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The map label for this gene is cqsS [H]

Identifier: 119356012

GI number: 119356012

Start: 186106

End: 188586

Strand: Direct

Name: cqsS [H]

Synonym: Cpha266_0165

Alternate gene names: 119356012

Gene position: 186106-188586 (Clockwise)

Preceding gene: 119356011

Following gene: 119356013

Centisome position: 5.94

GC content: 48.05

Gene sequence:

>2481_bases
ATGCCCGCCAGTTATTCTTCCAGACCATCTGTTCTGAAACGGGGAGTTGATTTTTTTCAGAATGATTATGAGCGTAACAA
GCTTACAATCGATTACATCAGGTATATCGGATTATGGGGGCATCCGTTGTATTACTTGCTTTGTGCGTTTATTTTTCCGC
AGCCTTACGAGTCGTTTGAGCTGCGTTTTGCCTCTGCGATTTCGTTTATTCCTATTCTTTTTCATCAGCGTTATCCCGAG
AAGTTCAGGTCCCTCCTGATGCTCTATTGGTATCTCTGGCTGACGTTTACTTTTCCTGTCGTATTTACGTATCTGATGTT
GATGAACGATTTTTCCGGATTGTGGCTGGTGGCGGAAACCGTTATGCTGTTTGTGTTTATCATCTTTATCACCAATTATT
TTCTTTTGTTTGTTCTGTTCTTTTCAGGCATTCTTATCGCCTATGCCGGATTTGTTCTTGATACGGGCGCCCACCTGCTG
ATTACAAAGGAAATCATTGAATACTTCGTTTCGATTCCTATCGCTATCCTGCTTGGATTACTGGTTAATTCCACCAATAA
AAAAGGGGAGCTGGCACAGGAGAGAAATTCGGTATTGCAATCTCTGGCAGGCAGTATCGCTCATGAGATGCGTAATCCTC
TCGGCCAGATTCGCCATTGTCTTTACAGCATCCAGAATCTGCTGCCGCAGGTTAACCCGGAAGAGTGTGATAAACCGCTC
GGCAAAGAGAAACTCGAGACGCTTTATGAACGGGTGTCGCGCGGTCAGTTAGCGGTAAAGCGAGGTGCCCAGGTGATCGA
TATGGTTCTCAGCGAGGTTCGTGAAAGGCCGATCGGACCGGAAAGTTTCACCTATTTGTCTGCAACCAGAGTTACTCGCA
ACGCACTTGATGAATTCGGCTATGAATCAGAGCAGGACCGGAGACGCGTTCATCTTGAAACGAAAGACTCTTTTATCTTT
CATATCAATGAAACTCTTTTTGTTTTCGTGCTTTTTAACTTGCTGAAGAACGCGTTGTTCTATTTTAAAACCCACCCGCA
TAGTGAAATCAGCGTTCGTCTGGAAAGGGGCGAGCGCTTCAATTATCTTTATTTCCGTGATACGGGTCCTGGTATATCCA
GCGAAACGCTTCCTTTTATATTCGACAGTTTTTATACTACCGGCAAGGCCTCCGGCACTGGCCTCGGTCTGTCGTATTGC
AAACGGATCATGACGGCTTTCGGGGGGAGTATTACCTGTAAATCGGTTGAAGGAGAGTATTCGGAGTTCATCCTTTCCTT
TCCTGTTATTTCAGAGCAGGATATGAACCTTTATACGGAACGGGTCATTGCTGTCGGGCAGGCTGATTTTCAGGGAAAAC
GATTGCTGATCGTCGACGATTCAGCTCTTTACCGCAGTATCCTGAAAAAGTATTTTGCCCCTCTGCAGGTAGAGATCGAT
GAAGCGGCAGGCGGTCGCGAAGCTCTTGATCTGTTGTCGATTCGGAGGTACGATCTTGTTATCATGGACCTGAACATGCC
GTCGATGAGCGGATATGAGACGGTCGAACGGTTACGGCGCGGAGAAGCCGGCCCTCAATCCTGCTCGGTACCGGTGGTGG
CACATAGTTCCGAGTCCGTCATGACTGCACGGAGCAAGTCTGAGAATGCTGGAATGCAGGCTTTTATTGCCAAGCCCTGC
AGTCAGGCGGAACTGATCAGTTCATTGCGTTCCGTACTCGATACCATTCCTGAAAGAAATTATCCGGGATCTCCGTTTTC
AGGTCGAAAGGTGCTGCTTGTCGATGATTCGGCCCTGAACCGCGACCTGCTTGCCATGTATCTCAGAGACTCGGGGATCG
AGGTGACGGTTTCTGATAGCGGCGCAGAGGCTTTGAATATTTTGAGGAATCAGGATTTCGAACTGCTGATAACCGATATT
CACATGCCGGGAATGGATGGGTTGGAGCTTACCCGCACGATTCGATCGAGCAGATCCGAGCAGTTGTGCCGGTTGCCCAT
CATTGGTCTCAGTGGAGCTGTTGAAGAAGAGGTTGTCGCAAGAAAAGCGGGAATGAACGACTTTCGTATTAAAACCGACA
GTCCTAATCTTTTACTTGCCTCCATCGGCAGGCAATTGTCTGTTTCCGGAGCAGAGCCGATCAGGGAAAAGGTTGTGAAA
GAGTATCCGCAAGCGGTCAAGGTGACGTCGCCATATGGGCTTTCAGCGTCGGAGAGTGAAGAGCTCCGGCAAATATTTCT
TGAAGAGTTTCGGGATACTCCCGTAAACCTGAGACGGGCTCTGAAAGAAAACGATATGAGGAGCCTGAAAGAGGAGTCGC
ATAAACTGAAAGGAAGCGCAGCTATTCTTGGCGCTATGGCTCTCAGCAAGGCTGCCGAGGAACTTGAACTGCATTGCCGT
TTCGAAAGGCGTGATGATCCTGCACCGAAGATTGAGCGCATTATTGAAGCGCTGGATGAGCTGTCTGCAAGAAACGATTG
A

Upstream 100 bases:

>100_bases
TATAGCTCAGAATATTCGTTCCGGAGAACTCCTCAATATCGAAGAGGATGTTTATAGTCATTACAGTTTCTGCGTGCTGA
AAAGCTAATATTGTATTGCC

Downstream 100 bases:

>100_bases
AATAAGCGAGCTTGTTGCGGTATCGCGTTTCGCTGGCTTTTTATCTGTTTTTCTCACTCCGGATTCTCTGCGCTGCGGGG
AGTCGCTTTTTATTTGTTGC

Product: multi-sensor hybrid histidine kinase

Products: NA

Alternate protein names: Cholerae quorum-sensing sensor [H]

Number of amino acids: Translated: 826; Mature: 825

Protein sequence:

>826_residues
MPASYSSRPSVLKRGVDFFQNDYERNKLTIDYIRYIGLWGHPLYYLLCAFIFPQPYESFELRFASAISFIPILFHQRYPE
KFRSLLMLYWYLWLTFTFPVVFTYLMLMNDFSGLWLVAETVMLFVFIIFITNYFLLFVLFFSGILIAYAGFVLDTGAHLL
ITKEIIEYFVSIPIAILLGLLVNSTNKKGELAQERNSVLQSLAGSIAHEMRNPLGQIRHCLYSIQNLLPQVNPEECDKPL
GKEKLETLYERVSRGQLAVKRGAQVIDMVLSEVRERPIGPESFTYLSATRVTRNALDEFGYESEQDRRRVHLETKDSFIF
HINETLFVFVLFNLLKNALFYFKTHPHSEISVRLERGERFNYLYFRDTGPGISSETLPFIFDSFYTTGKASGTGLGLSYC
KRIMTAFGGSITCKSVEGEYSEFILSFPVISEQDMNLYTERVIAVGQADFQGKRLLIVDDSALYRSILKKYFAPLQVEID
EAAGGREALDLLSIRRYDLVIMDLNMPSMSGYETVERLRRGEAGPQSCSVPVVAHSSESVMTARSKSENAGMQAFIAKPC
SQAELISSLRSVLDTIPERNYPGSPFSGRKVLLVDDSALNRDLLAMYLRDSGIEVTVSDSGAEALNILRNQDFELLITDI
HMPGMDGLELTRTIRSSRSEQLCRLPIIGLSGAVEEEVVARKAGMNDFRIKTDSPNLLLASIGRQLSVSGAEPIREKVVK
EYPQAVKVTSPYGLSASESEELRQIFLEEFRDTPVNLRRALKENDMRSLKEESHKLKGSAAILGAMALSKAAEELELHCR
FERRDDPAPKIERIIEALDELSARND

Sequences:

>Translated_826_residues
MPASYSSRPSVLKRGVDFFQNDYERNKLTIDYIRYIGLWGHPLYYLLCAFIFPQPYESFELRFASAISFIPILFHQRYPE
KFRSLLMLYWYLWLTFTFPVVFTYLMLMNDFSGLWLVAETVMLFVFIIFITNYFLLFVLFFSGILIAYAGFVLDTGAHLL
ITKEIIEYFVSIPIAILLGLLVNSTNKKGELAQERNSVLQSLAGSIAHEMRNPLGQIRHCLYSIQNLLPQVNPEECDKPL
GKEKLETLYERVSRGQLAVKRGAQVIDMVLSEVRERPIGPESFTYLSATRVTRNALDEFGYESEQDRRRVHLETKDSFIF
HINETLFVFVLFNLLKNALFYFKTHPHSEISVRLERGERFNYLYFRDTGPGISSETLPFIFDSFYTTGKASGTGLGLSYC
KRIMTAFGGSITCKSVEGEYSEFILSFPVISEQDMNLYTERVIAVGQADFQGKRLLIVDDSALYRSILKKYFAPLQVEID
EAAGGREALDLLSIRRYDLVIMDLNMPSMSGYETVERLRRGEAGPQSCSVPVVAHSSESVMTARSKSENAGMQAFIAKPC
SQAELISSLRSVLDTIPERNYPGSPFSGRKVLLVDDSALNRDLLAMYLRDSGIEVTVSDSGAEALNILRNQDFELLITDI
HMPGMDGLELTRTIRSSRSEQLCRLPIIGLSGAVEEEVVARKAGMNDFRIKTDSPNLLLASIGRQLSVSGAEPIREKVVK
EYPQAVKVTSPYGLSASESEELRQIFLEEFRDTPVNLRRALKENDMRSLKEESHKLKGSAAILGAMALSKAAEELELHCR
FERRDDPAPKIERIIEALDELSARND
>Mature_825_residues
PASYSSRPSVLKRGVDFFQNDYERNKLTIDYIRYIGLWGHPLYYLLCAFIFPQPYESFELRFASAISFIPILFHQRYPEK
FRSLLMLYWYLWLTFTFPVVFTYLMLMNDFSGLWLVAETVMLFVFIIFITNYFLLFVLFFSGILIAYAGFVLDTGAHLLI
TKEIIEYFVSIPIAILLGLLVNSTNKKGELAQERNSVLQSLAGSIAHEMRNPLGQIRHCLYSIQNLLPQVNPEECDKPLG
KEKLETLYERVSRGQLAVKRGAQVIDMVLSEVRERPIGPESFTYLSATRVTRNALDEFGYESEQDRRRVHLETKDSFIFH
INETLFVFVLFNLLKNALFYFKTHPHSEISVRLERGERFNYLYFRDTGPGISSETLPFIFDSFYTTGKASGTGLGLSYCK
RIMTAFGGSITCKSVEGEYSEFILSFPVISEQDMNLYTERVIAVGQADFQGKRLLIVDDSALYRSILKKYFAPLQVEIDE
AAGGREALDLLSIRRYDLVIMDLNMPSMSGYETVERLRRGEAGPQSCSVPVVAHSSESVMTARSKSENAGMQAFIAKPCS
QAELISSLRSVLDTIPERNYPGSPFSGRKVLLVDDSALNRDLLAMYLRDSGIEVTVSDSGAEALNILRNQDFELLITDIH
MPGMDGLELTRTIRSSRSEQLCRLPIIGLSGAVEEEVVARKAGMNDFRIKTDSPNLLLASIGRQLSVSGAEPIREKVVKE
YPQAVKVTSPYGLSASESEELRQIFLEEFRDTPVNLRRALKENDMRSLKEESHKLKGSAAILGAMALSKAAEELELHCRF
ERRDDPAPKIERIIEALDELSARND

Specific function: Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to luxU and luxO [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=454, Percent_Identity=24.8898678414097, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI48994928, Length=254, Percent_Identity=28.3464566929134, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1790436, Length=257, Percent_Identity=29.9610894941634, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789149, Length=386, Percent_Identity=23.5751295336788, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 93663; Mature: 93532

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS00061 ADH_SHORT ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PASYSSRPSVLKRGVDFFQNDYERNKLTIDYIRYIGLWGHPLYYLLCAFIFPQPYESFE
CCCCCCCHHHHHHHHHHHHCCHHCCCEEHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHH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HHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA