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The map label for this gene is leuD1 [H]

Identifier: 119356678

GI number: 119356678

Start: 969620

End: 970186

Strand: Reverse

Name: leuD1 [H]

Synonym: Cpha266_0847

Alternate gene names: 119356678

Gene position: 970186-969620 (Counterclockwise)

Preceding gene: 119356679

Following gene: 119356677

Centisome position: 30.96

GC content: 49.38

Gene sequence:

>567_bases
ATGGAAACCATTATACAGGGAAAAGCCTACGTTTTAGGCAAAAACATCGATACCGACCAGATCATACCGGCTGAACATCT
TGTTTACAGCCTTTCCGATCCTGAAGAGGTCAAGCTCTATGGCAAGTACGCACTTTCAGGCGTTCCTCCCGAACAGGGCG
GGCTTCCTGAAGGCAACACGCCCTTTGTCTCTGAAGGAACCTGCCACTCAGACTACTCGATCATCATTGCCGGACCAAAC
TTCGGCTGCGGTTCCTCACGCGAGCACGCCCCCTTTGCCCTGCAGGTTGCAGGAGCAAAAGCCATAGTTGCGGAATCATA
TGCAAGAATCTTTTACCGTAACTGTGTTGACGGCGGTTTTGTTATCCCTTATGAAACCCGGCAACAACTGAACCAAATCA
TCAAAACTGGCGACGAACTCAAAATAGATGTCGAAGCAAACACGCTCACGAACGTAACAGAGAACGTCACATGGCAGCTC
AATCCGCTCGGAGATGTGATCAACATCGTCAAGGCGGGCGGAATATTTGCCTATGCAAGACAGGAAAACCTAATGGCTAA
CGAGTAA

Upstream 100 bases:

>100_bases
CTACCTTGCCTCACCGTTGACGGCAGCAGCGTCAGCCATTACCGGCAAGCTCACCGACCCGAGAGATTTCCTCTGATCAT
GAACTTGTAAGGAAAATAAA

Downstream 100 bases:

>100_bases
TGACAAACCCTCTTTCGAAAACGATAGAACTCTATGACACCACCCTGCGTGACGGCACGCAGGGCGAGCACATCAATCTT
TCAGTTCAGGACAAACTGCT

Product: 3-isopropylmalate dehydratase, small subunit

Products: NA

Alternate protein names: Alpha-IPM isomerase 1; IPMI 1; Isopropylmalate isomerase 1 [H]

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
METIIQGKAYVLGKNIDTDQIIPAEHLVYSLSDPEEVKLYGKYALSGVPPEQGGLPEGNTPFVSEGTCHSDYSIIIAGPN
FGCGSSREHAPFALQVAGAKAIVAESYARIFYRNCVDGGFVIPYETRQQLNQIIKTGDELKIDVEANTLTNVTENVTWQL
NPLGDVINIVKAGGIFAYARQENLMANE

Sequences:

>Translated_188_residues
METIIQGKAYVLGKNIDTDQIIPAEHLVYSLSDPEEVKLYGKYALSGVPPEQGGLPEGNTPFVSEGTCHSDYSIIIAGPN
FGCGSSREHAPFALQVAGAKAIVAESYARIFYRNCVDGGFVIPYETRQQLNQIIKTGDELKIDVEANTLTNVTENVTWQL
NPLGDVINIVKAGGIFAYARQENLMANE
>Mature_188_residues
METIIQGKAYVLGKNIDTDQIIPAEHLVYSLSDPEEVKLYGKYALSGVPPEQGGLPEGNTPFVSEGTCHSDYSIIIAGPN
FGCGSSREHAPFALQVAGAKAIVAESYARIFYRNCVDGGFVIPYETRQQLNQIIKTGDELKIDVEANTLTNVTENVTWQL
NPLGDVINIVKAGGIFAYARQENLMANE

Specific function: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate [H]

COG id: COG0066

COG function: function code E; 3-isopropylmalate dehydratase small subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the leuD family. LeuD type 2 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786258, Length=138, Percent_Identity=34.7826086956522, Blast_Score=67, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6321429, Length=148, Percent_Identity=35.8108108108108, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012305
- InterPro:   IPR015937
- InterPro:   IPR015928
- InterPro:   IPR000573
- InterPro:   IPR011824
- InterPro:   IPR011827 [H]

Pfam domain/function: PF00694 Aconitase_C [H]

EC number: =4.2.1.33 [H]

Molecular weight: Translated: 20438; Mature: 20438

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIIQGKAYVLGKNIDTDQIIPAEHLVYSLSDPEEVKLYGKYALSGVPPEQGGLPEGNT
CCCEECCCEEEEECCCCCCCCCCHHHEEEECCCCHHEEEEEEEEECCCCCCCCCCCCCCC
PFVSEGTCHSDYSIIIAGPNFGCGSSREHAPFALQVAGAKAIVAESYARIFYRNCVDGGF
CCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCE
VIPYETRQQLNQIIKTGDELKIDVEANTLTNVTENVTWQLNPLGDVINIVKAGGIFAYAR
EECHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEECCHHHHHHHHHCCCEEEEEE
QENLMANE
CCCCCCCC
>Mature Secondary Structure
METIIQGKAYVLGKNIDTDQIIPAEHLVYSLSDPEEVKLYGKYALSGVPPEQGGLPEGNT
CCCEECCCEEEEECCCCCCCCCCHHHEEEECCCCHHEEEEEEEEECCCCCCCCCCCCCCC
PFVSEGTCHSDYSIIIAGPNFGCGSSREHAPFALQVAGAKAIVAESYARIFYRNCVDGGF
CCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCE
VIPYETRQQLNQIIKTGDELKIDVEANTLTNVTENVTWQLNPLGDVINIVKAGGIFAYAR
EECHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEECCHHHHHHHHHCCCEEEEEE
QENLMANE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]