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The map label for this gene is mrpA [H]

Identifier: 118581619

GI number: 118581619

Start: 3535309

End: 3537612

Strand: Direct

Name: mrpA [H]

Synonym: Ppro_3218

Alternate gene names: 118581619

Gene position: 3535309-3537612 (Clockwise)

Preceding gene: 118581618

Following gene: 118581620

Centisome position: 88.21

GC content: 64.45

Gene sequence:

>2304_bases
ATGTCCATGCTGGCTGCTCTGCTGACATCTTTCGGGACGGCTCTTCTCGCCCCACTGCTGCATCAGCTCATCCCCCGTCG
GGCCGGATGGCTGTGGGGGCTCCCGCCGCTGGCCCTGTTCTGCTTTTTCCTGGCTCGGACCGGACCAGCGGCATCGGGCG
CGGTGCAGCAGGAGAGCTACGCCTGGATTCCCTCCTTGGGAGTCACCTGTATCCTGGCCATGGACAGCCTCAGCATCCTG
TTCGCCTTGCTGATCAGCGGCATCGGCACCATTGTGCTGATCTATGCTTCTTCGTACCTGCGCCACCATCGCCATCTGGG
CCGATTTTACGGCCTGATCCTGGCGTTCATGGCAGCCATGCTCGGAACCGTGCTGGCGGGAGACCTGCTGACCCTCTTCA
TGTTCTGGGAACTGACCGGCTTCTGCTCTTTCATGCTGATCGGCTTCGAGCACGAAAACAGGGCTTCACGCGACGCCGCG
CTCCAGGCACTGCTGGTCACCGGCGCCGGGGGACTGGCCCTGCTGGCAGGGATAGTCCTGATGGGGCGGGCCACGGGGAG
CATGGATCTGAAAACCATTCTGGCCAGCGGAGACGTGCTGCGAGCCCATCCCCATTACCTGGCCATGCTGCTGCTGATAC
TGAGCGGTGCGTTTACCAAGTCGGCCCAGTTCCCCTTCCATTTCTGGCTCCCGGGCGCCATGGCCGCACCTACCCCGGTC
AGCGCCTATCTGCACTCGGCCACCATGGTCAAACTGGGAATCTATCTGCTGGCGCGCCTTGCGCCGGTAGTGGGCGGCAC
CAAAGAGTGGTTCGTCTGCCTGACCCTGGTCGGAGCCACGACCATGCTGCTGGGAGGGGCAACAGCCATTCTCCGCGACG
ACCTGAAGCAGATCCTGGCCTGGTCCACCGTCAGCGCCCTGGGTACCCTGACCTTGCTGCTGGGATTGGGAACCCCGCTG
GCCGTCACGACCGCCATGCTCCTGCTGCCGGTGCACGCCCTGTACAAAAGCGCCCTGTTTCTGGCTGCCGGGGCAGTAGA
CCATTCCGTCGGAAGCCGGGCCATATCCCGCCTGGGGGGACTGGCCGGAAGCATCCCCTGGGTGGCGGCGGGCGCGCTCA
TTGCAGCACTGTCCATGGCCGGACTGCCCCCTCTGGCCGGTTTCATCGCCAAGGAGCTGCTCTATGAAACGACGCTCCAA
GCTCCCCTCTGGCCGGTGCTGACCACAGCTTTCATGACAACCGCAAACGCCCTGGCAATCGTGGCAGCGCTAATGGCCGG
CTATGCCCCCTTTTTCGGCAAACGGAAAGAGCCGGGCCCGCCCCCCCACCGGGTGGAGGCGCATCTCTGGCTCCCCGTAC
TTGTCCCTGCCCTGGCCGGCCTTCTGATCGGGCTGTTTCCCGCTCCGTTCGGGCACTGGCTGGTGGCGCCGGCGGTGGAA
ACGACGCTCGCCACCCCTGTTCCCGTTGCACTGGCCCTCTGGCACGGAATCAACCCGCCCCTCGTGCTCAGCCTGCTCAC
CCTGGTTGCGGGCCTTGCCATTGCCGTCGGCCGCATCCCGCTCATAAAACGGCTGCCGTCGCTGGACGGCACCAAGCTGT
GGGGACCGGAACAGCTGTACGCACGAATGCTCGAAGGCCTGCCCAGGCTCGCTGCTGTCCTGACAGCGTCTCTGCAGAAC
GGTCGTCTGCGTCACTACCTCATGACCGTAGTGGGGGGCGCGGTCGGCCTGATGTGCCTTGCACTCATCTCAGGGCCGGC
CTCCCTGCCCACACCGCAACGTCCCGACGGCGGGCTCCACGAATGGCTGACCGCAGCCGTCATTCTGGGAGGCGCCCTGA
TGGCGGCCACCACAAGATCGCGCTTGGCCGCCGTGGCTGCCCTCGGCACGGTGGGGTACGGCGTAGCCCTGATCTACATC
ATCTTCGGAGCACCGGACTTGGCAATGACCCAGTTCTGCATCGAGACACTCTCTATCATCATGTTCGTACTGGTTCTGTA
CCGCTTGCCCCGCTTCACTCCCCTCTCTTCACCCCTGTCCCGCCTGCGGGATTTGCTGGTGTCCCTCTCCATCGGCTGCG
CCATGGGCCTGCTGGTACTGATGGCGGTCTCCCGGCCGATGTTCCCCCACATCGGCGACTGGTTCCTCCGGCAAAGCTTG
CCCGCTGGACATGGACGGAACGTGGTCAACGTCATCCTGGTGGATTTCCGTGCCCTGGATACGCTGGGAGAAATCACCGT
CCTGGCGGTAGCGGCCCTGGGGGTATACGGATTGCTGAAGAAACGGTCCGGGGAGGATAGCTAA

Upstream 100 bases:

>100_bases
CACGCATCGGAATCCTCTCAGCCATTTTGACGAAACACCGCCCGGCACGACGCGAGCGAGGGTCGACAGCCTTGAACCAC
CAACACCGAGGGAGAACCTC

Downstream 100 bases:

>100_bases
CCATGTATTCCCTGATCCTTGCCACCGCCATACGGATCCTGCTACCACTGATGCTGCTGTTCTCCCTCTTCCTGCTGCTG
CGGGGGCACAACGAGCCTGG

Product: putative monovalent cation/H+ antiporter subunit A

Products: NA

Alternate protein names: Mrp complex subunit A; Multiple resistance and pH homeostasis protein A [H]

Number of amino acids: Translated: 767; Mature: 766

Protein sequence:

>767_residues
MSMLAALLTSFGTALLAPLLHQLIPRRAGWLWGLPPLALFCFFLARTGPAASGAVQQESYAWIPSLGVTCILAMDSLSIL
FALLISGIGTIVLIYASSYLRHHRHLGRFYGLILAFMAAMLGTVLAGDLLTLFMFWELTGFCSFMLIGFEHENRASRDAA
LQALLVTGAGGLALLAGIVLMGRATGSMDLKTILASGDVLRAHPHYLAMLLLILSGAFTKSAQFPFHFWLPGAMAAPTPV
SAYLHSATMVKLGIYLLARLAPVVGGTKEWFVCLTLVGATTMLLGGATAILRDDLKQILAWSTVSALGTLTLLLGLGTPL
AVTTAMLLLPVHALYKSALFLAAGAVDHSVGSRAISRLGGLAGSIPWVAAGALIAALSMAGLPPLAGFIAKELLYETTLQ
APLWPVLTTAFMTTANALAIVAALMAGYAPFFGKRKEPGPPPHRVEAHLWLPVLVPALAGLLIGLFPAPFGHWLVAPAVE
TTLATPVPVALALWHGINPPLVLSLLTLVAGLAIAVGRIPLIKRLPSLDGTKLWGPEQLYARMLEGLPRLAAVLTASLQN
GRLRHYLMTVVGGAVGLMCLALISGPASLPTPQRPDGGLHEWLTAAVILGGALMAATTRSRLAAVAALGTVGYGVALIYI
IFGAPDLAMTQFCIETLSIIMFVLVLYRLPRFTPLSSPLSRLRDLLVSLSIGCAMGLLVLMAVSRPMFPHIGDWFLRQSL
PAGHGRNVVNVILVDFRALDTLGEITVLAVAALGVYGLLKKRSGEDS

Sequences:

>Translated_767_residues
MSMLAALLTSFGTALLAPLLHQLIPRRAGWLWGLPPLALFCFFLARTGPAASGAVQQESYAWIPSLGVTCILAMDSLSIL
FALLISGIGTIVLIYASSYLRHHRHLGRFYGLILAFMAAMLGTVLAGDLLTLFMFWELTGFCSFMLIGFEHENRASRDAA
LQALLVTGAGGLALLAGIVLMGRATGSMDLKTILASGDVLRAHPHYLAMLLLILSGAFTKSAQFPFHFWLPGAMAAPTPV
SAYLHSATMVKLGIYLLARLAPVVGGTKEWFVCLTLVGATTMLLGGATAILRDDLKQILAWSTVSALGTLTLLLGLGTPL
AVTTAMLLLPVHALYKSALFLAAGAVDHSVGSRAISRLGGLAGSIPWVAAGALIAALSMAGLPPLAGFIAKELLYETTLQ
APLWPVLTTAFMTTANALAIVAALMAGYAPFFGKRKEPGPPPHRVEAHLWLPVLVPALAGLLIGLFPAPFGHWLVAPAVE
TTLATPVPVALALWHGINPPLVLSLLTLVAGLAIAVGRIPLIKRLPSLDGTKLWGPEQLYARMLEGLPRLAAVLTASLQN
GRLRHYLMTVVGGAVGLMCLALISGPASLPTPQRPDGGLHEWLTAAVILGGALMAATTRSRLAAVAALGTVGYGVALIYI
IFGAPDLAMTQFCIETLSIIMFVLVLYRLPRFTPLSSPLSRLRDLLVSLSIGCAMGLLVLMAVSRPMFPHIGDWFLRQSL
PAGHGRNVVNVILVDFRALDTLGEITVLAVAALGVYGLLKKRSGEDS
>Mature_766_residues
SMLAALLTSFGTALLAPLLHQLIPRRAGWLWGLPPLALFCFFLARTGPAASGAVQQESYAWIPSLGVTCILAMDSLSILF
ALLISGIGTIVLIYASSYLRHHRHLGRFYGLILAFMAAMLGTVLAGDLLTLFMFWELTGFCSFMLIGFEHENRASRDAAL
QALLVTGAGGLALLAGIVLMGRATGSMDLKTILASGDVLRAHPHYLAMLLLILSGAFTKSAQFPFHFWLPGAMAAPTPVS
AYLHSATMVKLGIYLLARLAPVVGGTKEWFVCLTLVGATTMLLGGATAILRDDLKQILAWSTVSALGTLTLLLGLGTPLA
VTTAMLLLPVHALYKSALFLAAGAVDHSVGSRAISRLGGLAGSIPWVAAGALIAALSMAGLPPLAGFIAKELLYETTLQA
PLWPVLTTAFMTTANALAIVAALMAGYAPFFGKRKEPGPPPHRVEAHLWLPVLVPALAGLLIGLFPAPFGHWLVAPAVET
TLATPVPVALALWHGINPPLVLSLLTLVAGLAIAVGRIPLIKRLPSLDGTKLWGPEQLYARMLEGLPRLAAVLTASLQNG
RLRHYLMTVVGGAVGLMCLALISGPASLPTPQRPDGGLHEWLTAAVILGGALMAATTRSRLAAVAALGTVGYGVALIYII
FGAPDLAMTQFCIETLSIIMFVLVLYRLPRFTPLSSPLSRLRDLLVSLSIGCAMGLLVLMAVSRPMFPHIGDWFLRQSLP
AGHGRNVVNVILVDFRALDTLGEITVLAVAALGVYGLLKKRSGEDS

Specific function: Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual N

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=330, Percent_Identity=32.7272727272727, Blast_Score=159, Evalue=1e-38,
Organism=Escherichia coli, GI1788829, Length=392, Percent_Identity=35.969387755102, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1788614, Length=343, Percent_Identity=34.9854227405248, Blast_Score=181, Evalue=2e-46,
Organism=Escherichia coli, GI1788827, Length=348, Percent_Identity=31.8965517241379, Blast_Score=130, Evalue=4e-31,
Organism=Escherichia coli, GI1788831, Length=340, Percent_Identity=28.8235294117647, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788613, Length=387, Percent_Identity=26.6149870801034, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI145693160, Length=423, Percent_Identity=25.0591016548463, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI2367154, Length=326, Percent_Identity=28.2208588957055, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005663
- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 80933; Mature: 80802

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMLAALLTSFGTALLAPLLHQLIPRRAGWLWGLPPLALFCFFLARTGPAASGAVQQESY
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
AWIPSLGVTCILAMDSLSILFALLISGIGTIVLIYASSYLRHHRHLGRFYGLILAFMAAM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGTVLAGDLLTLFMFWELTGFCSFMLIGFEHENRASRDAALQALLVTGAGGLALLAGIVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
MGRATGSMDLKTILASGDVLRAHPHYLAMLLLILSGAFTKSAQFPFHFWLPGAMAAPTPV
HHCCCCCHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHH
SAYLHSATMVKLGIYLLARLAPVVGGTKEWFVCLTLVGATTMLLGGATAILRDDLKQILA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WSTVSALGTLTLLLGLGTPLAVTTAMLLLPVHALYKSALFLAAGAVDHSVGSRAISRLGG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LAGSIPWVAAGALIAALSMAGLPPLAGFIAKELLYETTLQAPLWPVLTTAFMTTANALAI
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VAALMAGYAPFFGKRKEPGPPPHRVEAHLWLPVLVPALAGLLIGLFPAPFGHWLVAPAVE
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
TTLATPVPVALALWHGINPPLVLSLLTLVAGLAIAVGRIPLIKRLPSLDGTKLWGPEQLY
HHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHH
ARMLEGLPRLAAVLTASLQNGRLRHYLMTVVGGAVGLMCLALISGPASLPTPQRPDGGLH
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
EWLTAAVILGGALMAATTRSRLAAVAALGTVGYGVALIYIIFGAPDLAMTQFCIETLSII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
MFVLVLYRLPRFTPLSSPLSRLRDLLVSLSIGCAMGLLVLMAVSRPMFPHIGDWFLRQSL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
PAGHGRNVVNVILVDFRALDTLGEITVLAVAALGVYGLLKKRSGEDS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SMLAALLTSFGTALLAPLLHQLIPRRAGWLWGLPPLALFCFFLARTGPAASGAVQQESY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
AWIPSLGVTCILAMDSLSILFALLISGIGTIVLIYASSYLRHHRHLGRFYGLILAFMAAM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGTVLAGDLLTLFMFWELTGFCSFMLIGFEHENRASRDAALQALLVTGAGGLALLAGIVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
MGRATGSMDLKTILASGDVLRAHPHYLAMLLLILSGAFTKSAQFPFHFWLPGAMAAPTPV
HHCCCCCHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHH
SAYLHSATMVKLGIYLLARLAPVVGGTKEWFVCLTLVGATTMLLGGATAILRDDLKQILA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WSTVSALGTLTLLLGLGTPLAVTTAMLLLPVHALYKSALFLAAGAVDHSVGSRAISRLGG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LAGSIPWVAAGALIAALSMAGLPPLAGFIAKELLYETTLQAPLWPVLTTAFMTTANALAI
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VAALMAGYAPFFGKRKEPGPPPHRVEAHLWLPVLVPALAGLLIGLFPAPFGHWLVAPAVE
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
TTLATPVPVALALWHGINPPLVLSLLTLVAGLAIAVGRIPLIKRLPSLDGTKLWGPEQLY
HHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHH
ARMLEGLPRLAAVLTASLQNGRLRHYLMTVVGGAVGLMCLALISGPASLPTPQRPDGGLH
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
EWLTAAVILGGALMAATTRSRLAAVAALGTVGYGVALIYIIFGAPDLAMTQFCIETLSII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
MFVLVLYRLPRFTPLSSPLSRLRDLLVSLSIGCAMGLLVLMAVSRPMFPHIGDWFLRQSL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
PAGHGRNVVNVILVDFRALDTLGEITVLAVAALGVYGLLKKRSGEDS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377; 10198001; 11356194 [H]