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The map label for this gene is trxA [H]

Identifier: 118581780

GI number: 118581780

Start: 3731857

End: 3732186

Strand: Direct

Name: trxA [H]

Synonym: Ppro_3380

Alternate gene names: 118581780

Gene position: 3731857-3732186 (Clockwise)

Preceding gene: 118581770

Following gene: 118581781

Centisome position: 93.11

GC content: 58.79

Gene sequence:

>330_bases
ATGGCCAGCGACAAGGTACTTGCGTTAAATGACGCCAATTTCGAACGGGATGTACTGCAGTCAGACCTGCCGGTTCTGGT
TGATTTCTGGGCCACCTGGTGCTCACCCTGCAAGGCGATTGCCCCGCTGATCGACGCAGTGGCGGACGAATATGCCGGCA
AGATCAAGGTAGGCAAGGTCAATGTTGACGAGAACCCCTCAACCCCGGGAAAATACGGCGTCCGCGGCATCCCGACCCTG
GTGCTGTTCAAGGGTGGCGTCGTGGTGGATCAGGTCGTCGGCGCCATCCCCAAATCCCAGCTGGAAGCCCTGATCGCCAA
GGCATTCTGA

Upstream 100 bases:

>100_bases
TGTTTCAACTAAACCTGTGGCCGGGAGTTTGGGCTTGATTTTTTCCCGCCCTGGTATATCATTCACCAACTTTAAACTTA
TCCAAAGGAGACAAACGTCT

Downstream 100 bases:

>100_bases
TCGGCATGGGATTGGTCCGGCTGCTCCGCCGACATGCCCCGGCGCTGCTCGTCCTGCTGATCCTCTTCCCGGCGGCGGCC
CATACTGTGCCGCTGGCCGG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MASDKVLALNDANFERDVLQSDLPVLVDFWATWCSPCKAIAPLIDAVADEYAGKIKVGKVNVDENPSTPGKYGVRGIPTL
VLFKGGVVVDQVVGAIPKSQLEALIAKAF

Sequences:

>Translated_109_residues
MASDKVLALNDANFERDVLQSDLPVLVDFWATWCSPCKAIAPLIDAVADEYAGKIKVGKVNVDENPSTPGKYGVRGIPTL
VLFKGGVVVDQVVGAIPKSQLEALIAKAF
>Mature_108_residues
ASDKVLALNDANFERDVLQSDLPVLVDFWATWCSPCKAIAPLIDAVADEYAGKIKVGKVNVDENPSTPGKYGVRGIPTLV
LFKGGVVVDQVVGAIPKSQLEALIAKAF

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=95, Percent_Identity=37.8947368421053, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI5031973, Length=82, Percent_Identity=41.4634146341463, Blast_Score=73, Evalue=5e-14,
Organism=Homo sapiens, GI21361657, Length=83, Percent_Identity=40.9638554216867, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=56.3106796116505, Blast_Score=131, Evalue=1e-32,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=41.304347826087, Blast_Score=96, Evalue=6e-22,
Organism=Escherichia coli, GI87081747, Length=108, Percent_Identity=29.6296296296296, Blast_Score=70, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=34.4086021505376, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554386, Length=87, Percent_Identity=42.5287356321839, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17556044, Length=82, Percent_Identity=36.5853658536585, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=83, Percent_Identity=42.1686746987952, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=98, Percent_Identity=36.734693877551, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=99, Percent_Identity=37.3737373737374, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=80, Percent_Identity=40, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=100, Percent_Identity=37, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=97, Percent_Identity=42.2680412371134, Blast_Score=73, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=93, Percent_Identity=39.7849462365591, Blast_Score=73, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=82, Percent_Identity=32.9268292682927, Blast_Score=62, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=39.5833333333333, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24639826, Length=77, Percent_Identity=46.7532467532467, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921434, Length=81, Percent_Identity=40.7407407407407, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=39.5833333333333, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24639068, Length=102, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24664269, Length=71, Percent_Identity=42.2535211267606, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17648013, Length=81, Percent_Identity=40.7407407407407, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583090, Length=81, Percent_Identity=40.7407407407407, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24658597, Length=92, Percent_Identity=35.8695652173913, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11599; Mature: 11467

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASDKVLALNDANFERDVLQSDLPVLVDFWATWCSPCKAIAPLIDAVADEYAGKIKVGKV
CCCCCEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
NVDENPSTPGKYGVRGIPTLVLFKGGVVVDQVVGAIPKSQLEALIAKAF
ECCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ASDKVLALNDANFERDVLQSDLPVLVDFWATWCSPCKAIAPLIDAVADEYAGKIKVGKV
CCCCEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
NVDENPSTPGKYGVRGIPTLVLFKGGVVVDQVVGAIPKSQLEALIAKAF
ECCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8756494; 8590279; 8905231; 9298645 [H]