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The map label for this gene is mrpD [H]

Identifier: 118581622

GI number: 118581622

Start: 3538387

End: 3539889

Strand: Direct

Name: mrpD [H]

Synonym: Ppro_3221

Alternate gene names: 118581622

Gene position: 3538387-3539889 (Clockwise)

Preceding gene: 118581621

Following gene: 118581623

Centisome position: 88.28

GC content: 61.54

Gene sequence:

>1503_bases
ATGAATAACCTGCTCTTTGTACCGCTGTTGATCCCGCTTGCCACCGCGACCGCGGGACTCCTGGCCTGGAGAAGGAGGAA
CCTGCAACGCATGCTGGGGGTCTGCGGAACGACATCCCTGCTGGTGGCCGGCTTGTGCCTACTGACGCAGGTGCGCGGAA
AGGGGATTCTGAGCGTCCAGGCGGGAAACTGGCCGGCTCCCTTCGGCATTACCCTGGTCGCCGACAGTTTCAGCGCCCTG
ATGATAGCCGCAACCGGCTTCATGGGACTGGCCGTATCGGTCTATTCGTTGACCGACGCGGATGCAGGCCAGGAATCGCT
CGGTTACCACCCCCTGCTGCAGGTCCTCCTGCTGGGGGTCTGCGGTTCGTTTCTCACCGCTGATCTCTTCAACCTCTATG
TCTGGTTCGAGGTGCTGATGATCTCTTCCTTCGTGCTGCTGGCCCTGGGGGGGCGCAGGGAACAGATCGAGGGCGCCATC
AAGTATGTAGCCCTCAACCTGACCGCTTCGGCCTTCTTTCTGGCAGGAATCGGCCTGCTCTACGGCGTAACCGGCACCCT
CAACATGGCCCATGTGGCGGTTCAGTTGCGCGAAACGGAACATACTGGCACCGTACCGATCATAGCGGCCCTGCTCTTCA
GCGCCTTTGGCGTCAAGGCGGCGGTCTTTCCGTTTCATTTCTGGCTGCCCGCCTCCTACCACACCGCGCCGATTGCGGTG
ACGACCCTTTTCTCGGCGCTGCTTTCAAAAGTCGGTATCTATGTTCTGATCAGGATATTCACCCTGATCTTCGTTCAGGA
GGCAATTGCCGGTCAGGCCATCATACTGACGGCAGCGGGCCTGACCATGCTGATCGGAGTTCTGGGCGCCATGGTTCAGT
ACGAGATGCGGCGCCTGCTGTCGTTTCATATCGTGAGCCAGATCGGGTACCTGCTGATGGGGCTGGGCCTCATGACACCG
CTGGCTCTGGCCGGCACCATATTCTTCATGGCCCACATCATCGCCGCGAAATCCGCTCTCTTTTTGACAACGGGCATCGT
GGCCCGCCTGACAGGCAGCAGCGAACTGCCCCGCTCCGGCGGCCTGTACCATCAGCGGCCGTTTCTGGCGGCGATCTTCC
TGCTGCCGGCGCTTTCCATGGCCGGATTGCCGCCGCTGTCCGGATTCTGGGCCAAACTGGCCCTGATAACGGCAAGCCTG
GGCCATGGGCACTACCTGCTGACCCTGGTGGCCCTGCTGGTAAGCCTCATGACGCTGTTCTCCATGACCAAGATCTGGAA
TGAGGCTTTCTGGAAGACACGTCCTCCCGGGGAGGAAACGGATCCGCGCCCCATGCCCGTTCTCTCCAGCGTGCAGTTGT
ACGCACCGGCCCTGGCATTGGCGCTGGTATCGGTGACGATGGGACTGGGCGCCGAACCGTTCTTCCGGCTGGCACTTGTT
GCCGCCGGCCAGTTGCTGGAACCAGCCGGCTATATCACCGCCGTCCTGGGGGTGCGACCGTGA

Upstream 100 bases:

>100_bases
GCATTTGCTCTGGTACTGATCAAACGGGTCTACCAGACGGTGGGAAGCGACGACCAGGACGAAATGATCACGGAAAACCG
GGTGTCGGAGAAGAAGCTCC

Downstream 100 bases:

>100_bases
CCGTTTTTCTGGCCAACATCCTGCTGGGGCTGGCCTGGATGGCCCTGACCGGCTCCTTCAGCGTCGGAGGGCTGTTTACC
GGCCTCTGCTTCGGCCTGTG

Product: putative monovalent cation/H+ antiporter subunit D

Products: NA

Alternate protein names: Mrp complex subunit D; Multiple resistance and pH homeostasis protein D [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MNNLLFVPLLIPLATATAGLLAWRRRNLQRMLGVCGTTSLLVAGLCLLTQVRGKGILSVQAGNWPAPFGITLVADSFSAL
MIAATGFMGLAVSVYSLTDADAGQESLGYHPLLQVLLLGVCGSFLTADLFNLYVWFEVLMISSFVLLALGGRREQIEGAI
KYVALNLTASAFFLAGIGLLYGVTGTLNMAHVAVQLRETEHTGTVPIIAALLFSAFGVKAAVFPFHFWLPASYHTAPIAV
TTLFSALLSKVGIYVLIRIFTLIFVQEAIAGQAIILTAAGLTMLIGVLGAMVQYEMRRLLSFHIVSQIGYLLMGLGLMTP
LALAGTIFFMAHIIAAKSALFLTTGIVARLTGSSELPRSGGLYHQRPFLAAIFLLPALSMAGLPPLSGFWAKLALITASL
GHGHYLLTLVALLVSLMTLFSMTKIWNEAFWKTRPPGEETDPRPMPVLSSVQLYAPALALALVSVTMGLGAEPFFRLALV
AAGQLLEPAGYITAVLGVRP

Sequences:

>Translated_500_residues
MNNLLFVPLLIPLATATAGLLAWRRRNLQRMLGVCGTTSLLVAGLCLLTQVRGKGILSVQAGNWPAPFGITLVADSFSAL
MIAATGFMGLAVSVYSLTDADAGQESLGYHPLLQVLLLGVCGSFLTADLFNLYVWFEVLMISSFVLLALGGRREQIEGAI
KYVALNLTASAFFLAGIGLLYGVTGTLNMAHVAVQLRETEHTGTVPIIAALLFSAFGVKAAVFPFHFWLPASYHTAPIAV
TTLFSALLSKVGIYVLIRIFTLIFVQEAIAGQAIILTAAGLTMLIGVLGAMVQYEMRRLLSFHIVSQIGYLLMGLGLMTP
LALAGTIFFMAHIIAAKSALFLTTGIVARLTGSSELPRSGGLYHQRPFLAAIFLLPALSMAGLPPLSGFWAKLALITASL
GHGHYLLTLVALLVSLMTLFSMTKIWNEAFWKTRPPGEETDPRPMPVLSSVQLYAPALALALVSVTMGLGAEPFFRLALV
AAGQLLEPAGYITAVLGVRP
>Mature_500_residues
MNNLLFVPLLIPLATATAGLLAWRRRNLQRMLGVCGTTSLLVAGLCLLTQVRGKGILSVQAGNWPAPFGITLVADSFSAL
MIAATGFMGLAVSVYSLTDADAGQESLGYHPLLQVLLLGVCGSFLTADLFNLYVWFEVLMISSFVLLALGGRREQIEGAI
KYVALNLTASAFFLAGIGLLYGVTGTLNMAHVAVQLRETEHTGTVPIIAALLFSAFGVKAAVFPFHFWLPASYHTAPIAV
TTLFSALLSKVGIYVLIRIFTLIFVQEAIAGQAIILTAAGLTMLIGVLGAMVQYEMRRLLSFHIVSQIGYLLMGLGLMTP
LALAGTIFFMAHIIAAKSALFLTTGIVARLTGSSELPRSGGLYHQRPFLAAIFLLPALSMAGLPPLSGFWAKLALITASL
GHGHYLLTLVALLVSLMTLFSMTKIWNEAFWKTRPPGEETDPRPMPVLSSVQLYAPALALALVSVTMGLGAEPFFRLALV
AAGQLLEPAGYITAVLGVRP

Specific function: Mrp complex is a Na(+)/H(+) antiporter involved in Na(+) excretion and Na(+) resistance [H]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=356, Percent_Identity=22.752808988764, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1788829, Length=390, Percent_Identity=27.6923076923077, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1788831, Length=354, Percent_Identity=27.4011299435028, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1788827, Length=339, Percent_Identity=25.3687315634218, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI145693160, Length=413, Percent_Identity=27.6029055690073, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788613, Length=346, Percent_Identity=28.3236994219653, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI2367154, Length=435, Percent_Identity=24.5977011494253, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788614, Length=433, Percent_Identity=23.3256351039261, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 53263; Mature: 53263

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLLFVPLLIPLATATAGLLAWRRRNLQRMLGVCGTTSLLVAGLCLLTQVRGKGILSVQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEE
AGNWPAPFGITLVADSFSALMIAATGFMGLAVSVYSLTDADAGQESLGYHPLLQVLLLGV
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHH
CGSFLTADLFNLYVWFEVLMISSFVLLALGGRREQIEGAIKYVALNLTASAFFLAGIGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGVTGTLNMAHVAVQLRETEHTGTVPIIAALLFSAFGVKAAVFPFHFWLPASYHTAPIAV
HHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHEECCCCCCCHHHHH
TTLFSALLSKVGIYVLIRIFTLIFVQEAIAGQAIILTAAGLTMLIGVLGAMVQYEMRRLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
SFHIVSQIGYLLMGLGLMTPLALAGTIFFMAHIIAAKSALFLTTGIVARLTGSSELPRSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GLYHQRPFLAAIFLLPALSMAGLPPLSGFWAKLALITASLGHGHYLLTLVALLVSLMTLF
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
SMTKIWNEAFWKTRPPGEETDPRPMPVLSSVQLYAPALALALVSVTMGLGAEPFFRLALV
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AAGQLLEPAGYITAVLGVRP
HHHHHCCCHHHHHHHHCCCC
>Mature Secondary Structure
MNNLLFVPLLIPLATATAGLLAWRRRNLQRMLGVCGTTSLLVAGLCLLTQVRGKGILSVQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEE
AGNWPAPFGITLVADSFSALMIAATGFMGLAVSVYSLTDADAGQESLGYHPLLQVLLLGV
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHHHHHH
CGSFLTADLFNLYVWFEVLMISSFVLLALGGRREQIEGAIKYVALNLTASAFFLAGIGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGVTGTLNMAHVAVQLRETEHTGTVPIIAALLFSAFGVKAAVFPFHFWLPASYHTAPIAV
HHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHEECCCCCCCHHHHH
TTLFSALLSKVGIYVLIRIFTLIFVQEAIAGQAIILTAAGLTMLIGVLGAMVQYEMRRLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
SFHIVSQIGYLLMGLGLMTPLALAGTIFFMAHIIAAKSALFLTTGIVARLTGSSELPRSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GLYHQRPFLAAIFLLPALSMAGLPPLSGFWAKLALITASLGHGHYLLTLVALLVSLMTLF
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
SMTKIWNEAFWKTRPPGEETDPRPMPVLSSVQLYAPALALALVSVTMGLGAEPFFRLALV
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AAGQLLEPAGYITAVLGVRP
HHHHHCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11356194 [H]