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The map label for this gene is pgsA1 [H]

Identifier: 119356377

GI number: 119356377

Start: 594433

End: 594987

Strand: Direct

Name: pgsA1 [H]

Synonym: Cpha266_0540

Alternate gene names: 119356377

Gene position: 594433-594987 (Clockwise)

Preceding gene: 119356376

Following gene: 119356381

Centisome position: 18.97

GC content: 45.23

Gene sequence:

>555_bases
GTGAACGGGAAAATATTCAACCTGCCGAATTCCCTCAGTTTTCTGAGAATATTGCTGATTCCCTGGTTTCTGTACTATTT
TCATACAGGAAATCTGACGGTATCAGTTACGCTGATGATTATTGCCATTCTCAGCGACTGGTTTGATGGGCAGACTGCCC
GCTGGACAAATGAAGTTTCAGAAATGGGCAAGATTCTCGATCCACTTGCCGATAAACTTTGTCTTGCAAGTGTCGCGCTC
TATTTTTTATGGGTCGGTCAGCTTCCGCTCTGGTTTGTACTGTTTGTCGTCAGCAGGGATGCGCTTATTTTTCTCGGGGC
GGCCTATGTGAAGTTTCGTCACCGTGTTGTTACAACCTCTCTCTGGCCTGGCAAGTGGGCTGTCGGGTTTCTTTCGATGA
TGTTTATTGCCATGGTTGTCCCTCATCCGTTTTTTGAGCGATATGCTCTTAAAGAGAGCTTTATGTATCTTTCCGTGGTG
ATGCTTTTCTACTCTTTTGTGGAATACTGCCTGAGGTTTTACAGAATTCAGAAGGGTCTTGACTACAAGGCATAG

Upstream 100 bases:

>100_bases
GTTTCATAAAAAGAGGCCGGAAGGGGGTTCATTGCTTTCAGGTCTTGTCGGGCGGATGGAATCGGAACAGTGTTACTCTA
CGAATTAATCTTTATACATT

Downstream 100 bases:

>100_bases
TTTTTCATCAATACCTTATGTTGACCCTTTGCTGTTCATCGGCATGTTAACCGCTCTTGCTTGCCCTGGGTGACCGACAG
CGTGGCACTCAAGTTATATC

Product: CDP-alcohol phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MNGKIFNLPNSLSFLRILLIPWFLYYFHTGNLTVSVTLMIIAILSDWFDGQTARWTNEVSEMGKILDPLADKLCLASVAL
YFLWVGQLPLWFVLFVVSRDALIFLGAAYVKFRHRVVTTSLWPGKWAVGFLSMMFIAMVVPHPFFERYALKESFMYLSVV
MLFYSFVEYCLRFYRIQKGLDYKA

Sequences:

>Translated_184_residues
MNGKIFNLPNSLSFLRILLIPWFLYYFHTGNLTVSVTLMIIAILSDWFDGQTARWTNEVSEMGKILDPLADKLCLASVAL
YFLWVGQLPLWFVLFVVSRDALIFLGAAYVKFRHRVVTTSLWPGKWAVGFLSMMFIAMVVPHPFFERYALKESFMYLSVV
MLFYSFVEYCLRFYRIQKGLDYKA
>Mature_184_residues
MNGKIFNLPNSLSFLRILLIPWFLYYFHTGNLTVSVTLMIIAILSDWFDGQTARWTNEVSEMGKILDPLADKLCLASVAL
YFLWVGQLPLWFVLFVVSRDALIFLGAAYVKFRHRVVTTSLWPGKWAVGFLSMMFIAMVVPHPFFERYALKESFMYLSVV
MLFYSFVEYCLRFYRIQKGLDYKA

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=108, Percent_Identity=31.4814814814815, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24650130, Length=108, Percent_Identity=37.037037037037, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24650126, Length=108, Percent_Identity=37.037037037037, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24650128, Length=108, Percent_Identity=37.037037037037, Blast_Score=77, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 21507; Mature: 21507

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGKIFNLPNSLSFLRILLIPWFLYYFHTGNLTVSVTLMIIAILSDWFDGQTARWTNEVS
CCCCEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EMGKILDPLADKLCLASVALYFLWVGQLPLWFVLFVVSRDALIFLGAAYVKFRHRVVTTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
LWPGKWAVGFLSMMFIAMVVPHPFFERYALKESFMYLSVVMLFYSFVEYCLRFYRIQKGL
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DYKA
CCCC
>Mature Secondary Structure
MNGKIFNLPNSLSFLRILLIPWFLYYFHTGNLTVSVTLMIIAILSDWFDGQTARWTNEVS
CCCCEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EMGKILDPLADKLCLASVALYFLWVGQLPLWFVLFVVSRDALIFLGAAYVKFRHRVVTTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
LWPGKWAVGFLSMMFIAMVVPHPFFERYALKESFMYLSVVMLFYSFVEYCLRFYRIQKGL
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DYKA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]