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The map label for this gene is coaBC [H]

Identifier: 119356183

GI number: 119356183

Start: 376893

End: 378125

Strand: Reverse

Name: coaBC [H]

Synonym: Cpha266_0344

Alternate gene names: 119356183

Gene position: 378125-376893 (Counterclockwise)

Preceding gene: 119356184

Following gene: 119356182

Centisome position: 12.07

GC content: 47.53

Gene sequence:

>1233_bases
ATGTTGAGAGGAAAAAATATCATCATAGCCATATGCGGCGGTATAGCAGCTTATAAAATCCCTGTACTGGTACGTCTTCT
TAAAAAAGGTGGCGCAAATGTCAAAGTCGTACTGACGGCCTCAGCAGCCAGATTTGTCAGCGAACTTACCCTCGCCACGG
TTTCACAGGAACAGGTTTATTGCTCTCTCTTTCCTCCTGTAGAAAGGGAAAACGTTGATTACACCCGGCATATCTCGCTC
GGAGAATGGGCTGATATCTTTGTCGTAGCGCCTGCAACAGCAAACACAATCGCAAAACTGGCCGCAGGCCTTTGTGATGA
CATGCTGTCCGCTTGTTTTCTGACTTTACGTCCAAATAAACCGGTGCTTTTGTTTCCGGCAATGGATGGAGAGATGTTCA
CCTCCTCATCGGTGCAGAGAAATCTTGCCATGCTTCTTGCAGATGGCGCTCGTATCATTAATCCGGATAGCGGTGAACTT
GCTTCCGGTCAGTGTGGACTCGGAAGAATGCCTGAACCCGAAGCAATCGCTGCGTTGATTGAAGAGGAGTTGCTGAAATC
CTGCAACAAGCACTCTTCGCTTCAGGGAAAAAGCGTGGTAATTACGGCAGGCCCGACCAGAGAAAAAATTGACGACGTTC
GATTTATTTCCAACTACTCATCGGGCAAAATGGGTTTTGCCATTGCCAGAGCGGCTGCAGAGCGAGGAGCGAAGGTTACG
CTTCTGGCTGGCCCGGTATCACTCATCACCCCTCCTCTGGTAGAACGTGTTGACGTTGAAAGCGCAAAAGAGATGTACGA
TGCTGCCCGTCAACTCTTCGAAACCTGTGATGTTTTTGTATCAGCCGCCGCTGTTGCCGATTATCGACCGGATTCGCCCT
TTCAGGGCAAACTGAAAAAAAACGGAGAGGAACTCTCCTTGACACTCAGGAAAAACCCGGATATTCTTGCGGAATTCAGC
AAACAGAAATCGCCATCGCAGATTGCTGTTGGTTTTGCTCTTGAATGTGAGGATGGTCTGAAAAACGCCATAAAAAAACG
GATAGAAAAAAAACTCGACCTTATTGCATTGAATTTCTATGACGGAAAGAGTTCGGGTTTTGAAGTAGAAACCAATATGC
TTACACTGATAGGAAGCGATGATACAGCAACGGTCCTGCCTCTTTTGTCGAAACCGGATGCGGCAAACCGTCTTTTGGAA
GCTGTAGAAAAACTCATCCAGCCTGACAGCTAA

Upstream 100 bases:

>100_bases
AGTTTCTGGAAACGAATTATCCCTTCATCCAACAAAAAGAAATAAGTCATACTGTTTTCAGTACATTATCGGGTATCTCT
GACAACAACCACGAAAACAT

Downstream 100 bases:

>100_bases
TCGAAGAACCAGTTTTTCTCATGCACCCTTTCTTATTCAGCGATCATGACGACACGCTGCCTTCAGTTCAGTCTGAGGCT
GGAGCTCCATTCAGAGATCT

Product: phosphopantothenate-cysteine ligase / phosphopantothenoylcysteine decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MLRGKNIIIAICGGIAAYKIPVLVRLLKKGGANVKVVLTASAARFVSELTLATVSQEQVYCSLFPPVERENVDYTRHISL
GEWADIFVVAPATANTIAKLAAGLCDDMLSACFLTLRPNKPVLLFPAMDGEMFTSSSVQRNLAMLLADGARIINPDSGEL
ASGQCGLGRMPEPEAIAALIEEELLKSCNKHSSLQGKSVVITAGPTREKIDDVRFISNYSSGKMGFAIARAAAERGAKVT
LLAGPVSLITPPLVERVDVESAKEMYDAARQLFETCDVFVSAAAVADYRPDSPFQGKLKKNGEELSLTLRKNPDILAEFS
KQKSPSQIAVGFALECEDGLKNAIKKRIEKKLDLIALNFYDGKSSGFEVETNMLTLIGSDDTATVLPLLSKPDAANRLLE
AVEKLIQPDS

Sequences:

>Translated_410_residues
MLRGKNIIIAICGGIAAYKIPVLVRLLKKGGANVKVVLTASAARFVSELTLATVSQEQVYCSLFPPVERENVDYTRHISL
GEWADIFVVAPATANTIAKLAAGLCDDMLSACFLTLRPNKPVLLFPAMDGEMFTSSSVQRNLAMLLADGARIINPDSGEL
ASGQCGLGRMPEPEAIAALIEEELLKSCNKHSSLQGKSVVITAGPTREKIDDVRFISNYSSGKMGFAIARAAAERGAKVT
LLAGPVSLITPPLVERVDVESAKEMYDAARQLFETCDVFVSAAAVADYRPDSPFQGKLKKNGEELSLTLRKNPDILAEFS
KQKSPSQIAVGFALECEDGLKNAIKKRIEKKLDLIALNFYDGKSSGFEVETNMLTLIGSDDTATVLPLLSKPDAANRLLE
AVEKLIQPDS
>Mature_410_residues
MLRGKNIIIAICGGIAAYKIPVLVRLLKKGGANVKVVLTASAARFVSELTLATVSQEQVYCSLFPPVERENVDYTRHISL
GEWADIFVVAPATANTIAKLAAGLCDDMLSACFLTLRPNKPVLLFPAMDGEMFTSSSVQRNLAMLLADGARIINPDSGEL
ASGQCGLGRMPEPEAIAALIEEELLKSCNKHSSLQGKSVVITAGPTREKIDDVRFISNYSSGKMGFAIARAAAERGAKVT
LLAGPVSLITPPLVERVDVESAKEMYDAARQLFETCDVFVSAAAVADYRPDSPFQGKLKKNGEELSLTLRKNPDILAEFS
KQKSPSQIAVGFALECEDGLKNAIKKRIEKKLDLIALNFYDGKSSGFEVETNMLTLIGSDDTATVLPLLSKPDAANRLLE
AVEKLIQPDS

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=200, Percent_Identity=32.5, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI87082301, Length=394, Percent_Identity=44.1624365482233, Blast_Score=275, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI17560194, Length=184, Percent_Identity=30.4347826086957, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322762, Length=193, Percent_Identity=28.4974093264249, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322925, Length=210, Percent_Identity=26.1904761904762, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324629, Length=79, Percent_Identity=41.7721518987342, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24657262, Length=188, Percent_Identity=28.1914893617021, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44121; Mature: 44121

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRGKNIIIAICGGIAAYKIPVLVRLLKKGGANVKVVLTASAARFVSELTLATVSQEQVY
CCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHCCCCCEE
CSLFPPVERENVDYTRHISLGEWADIFVVAPATANTIAKLAAGLCDDMLSACFLTLRPNK
EEECCCCCCCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEECCCC
PVLLFPAMDGEMFTSSSVQRNLAMLLADGARIINPDSGELASGQCGLGRMPEPEAIAALI
CEEEEECCCCCHHCCHHHHHHHHHHEECCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
EEELLKSCNKHSSLQGKSVVITAGPTREKIDDVRFISNYSSGKMGFAIARAAAERGAKVT
HHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEE
LLAGPVSLITPPLVERVDVESAKEMYDAARQLFETCDVFVSAAAVADYRPDSPFQGKLKK
EEECCHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHC
NGEELSLTLRKNPDILAEFSKQKSPSQIAVGFALECEDGLKNAIKKRIEKKLDLIALNFY
CCCEEEEEEECCCCHHHHHHCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHCEEEEEEE
DGKSSGFEVETNMLTLIGSDDTATVLPLLSKPDAANRLLEAVEKLIQPDS
CCCCCCEEEEEEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLRGKNIIIAICGGIAAYKIPVLVRLLKKGGANVKVVLTASAARFVSELTLATVSQEQVY
CCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHCCCCCEE
CSLFPPVERENVDYTRHISLGEWADIFVVAPATANTIAKLAAGLCDDMLSACFLTLRPNK
EEECCCCCCCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEECCCC
PVLLFPAMDGEMFTSSSVQRNLAMLLADGARIINPDSGELASGQCGLGRMPEPEAIAALI
CEEEEECCCCCHHCCHHHHHHHHHHEECCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
EEELLKSCNKHSSLQGKSVVITAGPTREKIDDVRFISNYSSGKMGFAIARAAAERGAKVT
HHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEE
LLAGPVSLITPPLVERVDVESAKEMYDAARQLFETCDVFVSAAAVADYRPDSPFQGKLKK
EEECCHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHC
NGEELSLTLRKNPDILAEFSKQKSPSQIAVGFALECEDGLKNAIKKRIEKKLDLIALNFY
CCCEEEEEEECCCCHHHHHHCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHCEEEEEEE
DGKSSGFEVETNMLTLIGSDDTATVLPLLSKPDAANRLLEAVEKLIQPDS
CCCCCCEEEEEEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]