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The map label for this gene is nadA

Identifier: 118581972

GI number: 118581972

Start: 3953033

End: 3953947

Strand: Direct

Name: nadA

Synonym: Ppro_3573

Alternate gene names: 118581972

Gene position: 3953033-3953947 (Clockwise)

Preceding gene: 118581964

Following gene: 118581975

Centisome position: 98.63

GC content: 62.73

Gene sequence:

>915_bases
ATGAACAATGGCATCAAGGAACAGATCAGAGAGCTTCTCAAGCAGCACAATGCCGTGCTGCTGGCCCACAACTACATGCG
TGACGAGGTGCAGGAGATCGCCGACATCACCGGTGACTCGCTGGCGCTCTCCATCGAGGCGGCCAAGACAGAGGCCGACG
TGATCGTCTTCTGCGGCGTGCACTTCATGGCCGAATCGGCAGCCATTCTCTCCCCGGACAAGAAGGTGCTGCTCCCCCGC
CTGGATGCCGGCTGCCCCATGGCCGACATGGTCGACGCCCGGGGACTGGAGGAGCTGAAGAAAAAACATCCCGGCGTGCC
GGTGGTCACCTACGTCAACTCCACCGCCGAGGTCAAGGCCCACTCCGACATCTGCTGCACCTCGGCCAATGCCACCAGGG
TGGTAAAGTCCCTGCCGGACAAGAAGGTCATTTTCGCGCCCGACCGTAACCTGGGGAGCTTCGTGGCCAAATCAGTGCCG
GACAAGGAGTTCATCTTCTGGGACGGCTACTGCCCCACCCACGAACGCATGACCGTTGAGGCGGTGCTGGCCAAGAAGAC
CGAATACCCCGAGGCACTGTTCATCTGCCACCCCGAGTGCGCCCCGGCGGTGACCGCCCTGGCCGACCAGGCCTGCTCCA
CCAGCGCCATGTACGACTACTGCCGTGACAGCAAGGCCCGCCAGTTCATCATCGGCACCGAGGCCGGCATCCTCTACCGC
CTGCGACTGGAGAATCCTGACAAGGAATTCATCCTGGCCTCGCCGGCCCTGTTCTGCCCCAACATGAAGCTGACTTCCCA
GGAGGACGTGCTCCATTCGCTCAAGACCCTGACTCCGGTGGTCAGCGTACCGGAGGATATCCGCCTGAAGGCCAAGCTGG
CCCTGGACCGCATGCTGGCCGTGCCCAGGGACTAG

Upstream 100 bases:

>100_bases
TCCGAAGGGCAACCGGCGTTTTAGGAAACCGCGGGACAAGCGCCCGCAATTTCGTGGCACTCCCGTTAATTTCAAAGCCC
CTGCGAAAGGACCGTTGCAA

Downstream 100 bases:

>100_bases
GTCGCCCAAAACCGGAGCGCGCCAGGTTCAGCCGCTCCCCCTAGACAAAAAAACGCCGCCACAGGCTCACCCATGGGGGT
GCTCCTGCGGCGGCGTTTTT

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MNNGIKEQIRELLKQHNAVLLAHNYMRDEVQEIADITGDSLALSIEAAKTEADVIVFCGVHFMAESAAILSPDKKVLLPR
LDAGCPMADMVDARGLEELKKKHPGVPVVTYVNSTAEVKAHSDICCTSANATRVVKSLPDKKVIFAPDRNLGSFVAKSVP
DKEFIFWDGYCPTHERMTVEAVLAKKTEYPEALFICHPECAPAVTALADQACSTSAMYDYCRDSKARQFIIGTEAGILYR
LRLENPDKEFILASPALFCPNMKLTSQEDVLHSLKTLTPVVSVPEDIRLKAKLALDRMLAVPRD

Sequences:

>Translated_304_residues
MNNGIKEQIRELLKQHNAVLLAHNYMRDEVQEIADITGDSLALSIEAAKTEADVIVFCGVHFMAESAAILSPDKKVLLPR
LDAGCPMADMVDARGLEELKKKHPGVPVVTYVNSTAEVKAHSDICCTSANATRVVKSLPDKKVIFAPDRNLGSFVAKSVP
DKEFIFWDGYCPTHERMTVEAVLAKKTEYPEALFICHPECAPAVTALADQACSTSAMYDYCRDSKARQFIIGTEAGILYR
LRLENPDKEFILASPALFCPNMKLTSQEDVLHSLKTLTPVVSVPEDIRLKAKLALDRMLAVPRD
>Mature_304_residues
MNNGIKEQIRELLKQHNAVLLAHNYMRDEVQEIADITGDSLALSIEAAKTEADVIVFCGVHFMAESAAILSPDKKVLLPR
LDAGCPMADMVDARGLEELKKKHPGVPVVTYVNSTAEVKAHSDICCTSANATRVVKSLPDKKVIFAPDRNLGSFVAKSVP
DKEFIFWDGYCPTHERMTVEAVLAKKTEYPEALFICHPECAPAVTALADQACSTSAMYDYCRDSKARQFIIGTEAGILYR
LRLENPDKEFILASPALFCPNMKLTSQEDVLHSLKTLTPVVSVPEDIRLKAKLALDRMLAVPRD

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily

Homologues:

Organism=Escherichia coli, GI1786964, Length=311, Percent_Identity=33.4405144694534, Blast_Score=170, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADA_PELPD (A1AUZ4)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_903222.1
- ProteinModelPortal:   A1AUZ4
- SMR:   A1AUZ4
- STRING:   A1AUZ4
- GeneID:   4572044
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_3573
- eggNOG:   COG0379
- HOGENOM:   HBG291157
- OMA:   IALEDMA
- PhylomeDB:   A1AUZ4
- ProtClustDB:   PRK09375
- GO:   GO:0005737
- HAMAP:   MF_00568
- InterPro:   IPR003473
- InterPro:   IPR023066
- TIGRFAMs:   TIGR00550

Pfam domain/function: PF02445 NadA

EC number: =2.5.1.72

Molecular weight: Translated: 33545; Mature: 33545

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: BINDING 23-23 BINDING 40-40 BINDING 111-111 BINDING 128-128 BINDING 197-197 BINDING 214-214

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNGIKEQIRELLKQHNAVLLAHNYMRDEVQEIADITGDSLALSIEAAKTEADVIVFCGV
CCCCHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEECH
HFMAESAAILSPDKKVLLPRLDAGCPMADMVDARGLEELKKKHPGVPVVTYVNSTAEVKA
HHHHCCCCEECCCCCEECCCCCCCCCHHHHHHHCCHHHHHHHCCCCCEEEEECCCEEEEE
HSDICCTSANATRVVKSLPDKKVIFAPDRNLGSFVAKSVPDKEFIFWDGYCPTHERMTVE
CCCEEEECCCHHHHHHHCCCCEEEECCCCCHHHHHHHCCCCCCEEEECCCCCCCCCEEHH
AVLAKKTEYPEALFICHPECAPAVTALADQACSTSAMYDYCRDSKARQFIIGTEAGILYR
HHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCEEEEECCCCEEEE
LRLENPDKEFILASPALFCPNMKLTSQEDVLHSLKTLTPVVSVPEDIRLKAKLALDRMLA
EEECCCCCCEEEECCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
VPRD
CCCC
>Mature Secondary Structure
MNNGIKEQIRELLKQHNAVLLAHNYMRDEVQEIADITGDSLALSIEAAKTEADVIVFCGV
CCCCHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEECH
HFMAESAAILSPDKKVLLPRLDAGCPMADMVDARGLEELKKKHPGVPVVTYVNSTAEVKA
HHHHCCCCEECCCCCEECCCCCCCCCHHHHHHHCCHHHHHHHCCCCCEEEEECCCEEEEE
HSDICCTSANATRVVKSLPDKKVIFAPDRNLGSFVAKSVPDKEFIFWDGYCPTHERMTVE
CCCEEEECCCHHHHHHHCCCCEEEECCCCCHHHHHHHCCCCCCEEEECCCCCCCCCEEHH
AVLAKKTEYPEALFICHPECAPAVTALADQACSTSAMYDYCRDSKARQFIIGTEAGILYR
HHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCEEEEECCCCEEEE
LRLENPDKEFILASPALFCPNMKLTSQEDVLHSLKTLTPVVSVPEDIRLKAKLALDRMLA
EEECCCCCCEEEECCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
VPRD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA