEWAYCLAVEKLLDLELPRRVEFIRVIVSELNRIASHLVAIGTYAIDLGAFTPFLFCFRDR
EHILSLLEWASGARMLYNYIWIGGLAYDVPADFNKRVKEFVDYFRPKAVELYQLLTENEIFVKRTKGIGIMPADVAINYG
WSGPMLRGSGVQWDLRRNDPYSVYPELDFKVPIPDGKFSDVGDCLSRHLVRALEMDESLSIIEQCIDKMPGSEGFNPRAA
VPKRVRAKAGEVYCRAENPRGELGFYIQSDGKSTKPLRCKARSSCFVNLSAMKDLSKGQLIPDLVAIIGSIDIVLGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=403, Percent_Identity=42.6799007444169, Blast_Score=311, Evalue=8e-85,
Organism=Homo sapiens, GI260898743, Length=397, Percent_Identity=41.8136020151133, Blast_Score=297, Evalue=9e-81,
Organism=Escherichia coli, GI145693162, Length=390, Percent_Identity=35.6410256410256, Blast_Score=251, Evalue=4e-68,
Organism=Escherichia coli, GI1789076, Length=372, Percent_Identity=29.3010752688172, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1788832, Length=379, Percent_Identity=29.287598944591, Blast_Score=135, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17555284, Length=398, Percent_Identity=41.4572864321608, Blast_Score=309, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17568379, Length=398, Percent_Identity=41.7085427135678, Blast_Score=308, Evalue=3e-84,
Organism=Drosophila melanogaster, GI24638644, Length=403, Percent_Identity=41.439205955335, Blast_Score=323, Evalue=9e-89,
Organism=Drosophila melanogaster, GI221459469, Length=396, Percent_Identity=41.4141414141414, Blast_Score=316, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_CHLPD (A1BF35)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911436.1
- ProteinModelPortal:   A1BF35
- SMR:   A1BF35
- STRING:   A1BF35
- GeneID:   4570733
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0964
- NMPDR:   fig|290317.7.peg.1026
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   GDCLSRH
- ProtClustDB:   CLSK637461
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR001135
- InterPro:   IPR022885

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 45014; Mature: 45014

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQELGITGQGSVRVTRKEGNVVVLEKDLATEQMVLAMGPQHPSTHGVLKLECFTDGEVVT
CCCCCCCCCCCEEEEEECCCEEEEECCCCCHHHHEEECCCCCCCCCEEEEEEECCCCEEE
HAEPYLGYLHRCFEKHCEVVDYPGIVPYTDRMDYLAGMNSEWAYCLAVEKLLDLELPRRV
CCCHHHHHHHHHHHHHCCEECCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCHHH
EFIRVIVSELNRIASHLVAIGTYAIDLGAFTPFLFCFRDREHILSLLEWASGARMLYNYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHH
WIGGLAYDVPADFNKRVKEFVDYFRPKAVELYQLLTENEIFVKRTKGIGIMPADVAINYG
HCCCEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCEEEHHEEEECC
WSGPMLRGSGVQWDLRRNDPYSVYPELDFKVPIPDGKFSDVGDCLSRHLVRALEMDESLS
CCCCCCCCCCCEEEECCCCCCEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHH
IIEQCIDKMPGSEGFNPRAAVPKRVRAKAGEVYCRAENPRGELGFYIQSDGKSTKPLRCK
HHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCEEEEEECCCCCCCCEEEE
ARSSCFVNLSAMKDLSKGQLIPDLVAIIGSIDIVLGEVDR
CCCCEEEEHHHHHCCCCCCHHHHHHHHHCCHHEEEECCCC
>Mature Secondary Structure
MQELGITGQGSVRVTRKEGNVVVLEKDLATEQMVLAMGPQHPSTHGVLKLECFTDGEVVT
CCCCCCCCCCCEEEEEECCCEEEEECCCCCHHHHEEECCCCCCCCCEEEEEEECCCCEEE
HAEPYLGYLHRCFEKHCEVVDYPGIVPYTDRMDYLAGMNSEWAYCLAVEKLLDLELPRRV
CCCHHHHHHHHHHHHHCCEECCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCHHH
EFIRVIVSELNRIASHLVAIGTYAIDLGAFTPFLFCFRDREHILSLLEWASGARMLYNYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHH
WIGGLAYDVPADFNKRVKEFVDYFRPKAVELYQLLTENEIFVKRTKGIGIMPADVAINYG
HCCCEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCEEEHHEEEECC
WSGPMLRGSGVQWDLRRNDPYSVYPELDFKVPIPDGKFSDVGDCLSRHLVRALEMDESLS
CCCCCCCCCCCEEEECCCCCCEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHH
IIEQCIDKMPGSEGFNPRAAVPKRVRAKAGEVYCRAENPRGELGFYIQSDGKSTKPLRCK
HHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCEEEEEECCCCCCCCEEEE
ARSSCFVNLSAMKDLSKGQLIPDLVAIIGSIDIVLGEVDR
CCCCEEEEHHHHHCCCCCCHHHHHHHHHCCHHEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA