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The map label for this gene is cysG [H]

Identifier: 119356281

GI number: 119356281

Start: 490096

End: 490854

Strand: Direct

Name: cysG [H]

Synonym: Cpha266_0443

Alternate gene names: 119356281

Gene position: 490096-490854 (Clockwise)

Preceding gene: 119356280

Following gene: 119356282

Centisome position: 15.64

GC content: 48.88

Gene sequence:

>759_bases
ATGACGCAGGAGAACATACATAATCCGGTTTCAATTGTCGGTACCGGTCCGGGAGATCCGGACCTGCTTACCGTGAGAGC
ATCGCGCATTATCAGGAGCGCCGATGTCATTCTGTATGATTGCGCTACAGCAAAACCAGCTCTCAGCATTGCTTCCGAGA
CAGCCATCATACACGAGGTGAATCGCCAGGCGTCTGCTGGAAAGCCGTCGATACTTGAACTTATCGAGATGTATTATCAT
GAAGGGCGAAAAGTGGTGCGTCTCAAGGTTGGTGATCCCATGCTTTTTGGCGGCGAGATTGACGAGTGTCGTGCCCTGAA
GGCGTTGAACATTCCTTTTGAAGTTGTTGCGGGCATAACGGCAGGATCTTCGGCGGCAAGTTCCTACGCTTTGCCGATAA
GCCTGAAATATCAAAGTAATTCGGTCACCTATATCATTGCCGATGAACCGGGTGCCGATTTCGCTCTGTTTCGAGATGCA
TCCAGGCTTCTTCGACATGGCTCAACCATTGTGCTCTACATGGCTACCAAAAATCTGGAAAATATTTTCAGGGTATTTGT
CGAAGAAGGTGTACCTGAAACAATGGCGGTTTTTGCTGTAGGAAAGTCAGGTTGGCCAGACGAGAGCAGTGCGGAGGGAA
CGATGCGGGATATTGTTGCTCAGATTGAGCTTCGGCAGCTCAAAGAGCCCATTATCTTCTTTCTGGGTCGTCATTTGACG
AAAGAAAAACATTTTCCGGTTATGAGTGCATGTTCGTGA

Upstream 100 bases:

>100_bases
TTAAGGTTAATTTGCTATTTTCCTTTTATGAAGAGTGATTTTCTTGGATTTCGTTATGTTTATTTATATATAACGCAAAT
TAATCCTGAAGGAGGCGATG

Downstream 100 bases:

>100_bases
AGATGTTATAAAACTGATAACAAGGGTGCTTTTTAATCATCGTTATATTTATTCGGATATAACGATTTCCAAACGAAAAC
TGTATGAAAAAAATAGTACT

Product: uroporphyrin-III C/tetrapyrrole methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MTQENIHNPVSIVGTGPGDPDLLTVRASRIIRSADVILYDCATAKPALSIASETAIIHEVNRQASAGKPSILELIEMYYH
EGRKVVRLKVGDPMLFGGEIDECRALKALNIPFEVVAGITAGSSAASSYALPISLKYQSNSVTYIIADEPGADFALFRDA
SRLLRHGSTIVLYMATKNLENIFRVFVEEGVPETMAVFAVGKSGWPDESSAEGTMRDIVAQIELRQLKEPIIFFLGRHLT
KEKHFPVMSACS

Sequences:

>Translated_252_residues
MTQENIHNPVSIVGTGPGDPDLLTVRASRIIRSADVILYDCATAKPALSIASETAIIHEVNRQASAGKPSILELIEMYYH
EGRKVVRLKVGDPMLFGGEIDECRALKALNIPFEVVAGITAGSSAASSYALPISLKYQSNSVTYIIADEPGADFALFRDA
SRLLRHGSTIVLYMATKNLENIFRVFVEEGVPETMAVFAVGKSGWPDESSAEGTMRDIVAQIELRQLKEPIIFFLGRHLT
KEKHFPVMSACS
>Mature_251_residues
TQENIHNPVSIVGTGPGDPDLLTVRASRIIRSADVILYDCATAKPALSIASETAIIHEVNRQASAGKPSILELIEMYYHE
GRKVVRLKVGDPMLFGGEIDECRALKALNIPFEVVAGITAGSSAASSYALPISLKYQSNSVTYIIADEPGADFALFRDAS
RLLRHGSTIVLYMATKNLENIFRVFVEEGVPETMAVFAVGKSGWPDESSAEGTMRDIVAQIELRQLKEPIIFFLGRHLTK
EKHFPVMSACS

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG2875

COG function: function code H; Precorrin-4 methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=248, Percent_Identity=29.0322580645161, Blast_Score=94, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 27496; Mature: 27365

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQENIHNPVSIVGTGPGDPDLLTVRASRIIRSADVILYDCATAKPALSIASETAIIHEV
CCCCCCCCCEEEEECCCCCCCEEEEEHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHH
NRQASAGKPSILELIEMYYHEGRKVVRLKVGDPMLFGGEIDECRALKALNIPFEVVAGIT
HHHCCCCCCHHHHHHHHHHHCCCEEEEEEECCCEEECCCHHHHHHHHHCCCCHHHHCCCC
AGSSAASSYALPISLKYQSNSVTYIIADEPGADFALFRDASRLLRHGSTIVLYMATKNLE
CCCCCCCCEEEEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCHH
NIFRVFVEEGVPETMAVFAVGKSGWPDESSAEGTMRDIVAQIELRQLKEPIIFFLGRHLT
HHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KEKHFPVMSACS
CCCCCCCCCCCC
>Mature Secondary Structure 
TQENIHNPVSIVGTGPGDPDLLTVRASRIIRSADVILYDCATAKPALSIASETAIIHEV
CCCCCCCCEEEEECCCCCCCEEEEEHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHH
NRQASAGKPSILELIEMYYHEGRKVVRLKVGDPMLFGGEIDECRALKALNIPFEVVAGIT
HHHCCCCCCHHHHHHHHHHHCCCEEEEEEECCCEEECCCHHHHHHHHHCCCCHHHHCCCC
AGSSAASSYALPISLKYQSNSVTYIIADEPGADFALFRDASRLLRHGSTIVLYMATKNLE
CCCCCCCCEEEEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCHH
NIFRVFVEEGVPETMAVFAVGKSGWPDESSAEGTMRDIVAQIELRQLKEPIIFFLGRHLT
HHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KEKHFPVMSACS
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]