Click here to switch to the map view.

The map label for this gene is rnhA

Identifier: 119356417

GI number: 119356417

Start: 652406

End: 652846

Strand: Reverse

Name: rnhA

Synonym: Cpha266_0581

Alternate gene names: 119356417

Gene position: 652846-652406 (Counterclockwise)

Preceding gene: 119356418

Following gene: 119356416

Centisome position: 20.83

GC content: 46.94

Gene sequence:

>441_bases
ATGCAGAAAAAAATAATCGTATACACTGACGGCGCTTGCAGCGGCAACCCCGGAAAAGGCGGCTGGGGAGCCCTGCTTAT
GTACGGCGCCTCAACTCGGGAAATCTCGGGTTACTCGCCTGCCACCACCAACAACCGTATGGAGCTCAGTGCAGCAATAG
AAGCACTCGAAACACTCAAGGAGCCCTGTATTGTGCACCTCTACAGCGATTCAAGCTACCTTGTCAATGCGATAAACGAA
GGATGGCTTAAACGCTGGACAGCCAATAACTGGAAAACCGCAGCAAAAAAAAGTGTTGAAAACATCGATTTGTGGCAAAA
AATCCTGACGTTGATTAAATTACATGACGTTACCTTTCATAAAGTTAAGGGCCACAGTGACAACCCCTACAACAACCGTT
GTGATGAACTGGCTCGTCAAGCCATAAAAAACAACAGATAA

Upstream 100 bases:

>100_bases
ACTTGCCAAACTGCTTAAGTAAAAGGGCAATTTCGGCTATAAAAGATTTTTCAATATCTCATAAAGGCTCAATCCTTAAC
GATTGAGCCTTTTTTTGTCG

Downstream 100 bases:

>100_bases
TCGCTTTCAAGCATGCAGAGCAGTGCCGAAGAACCTCAGGTAAGACCGGAAAAACGCTCCCTGAAAAAAGGAGCGGGACT
GCTCATCTCGATAAGCATAC

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MQKKIIVYTDGACSGNPGKGGWGALLMYGASTREISGYSPATTNNRMELSAAIEALETLKEPCIVHLYSDSSYLVNAINE
GWLKRWTANNWKTAAKKSVENIDLWQKILTLIKLHDVTFHKVKGHSDNPYNNRCDELARQAIKNNR

Sequences:

>Translated_146_residues
MQKKIIVYTDGACSGNPGKGGWGALLMYGASTREISGYSPATTNNRMELSAAIEALETLKEPCIVHLYSDSSYLVNAINE
GWLKRWTANNWKTAAKKSVENIDLWQKILTLIKLHDVTFHKVKGHSDNPYNNRCDELARQAIKNNR
>Mature_146_residues
MQKKIIVYTDGACSGNPGKGGWGALLMYGASTREISGYSPATTNNRMELSAAIEALETLKEPCIVHLYSDSSYLVNAINE
GWLKRWTANNWKTAAKKSVENIDLWQKILTLIKLHDVTFHKVKGHSDNPYNNRCDELARQAIKNNR

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain

Homologues:

Organism=Homo sapiens, GI21359816, Length=150, Percent_Identity=32, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1786408, Length=144, Percent_Identity=49.3055555555556, Blast_Score=143, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI115532542, Length=142, Percent_Identity=38.0281690140845, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17137476, Length=144, Percent_Identity=30.5555555555556, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552509, Length=144, Percent_Identity=30.5555555555556, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH_CHLPD (A1BE10)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911061.1
- ProteinModelPortal:   A1BE10
- STRING:   A1BE10
- GeneID:   4569176
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0581
- NMPDR:   fig|290317.7.peg.609
- eggNOG:   COG0328
- HOGENOM:   HBG742437
- OMA:   NGWRTAD
- ProtClustDB:   PRK00203
- GO:   GO:0005737
- HAMAP:   MF_00042
- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156

Pfam domain/function: PF00075 RnaseH; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 16383; Mature: 16383

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKIIVYTDGACSGNPGKGGWGALLMYGASTREISGYSPATTNNRMELSAAIEALETLK
CCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
EPCIVHLYSDSSYLVNAINEGWLKRWTANNWKTAAKKSVENIDLWQKILTLIKLHDVTFH
CCEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
KVKGHSDNPYNNRCDELARQAIKNNR
EECCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQKKIIVYTDGACSGNPGKGGWGALLMYGASTREISGYSPATTNNRMELSAAIEALETLK
CCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
EPCIVHLYSDSSYLVNAINEGWLKRWTANNWKTAAKKSVENIDLWQKILTLIKLHDVTFH
CCEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
KVKGHSDNPYNNRCDELARQAIKNNR
EECCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA