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The map label for this gene is czcD [H]

Identifier: 119356528

GI number: 119356528

Start: 791619

End: 792557

Strand: Direct

Name: czcD [H]

Synonym: Cpha266_0693

Alternate gene names: 119356528

Gene position: 791619-792557 (Clockwise)

Preceding gene: 119356527

Following gene: 119356529

Centisome position: 25.26

GC content: 50.37

Gene sequence:

>939_bases
ATGGCCAACAACGCTGTATCAGCAGGTGATCATCATCATCATTCCGACGGGCATGATCATGTTCATCATCACGCTGCGAA
AAATATCAAAACCGCATTTTTTCTTAATCTTGGCTTTACCCTTGTTGAAATAATCGGTGGTTTTATTACCGGCAGTACGG
CAATTCTTGCCAATGCCGTGCACGATCTTGGAGATTCGTTTGCGCTTGGCCAGGCATGGTATTTTGAACGTCTCTCCGGT
GAAAAAAGCAACGCCCGCTACTCCTATGGTTACAAGCGCTTTTCGCTTCTTGGCGCGCTTATCAGCACCGTGTTTCTTCT
TGGCAGTTCGCTCTTTGTGCTGGCCGGGGCTGTGCCAAGGATTCTTCATCCCCATCATCCTGATGCGGGCGGGATGATTC
TTCTTGCGGTCATCGGTGTTGCCGTCAACGGCATCGCCATGGCAAGGCTGTCAAAAGAGAGCGGCATGAACGCAAGGGTT
GTTGCACTGCACCTTCTTGAAGATGTGCTTGGATGGCTAACGGTGCTTCTTGTCGGTATTGTGCTCATATTCTGGAACTT
GCCCGTTCTCGATCCGGTGCTTGCGGTACTCATCACCCTCTACATCCTTCGCGGCGTCGTAAAAAATCTCATGGCACAGA
TTCCTGTTTTTCTCCAGGCGGTACCTGCCGAACTCGATCTTTCAGCAATTTCAGCCGAAATAGAAGCAATGAGTACGGTT
CGGGCTGTTCATCATGCGCACATCTGGTCGCTTGACGGCAGTCACAACGTCTTTACCGTCCACCTTGAAGTTGAACGGAT
GCTCGATGCCGAAGATTACATGCAGTTGAAAGACCGCATTAAAACCCTTGTTAAACAACACGGCATCTACCACTCAACCG
TCGAGATCGAGTTTCCCGGCGAGATATGCCGGAATATGCCTGATGCCGGGACTGGGTAG

Upstream 100 bases:

>100_bases
GTGTTTGAATGAAAAGAGGTGTTATACCAATAGCATTGATGTGCGATTCAAGGGCTGCGTGTCGGGAAGAGCAAAAGGAT
AATATAACGGGCTTTATCTC

Downstream 100 bases:

>100_bases
TAGGGTGTGGGTAGTAGGGTGTGGGGAGTGGGTTTGTTTATTTTCCTGAATGTCTTCGTGTTACCGGTAAATTTTTTTCT
GTCATCCCGATTTTTTTCCT

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MANNAVSAGDHHHHSDGHDHVHHHAAKNIKTAFFLNLGFTLVEIIGGFITGSTAILANAVHDLGDSFALGQAWYFERLSG
EKSNARYSYGYKRFSLLGALISTVFLLGSSLFVLAGAVPRILHPHHPDAGGMILLAVIGVAVNGIAMARLSKESGMNARV
VALHLLEDVLGWLTVLLVGIVLIFWNLPVLDPVLAVLITLYILRGVVKNLMAQIPVFLQAVPAELDLSAISAEIEAMSTV
RAVHHAHIWSLDGSHNVFTVHLEVERMLDAEDYMQLKDRIKTLVKQHGIYHSTVEIEFPGEICRNMPDAGTG

Sequences:

>Translated_312_residues
MANNAVSAGDHHHHSDGHDHVHHHAAKNIKTAFFLNLGFTLVEIIGGFITGSTAILANAVHDLGDSFALGQAWYFERLSG
EKSNARYSYGYKRFSLLGALISTVFLLGSSLFVLAGAVPRILHPHHPDAGGMILLAVIGVAVNGIAMARLSKESGMNARV
VALHLLEDVLGWLTVLLVGIVLIFWNLPVLDPVLAVLITLYILRGVVKNLMAQIPVFLQAVPAELDLSAISAEIEAMSTV
RAVHHAHIWSLDGSHNVFTVHLEVERMLDAEDYMQLKDRIKTLVKQHGIYHSTVEIEFPGEICRNMPDAGTG
>Mature_311_residues
ANNAVSAGDHHHHSDGHDHVHHHAAKNIKTAFFLNLGFTLVEIIGGFITGSTAILANAVHDLGDSFALGQAWYFERLSGE
KSNARYSYGYKRFSLLGALISTVFLLGSSLFVLAGAVPRILHPHHPDAGGMILLAVIGVAVNGIAMARLSKESGMNARVV
ALHLLEDVLGWLTVLLVGIVLIFWNLPVLDPVLAVLITLYILRGVVKNLMAQIPVFLQAVPAELDLSAISAEIEAMSTVR
AVHHAHIWSLDGSHNVFTVHLEVERMLDAEDYMQLKDRIKTLVKQHGIYHSTVEIEFPGEICRNMPDAGTG

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=325, Percent_Identity=24.3076923076923, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI64762489, Length=310, Percent_Identity=25.1612903225806, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI289803013, Length=290, Percent_Identity=25.1724137931034, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI289803009, Length=290, Percent_Identity=25.1724137931034, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI289803007, Length=290, Percent_Identity=25.1724137931034, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI289803003, Length=290, Percent_Identity=25.1724137931034, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI21359890, Length=322, Percent_Identity=21.7391304347826, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI52352803, Length=217, Percent_Identity=25.8064516129032, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI52351208, Length=162, Percent_Identity=25.9259259259259, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786966, Length=278, Percent_Identity=30.5755395683453, Blast_Score=115, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17555794, Length=311, Percent_Identity=25.7234726688103, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI193210990, Length=324, Percent_Identity=25, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17555796, Length=314, Percent_Identity=24.8407643312102, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI32564488, Length=290, Percent_Identity=25.5172413793103, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24656728, Length=160, Percent_Identity=30, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24656724, Length=160, Percent_Identity=30, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24656720, Length=160, Percent_Identity=30, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24656715, Length=160, Percent_Identity=30, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21357035, Length=160, Percent_Identity=30, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33957; Mature: 33826

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANNAVSAGDHHHHSDGHDHVHHHAAKNIKTAFFLNLGFTLVEIIGGFITGSTAILANAV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
HDLGDSFALGQAWYFERLSGEKSNARYSYGYKRFSLLGALISTVFLLGSSLFVLAGAVPR
HHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILHPHHPDAGGMILLAVIGVAVNGIAMARLSKESGMNARVVALHLLEDVLGWLTVLLVGI
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VLIFWNLPVLDPVLAVLITLYILRGVVKNLMAQIPVFLQAVPAELDLSAISAEIEAMSTV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
RAVHHAHIWSLDGSHNVFTVHLEVERMLDAEDYMQLKDRIKTLVKQHGIYHSTVEIEFPG
HHHHHHHEEECCCCCCEEEEEEEHHHHHCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCH
EICRNMPDAGTG
HHHCCCCCCCCC
>Mature Secondary Structure 
ANNAVSAGDHHHHSDGHDHVHHHAAKNIKTAFFLNLGFTLVEIIGGFITGSTAILANAV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
HDLGDSFALGQAWYFERLSGEKSNARYSYGYKRFSLLGALISTVFLLGSSLFVLAGAVPR
HHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILHPHHPDAGGMILLAVIGVAVNGIAMARLSKESGMNARVVALHLLEDVLGWLTVLLVGI
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VLIFWNLPVLDPVLAVLITLYILRGVVKNLMAQIPVFLQAVPAELDLSAISAEIEAMSTV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
RAVHHAHIWSLDGSHNVFTVHLEVERMLDAEDYMQLKDRIKTLVKQHGIYHSTVEIEFPG
HHHHHHHEEECCCCCCEEEEEEEHHHHHCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCH
EICRNMPDAGTG
HHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA