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The map label for this gene is lpxB [H]

Identifier: 119356249

GI number: 119356249

Start: 454044

End: 455186

Strand: Direct

Name: lpxB [H]

Synonym: Cpha266_0411

Alternate gene names: 119356249

Gene position: 454044-455186 (Clockwise)

Preceding gene: 119356242

Following gene: 119356250

Centisome position: 14.49

GC content: 50.31

Gene sequence:

>1143_bases
ATGCCAAAGAAGCTATTTGTATTAGCCGGTGAGGTATCCGGTGATCTGCATGCCGCAGGAGTCGTTGCTGAGTTGCTGAA
GGCAAGACCCGATGTTCGTGTATTCGGTATTGGCGGCGAGAAATTGCGTGCGCTTGGCGCAGAGCTTTTCTATGATACCC
GAAGGATGAGCATTATGGGTTTTCTTGAGGTGCTCAAGCATGCAGGATTTCTGCAGAGGGTGATTCGTGAGATGAAAGAA
CTTGTTCGACAGGAAAAGCCCGATCTGGCATTTCTTGTCGATTATCCCGGCATGAATCTGCTTATGGCGCGTTTCTTTCA
TGAAGAGGGGGTTCCGGTGATTTATTACATATCTCCGCAGGTCTGGGCATGGAAAGAGGGGCGCGTGAAGGCAATCGGGC
GCTATGTTGATCGGCTGCTTGTTATTTTTGACTTCGAGGTTGAATTTTTCCGGCGTCATGGTATCCGCGCGGAATTTGTG
GGCCATCCGGTTATCGAAGAGCTTTCTGCTGTTTCTTTGCCGCCCCGGGAGCTCTTTTTTCGACGGCACCATATTCTCCC
TGGTCAGCGGCTGGTCGGTATGCTGCCTGGAAGCCGCAGGCAGGAGATTGCTCTTGTTTTTCCGGAAATGCTGAAAGCTG
CCCGAATGCTTGCGGCTGACTATGATGTGGTGTTTCTGCTGGGCAGGTCGCCGCAGATGGATGAAAAGCATTTCAGTCTT
GTTTCTGCATTTGATGATATCAGGATTGTCGAGTGCACGGCTTATGAAGTTATGCGGTTCAGCGAGCTTGAGCTGGTAAC
CTCTGGAACCGCAACGCTGGAATCGCTCTGTTTTGGGGTTCCGATGATTGTTCTCTATAAAACAGCCTGGCTGAACTATG
CTGTTGGTCGCCTTCTTGTCAGGCTAACGAGTATCTCGCTGGCCAATATTGTCACAAAAGGGCTTGGTTCAAAAGATCAG
GTTGTCCCCGAACTGTTGCAGCATGAAGCGACCGCTTCGGGAATTTACATGATTGCGCGGCGTTTACTTGATCATCCGCA
GCTTCTTGCCGAAATGCGGCAGGAACTTCTCGATGCAAGGGAAAAACTGGCCAGCGCCTCTCCGTCGCAGATTATTTCAG
AGATACTACAGGAATATCTTTAA

Upstream 100 bases:

>100_bases
TTGATTTTGATATAATGGGATCAAGCCGAAAGTATTAAATACTCAAACTAAATATAAAATACGGTTTCCCCGTCGCTCAT
CCAATTTTCCCCGCTTTTTG

Downstream 100 bases:

>100_bases
CAATGTTAGTAAACAATGGAAAAAGCTGCTGATCTTCTTCTTGGTAATCCAGTGCTGCTCTTAATCGCGGTGATTGCCGC
CGTGATGGTTCTTTTTTCGT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MPKKLFVLAGEVSGDLHAAGVVAELLKARPDVRVFGIGGEKLRALGAELFYDTRRMSIMGFLEVLKHAGFLQRVIREMKE
LVRQEKPDLAFLVDYPGMNLLMARFFHEEGVPVIYYISPQVWAWKEGRVKAIGRYVDRLLVIFDFEVEFFRRHGIRAEFV
GHPVIEELSAVSLPPRELFFRRHHILPGQRLVGMLPGSRRQEIALVFPEMLKAARMLAADYDVVFLLGRSPQMDEKHFSL
VSAFDDIRIVECTAYEVMRFSELELVTSGTATLESLCFGVPMIVLYKTAWLNYAVGRLLVRLTSISLANIVTKGLGSKDQ
VVPELLQHEATASGIYMIARRLLDHPQLLAEMRQELLDAREKLASASPSQIISEILQEYL

Sequences:

>Translated_380_residues
MPKKLFVLAGEVSGDLHAAGVVAELLKARPDVRVFGIGGEKLRALGAELFYDTRRMSIMGFLEVLKHAGFLQRVIREMKE
LVRQEKPDLAFLVDYPGMNLLMARFFHEEGVPVIYYISPQVWAWKEGRVKAIGRYVDRLLVIFDFEVEFFRRHGIRAEFV
GHPVIEELSAVSLPPRELFFRRHHILPGQRLVGMLPGSRRQEIALVFPEMLKAARMLAADYDVVFLLGRSPQMDEKHFSL
VSAFDDIRIVECTAYEVMRFSELELVTSGTATLESLCFGVPMIVLYKTAWLNYAVGRLLVRLTSISLANIVTKGLGSKDQ
VVPELLQHEATASGIYMIARRLLDHPQLLAEMRQELLDAREKLASASPSQIISEILQEYL
>Mature_379_residues
PKKLFVLAGEVSGDLHAAGVVAELLKARPDVRVFGIGGEKLRALGAELFYDTRRMSIMGFLEVLKHAGFLQRVIREMKEL
VRQEKPDLAFLVDYPGMNLLMARFFHEEGVPVIYYISPQVWAWKEGRVKAIGRYVDRLLVIFDFEVEFFRRHGIRAEFVG
HPVIEELSAVSLPPRELFFRRHHILPGQRLVGMLPGSRRQEIALVFPEMLKAARMLAADYDVVFLLGRSPQMDEKHFSLV
SAFDDIRIVECTAYEVMRFSELELVTSGTATLESLCFGVPMIVLYKTAWLNYAVGRLLVRLTSISLANIVTKGLGSKDQV
VPELLQHEATASGIYMIARRLLDHPQLLAEMRQELLDAREKLASASPSQIISEILQEYL

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=338, Percent_Identity=29.2899408284024, Blast_Score=156, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 43113; Mature: 42982

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKKLFVLAGEVSGDLHAAGVVAELLKARPDVRVFGIGGEKLRALGAELFYDTRRMSIMG
CCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
FLEVLKHAGFLQRVIREMKELVRQEKPDLAFLVDYPGMNLLMARFFHEEGVPVIYYISPQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCC
VWAWKEGRVKAIGRYVDRLLVIFDFEVEFFRRHGIRAEFVGHPVIEELSAVSLPPRELFF
EEEECCCHHHHHHHHHHHHHHHEEHHHHHHHHCCCCEECCCCHHHHHHHHCCCCHHHHHH
RRHHILPGQRLVGMLPGSRRQEIALVFPEMLKAARMLAADYDVVFLLGRSPQMDEKHFSL
HHHCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
VSAFDDIRIVECTAYEVMRFSELELVTSGTATLESLCFGVPMIVLYKTAWLNYAVGRLLV
HHHHCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
RLTSISLANIVTKGLGSKDQVVPELLQHEATASGIYMIARRLLDHPQLLAEMRQELLDAR
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
EKLASASPSQIISEILQEYL
HHHHCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
PKKLFVLAGEVSGDLHAAGVVAELLKARPDVRVFGIGGEKLRALGAELFYDTRRMSIMG
CCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
FLEVLKHAGFLQRVIREMKELVRQEKPDLAFLVDYPGMNLLMARFFHEEGVPVIYYISPQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCC
VWAWKEGRVKAIGRYVDRLLVIFDFEVEFFRRHGIRAEFVGHPVIEELSAVSLPPRELFF
EEEECCCHHHHHHHHHHHHHHHEEHHHHHHHHCCCCEECCCCHHHHHHHHCCCCHHHHHH
RRHHILPGQRLVGMLPGSRRQEIALVFPEMLKAARMLAADYDVVFLLGRSPQMDEKHFSL
HHHCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHH
VSAFDDIRIVECTAYEVMRFSELELVTSGTATLESLCFGVPMIVLYKTAWLNYAVGRLLV
HHHHCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
RLTSISLANIVTKGLGSKDQVVPELLQHEATASGIYMIARRLLDHPQLLAEMRQELLDAR
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
EKLASASPSQIISEILQEYL
HHHHCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA