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The map label for this gene is proA

Identifier: 118581908

GI number: 118581908

Start: 3878523

End: 3879779

Strand: Reverse

Name: proA

Synonym: Ppro_3508

Alternate gene names: 118581908

Gene position: 3879779-3878523 (Counterclockwise)

Preceding gene: 118581909

Following gene: 118581907

Centisome position: 96.8

GC content: 63.72

Gene sequence:

>1257_bases
ATGACTATCGCCGAACAGGTTGCACAGATTGCCCATGAGGCGCGCCAGGCCTCGTTCGTACTTTCGCGACTCAGCACCAG
GGTCAAGAACGAGCTGTTGCTGGCCATGGCTGAGGCTCTGGAACAGCAGGCCCCCCACCTGATAGCCGAAAACGCCAAGG
ATCTGGAGGAGGGGAAACAGAAGGGGCTCTCCAGCGCCATGCTCGACCGGCTGATGCTGGACGCCAAGCGCATATCCGCC
ATGGCCGACGCCCTGCGCGAAGTAGCCGCTCTCCCCGACCCGGTGGGCGAAGTCACCAAAATGTGGAAGCGCCCCAACAA
CCTGATGGTGGGCAAGATGCGCATCCCCCTGGGGGTGATCGGCATTATCTTCGAGGCGCGGCCCAACGTGACCGCCGATG
CCGCGGCGCTCTGCCTCAAGGCGGGCAACGCCGTGATCCTGCGCGGCGGCAAGGAGGCGATCAACTCCAATCGGGCCATC
GCCGCCATCCTGCGCGAAGCCATGGTTTCCAAGGGGGTTCCGGCCGGAGCCCTGGCCCTGATCCCCTTCACCGACCGCCA
GGGGGTGCTGGAGATGCTCAAGCAGGAGGAGTGCATCGACCTGATCATCCCCCGCGGCGGCGAGGGGCTGATCCGTTTCG
TGACCGAAAACTCGCGTATCCCGGTGATCAAGCATTACAAGGGGGTCTGCCACATCTTCGTGGACGAGAGTGCCGACTTC
GACATGGCCGAACGGATCATCATCAACGCCAAGACCCAGCGCCCCGGTGTGTGCAACGCCCTGGAGACCTTGCTGATCCA
CGAATCGGTTGCGGCCGCCTTCATTCCCCGCATCGCATCCATCCTGGGCGGCATGCAGGTTGAACTGCGCGGAGACGAAC
GTTTCCGCGCCCTGGCCCCCCAGGCCAAGCCGGCCAGCGAAGAGGACTGGTACGCCGAATACCTGGAGCTGATCCTGGCC
TGCCGGGTGGTGGACGACCTGGACCAGGCCATCGACCACATCAACCGCTACGGCTCGCTGCACACCGAATCCATCATCAC
CAGCGACTACGGCCGGGCCCAGCGCTTCATCCGCGAGGTCAATTCCAGCTGCGTGGTGGTCAACGCCTCCACCCGCTTTG
CCGACGGCAACCAGTTAGGCTTAGGTGCGGAGATCGGCATATCAACAACCAAGCTGCACTCCTTCGGCCCCATGGGGCTG
GAGGACCTGACCACCACCAAGTTCATCGTCTACGGCGACGGCCAGGTCAGGGAGTGA

Upstream 100 bases:

>100_bases
AGGACTCCCCCGTGTCTGTTCCGCCTTCATTCCGCTTGAAGTGACCGCTGAATTGCCCTACAATACAACCCCGACTATTG
CACGCAAGGGGAATAATTTC

Downstream 100 bases:

>100_bases
CCTCCCGGTTCGCGCATCCGGCATACCTCTTTTCAGGAGCACTACATGACCATCGACCAGCAGATCGAACGTTTCCTGGC
CTCTCCCGCATTCGGGGTTG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTIAEQVAQIAHEARQASFVLSRLSTRVKNELLLAMAEALEQQAPHLIAENAKDLEEGKQKGLSSAMLDRLMLDAKRISA
MADALREVAALPDPVGEVTKMWKRPNNLMVGKMRIPLGVIGIIFEARPNVTADAAALCLKAGNAVILRGGKEAINSNRAI
AAILREAMVSKGVPAGALALIPFTDRQGVLEMLKQEECIDLIIPRGGEGLIRFVTENSRIPVIKHYKGVCHIFVDESADF
DMAERIIINAKTQRPGVCNALETLLIHESVAAAFIPRIASILGGMQVELRGDERFRALAPQAKPASEEDWYAEYLELILA
CRVVDDLDQAIDHINRYGSLHTESIITSDYGRAQRFIREVNSSCVVVNASTRFADGNQLGLGAEIGISTTKLHSFGPMGL
EDLTTTKFIVYGDGQVRE

Sequences:

>Translated_418_residues
MTIAEQVAQIAHEARQASFVLSRLSTRVKNELLLAMAEALEQQAPHLIAENAKDLEEGKQKGLSSAMLDRLMLDAKRISA
MADALREVAALPDPVGEVTKMWKRPNNLMVGKMRIPLGVIGIIFEARPNVTADAAALCLKAGNAVILRGGKEAINSNRAI
AAILREAMVSKGVPAGALALIPFTDRQGVLEMLKQEECIDLIIPRGGEGLIRFVTENSRIPVIKHYKGVCHIFVDESADF
DMAERIIINAKTQRPGVCNALETLLIHESVAAAFIPRIASILGGMQVELRGDERFRALAPQAKPASEEDWYAEYLELILA
CRVVDDLDQAIDHINRYGSLHTESIITSDYGRAQRFIREVNSSCVVVNASTRFADGNQLGLGAEIGISTTKLHSFGPMGL
EDLTTTKFIVYGDGQVRE
>Mature_417_residues
TIAEQVAQIAHEARQASFVLSRLSTRVKNELLLAMAEALEQQAPHLIAENAKDLEEGKQKGLSSAMLDRLMLDAKRISAM
ADALREVAALPDPVGEVTKMWKRPNNLMVGKMRIPLGVIGIIFEARPNVTADAAALCLKAGNAVILRGGKEAINSNRAIA
AILREAMVSKGVPAGALALIPFTDRQGVLEMLKQEECIDLIIPRGGEGLIRFVTENSRIPVIKHYKGVCHIFVDESADFD
MAERIIINAKTQRPGVCNALETLLIHESVAAAFIPRIASILGGMQVELRGDERFRALAPQAKPASEEDWYAEYLELILAC
RVVDDLDQAIDHINRYGSLHTESIITSDYGRAQRFIREVNSSCVVVNASTRFADGNQLGLGAEIGISTTKLHSFGPMGLE
DLTTTKFIVYGDGQVRE

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=413, Percent_Identity=38.0145278450363, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI21361368, Length=413, Percent_Identity=38.0145278450363, Blast_Score=280, Evalue=2e-75,
Organism=Escherichia coli, GI1786438, Length=414, Percent_Identity=48.0676328502416, Blast_Score=377, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17569967, Length=416, Percent_Identity=37.5, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17569969, Length=416, Percent_Identity=37.5, Blast_Score=276, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6324899, Length=428, Percent_Identity=38.3177570093458, Blast_Score=296, Evalue=5e-81,
Organism=Drosophila melanogaster, GI21357643, Length=406, Percent_Identity=36.9458128078818, Blast_Score=265, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_PELPD (A1AUT0)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_903158.1
- ProteinModelPortal:   A1AUT0
- SMR:   A1AUT0
- STRING:   A1AUT0
- GeneID:   4574357
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_3508
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   GICGAME
- PhylomeDB:   A1AUT0
- ProtClustDB:   PRK00197
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45618; Mature: 45487

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIAEQVAQIAHEARQASFVLSRLSTRVKNELLLAMAEALEQQAPHLIAENAKDLEEGKQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHH
KGLSSAMLDRLMLDAKRISAMADALREVAALPDPVGEVTKMWKRPNNLMVGKMRIPLGVI
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCEEE
GIIFEARPNVTADAAALCLKAGNAVILRGGKEAINSNRAIAAILREAMVSKGVPAGALAL
EEEEECCCCCCHHHHHHHHHCCCEEEEECCHHHHCCCHHHHHHHHHHHHHCCCCCCEEEE
IPFTDRQGVLEMLKQEECIDLIIPRGGEGLIRFVTENSRIPVIKHYKGVCHIFVDESADF
EEECCCHHHHHHHHHCCCCEEEECCCCCCEEEEEECCCCCCHHHCCCCEEEEEECCCCCC
DMAERIIINAKTQRPGVCNALETLLIHESVAAAFIPRIASILGGMQVELRGDERFRALAP
CCHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCC
QAKPASEEDWYAEYLELILACRVVDDLDQAIDHINRYGSLHTESIITSDYGRAQRFIREV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHC
NSSCVVVNASTRFADGNQLGLGAEIGISTTKLHSFGPMGLEDLTTTKFIVYGDGQVRE
CCCEEEEECCCEECCCCCCCCCCCCCCCHHHCCCCCCCCCHHCCCEEEEEECCCCCCC
>Mature Secondary Structure 
TIAEQVAQIAHEARQASFVLSRLSTRVKNELLLAMAEALEQQAPHLIAENAKDLEEGKQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHH
KGLSSAMLDRLMLDAKRISAMADALREVAALPDPVGEVTKMWKRPNNLMVGKMRIPLGVI
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCEEE
GIIFEARPNVTADAAALCLKAGNAVILRGGKEAINSNRAIAAILREAMVSKGVPAGALAL
EEEEECCCCCCHHHHHHHHHCCCEEEEECCHHHHCCCHHHHHHHHHHHHHCCCCCCEEEE
IPFTDRQGVLEMLKQEECIDLIIPRGGEGLIRFVTENSRIPVIKHYKGVCHIFVDESADF
EEECCCHHHHHHHHHCCCCEEEECCCCCCEEEEEECCCCCCHHHCCCCEEEEEECCCCCC
DMAERIIINAKTQRPGVCNALETLLIHESVAAAFIPRIASILGGMQVELRGDERFRALAP
CCHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCC
QAKPASEEDWYAEYLELILACRVVDDLDQAIDHINRYGSLHTESIITSDYGRAQRFIREV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHC
NSSCVVVNASTRFADGNQLGLGAEIGISTTKLHSFGPMGLEDLTTTKFIVYGDGQVRE
CCCEEEEECCCEECCCCCCCCCCCCCCCHHHCCCCCCCCCHHCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA