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The map label for this gene is lon [H]

Identifier: 118581608

GI number: 118581608

Start: 3523549

End: 3525864

Strand: Direct

Name: lon [H]

Synonym: Ppro_3207

Alternate gene names: 118581608

Gene position: 3523549-3525864 (Clockwise)

Preceding gene: 118581607

Following gene: 118581609

Centisome position: 87.91

GC content: 63.04

Gene sequence:

>2316_bases
ATGCCCTACACCGACATGGAACTACCCGAAAAGCTCCCCGTTTTCCTGCAGAAAGAAATCGTCCCCTTCCCCTACATGAT
CTTCCCGCTCTTCGTGGACGAGCGTGACATGCTGACCTTCTCCATGGCCAGCACCCAGGAGAACCTGGTGGCGGTCGTCC
TGCGCAACGGCGATGCCACAGGCAACGGCCAGACACTCGATTACCGTTCCATCGGCACCCTCTGCCGGATCACCAAGATC
ACCAAGATCGGCGACACCAAGTTCAAGGTAACCATGGAGGGGCTGAACAGGCTGCGGATCCTGGAACTGGACACCTCCGG
GACGGTTCCCCAGGCCCACTGCGAATTGGTGCGGGAATTCGTCGAAAAGGGCATGGTCTCCGACGCCCTGGTGCAAAGCC
TGAACGCCCTCTTGAAGATCTCCCTCTCCCACGGCAAGCCGCTGCCCGACGACGTGATGAAGATGATCGATTACATCGAC
AACCCGGCCCGCCTCTCGGACCTGGTGGCACTGTACGTCAACCTGCCGCTGGAGGGGCTCCAGGAGCTGCTGGAAACCAC
CGATCCCCTGGAGCGACTCAAGAAGGTCTACGTCTACCTGACCAACGAGGTCCAGCGCCTGCAGGTCAAGAGCGAGATCA
ACACCGAGGTCAACCGCAAGGTCGGCAAGAACCAGAAGGAATACATCCTGCGCGAGCAGATGAAGCATATCCAGGACGAA
CTGGGCGAGGAGGATGCCCGCACCGCGGATATGAACGACCTACGCAAACGCATCGAAGAGGCCGGCCTTCCCGAGGATGT
GCACAAGATAGCCGTCAAGGAGCTGAAACGGCTGGAGCGCATCAACCAGGCCTCCCCCGAGTACACCGTGTCGCGCACCT
ACCTGGACTACCTGGCCGGCATGCCCTGGAACAGCTCCACCATTGACAGTCTGGACATCATCAGGGCCGAGGAGATCCTC
AACGAGGACCACTACGACCTGAAGAAGATCAAGGAGCGCATCCTGGAGTTCCTGGCGGTACGCTCGCTGAAGGACGACAT
GAAGGGGCCGGTGCTCTGCTTCGTCGGCCCGCCGGGCGTGGGCAAGACCAGCCTGGGCAAGTCCATCGCCCGCTCCCTGG
GCAGAAAGTTCGTGCGCATCTCCCTGGGCGGCATGCGGGACGAGGCCGAGATCCGCGGCCACCGCCGCACCTACATCGGC
GCGCTCCCCGGCCGGATCATCAAGGAGATCTTCCGCTGCGGCAGCAACAACCCGGTGTTCATGCTGGACGAGATCGACAA
GCTGGGCCAGGACTTCCGCGGCGACCCGGCCTCGGCGCTCCTTGAGGTGCTGGACCCGGAGCAGAACTTCTCTTTCCAGG
ACCACTACCTGGACGTCCCCTTCGACCTGTCCAAGGTCATGTTCATCACCACCGCCAACCAGCTGGACCCGATCCCCGGC
CCGCTCAAGGACAGGATGGAAGTCATCCGCCTGGCCGGGTACAGCACCGAGGAGAAGCTGCACATCGCCCGCAACTTCAT
CGTCAGGCGCGAGATCGAAGAGAACGGGCTGAAGGAGATGCAGCCAGAGTTCCTGGACAACGCCATCGTCAAGATCGTCT
CCGACTACACCAGGGAGGCGGGAGTGCGCAACATGCAGCGCACCATCGCCACCATCTGCCGCAAGGTGGCCAAGGAGATC
ACCCAGAAGAAGCCGCTGCGCACCCCCATAACCCCCGAGGTGGTGGCGGAACTGCTGGGGCCGCGCAAGTTCCACAATGA
AGTGGCTGCCGAGAACGACCGCATCGGCGTGGTCACCGGCATGGCCTGGACCGAGTCCGGCGGCGACATCCTCTTTGTGG
AGGTCACCAGCATGCCGGGCAAGGCGGAGCTGATCCTGACCGGCTCCCTGGGAGACGTGATGAAGGAGTCTGCCCGGGCG
GCCCTCTCCTACATCGAGGCCCATGCGGTCGATTTCGGCATCGAGCCATCCGCCTTCGAGAACCGGGGCATCCACGTCCA
TGTCCCCTCCGGTGCCATCCCCAAGGACGGCCCCTCTGCCGGGGTGACCATCGTCACGGCACTGGTGTCGCTTTTGACCG
GAAAGCCGGCCAGGCGCGACGTGGCCATGACCGGCGAGATCACCCTCACCGGCCGTGTCCTGGCCATCGGCGGGTTGAAG
GAGAAGGTGCTGGCGGCCCACCGGGCCGGGGTCAGGAAGATCGTGGCGCCGGAGCGCAACCGCGACGACCTGGAAGACAT
CCCGGACAACGTGCGCAACGATCTGGAATTCATCTTCATCAACGAGGCGCGCGAGGCACTGGAAGCCGCGCTCTGA

Upstream 100 bases:

>100_bases
CCCGCATACTGACGGGAACCAGCGTCATAATCGCCCCCGACAAACCGGTACACCGCATAACAATCAATCAAAACATTACA
TACGCACACCAGGACCCCCT

Downstream 100 bases:

>100_bases
TCCATGAACATCATCGTCGTCGACAGGGTGCTGATCCGCTTCTTCCACGGATTGCAGAGCTATTTCAGCCTGGGAGGGGG
GATGCTGGCACGCATCTTCC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 771; Mature: 770

Protein sequence:

>771_residues
MPYTDMELPEKLPVFLQKEIVPFPYMIFPLFVDERDMLTFSMASTQENLVAVVLRNGDATGNGQTLDYRSIGTLCRITKI
TKIGDTKFKVTMEGLNRLRILELDTSGTVPQAHCELVREFVEKGMVSDALVQSLNALLKISLSHGKPLPDDVMKMIDYID
NPARLSDLVALYVNLPLEGLQELLETTDPLERLKKVYVYLTNEVQRLQVKSEINTEVNRKVGKNQKEYILREQMKHIQDE
LGEEDARTADMNDLRKRIEEAGLPEDVHKIAVKELKRLERINQASPEYTVSRTYLDYLAGMPWNSSTIDSLDIIRAEEIL
NEDHYDLKKIKERILEFLAVRSLKDDMKGPVLCFVGPPGVGKTSLGKSIARSLGRKFVRISLGGMRDEAEIRGHRRTYIG
ALPGRIIKEIFRCGSNNPVFMLDEIDKLGQDFRGDPASALLEVLDPEQNFSFQDHYLDVPFDLSKVMFITTANQLDPIPG
PLKDRMEVIRLAGYSTEEKLHIARNFIVRREIEENGLKEMQPEFLDNAIVKIVSDYTREAGVRNMQRTIATICRKVAKEI
TQKKPLRTPITPEVVAELLGPRKFHNEVAAENDRIGVVTGMAWTESGGDILFVEVTSMPGKAELILTGSLGDVMKESARA
ALSYIEAHAVDFGIEPSAFENRGIHVHVPSGAIPKDGPSAGVTIVTALVSLLTGKPARRDVAMTGEITLTGRVLAIGGLK
EKVLAAHRAGVRKIVAPERNRDDLEDIPDNVRNDLEFIFINEAREALEAAL

Sequences:

>Translated_771_residues
MPYTDMELPEKLPVFLQKEIVPFPYMIFPLFVDERDMLTFSMASTQENLVAVVLRNGDATGNGQTLDYRSIGTLCRITKI
TKIGDTKFKVTMEGLNRLRILELDTSGTVPQAHCELVREFVEKGMVSDALVQSLNALLKISLSHGKPLPDDVMKMIDYID
NPARLSDLVALYVNLPLEGLQELLETTDPLERLKKVYVYLTNEVQRLQVKSEINTEVNRKVGKNQKEYILREQMKHIQDE
LGEEDARTADMNDLRKRIEEAGLPEDVHKIAVKELKRLERINQASPEYTVSRTYLDYLAGMPWNSSTIDSLDIIRAEEIL
NEDHYDLKKIKERILEFLAVRSLKDDMKGPVLCFVGPPGVGKTSLGKSIARSLGRKFVRISLGGMRDEAEIRGHRRTYIG
ALPGRIIKEIFRCGSNNPVFMLDEIDKLGQDFRGDPASALLEVLDPEQNFSFQDHYLDVPFDLSKVMFITTANQLDPIPG
PLKDRMEVIRLAGYSTEEKLHIARNFIVRREIEENGLKEMQPEFLDNAIVKIVSDYTREAGVRNMQRTIATICRKVAKEI
TQKKPLRTPITPEVVAELLGPRKFHNEVAAENDRIGVVTGMAWTESGGDILFVEVTSMPGKAELILTGSLGDVMKESARA
ALSYIEAHAVDFGIEPSAFENRGIHVHVPSGAIPKDGPSAGVTIVTALVSLLTGKPARRDVAMTGEITLTGRVLAIGGLK
EKVLAAHRAGVRKIVAPERNRDDLEDIPDNVRNDLEFIFINEAREALEAAL
>Mature_770_residues
PYTDMELPEKLPVFLQKEIVPFPYMIFPLFVDERDMLTFSMASTQENLVAVVLRNGDATGNGQTLDYRSIGTLCRITKIT
KIGDTKFKVTMEGLNRLRILELDTSGTVPQAHCELVREFVEKGMVSDALVQSLNALLKISLSHGKPLPDDVMKMIDYIDN
PARLSDLVALYVNLPLEGLQELLETTDPLERLKKVYVYLTNEVQRLQVKSEINTEVNRKVGKNQKEYILREQMKHIQDEL
GEEDARTADMNDLRKRIEEAGLPEDVHKIAVKELKRLERINQASPEYTVSRTYLDYLAGMPWNSSTIDSLDIIRAEEILN
EDHYDLKKIKERILEFLAVRSLKDDMKGPVLCFVGPPGVGKTSLGKSIARSLGRKFVRISLGGMRDEAEIRGHRRTYIGA
LPGRIIKEIFRCGSNNPVFMLDEIDKLGQDFRGDPASALLEVLDPEQNFSFQDHYLDVPFDLSKVMFITTANQLDPIPGP
LKDRMEVIRLAGYSTEEKLHIARNFIVRREIEENGLKEMQPEFLDNAIVKIVSDYTREAGVRNMQRTIATICRKVAKEIT
QKKPLRTPITPEVVAELLGPRKFHNEVAAENDRIGVVTGMAWTESGGDILFVEVTSMPGKAELILTGSLGDVMKESARAA
LSYIEAHAVDFGIEPSAFENRGIHVHVPSGAIPKDGPSAGVTIVTALVSLLTGKPARRDVAMTGEITLTGRVLAIGGLKE
KVLAAHRAGVRKIVAPERNRDDLEDIPDNVRNDLEFIFINEAREALEAAL

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=837, Percent_Identity=39.0681003584229, Blast_Score=564, Evalue=1e-160,
Organism=Homo sapiens, GI21396489, Length=623, Percent_Identity=43.4991974317817, Blast_Score=533, Evalue=1e-151,
Organism=Escherichia coli, GI1786643, Length=763, Percent_Identity=46.264744429882, Blast_Score=685, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=685, Percent_Identity=39.7080291970803, Blast_Score=489, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17556486, Length=521, Percent_Identity=42.2264875239923, Blast_Score=449, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6319449, Length=658, Percent_Identity=41.9452887537994, Blast_Score=506, Evalue=1e-144,
Organism=Drosophila melanogaster, GI221513036, Length=616, Percent_Identity=44.9675324675325, Blast_Score=537, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24666867, Length=616, Percent_Identity=44.9675324675325, Blast_Score=536, Evalue=1e-152,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 86375; Mature: 86244

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYTDMELPEKLPVFLQKEIVPFPYMIFPLFVDERDMLTFSMASTQENLVAVVLRNGDAT
CCCCCCCCCCHHHHHHHHHCCCCCCEEHEEEECCCCCEEEEHHCCCCCEEEEEEECCCCC
GNGQTLDYRSIGTLCRITKITKIGDTKFKVTMEGLNRLRILELDTSGTVPQAHCELVREF
CCCCEEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHH
VEKGMVSDALVQSLNALLKISLSHGKPLPDDVMKMIDYIDNPARLSDLVALYVNLPLEGL
HHCCCHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHH
QELLETTDPLERLKKVYVYLTNEVQRLQVKSEINTEVNRKVGKNQKEYILREQMKHIQDE
HHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LGEEDARTADMNDLRKRIEEAGLPEDVHKIAVKELKRLERINQASPEYTVSRTYLDYLAG
HCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
MPWNSSTIDSLDIIRAEEILNEDHYDLKKIKERILEFLAVRSLKDDMKGPVLCFVGPPGV
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GKTSLGKSIARSLGRKFVRISLGGMRDEAEIRGHRRTYIGALPGRIIKEIFRCGSNNPVF
CHHHHHHHHHHHHHHHEEEEECCCCCCHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCEE
MLDEIDKLGQDFRGDPASALLEVLDPEQNFSFQDHYLDVPFDLSKVMFITTANQLDPIPG
EEHHHHHHCHHCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCCCCEEEEEECCCCCCCCC
PLKDRMEVIRLAGYSTEEKLHIARNFIVRREIEENGLKEMQPEFLDNAIVKIVSDYTREA
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHH
GVRNMQRTIATICRKVAKEITQKKPLRTPITPEVVAELLGPRKFHNEVAAENDRIGVVTG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCEEEEEE
MAWTESGGDILFVEVTSMPGKAELILTGSLGDVMKESARAALSYIEAHAVDFGIEPSAFE
EEEECCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NRGIHVHVPSGAIPKDGPSAGVTIVTALVSLLTGKPARRDVAMTGEITLTGRVLAIGGLK
CCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECEEEEECEEEEECCHH
EKVLAAHRAGVRKIVAPERNRDDLEDIPDNVRNDLEFIFINEAREALEAAL
HHHHHHHHHCHHHHCCCCCCCCHHHHCCHHHHCCCEEEEEHHHHHHHHHCC
>Mature Secondary Structure 
PYTDMELPEKLPVFLQKEIVPFPYMIFPLFVDERDMLTFSMASTQENLVAVVLRNGDAT
CCCCCCCCCHHHHHHHHHCCCCCCEEHEEEECCCCCEEEEHHCCCCCEEEEEEECCCCC
GNGQTLDYRSIGTLCRITKITKIGDTKFKVTMEGLNRLRILELDTSGTVPQAHCELVREF
CCCCEEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHH
VEKGMVSDALVQSLNALLKISLSHGKPLPDDVMKMIDYIDNPARLSDLVALYVNLPLEGL
HHCCCHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHH
QELLETTDPLERLKKVYVYLTNEVQRLQVKSEINTEVNRKVGKNQKEYILREQMKHIQDE
HHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LGEEDARTADMNDLRKRIEEAGLPEDVHKIAVKELKRLERINQASPEYTVSRTYLDYLAG
HCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
MPWNSSTIDSLDIIRAEEILNEDHYDLKKIKERILEFLAVRSLKDDMKGPVLCFVGPPGV
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GKTSLGKSIARSLGRKFVRISLGGMRDEAEIRGHRRTYIGALPGRIIKEIFRCGSNNPVF
CHHHHHHHHHHHHHHHEEEEECCCCCCHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCEE
MLDEIDKLGQDFRGDPASALLEVLDPEQNFSFQDHYLDVPFDLSKVMFITTANQLDPIPG
EEHHHHHHCHHCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCCCCEEEEEECCCCCCCCC
PLKDRMEVIRLAGYSTEEKLHIARNFIVRREIEENGLKEMQPEFLDNAIVKIVSDYTREA
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHH
GVRNMQRTIATICRKVAKEITQKKPLRTPITPEVVAELLGPRKFHNEVAAENDRIGVVTG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCEEEEEE
MAWTESGGDILFVEVTSMPGKAELILTGSLGDVMKESARAALSYIEAHAVDFGIEPSAFE
EEEECCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NRGIHVHVPSGAIPKDGPSAGVTIVTALVSLLTGKPARRDVAMTGEITLTGRVLAIGGLK
CCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECEEEEECEEEEECCHH
EKVLAAHRAGVRKIVAPERNRDDLEDIPDNVRNDLEFIFINEAREALEAAL
HHHHHHHHHCHHHHCCCCCCCCHHHHCCHHHHCCCEEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA