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The map label for this gene is penA [H]

Identifier: 118581695

GI number: 118581695

Start: 3632590

End: 3634563

Strand: Reverse

Name: penA [H]

Synonym: Ppro_3295

Alternate gene names: 118581695

Gene position: 3634563-3632590 (Counterclockwise)

Preceding gene: 118581696

Following gene: 118581694

Centisome position: 90.68

GC content: 62.11

Gene sequence:

>1974_bases
ATGAGAGACGACCGTGAAAAATGGGCCAGGACCCGGATAGTCATCATCGGGTTTTTCTTTGGCCTGTTGTTCATGGCTGT
CAGCGCCAAAGCCTTCAAGCTCCAGATCCTGCAGCACGAGGAGATGGTCAAGAGAGCCGAACGTCAGCACCAGCGCTCCG
TACCGCTCACCCCGGGGCGCGGCGCCATCATGGACCGCAACGGCAACAACCTGGCCGTGTCCGTGGAGATGTATTCCTGC
TACGGCGAGGCGCGCCATATCCAGGACGTAGAGGCAACCGCGACGGCTTTGGCGCCTTTCCTGGAGGTTCCCCGCCAGGA
GATCGTCAGGAAAATACGCAACAGCAGGAATTTTGTCTGGCTGGAACGGCGGATCCCGCCCGAGCGGGCGACCAGAATCA
GGAATCTCAAGCTGCGCGGCATCGGCTTTGCCCCGGAGACGAAACGTTTCTACCCCAATTCCGAAGTTGCCGCCCATGTG
ATCGGTTTCACCGGCATCGATCCCAATGGCCTGGACGGGGTGGAGTTCAAGTACGATTCGGTCATTTTGGGCAATACCGG
CCTGCTGGTGACGGAGCGGGATGCCCTGGGCCGCGACATCGCCCCGCGGGCCGAACTGGTCAAGAGCTCGTCCCCCGGCA
AGAACGTCGTGCTCACCCTGGACAAGAACATCCAGTACATAACGGAAAAGGAGCTGGCCCAGGCGGTAACCTCCAGCGGC
GCCAAAGGTGGCATGGCCCTGGTGCTGGAGCCTGACAGCGGCAGGGTGCTGGCCATGGCCAACTACCCGACCTTCAACCC
CAACTCCTATTTCCGCTATTCCCATGCTGAACTGCGTAACCGGGCCGTTGCTGACAGCTTCGAGCCCGGTTCGACCTTCA
AGGTATTTCTGATCGCCGCTGCCCTGAATGAGAGGCTGGTCCGGCCCACGGATGCCTTCCATTGCGAGAACGGCAGCTAC
ACCATCGCCACCCACACCGTTCACGACACCCACAGCTACGGACGTCTGTCGGTATCGGATATCCTCAAATATTCCAGCAA
TATCGGAGCCGCCAAGATCGGCTTCAAGCTGGGCAGCGACCGGCTCTCCCGCTATCTGCACAACTTCGGTTTCGGCGAGC
GCTCCGGCATCGATCTGCCCGGCGAGTCGCCGGGCAACATGCGCAGCAGGCAGCGCTGGTATGGCATCGATCTGGCCACC
ATCTCCTTCGGCCAGGGCATATCCGCCTCCTCGATTCAACTGGCAACGGCGATCTCGGCCGTGGCCAATGGCGGCAACCT
GATGAAGCCGTATGTGGTGGAGCGCATCCTGGACGACAGTGGCAACGAGTTGCAGAGATTCACCCCCCAGGTGGTGCGCC
GGGTAATTTCGGCCGATACGGCCGCAAAGGTCACCAGGATGATGGAGACGGTCACCGCCGAGGGGGGAACCGGGACCAAT
GCCGCCGTGGAGGGATTCCGGGTGGCCGGCAAGACCGGCACGGCCCAGAAGGCCGACCCGGTGACCCGCCGCTACTCCGC
CTCAAAACGGACCGCCTCGTTCATCGGCTTCATCCCCGCCGACAGGCCGCGGCTGACCATTCTGGTGGTTATCGATGAAC
CCAGAACCAGTTCCTACGGCGGCGTGGTGGCGGCGCCCGCCTTCCGCGGTATCGCGCTCAACAGCCTGGCCTATCTGAAG
GTCCTGCCCAAAAATGGCACGCTCAGGAAACCCGGCCCCATGGAGGCAAAGTCCCGGGAAGCCGAACAGCGGGACAGCAT
GTCCGAGGGGGACGCGCTGGACATGCCGGTGAGCGGCGAGGTCATGCCCGATTTCCACGGCATGAGCATGCGCCGGGTCC
TGCAGGTCATGGAAAAACGGAACATCAACATCAGGCTGTTGGGCAGCGGCCGCGCCATGGAACAGAACCCCCCTCCGGGG
CAGCCTATCAGGAGTGTTGACGAAGTATGGATCAGGTTCGTACCCTCGGCATGA

Upstream 100 bases:

>100_bases
TGGAGGTTGCCTCCCTGCGCACCCCCTCACGCATCGAAACCATCGCCAAGGACGAACTGGGCATGGCGCTTCCGACCGAA
CAGCAGGTGATCATTGTCAA

Downstream 100 bases:

>100_bases
GGGAGCCTGTCCGCCCGTACTGCACCCCTTCGGGAGACCGTATGAAGCTTACCCAGTTGCTGGCAGCGCTTGACAGCCAT
GACCTTCATGGCGATGGCGC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 657; Mature: 657

Protein sequence:

>657_residues
MRDDREKWARTRIVIIGFFFGLLFMAVSAKAFKLQILQHEEMVKRAERQHQRSVPLTPGRGAIMDRNGNNLAVSVEMYSC
YGEARHIQDVEATATALAPFLEVPRQEIVRKIRNSRNFVWLERRIPPERATRIRNLKLRGIGFAPETKRFYPNSEVAAHV
IGFTGIDPNGLDGVEFKYDSVILGNTGLLVTERDALGRDIAPRAELVKSSSPGKNVVLTLDKNIQYITEKELAQAVTSSG
AKGGMALVLEPDSGRVLAMANYPTFNPNSYFRYSHAELRNRAVADSFEPGSTFKVFLIAAALNERLVRPTDAFHCENGSY
TIATHTVHDTHSYGRLSVSDILKYSSNIGAAKIGFKLGSDRLSRYLHNFGFGERSGIDLPGESPGNMRSRQRWYGIDLAT
ISFGQGISASSIQLATAISAVANGGNLMKPYVVERILDDSGNELQRFTPQVVRRVISADTAAKVTRMMETVTAEGGTGTN
AAVEGFRVAGKTGTAQKADPVTRRYSASKRTASFIGFIPADRPRLTILVVIDEPRTSSYGGVVAAPAFRGIALNSLAYLK
VLPKNGTLRKPGPMEAKSREAEQRDSMSEGDALDMPVSGEVMPDFHGMSMRRVLQVMEKRNINIRLLGSGRAMEQNPPPG
QPIRSVDEVWIRFVPSA

Sequences:

>Translated_657_residues
MRDDREKWARTRIVIIGFFFGLLFMAVSAKAFKLQILQHEEMVKRAERQHQRSVPLTPGRGAIMDRNGNNLAVSVEMYSC
YGEARHIQDVEATATALAPFLEVPRQEIVRKIRNSRNFVWLERRIPPERATRIRNLKLRGIGFAPETKRFYPNSEVAAHV
IGFTGIDPNGLDGVEFKYDSVILGNTGLLVTERDALGRDIAPRAELVKSSSPGKNVVLTLDKNIQYITEKELAQAVTSSG
AKGGMALVLEPDSGRVLAMANYPTFNPNSYFRYSHAELRNRAVADSFEPGSTFKVFLIAAALNERLVRPTDAFHCENGSY
TIATHTVHDTHSYGRLSVSDILKYSSNIGAAKIGFKLGSDRLSRYLHNFGFGERSGIDLPGESPGNMRSRQRWYGIDLAT
ISFGQGISASSIQLATAISAVANGGNLMKPYVVERILDDSGNELQRFTPQVVRRVISADTAAKVTRMMETVTAEGGTGTN
AAVEGFRVAGKTGTAQKADPVTRRYSASKRTASFIGFIPADRPRLTILVVIDEPRTSSYGGVVAAPAFRGIALNSLAYLK
VLPKNGTLRKPGPMEAKSREAEQRDSMSEGDALDMPVSGEVMPDFHGMSMRRVLQVMEKRNINIRLLGSGRAMEQNPPPG
QPIRSVDEVWIRFVPSA
>Mature_657_residues
MRDDREKWARTRIVIIGFFFGLLFMAVSAKAFKLQILQHEEMVKRAERQHQRSVPLTPGRGAIMDRNGNNLAVSVEMYSC
YGEARHIQDVEATATALAPFLEVPRQEIVRKIRNSRNFVWLERRIPPERATRIRNLKLRGIGFAPETKRFYPNSEVAAHV
IGFTGIDPNGLDGVEFKYDSVILGNTGLLVTERDALGRDIAPRAELVKSSSPGKNVVLTLDKNIQYITEKELAQAVTSSG
AKGGMALVLEPDSGRVLAMANYPTFNPNSYFRYSHAELRNRAVADSFEPGSTFKVFLIAAALNERLVRPTDAFHCENGSY
TIATHTVHDTHSYGRLSVSDILKYSSNIGAAKIGFKLGSDRLSRYLHNFGFGERSGIDLPGESPGNMRSRQRWYGIDLAT
ISFGQGISASSIQLATAISAVANGGNLMKPYVVERILDDSGNELQRFTPQVVRRVISADTAAKVTRMMETVTAEGGTGTN
AAVEGFRVAGKTGTAQKADPVTRRYSASKRTASFIGFIPADRPRLTILVVIDEPRTSSYGGVVAAPAFRGIALNSLAYLK
VLPKNGTLRKPGPMEAKSREAEQRDSMSEGDALDMPVSGEVMPDFHGMSMRRVLQVMEKRNINIRLLGSGRAMEQNPPPG
QPIRSVDEVWIRFVPSA

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=557, Percent_Identity=32.3159784560144, Blast_Score=295, Evalue=8e-81,
Organism=Escherichia coli, GI1786854, Length=578, Percent_Identity=25.0865051903114, Blast_Score=143, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 72323; Mature: 72323

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDDREKWARTRIVIIGFFFGLLFMAVSAKAFKLQILQHEEMVKRAERQHQRSVPLTPGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCC
GAIMDRNGNNLAVSVEMYSCYGEARHIQDVEATATALAPFLEVPRQEIVRKIRNSRNFVW
CEEEECCCCEEEEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEE
LERRIPPERATRIRNLKLRGIGFAPETKRFYPNSEVAAHVIGFTGIDPNGLDGVEFKYDS
EECCCCHHHHHHHHCEEEEECCCCCCCCCCCCCCHHEEEEEEEECCCCCCCCCCEEEECE
VILGNTGLLVTERDALGRDIAPRAELVKSSSPGKNVVLTLDKNIQYITEKELAQAVTSSG
EEECCCCEEEEECHHCCCCCCCHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCC
AKGGMALVLEPDSGRVLAMANYPTFNPNSYFRYSHAELRNRAVADSFEPGSTFKVFLIAA
CCCCEEEEEECCCCCEEEEECCCCCCCCCCEEECHHHHHHHHHCCCCCCCCCEEEEEEEE
ALNERLVRPTDAFHCENGSYTIATHTVHDTHSYGRLSVSDILKYSSNIGAAKIGFKLGSD
HHHHHCCCCCCCEEECCCCEEEEEEEEECCCCCCCEEHHHHHHHHCCCCEEEEEEEECHH
RLSRYLHNFGFGERSGIDLPGESPGNMRSRQRWYGIDLATISFGQGISASSIQLATAISA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEECEEEEEEECCCCCCCCHHHHHHHHHH
VANGGNLMKPYVVERILDDSGNELQRFTPQVVRRVISADTAAKVTRMMETVTAEGGTGTN
HHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC
AAVEGFRVAGKTGTAQKADPVTRRYSASKRTASFIGFIPADRPRLTILVVIDEPRTSSYG
HHHCCEEEECCCCCCCCCCCHHHHHCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCC
GVVAAPAFRGIALNSLAYLKVLPKNGTLRKPGPMEAKSREAEQRDSMSEGDALDMPVSGE
CEEECCCCCCHHHCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
VMPDFHGMSMRRVLQVMEKRNINIRLLGSGRAMEQNPPPGQPIRSVDEVWIRFVPSA
CCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHEECCCC
>Mature Secondary Structure
MRDDREKWARTRIVIIGFFFGLLFMAVSAKAFKLQILQHEEMVKRAERQHQRSVPLTPGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCC
GAIMDRNGNNLAVSVEMYSCYGEARHIQDVEATATALAPFLEVPRQEIVRKIRNSRNFVW
CEEEECCCCEEEEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEE
LERRIPPERATRIRNLKLRGIGFAPETKRFYPNSEVAAHVIGFTGIDPNGLDGVEFKYDS
EECCCCHHHHHHHHCEEEEECCCCCCCCCCCCCCHHEEEEEEEECCCCCCCCCCEEEECE
VILGNTGLLVTERDALGRDIAPRAELVKSSSPGKNVVLTLDKNIQYITEKELAQAVTSSG
EEECCCCEEEEECHHCCCCCCCHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCC
AKGGMALVLEPDSGRVLAMANYPTFNPNSYFRYSHAELRNRAVADSFEPGSTFKVFLIAA
CCCCEEEEEECCCCCEEEEECCCCCCCCCCEEECHHHHHHHHHCCCCCCCCCEEEEEEEE
ALNERLVRPTDAFHCENGSYTIATHTVHDTHSYGRLSVSDILKYSSNIGAAKIGFKLGSD
HHHHHCCCCCCCEEECCCCEEEEEEEEECCCCCCCEEHHHHHHHHCCCCEEEEEEEECHH
RLSRYLHNFGFGERSGIDLPGESPGNMRSRQRWYGIDLATISFGQGISASSIQLATAISA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEECEEEEEEECCCCCCCCHHHHHHHHHH
VANGGNLMKPYVVERILDDSGNELQRFTPQVVRRVISADTAAKVTRMMETVTAEGGTGTN
HHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC
AAVEGFRVAGKTGTAQKADPVTRRYSASKRTASFIGFIPADRPRLTILVVIDEPRTSSYG
HHHCCEEEECCCCCCCCCCCHHHHHCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCC
GVVAAPAFRGIALNSLAYLKVLPKNGTLRKPGPMEAKSREAEQRDSMSEGDALDMPVSGE
CEEECCCCCCHHHCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
VMPDFHGMSMRRVLQVMEKRNINIRLLGSGRAMEQNPPPGQPIRSVDEVWIRFVPSA
CCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]