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The map label for this gene is uvrC

Identifier: 119356545

GI number: 119356545

Start: 809697

End: 811592

Strand: Reverse

Name: uvrC

Synonym: Cpha266_0710

Alternate gene names: 119356545

Gene position: 811592-809697 (Counterclockwise)

Preceding gene: 119356546

Following gene: 119356544

Centisome position: 25.9

GC content: 48.68

Gene sequence:

>1896_bases
ATGGATAGTAATCCACTCCACCATAGCAATCCTCCGGTCGGAAGCCTTCCTCTGGATAAAGTCGCCTCGCTGCCCTCCTC
GCCGGGGGTTTACCAGTTCAAAAATGCACAGGGCCGGGTTATTTACATCGGCAAGGCAAAAAACCTGAGAAACCGCGTAC
GATCCTATTTCAGAAACCCGCAGCAGCTTTTCGGTAAAACACTGGTCATGGTCGGCAAAATTGCCGATATCGAAGTTATC
ATCACCTCATCGGAGGTTGAGGCGCTGATCCTTGAAAACAATCTCATCAAGGAGCTCAAACCACGCTACAATGTTAACCT
GAAAGATGACAAAACCTATCCCTATCTGGTTATCACCAATGAACCATTTCCGAGGATTCTCGTTACCAGACAGGTTAAAA
AGGATGGATCAACCTGGTTTGGCCCCTATACCGAAGCACGGCAACTTCGGTCGATTCTTGATTTCATAGGTTCAATCTTT
CCGATAAGAAGCTGCAAATTAAGGCTCTCCCCGGAAAATATTTCCCGAGGGAAATTCAAGGTCTGCCTCGATTACCACAT
TCACAAATGCAAGGGTCCCTGCGAAGGTTTGCTCACAGAAGAGGAGTATCTCCTGATGATCGTCGAAATCACTCGTCTTC
TGAAAGGAAAAACATCGGCAACCATCCGCTCGCTCAACGAGAGAATGCTCTCTTTTGCCAAAGAGCTGAAGTTTGAACAG
GCCGCTGAATTAAAAACGCAGATCGACAGCCTTAAACGATATGCTGAACGACAAAAAGTGGTCACAAGCGACACTCTCGA
CCGCGATGTATTTGCCGTTGCTTCCCGAAATGATGACGGATGTGGCGTGGTTTTTAAAATCCGTGAAGGGAAACTGCTCG
GTTCCGAACGACTCTACATGAACAACACCGAAGGGGTATCGGTGCAGGATCTTCTTGCCCGCGTTGTTGAACGATACTAT
CTCGAAACCTGCAATCTTCTGCCTGACGAAATTTTTCTGCAGACAGAGCTTCCTGCTGAAGAAAAAGAGACGCTGGAAAA
CCTTCTCATCTCGAAAATAAGCGCAGAGGGCAAACAGAAAAGAACCATTCGCCTGACAGTACCGATTATCGGCGAAAAAG
CACATCTGATACAGCTTTGTCGGGAGAATGCCCGTCACCATCTTGAAGAGTATCTGATACAGAAGCAGAAACGGGGCGAA
GCATTACGGGAACACAGTGGCCTGATTGCCCTTGCGGAACTCCTGCATCTTCCGAAAACACCCAACCGTATTGAGTGCTT
TGACAACTCTCATTTTCATGGAACCGATTATGTCAGCTCCATGGTCGCTTTTGTTCATGGAAAAGCAAAAAAATCAGACT
ACAGAAAATTCAAACTTAAAACCGTTCAGGGATCCGATGACTATGCTGCCATGCATGAAGTATTGACCCGACGATACAGC
GGAACCCTTTCCGTAGAACTTCCGCTTCCCGACCTTATCGTTGTGGACGGAGGGAAGGGACAGCTCTCCACGGCAGTCAA
GGTTCTTGTTTCGCTTAAACTCGACATCCCGGTCATCGGACTGGCAAAACGCATTGAGGAGATCTTCACGCCGCACACCA
GCGACCCCTTCAATCTCCCCAAAACCTCTCCTGCTCTGAAACTTATCCAGCAGCTCCGGGATGAAGCGCACCGTTTTGCC
GTAACCTATCACCGCAAGCTTCGAACTGAGAGAACCCTTGAAACAGAGCTTACCACAATCCAGGGAATAGGCGAAAAAAC
AGCACAGAAGCTGCTCAGGCATTTCGGCTCGGTCGACCTGATCAGAACGGCTGGAGTCGATGAACTCAGGGCTGCGGCAG
GAAACAAAACCGCAGCCCTTCTTTACCGGTTCTACCATCCCCTCGAAGAGGGATAA

Upstream 100 bases:

>100_bases
GTAAAAGAAAAAGCCTCAGAATGTCTGCGGCTTTTTCTTTTTTTTGTATCCTGCACTTTCAGCTTCATTCGATTCGTCCG
ATAGCAGACCCGTTTTTTTC

Downstream 100 bases:

>100_bases
GGTGAAGAGGCAAAGGGGTGGTCCGGAAATCTTGTTCTTATGAAAATTCTGTTATATTTGACTTATGCGCAGTTTGCTGT
TATTACTATTTGAAACCCAT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MDSNPLHHSNPPVGSLPLDKVASLPSSPGVYQFKNAQGRVIYIGKAKNLRNRVRSYFRNPQQLFGKTLVMVGKIADIEVI
ITSSEVEALILENNLIKELKPRYNVNLKDDKTYPYLVITNEPFPRILVTRQVKKDGSTWFGPYTEARQLRSILDFIGSIF
PIRSCKLRLSPENISRGKFKVCLDYHIHKCKGPCEGLLTEEEYLLMIVEITRLLKGKTSATIRSLNERMLSFAKELKFEQ
AAELKTQIDSLKRYAERQKVVTSDTLDRDVFAVASRNDDGCGVVFKIREGKLLGSERLYMNNTEGVSVQDLLARVVERYY
LETCNLLPDEIFLQTELPAEEKETLENLLISKISAEGKQKRTIRLTVPIIGEKAHLIQLCRENARHHLEEYLIQKQKRGE
ALREHSGLIALAELLHLPKTPNRIECFDNSHFHGTDYVSSMVAFVHGKAKKSDYRKFKLKTVQGSDDYAAMHEVLTRRYS
GTLSVELPLPDLIVVDGGKGQLSTAVKVLVSLKLDIPVIGLAKRIEEIFTPHTSDPFNLPKTSPALKLIQQLRDEAHRFA
VTYHRKLRTERTLETELTTIQGIGEKTAQKLLRHFGSVDLIRTAGVDELRAAAGNKTAALLYRFYHPLEEG

Sequences:

>Translated_631_residues
MDSNPLHHSNPPVGSLPLDKVASLPSSPGVYQFKNAQGRVIYIGKAKNLRNRVRSYFRNPQQLFGKTLVMVGKIADIEVI
ITSSEVEALILENNLIKELKPRYNVNLKDDKTYPYLVITNEPFPRILVTRQVKKDGSTWFGPYTEARQLRSILDFIGSIF
PIRSCKLRLSPENISRGKFKVCLDYHIHKCKGPCEGLLTEEEYLLMIVEITRLLKGKTSATIRSLNERMLSFAKELKFEQ
AAELKTQIDSLKRYAERQKVVTSDTLDRDVFAVASRNDDGCGVVFKIREGKLLGSERLYMNNTEGVSVQDLLARVVERYY
LETCNLLPDEIFLQTELPAEEKETLENLLISKISAEGKQKRTIRLTVPIIGEKAHLIQLCRENARHHLEEYLIQKQKRGE
ALREHSGLIALAELLHLPKTPNRIECFDNSHFHGTDYVSSMVAFVHGKAKKSDYRKFKLKTVQGSDDYAAMHEVLTRRYS
GTLSVELPLPDLIVVDGGKGQLSTAVKVLVSLKLDIPVIGLAKRIEEIFTPHTSDPFNLPKTSPALKLIQQLRDEAHRFA
VTYHRKLRTERTLETELTTIQGIGEKTAQKLLRHFGSVDLIRTAGVDELRAAAGNKTAALLYRFYHPLEEG
>Mature_631_residues
MDSNPLHHSNPPVGSLPLDKVASLPSSPGVYQFKNAQGRVIYIGKAKNLRNRVRSYFRNPQQLFGKTLVMVGKIADIEVI
ITSSEVEALILENNLIKELKPRYNVNLKDDKTYPYLVITNEPFPRILVTRQVKKDGSTWFGPYTEARQLRSILDFIGSIF
PIRSCKLRLSPENISRGKFKVCLDYHIHKCKGPCEGLLTEEEYLLMIVEITRLLKGKTSATIRSLNERMLSFAKELKFEQ
AAELKTQIDSLKRYAERQKVVTSDTLDRDVFAVASRNDDGCGVVFKIREGKLLGSERLYMNNTEGVSVQDLLARVVERYY
LETCNLLPDEIFLQTELPAEEKETLENLLISKISAEGKQKRTIRLTVPIIGEKAHLIQLCRENARHHLEEYLIQKQKRGE
ALREHSGLIALAELLHLPKTPNRIECFDNSHFHGTDYVSSMVAFVHGKAKKSDYRKFKLKTVQGSDDYAAMHEVLTRRYS
GTLSVELPLPDLIVVDGGKGQLSTAVKVLVSLKLDIPVIGLAKRIEEIFTPHTSDPFNLPKTSPALKLIQQLRDEAHRFA
VTYHRKLRTERTLETELTTIQGIGEKTAQKLLRHFGSVDLIRTAGVDELRAAAGNKTAALLYRFYHPLEEG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=608, Percent_Identity=35.6907894736842, Blast_Score=357, Evalue=1e-99,
Organism=Escherichia coli, GI1788037, Length=186, Percent_Identity=30.6451612903226, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_CHLPD (A1BED8)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911189.1
- ProteinModelPortal:   A1BED8
- STRING:   A1BED8
- GeneID:   4569884
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0710
- NMPDR:   fig|290317.7.peg.745
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK14671
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 71554; Mature: 71554

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSNPLHHSNPPVGSLPLDKVASLPSSPGVYQFKNAQGRVIYIGKAKNLRNRVRSYFRNP
CCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHCCH
QQLFGKTLVMVGKIADIEVIITSSEVEALILENNLIKELKPRYNVNLKDDKTYPYLVITN
HHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCHHHHHCCCCCCCCCCCCCCCCEEEEEC
EPFPRILVTRQVKKDGSTWFGPYTEARQLRSILDFIGSIFPIRSCKLRLSPENISRGKFK
CCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEE
VCLDYHIHKCKGPCEGLLTEEEYLLMIVEITRLLKGKTSATIRSLNERMLSFAKELKFEQ
EEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AAELKTQIDSLKRYAERQKVVTSDTLDRDVFAVASRNDDGCGVVFKIREGKLLGSERLYM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEECCCEECCCEEEE
NNTEGVSVQDLLARVVERYYLETCNLLPDEIFLQTELPAEEKETLENLLISKISAEGKQK
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCC
RTIRLTVPIIGEKAHLIQLCRENARHHLEEYLIQKQKRGEALREHSGLIALAELLHLPKT
EEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
PNRIECFDNSHFHGTDYVSSMVAFVHGKAKKSDYRKFKLKTVQGSDDYAAMHEVLTRRYS
CCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCC
GTLSVELPLPDLIVVDGGKGQLSTAVKVLVSLKLDIPVIGLAKRIEEIFTPHTSDPFNLP
CEEEEEECCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCC
KTSPALKLIQQLRDEAHRFAVTYHRKLRTERTLETELTTIQGIGEKTAQKLLRHFGSVDL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEE
IRTAGVDELRAAAGNKTAALLYRFYHPLEEG
EECCCHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDSNPLHHSNPPVGSLPLDKVASLPSSPGVYQFKNAQGRVIYIGKAKNLRNRVRSYFRNP
CCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHCCH
QQLFGKTLVMVGKIADIEVIITSSEVEALILENNLIKELKPRYNVNLKDDKTYPYLVITN
HHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCHHHHHCCCCCCCCCCCCCCCCEEEEEC
EPFPRILVTRQVKKDGSTWFGPYTEARQLRSILDFIGSIFPIRSCKLRLSPENISRGKFK
CCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEE
VCLDYHIHKCKGPCEGLLTEEEYLLMIVEITRLLKGKTSATIRSLNERMLSFAKELKFEQ
EEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AAELKTQIDSLKRYAERQKVVTSDTLDRDVFAVASRNDDGCGVVFKIREGKLLGSERLYM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEECCCEECCCEEEE
NNTEGVSVQDLLARVVERYYLETCNLLPDEIFLQTELPAEEKETLENLLISKISAEGKQK
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCC
RTIRLTVPIIGEKAHLIQLCRENARHHLEEYLIQKQKRGEALREHSGLIALAELLHLPKT
EEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCC
PNRIECFDNSHFHGTDYVSSMVAFVHGKAKKSDYRKFKLKTVQGSDDYAAMHEVLTRRYS
CCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCC
GTLSVELPLPDLIVVDGGKGQLSTAVKVLVSLKLDIPVIGLAKRIEEIFTPHTSDPFNLP
CEEEEEECCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCC
KTSPALKLIQQLRDEAHRFAVTYHRKLRTERTLETELTTIQGIGEKTAQKLLRHFGSVDL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEE
IRTAGVDELRAAAGNKTAALLYRFYHPLEEG
EECCCHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA