Click here to switch to the map view.

The map label for this gene is uvrC [H]

Identifier: 118581649

GI number: 118581649

Start: 3567608

End: 3569461

Strand: Reverse

Name: uvrC [H]

Synonym: Ppro_3248

Alternate gene names: 118581649

Gene position: 3569461-3567608 (Counterclockwise)

Preceding gene: 118581652

Following gene: 118581647

Centisome position: 89.06

GC content: 66.18

Gene sequence:

>1854_bases
ATGTGGCCCATGGCTCTTGAGGACAAGATACGGCAACTGCCGGCCGCGCCGGGCGTGTACATTATGCGCGATGCCGGGGG
CGAGATACTGTACGTTGGCAAGGCGCGCAGCCTGCGCCAGCGCGTGCGCTCCTACTTCGGCGCGTCAGCCGATTCCCGTT
ATCAGGTCAGGTTCCTGATGGCCAGGTGCGTCGACATCGACATCGTGCTGACCGATACGGAGAAGGAGGCCCTGCTGCTG
GAGAATACGCTGATCAAGCAGCACCGCCCTCGCTACAACCTGGACCTGAAGGATGACAAGACCTACTTCTCCCTGCGCTT
GGACCCGGCCGAGCCGTTCCCCCGCTTCACCCTGGTGCGCAAGATTCCCCGTGACTCGGCCCGCTATTTCGGTCCCTATG
CCTCGGCTTCGGCGGCCCGGGACGTGCTGCGCCAGCTCCTGCGCATGTTCCCCCTTCGCCACTATCCCCTGACCCGCTGC
ATGGCCCGCAAGCGCCCCTGCCTGTACCACCAGATCGGCCAGTGCAGCGCCCCCTGCGCCGGCCTGGTCACCGCCGCTGA
CTACGCCACGCTGGTGGAGGGGGCCATGCTCTTTCTGGAGGGGAAGAGCAAGCAGCTGGTGGCGGAGTTCAAGCGCCGCA
TGCTGGAGGCTTCCGACCAGCTGCGCTTCGAGGAGGCCGCCCGCTGGCGCAACCTGCTGCGCTCCATCCAGGTCACCGTG
GAGAAGCAGAAGATGGTTACCCGTGGCGGGGACTGTGATGTGCTCGGTTTCCACCGTGATGGCCCGCGGCTGCAGCTGGC
GCTGCTCTTCATCCGTGGCGGCGTGCTCACCGGGAGCCGCCAGTTCAGCCTGAACTGGGAGCTGGATGACGCCGAGGGGA
TCGCCTCCTTCCTGCGCCAGTACTACCGGGAGGGGACCTTCATTCCGGATGAGATCCATCTGCCGCTGGAGATCGAGGAC
GGGGCGCCCCTGGCCGAACTGCTGTCCGAGTCCAGGGGGAAGAGGGTCGTCATAGCCCGGCCGCTGCGGGGCGTCAAGCG
CGAGCTGGTGGAGCTGGCCGGCAAGAATGCCGCCACCCAGCTTAGGGAGCGGGACGAGAAACAGGCCGCGGCTGATGCCG
TGCTGGAGGCGCTGCGGCAACGGCTGAAGCTGACGCGCCTGCCGCGGCGCATCGAGTGCTATGACATCTCCACCATCCAG
GGGCGCTTCTCCGTGGGGAGCGGAGTGGTCTTCAGCGAGGGCCGCCCCGACAAGCCCCACTACCGGCGCTACCGCATCCG
CCATGTGGAGGGGCAGAACGACTTCGCCATGCTGGCGGAAGTCTTTTCGCGCCGCTTCAGGCCGGAGAAACTGGAGGCGG
AGCCGCTGCCCGACCTGGTGGTTGTTGACGGCGGCATCGGCCAGCTGAACGCCGTTGCCCAGATAATAGCTGAGCTGGGG
CTGGAAGGGCGCATTGATCTGGTTTCGCTGGCCAAAAGCCGGGTGGAGCGGGATGCGGAGGCGGAGGAGCTGCGCAAGAG
CGACGAACGGGTCTTCCTGCCGGGGCGTAGGAATCCTGTGGTGCTGCGCCAGAACTCGGGCCCGCTTCTGCTCCTGGCAG
CCATCCGCGACGAGGCGCACCGCTTCGCCATCGGCTACCACCGCACCCTGCGGGGCAAGGAGGGGATCGCCTCGGCCATC
GAGGGCGTAGCTGGTATAGGTTCAAAGCGGCGCGCCGCGCTTTTGAAGCGCTTCGGCAGTCTGCAGTTGCTGAAGCAGGC
CAGCCTGGAGGAGATCGTCGCGGTTGAAGGAATGAGCCGGACAACGGCGGAAGCCGTCTTCGACTGGTTGCACGGAGAGA
AAGGTGAGGAGTGA

Upstream 100 bases:

>100_bases
GCGTTGCCCAGGCGTTAGACGCCTGCCTGCTCGCCCCAGAGAGGCGTGGTCCGGCGCTGGACCCACGGCGGGCTTTTCAT
TCCGCGCACAACCGGCTAGT

Downstream 100 bases:

>100_bases
GGCCCGCAAGAACTACTCGGCATTCCGGGCATGAAAAAGCCCACCTGGTCAATCAGGTGGGCTTCGTTTGTGAGTGTTAT
TCCCTTTTCGGGCATCTATC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MWPMALEDKIRQLPAAPGVYIMRDAGGEILYVGKARSLRQRVRSYFGASADSRYQVRFLMARCVDIDIVLTDTEKEALLL
ENTLIKQHRPRYNLDLKDDKTYFSLRLDPAEPFPRFTLVRKIPRDSARYFGPYASASAARDVLRQLLRMFPLRHYPLTRC
MARKRPCLYHQIGQCSAPCAGLVTAADYATLVEGAMLFLEGKSKQLVAEFKRRMLEASDQLRFEEAARWRNLLRSIQVTV
EKQKMVTRGGDCDVLGFHRDGPRLQLALLFIRGGVLTGSRQFSLNWELDDAEGIASFLRQYYREGTFIPDEIHLPLEIED
GAPLAELLSESRGKRVVIARPLRGVKRELVELAGKNAATQLRERDEKQAAADAVLEALRQRLKLTRLPRRIECYDISTIQ
GRFSVGSGVVFSEGRPDKPHYRRYRIRHVEGQNDFAMLAEVFSRRFRPEKLEAEPLPDLVVVDGGIGQLNAVAQIIAELG
LEGRIDLVSLAKSRVERDAEAEELRKSDERVFLPGRRNPVVLRQNSGPLLLLAAIRDEAHRFAIGYHRTLRGKEGIASAI
EGVAGIGSKRRAALLKRFGSLQLLKQASLEEIVAVEGMSRTTAEAVFDWLHGEKGEE

Sequences:

>Translated_617_residues
MWPMALEDKIRQLPAAPGVYIMRDAGGEILYVGKARSLRQRVRSYFGASADSRYQVRFLMARCVDIDIVLTDTEKEALLL
ENTLIKQHRPRYNLDLKDDKTYFSLRLDPAEPFPRFTLVRKIPRDSARYFGPYASASAARDVLRQLLRMFPLRHYPLTRC
MARKRPCLYHQIGQCSAPCAGLVTAADYATLVEGAMLFLEGKSKQLVAEFKRRMLEASDQLRFEEAARWRNLLRSIQVTV
EKQKMVTRGGDCDVLGFHRDGPRLQLALLFIRGGVLTGSRQFSLNWELDDAEGIASFLRQYYREGTFIPDEIHLPLEIED
GAPLAELLSESRGKRVVIARPLRGVKRELVELAGKNAATQLRERDEKQAAADAVLEALRQRLKLTRLPRRIECYDISTIQ
GRFSVGSGVVFSEGRPDKPHYRRYRIRHVEGQNDFAMLAEVFSRRFRPEKLEAEPLPDLVVVDGGIGQLNAVAQIIAELG
LEGRIDLVSLAKSRVERDAEAEELRKSDERVFLPGRRNPVVLRQNSGPLLLLAAIRDEAHRFAIGYHRTLRGKEGIASAI
EGVAGIGSKRRAALLKRFGSLQLLKQASLEEIVAVEGMSRTTAEAVFDWLHGEKGEE
>Mature_617_residues
MWPMALEDKIRQLPAAPGVYIMRDAGGEILYVGKARSLRQRVRSYFGASADSRYQVRFLMARCVDIDIVLTDTEKEALLL
ENTLIKQHRPRYNLDLKDDKTYFSLRLDPAEPFPRFTLVRKIPRDSARYFGPYASASAARDVLRQLLRMFPLRHYPLTRC
MARKRPCLYHQIGQCSAPCAGLVTAADYATLVEGAMLFLEGKSKQLVAEFKRRMLEASDQLRFEEAARWRNLLRSIQVTV
EKQKMVTRGGDCDVLGFHRDGPRLQLALLFIRGGVLTGSRQFSLNWELDDAEGIASFLRQYYREGTFIPDEIHLPLEIED
GAPLAELLSESRGKRVVIARPLRGVKRELVELAGKNAATQLRERDEKQAAADAVLEALRQRLKLTRLPRRIECYDISTIQ
GRFSVGSGVVFSEGRPDKPHYRRYRIRHVEGQNDFAMLAEVFSRRFRPEKLEAEPLPDLVVVDGGIGQLNAVAQIIAELG
LEGRIDLVSLAKSRVERDAEAEELRKSDERVFLPGRRNPVVLRQNSGPLLLLAAIRDEAHRFAIGYHRTLRGKEGIASAI
EGVAGIGSKRRAALLKRFGSLQLLKQASLEEIVAVEGMSRTTAEAVFDWLHGEKGEE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=609, Percent_Identity=37.4384236453202, Blast_Score=364, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 69802; Mature: 69802

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWPMALEDKIRQLPAAPGVYIMRDAGGEILYVGKARSLRQRVRSYFGASADSRYQVRFLM
CCCCCHHHHHHHCCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHH
ARCVDIDIVLTDTEKEALLLENTLIKQHRPRYNLDLKDDKTYFSLRLDPAEPFPRFTLVR
HHHCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHH
KIPRDSARYFGPYASASAARDVLRQLLRMFPLRHYPLTRCMARKRPCLYHQIGQCSAPCA
HCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHCCCCCCHH
GLVTAADYATLVEGAMLFLEGKSKQLVAEFKRRMLEASDQLRFEEAARWRNLLRSIQVTV
HHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKQKMVTRGGDCDVLGFHRDGPRLQLALLFIRGGVLTGSRQFSLNWELDDAEGIASFLRQ
HHHHHHHCCCCCCEEEECCCCCCEEEEEEEECCCEEECCEEEEEEECCCCHHHHHHHHHH
YYREGTFIPDEIHLPLEIEDGAPLAELLSESRGKRVVIARPLRGVKRELVELAGKNAATQ
HHHCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCHHHH
LRERDEKQAAADAVLEALRQRLKLTRLPRRIECYDISTIQGRFSVGSGVVFSEGRPDKPH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCEECCCCEEECCCCCCCCH
YRRYRIRHVEGQNDFAMLAEVFSRRFRPEKLEAEPLPDLVVVDGGIGQLNAVAQIIAELG
HHHEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHC
LEGRIDLVSLAKSRVERDAEAEELRKSDERVFLPGRRNPVVLRQNSGPLLLLAAIRDEAH
CCCCHHHHHHHHHHHHCCCHHHHHHCCCCEEECCCCCCCEEEEECCCCEEEEEEHHHCHH
RFAIGYHRTLRGKEGIASAIEGVAGIGSKRRAALLKRFGSLQLLKQASLEEIVAVEGMSR
HEEEHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCH
TTAEAVFDWLHGEKGEE
HHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MWPMALEDKIRQLPAAPGVYIMRDAGGEILYVGKARSLRQRVRSYFGASADSRYQVRFLM
CCCCCHHHHHHHCCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHH
ARCVDIDIVLTDTEKEALLLENTLIKQHRPRYNLDLKDDKTYFSLRLDPAEPFPRFTLVR
HHHCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHH
KIPRDSARYFGPYASASAARDVLRQLLRMFPLRHYPLTRCMARKRPCLYHQIGQCSAPCA
HCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHCCCCCCHH
GLVTAADYATLVEGAMLFLEGKSKQLVAEFKRRMLEASDQLRFEEAARWRNLLRSIQVTV
HHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKQKMVTRGGDCDVLGFHRDGPRLQLALLFIRGGVLTGSRQFSLNWELDDAEGIASFLRQ
HHHHHHHCCCCCCEEEECCCCCCEEEEEEEECCCEEECCEEEEEEECCCCHHHHHHHHHH
YYREGTFIPDEIHLPLEIEDGAPLAELLSESRGKRVVIARPLRGVKRELVELAGKNAATQ
HHHCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCHHHH
LRERDEKQAAADAVLEALRQRLKLTRLPRRIECYDISTIQGRFSVGSGVVFSEGRPDKPH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCEECCCCEEECCCCCCCCH
YRRYRIRHVEGQNDFAMLAEVFSRRFRPEKLEAEPLPDLVVVDGGIGQLNAVAQIIAELG
HHHEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHC
LEGRIDLVSLAKSRVERDAEAEELRKSDERVFLPGRRNPVVLRQNSGPLLLLAAIRDEAH
CCCCHHHHHHHHHHHHCCCHHHHHHCCCCEEECCCCCCCEEEEECCCCEEEEEEHHHCHH
RFAIGYHRTLRGKEGIASAIEGVAGIGSKRRAALLKRFGSLQLLKQASLEEIVAVEGMSR
HEEEHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCH
TTAEAVFDWLHGEKGEE
HHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA