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The map label for this gene is hemC

Identifier: 118581775

GI number: 118581775

Start: 3727050

End: 3727982

Strand: Reverse

Name: hemC

Synonym: Ppro_3375

Alternate gene names: 118581775

Gene position: 3727982-3727050 (Counterclockwise)

Preceding gene: 118581776

Following gene: 118581774

Centisome position: 93.01

GC content: 65.49

Gene sequence:

>933_bases
ATGCCCCCCAGGCAGCTTCGTATCGGTACCCGCGCCAGCCAACTGGCGCTCTGGCAGGCCAACTGGGTCAAATCCGAGCT
GGAGAAGAGATATCCCGCTATGGAAGTGACCCTCACCAAAATTAAGACCATGGGGGACAGGATCCTTGACGTCCCCCTGG
CCCAGGTTGGCGGCAAGGGGCTGTTCGTCAAGGAGATCGAGGAAGCCATGCTGCGGGGGGAGATCGACATCGCCGTGCAC
AGTATGAAGGATGTTCCCACCGAGTTTCCCGAGGGGCTGGGGCTGTACTGCATCACGGAGCGTGAGGACCCTCGCGACGC
GGTTGTTTCCCGCGCTGCGCGGTTCTCCCACCTGCCGCCCGGCGCCAGGGTCGGCACCAGCGCCCTGCGCCGCCAGGCCC
AGTTGCTCCATGCCCGTCCCGACCTGGAGATGGTAACGATCCGTGGCAACGTGGAGACCCGCATCCGCAAGCTGGATGAG
GAAAACCTGGATGCGGTCATCCTGGCCGCCGCGGGGCTGAAGCGTCTCGGCCTCACCCAGCGGGTGGCCGAGTACCTGGA
TGTGGAGTTCTCCATTCCGGCCATCGGCCAGGGCGCCCTGGGGATCGAGTGCCGCCTGTCTGACCCGGTCGTCACCGAGG
CCATCGCATTCTTCAACCACCCCGACACCAGCCATGCCGTACGGGCCGAACGGGCCCTGCTCAGGCGCTGCCAGGGGGGA
TGCCAGGTACCCATCGCCGCCCATGGTACGATACGGGGGGGCGAGCTCAGGCTGGTCGGTCTCATCGCGGCGGTGGATGG
ACGGGAGTTTGTGCGCGACGAGATCAGCGGTCCGGTTGATCAATGTGAGCACCTGGGGGAGGAACTGGCCGACCGCCTGC
TCTCCCGGGGGGGCAGGGCAATTCTGGAGGAGGTTTACCAGCGTGAAATCTGA

Upstream 100 bases:

>100_bases
GCGTGGACGTATAACAACTATTAGATTTCTTTGCGTCTTCGCGCCTTTGCGTGAGATGGATTTCCGTTATTACGTTCATG
ATTCAAGAGGGAGAACGGTT

Downstream 100 bases:

>100_bases
AACGAGAGGAATAGTATATCTTGTGGGATCCGGCCCCGGCGATCCGGGACTGATCACCCTGCGCGGCATGGAGTGCCTGC
GCCAGGCAGAGGTGGTGGTG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MPPRQLRIGTRASQLALWQANWVKSELEKRYPAMEVTLTKIKTMGDRILDVPLAQVGGKGLFVKEIEEAMLRGEIDIAVH
SMKDVPTEFPEGLGLYCITEREDPRDAVVSRAARFSHLPPGARVGTSALRRQAQLLHARPDLEMVTIRGNVETRIRKLDE
ENLDAVILAAAGLKRLGLTQRVAEYLDVEFSIPAIGQGALGIECRLSDPVVTEAIAFFNHPDTSHAVRAERALLRRCQGG
CQVPIAAHGTIRGGELRLVGLIAAVDGREFVRDEISGPVDQCEHLGEELADRLLSRGGRAILEEVYQREI

Sequences:

>Translated_310_residues
MPPRQLRIGTRASQLALWQANWVKSELEKRYPAMEVTLTKIKTMGDRILDVPLAQVGGKGLFVKEIEEAMLRGEIDIAVH
SMKDVPTEFPEGLGLYCITEREDPRDAVVSRAARFSHLPPGARVGTSALRRQAQLLHARPDLEMVTIRGNVETRIRKLDE
ENLDAVILAAAGLKRLGLTQRVAEYLDVEFSIPAIGQGALGIECRLSDPVVTEAIAFFNHPDTSHAVRAERALLRRCQGG
CQVPIAAHGTIRGGELRLVGLIAAVDGREFVRDEISGPVDQCEHLGEELADRLLSRGGRAILEEVYQREI
>Mature_309_residues
PPRQLRIGTRASQLALWQANWVKSELEKRYPAMEVTLTKIKTMGDRILDVPLAQVGGKGLFVKEIEEAMLRGEIDIAVHS
MKDVPTEFPEGLGLYCITEREDPRDAVVSRAARFSHLPPGARVGTSALRRQAQLLHARPDLEMVTIRGNVETRIRKLDEE
NLDAVILAAAGLKRLGLTQRVAEYLDVEFSIPAIGQGALGIECRLSDPVVTEAIAFFNHPDTSHAVRAERALLRRCQGGC
QVPIAAHGTIRGGELRLVGLIAAVDGREFVRDEISGPVDQCEHLGEELADRLLSRGGRAILEEVYQREI

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=338, Percent_Identity=38.7573964497041, Blast_Score=232, Evalue=3e-61,
Organism=Homo sapiens, GI66933009, Length=338, Percent_Identity=38.7573964497041, Blast_Score=232, Evalue=4e-61,
Organism=Escherichia coli, GI48994974, Length=303, Percent_Identity=54.7854785478548, Blast_Score=307, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6319996, Length=321, Percent_Identity=37.0716510903427, Blast_Score=201, Evalue=1e-52,
Organism=Drosophila melanogaster, GI20130425, Length=291, Percent_Identity=36.7697594501718, Blast_Score=195, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_PELPD (A1AUE7)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_903025.1
- ProteinModelPortal:   A1AUE7
- SMR:   A1AUE7
- STRING:   A1AUE7
- GeneID:   4571582
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_3375
- eggNOG:   COG0181
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- PhylomeDB:   A1AUE7
- ProtClustDB:   PRK00072
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 34215; Mature: 34084

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPRQLRIGTRASQLALWQANWVKSELEKRYPAMEVTLTKIKTMGDRILDVPLAQVGGKG
CCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHCCCC
LFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVVSRAARFSHLPP
CHHHHHHHHHHCCCHHHEEECHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCC
GARVGTSALRRQAQLLHARPDLEMVTIRGNVETRIRKLDEENLDAVILAAAGLKRLGLTQ
CCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCCCCCEEEEEHHHHHHHHHHH
RVAEYLDVEFSIPAIGQGALGIECRLSDPVVTEAIAFFNHPDTSHAVRAERALLRRCQGG
HHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
CQVPIAAHGTIRGGELRLVGLIAAVDGREFVRDEISGPVDQCEHLGEELADRLLSRGGRA
CCEEEEECCEECCCCEEEEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHH
ILEEVYQREI
HHHHHHHHCC
>Mature Secondary Structure 
PPRQLRIGTRASQLALWQANWVKSELEKRYPAMEVTLTKIKTMGDRILDVPLAQVGGKG
CCCCEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHCCCC
LFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVVSRAARFSHLPP
CHHHHHHHHHHCCCHHHEEECHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCC
GARVGTSALRRQAQLLHARPDLEMVTIRGNVETRIRKLDEENLDAVILAAAGLKRLGLTQ
CCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCCCCCEEEEEHHHHHHHHHHH
RVAEYLDVEFSIPAIGQGALGIECRLSDPVVTEAIAFFNHPDTSHAVRAERALLRRCQGG
HHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
CQVPIAAHGTIRGGELRLVGLIAAVDGREFVRDEISGPVDQCEHLGEELADRLLSRGGRA
CCEEEEECCEECCCCEEEEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHH
ILEEVYQREI
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA