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The map label for this gene is rnd [H]

Identifier: 118582016

GI number: 118582016

Start: 3997981

End: 3999129

Strand: Reverse

Name: rnd [H]

Synonym: Ppro_3617

Alternate gene names: 118582016

Gene position: 3999129-3997981 (Counterclockwise)

Preceding gene: 118582017

Following gene: 118582015

Centisome position: 99.78

GC content: 62.4

Gene sequence:

>1149_bases
TTGACATCACTGGAACAGCGGGCGGGGGCCTGCGAAATGATAACCGACGGAGGGAGGCTGGCCGAAGTGGCCGGCAGTAT
CAATTCCGAACGAGAAGTTGCCGTGGATCTGGAGATGGATTCGCTGCACCACTACCGCGAAAAAGTCTGTCTGATACAGA
TATCAACCAGAACCGAGAGCTGGCTGATCGACCCCCTGGCACTGAAGGATCTGTCGCCGCTGGCCGCTCCGCTGGGCAAC
CGGGACATACTGATCGTCATGCACGGTGCCGACTATGACATCCGCTCGCTGCACCGCGATCATGGCATCGAAGTGACGAA
CCTGTTCGACACCATGATCGCTTCGCGCCTGCTGGGTATCACCGAATTCGGTCTGGCCGCGCTGCTCAAGGCTCGTTTCG
GCATCGAACTGAACAAGAAATACCAGAAGGCAGACTGGAGCAAGCGCCCGCTCTCCCCCGAGATGCGCGCCTATGCCGTT
GCCGATACCGCCGACCTTTTGCGCCTGTACGACATGCTGCGGGACGAACTGCTGGAGAAGGGGCGCCTGGCCTGGCTGGA
GGAGGAGTGCCGCCTGGTCTGCCAGGCCAGGGTCAGCGAGAAAGAGGGTCCGCTGTTTCTCGCCTGCAAGGGAGCCGGCA
AGCTGCGGGGACGGGCGCTCGCGGTGCTGGAAGAACTCCTGCAGCTGCGCGACAGCCAGGCGCGGGAACTGGACCGCCCG
CCTTTCAAGGTCATCTCGGGCGATACGCTGCTGGAAATAGCAGAAAAGAAACCCCGCTCCCTGGCCGAACTGTCGTTCAT
CAAGGGCATGACCCCCGGGCAGATCCAGCGTCTTGGCGAAAGGGTTCTGTCAGCCGTGGCCGACGCCCTGGTACTGCCCG
AGGAACGGTTGCCCCGTTTTCCCCGTTTGCAGCGCGAGGAGCCTGTCGACGGAACAAAGGAACGCATCAAGTGCCTCAAA
TCCTGGCGCCAGGGGGAGAGCCGCAGGCTGGGGCTCGAGCCGGGGGTGATAGCTCCCAACTGGCTATTGGAGGGGATCGC
CGATGCCAATCCCGCCAGTATCGCTGCACTGGACGGCATCGCCGGCATGCGCGACTGGCAGAAGGGGCTGTATGGTCAGG
AGTTGCTGACTGAACTGTCGGCGGGCTGA

Upstream 100 bases:

>100_bases
TCCGCATGTCCCGCGACCAGATGGTGGCCCTGATCGCCGGGGCGGGATTCAAGGCCGCCCAACGCACGACAACGTACAAA
ATACTGAGGGAGTTTAGCGT

Downstream 100 bases:

>100_bases
TGGCGTGAGCAGCCCATGAATCATCCCTATCTGAGCATCGTTGTTGCGGTTCGCGATGATGAATACAATCTGACCCCCTT
CATGGAGCGGCTCTACCCGG

Product: 3'-5' exonuclease

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MTSLEQRAGACEMITDGGRLAEVAGSINSEREVAVDLEMDSLHHYREKVCLIQISTRTESWLIDPLALKDLSPLAAPLGN
RDILIVMHGADYDIRSLHRDHGIEVTNLFDTMIASRLLGITEFGLAALLKARFGIELNKKYQKADWSKRPLSPEMRAYAV
ADTADLLRLYDMLRDELLEKGRLAWLEEECRLVCQARVSEKEGPLFLACKGAGKLRGRALAVLEELLQLRDSQARELDRP
PFKVISGDTLLEIAEKKPRSLAELSFIKGMTPGQIQRLGERVLSAVADALVLPEERLPRFPRLQREEPVDGTKERIKCLK
SWRQGESRRLGLEPGVIAPNWLLEGIADANPASIAALDGIAGMRDWQKGLYGQELLTELSAG

Sequences:

>Translated_382_residues
MTSLEQRAGACEMITDGGRLAEVAGSINSEREVAVDLEMDSLHHYREKVCLIQISTRTESWLIDPLALKDLSPLAAPLGN
RDILIVMHGADYDIRSLHRDHGIEVTNLFDTMIASRLLGITEFGLAALLKARFGIELNKKYQKADWSKRPLSPEMRAYAV
ADTADLLRLYDMLRDELLEKGRLAWLEEECRLVCQARVSEKEGPLFLACKGAGKLRGRALAVLEELLQLRDSQARELDRP
PFKVISGDTLLEIAEKKPRSLAELSFIKGMTPGQIQRLGERVLSAVADALVLPEERLPRFPRLQREEPVDGTKERIKCLK
SWRQGESRRLGLEPGVIAPNWLLEGIADANPASIAALDGIAGMRDWQKGLYGQELLTELSAG
>Mature_381_residues
TSLEQRAGACEMITDGGRLAEVAGSINSEREVAVDLEMDSLHHYREKVCLIQISTRTESWLIDPLALKDLSPLAAPLGNR
DILIVMHGADYDIRSLHRDHGIEVTNLFDTMIASRLLGITEFGLAALLKARFGIELNKKYQKADWSKRPLSPEMRAYAVA
DTADLLRLYDMLRDELLEKGRLAWLEEECRLVCQARVSEKEGPLFLACKGAGKLRGRALAVLEELLQLRDSQARELDRPP
FKVISGDTLLEIAEKKPRSLAELSFIKGMTPGQIQRLGERVLSAVADALVLPEERLPRFPRLQREEPVDGTKERIKCLKS
WRQGESRRLGLEPGVIAPNWLLEGIADANPASIAALDGIAGMRDWQKGLYGQELLTELSAG

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=259, Percent_Identity=37.0656370656371, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI50301240, Length=259, Percent_Identity=37.0656370656371, Blast_Score=142, Evalue=4e-34,
Organism=Escherichia coli, GI1788105, Length=313, Percent_Identity=31.3099041533546, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17531757, Length=258, Percent_Identity=38.3720930232558, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI32564304, Length=107, Percent_Identity=42.9906542056075, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324574, Length=283, Percent_Identity=35.6890459363958, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI161078302, Length=275, Percent_Identity=32.7272727272727, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 42581; Mature: 42450

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLEQRAGACEMITDGGRLAEVAGSINSEREVAVDLEMDSLHHYREKVCLIQISTRTES
CCCHHHHCCCCEEECCCCHHHHHHHCCCCCCEEEEEEEHHHHHHHHHCEEEEEEECCCCH
WLIDPLALKDLSPLAAPLGNRDILIVMHGADYDIRSLHRDHGIEVTNLFDTMIASRLLGI
HEECHHHHHCCCHHHCCCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
TEFGLAALLKARFGIELNKKYQKADWSKRPLSPEMRAYAVADTADLLRLYDMLRDELLEK
HHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHC
GRLAWLEEECRLVCQARVSEKEGPLFLACKGAGKLRGRALAVLEELLQLRDSQARELDRP
CCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCHHHHHCCCC
PFKVISGDTLLEIAEKKPRSLAELSFIKGMTPGQIQRLGERVLSAVADALVLPEERLPRF
CCEEECCCHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCC
PRLQREEPVDGTKERIKCLKSWRQGESRRLGLEPGVIAPNWLLEGIADANPASIAALDGI
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHH
AGMRDWQKGLYGQELLTELSAG
HHHHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure 
TSLEQRAGACEMITDGGRLAEVAGSINSEREVAVDLEMDSLHHYREKVCLIQISTRTES
CCHHHHCCCCEEECCCCHHHHHHHCCCCCCEEEEEEEHHHHHHHHHCEEEEEEECCCCH
WLIDPLALKDLSPLAAPLGNRDILIVMHGADYDIRSLHRDHGIEVTNLFDTMIASRLLGI
HEECHHHHHCCCHHHCCCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
TEFGLAALLKARFGIELNKKYQKADWSKRPLSPEMRAYAVADTADLLRLYDMLRDELLEK
HHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHC
GRLAWLEEECRLVCQARVSEKEGPLFLACKGAGKLRGRALAVLEELLQLRDSQARELDRP
CCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCHHHHHCCCC
PFKVISGDTLLEIAEKKPRSLAELSFIKGMTPGQIQRLGERVLSAVADALVLPEERLPRF
CCEEECCCHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCC
PRLQREEPVDGTKERIKCLKSWRQGESRRLGLEPGVIAPNWLLEGIADANPASIAALDGI
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHH
AGMRDWQKGLYGQELLTELSAG
HHHHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]