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The map label for this gene is hldE [H]

Identifier: 119356185

GI number: 119356185

Start: 382706

End: 383263

Strand: Reverse

Name: hldE [H]

Synonym: Cpha266_0346

Alternate gene names: 119356185

Gene position: 383263-382706 (Counterclockwise)

Preceding gene: 119356187

Following gene: 119356184

Centisome position: 12.23

GC content: 49.82

Gene sequence:

>558_bases
TTGCTTGTATTGCAGTTGCACGTGATTTTTCTCCAATTAGCCGACCGTTACCTGATGAATAGCAAACTACTAACCCGTGC
AAAGGCGAAAGAACAAGTCATCGCATGGCAATCTTCAGGAAAAAAAGTGGTGTTTTCGAACGGTTGTTTTGACATTCTGC
ATGCAGGTCACGTTCAGTATCTCTCAAGAGCCCGTCAGCTTGGCGATATCCTGCTGATAGGGCTCAACAGTGACGCTTCG
ATACAACGCATTAAAGGGCCGCTACGGCCTGTATGCGCCGAGCAGGATCGCGCTGCCGTACTGTCTGCGCTGCAAATGGT
TGATGCCATTACACTCTTTGATGAAGACACTCCGGAGGCGTTGATCGAGGCACTGCTTCCTGATATTCTGGTCAAGGGTG
CCGACTGGGATATCGAACGCATTGCTGGAGCAAAGGCAGTTCTTCAGAGTGGGGGAAAGGTGCTTACCCTGCCGATTCTG
GAAGGCCGGTCGACAACCGGTATCATTGAGAAGGTCATTCAAATTTACGGCAAACACACTCCTCGTGGAAAAGAGTAA

Upstream 100 bases:

>100_bases
GCTCAGCACTCGGCAAACCGGAAGTGATAAGAAGAAAAAAGAAGAAATCCTTTCGCAAGAGTGTGCCGAGCATACGCGAA
ATTGAATAAATTATCCGAAA

Downstream 100 bases:

>100_bases
AAAAGTCTTTATCGGATTTCTGGCGCTGCTGTCGGCGGGCGTTCTTCTCCTGTCGATTGTTGCCGCAATTGTCCTGAACA
GCGGATTCCTTGACCGGTTC

Product: rfaE bifunctional protein

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MLVLQLHVIFLQLADRYLMNSKLLTRAKAKEQVIAWQSSGKKVVFSNGCFDILHAGHVQYLSRARQLGDILLIGLNSDAS
IQRIKGPLRPVCAEQDRAAVLSALQMVDAITLFDEDTPEALIEALLPDILVKGADWDIERIAGAKAVLQSGGKVLTLPIL
EGRSTTGIIEKVIQIYGKHTPRGKE

Sequences:

>Translated_185_residues
MLVLQLHVIFLQLADRYLMNSKLLTRAKAKEQVIAWQSSGKKVVFSNGCFDILHAGHVQYLSRARQLGDILLIGLNSDAS
IQRIKGPLRPVCAEQDRAAVLSALQMVDAITLFDEDTPEALIEALLPDILVKGADWDIERIAGAKAVLQSGGKVLTLPIL
EGRSTTGIIEKVIQIYGKHTPRGKE
>Mature_185_residues
MLVLQLHVIFLQLADRYLMNSKLLTRAKAKEQVIAWQSSGKKVVFSNGCFDILHAGHVQYLSRARQLGDILLIGLNSDAS
IQRIKGPLRPVCAEQDRAAVLSALQMVDAITLFDEDTPEALIEALLPDILVKGADWDIERIAGAKAVLQSGGKVLTLPIL
EGRSTTGIIEKVIQIYGKHTPRGKE

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=152, Percent_Identity=51.9736842105263, Blast_Score=154, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.- [C]

Molecular weight: Translated: 20291; Mature: 20291

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLQLHVIFLQLADRYLMNSKLLTRAKAKEQVIAWQSSGKKVVFSNGCFDILHAGHVQY
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCHHHHHHHHHHH
LSRARQLGDILLIGLNSDASIQRIKGPLRPVCAEQDRAAVLSALQMVDAITLFDEDTPEA
HHHHHHCCCEEEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
LIEALLPDILVKGADWDIERIAGAKAVLQSGGKVLTLPILEGRSTTGIIEKVIQIYGKHT
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCC
PRGKE
CCCCC
>Mature Secondary Structure
MLVLQLHVIFLQLADRYLMNSKLLTRAKAKEQVIAWQSSGKKVVFSNGCFDILHAGHVQY
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCHHHHHHHHHHH
LSRARQLGDILLIGLNSDASIQRIKGPLRPVCAEQDRAAVLSALQMVDAITLFDEDTPEA
HHHHHHCCCEEEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
LIEALLPDILVKGADWDIERIAGAKAVLQSGGKVLTLPILEGRSTTGIIEKVIQIYGKHT
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCC
PRGKE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA