Click here to switch to the map view.

The map label for this gene is hldD [H]

Identifier: 118581979

GI number: 118581979

Start: 3960624

End: 3961907

Strand: Direct

Name: hldD [H]

Synonym: Ppro_3580

Alternate gene names: 118581979

Gene position: 3960624-3961907 (Clockwise)

Preceding gene: 118581978

Following gene: 118581983

Centisome position: 98.82

GC content: 62.15

Gene sequence:

>1284_bases
ATGATAATCGTAACCGGTGGCGCGGGCCTGATCGGCAGCGCCGTGGTACACAGACTCAACCAGCTGGGCCGGGAAGACAT
CCTGGTGGTGGACCATCTGGAACACTCGGACAAGTGGCGGAACCTGGCGCCGCTGCGCTTCATGGACTACATGGAGAAGG
ATGATTTCGAGGCGCGCCTGGATGCCGGCTCCCTGCAACGCAAGCCCCTGCGGGGCGCAGGCGGGGTGGAGGCTGTCCTG
CACCTGGGGGCCTGCTCGGCCACCACGGAAACTGATGCCAGCTACCTGGCCAAAAACAACTTCGAGTACACCCGCAAGCT
GGCCCTGGTCGCCCTGGAAACCAACGCGCGCTTCATCTACGCCTCCAGCGCGGCCACCTACGGCAACGGCGAGAACGGAT
TCGAGGACGAGGAGCAGGACCTGCCGCGCCTGCGGCCCCTGAACGCATACGGCTACTCCAAGCAGCTCTTCGACCTGTGG
GCGCTGCGCCACGGACTTCTGGGCAAGATCGCGGGACTGAAGTACTTCAACGTCTTCGGCCCCAATGAGCAGCACAAGGG
GGAGATGCGCTCCCTGGTACTGAAAGCCTACGAGCAGATCATGGAGAGCGGAACATTACGGCTGTTCAAGTCCCATCGCC
CCGACTACGCCGACGGCGAACAGGTGCGCGACTTCATCTACGTCATGGACGCGGCCGCCGCCACCGTCCATTTCCTGATC
AACCGCCAGGCAAACGGCATCTTCAATATCGGCGGCGGCGGCACGGTCAGCTGGAACAGGCTGGCAACGGCCGTGTTCAG
CGCCATGGGGCGGCCGGTCAACATCCACTACATCGACATGCCGGAATCGATCCGCGACACCTACCAGTACCGCACCTGCG
CCGAGACAGCCAAACTGCGCGCGGCCGGTTTCAGCGAGGAGATCAGCACGGTGGAGGAGGGGGTCAGGGATTACATCCAG
AACTACCTGATGCCCGGAAAGCGTTTGGGGGGACTAGGTTGGTTCAGCGGTACTGTCGAAGCTTTTAAAAAGCAGAGGAT
TTGGCACACAAGGCGCTTCTACGAAGACACAATCAGTGCGCCCCGTTTTCCACCATGGAAGCGGGGCGTTTCAATTCCCC
CCCAGCTCTTGCCAGCGGAAGCAGGCGCTGGTGTGGTCGTTGACCATGCCCACCGCCTGCATGAAGGCATAGCAGATGGT
GCTGCCAACAAAGGAAAAGCCGCGCCGCCTCAGGTCGCGGCTTACGCAATCGGAGAGAGGGGTACTGGCCGGCACCTGCG
TTAG

Upstream 100 bases:

>100_bases
GATGTTCATCGTCCCCAAGGGAACGTGTGCCGGTTGACAGCGCAAATCCCATGGGTTATGAACAAGGCTGTACTCGAAAC
CAACAGCAGGGGAGACAGGA

Downstream 100 bases:

>100_bases
ATCGCTCCAGGCGTTCTGGATCGGCCCGCCATCCACGAAGCGCCACAGGTAGGCGTCGAAGGAGCCAAACTCTTCCTGAA
CCGCCAGGAAGGCGCGGGCA

Product: ADP-L-glycero-D-manno-heptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MIIVTGGAGLIGSAVVHRLNQLGREDILVVDHLEHSDKWRNLAPLRFMDYMEKDDFEARLDAGSLQRKPLRGAGGVEAVL
HLGACSATTETDASYLAKNNFEYTRKLALVALETNARFIYASSAATYGNGENGFEDEEQDLPRLRPLNAYGYSKQLFDLW
ALRHGLLGKIAGLKYFNVFGPNEQHKGEMRSLVLKAYEQIMESGTLRLFKSHRPDYADGEQVRDFIYVMDAAAATVHFLI
NRQANGIFNIGGGGTVSWNRLATAVFSAMGRPVNIHYIDMPESIRDTYQYRTCAETAKLRAAGFSEEISTVEEGVRDYIQ
NYLMPGKRLGGLGWFSGTVEAFKKQRIWHTRRFYEDTISAPRFPPWKRGVSIPPQLLPAEAGAGVVVDHAHRLHEGIADG
AANKGKAAPPQVAAYAIGERGTGRHLR

Sequences:

>Translated_427_residues
MIIVTGGAGLIGSAVVHRLNQLGREDILVVDHLEHSDKWRNLAPLRFMDYMEKDDFEARLDAGSLQRKPLRGAGGVEAVL
HLGACSATTETDASYLAKNNFEYTRKLALVALETNARFIYASSAATYGNGENGFEDEEQDLPRLRPLNAYGYSKQLFDLW
ALRHGLLGKIAGLKYFNVFGPNEQHKGEMRSLVLKAYEQIMESGTLRLFKSHRPDYADGEQVRDFIYVMDAAAATVHFLI
NRQANGIFNIGGGGTVSWNRLATAVFSAMGRPVNIHYIDMPESIRDTYQYRTCAETAKLRAAGFSEEISTVEEGVRDYIQ
NYLMPGKRLGGLGWFSGTVEAFKKQRIWHTRRFYEDTISAPRFPPWKRGVSIPPQLLPAEAGAGVVVDHAHRLHEGIADG
AANKGKAAPPQVAAYAIGERGTGRHLR
>Mature_427_residues
MIIVTGGAGLIGSAVVHRLNQLGREDILVVDHLEHSDKWRNLAPLRFMDYMEKDDFEARLDAGSLQRKPLRGAGGVEAVL
HLGACSATTETDASYLAKNNFEYTRKLALVALETNARFIYASSAATYGNGENGFEDEEQDLPRLRPLNAYGYSKQLFDLW
ALRHGLLGKIAGLKYFNVFGPNEQHKGEMRSLVLKAYEQIMESGTLRLFKSHRPDYADGEQVRDFIYVMDAAAATVHFLI
NRQANGIFNIGGGGTVSWNRLATAVFSAMGRPVNIHYIDMPESIRDTYQYRTCAETAKLRAAGFSEEISTVEEGVRDYIQ
NYLMPGKRLGGLGWFSGTVEAFKKQRIWHTRRFYEDTISAPRFPPWKRGVSIPPQLLPAEAGAGVVVDHAHRLHEGIADG
AANKGKAAPPQVAAYAIGERGTGRHLR

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790049, Length=323, Percent_Identity=42.4148606811146, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1786974, Length=298, Percent_Identity=28.5234899328859, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 47388; Mature: 47388

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIVTGGAGLIGSAVVHRLNQLGREDILVVDHLEHSDKWRNLAPLRFMDYMEKDDFEARL
CEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHCCCCCHHHHHHHCCCCCHHHC
DAGSLQRKPLRGAGGVEAVLHLGACSATTETDASYLAKNNFEYTRKLALVALETNARFIY
CCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHCCCHHEEEEEEEEEECCCEEEE
ASSAATYGNGENGFEDEEQDLPRLRPLNAYGYSKQLFDLWALRHGLLGKIAGLKYFNVFG
ECCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECC
PNEQHKGEMRSLVLKAYEQIMESGTLRLFKSHRPDYADGEQVRDFIYVMDAAAATVHFLI
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NRQANGIFNIGGGGTVSWNRLATAVFSAMGRPVNIHYIDMPESIRDTYQYRTCAETAKLR
CCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHH
AAGFSEEISTVEEGVRDYIQNYLMPGKRLGGLGWFSGTVEAFKKQRIWHTRRFYEDTISA
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PRFPPWKRGVSIPPQLLPAEAGAGVVVDHAHRLHEGIADGAANKGKAAPPQVAAYAIGER
CCCCCCCCCCCCCHHHCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCC
GTGRHLR
CCCCCCC
>Mature Secondary Structure
MIIVTGGAGLIGSAVVHRLNQLGREDILVVDHLEHSDKWRNLAPLRFMDYMEKDDFEARL
CEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHCCCCCHHHHHHHCCCCCHHHC
DAGSLQRKPLRGAGGVEAVLHLGACSATTETDASYLAKNNFEYTRKLALVALETNARFIY
CCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHCCCHHEEEEEEEEEECCCEEEE
ASSAATYGNGENGFEDEEQDLPRLRPLNAYGYSKQLFDLWALRHGLLGKIAGLKYFNVFG
ECCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECC
PNEQHKGEMRSLVLKAYEQIMESGTLRLFKSHRPDYADGEQVRDFIYVMDAAAATVHFLI
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NRQANGIFNIGGGGTVSWNRLATAVFSAMGRPVNIHYIDMPESIRDTYQYRTCAETAKLR
CCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHH
AAGFSEEISTVEEGVRDYIQNYLMPGKRLGGLGWFSGTVEAFKKQRIWHTRRFYEDTISA
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PRFPPWKRGVSIPPQLLPAEAGAGVVVDHAHRLHEGIADGAANKGKAAPPQVAAYAIGER
CCCCCCCCCCCCCHHHCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCC
GTGRHLR
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA