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The map label for this gene is degS [H]

Identifier: 118581563

GI number: 118581563

Start: 3471347

End: 3472492

Strand: Direct

Name: degS [H]

Synonym: Ppro_3162

Alternate gene names: 118581563

Gene position: 3471347-3472492 (Clockwise)

Preceding gene: 118581562

Following gene: 118581564

Centisome position: 86.61

GC content: 61.61

Gene sequence:

>1146_bases
ATGGGCGAGAAAAAGCAGACAGCAGGCCGGTCATCCTGTTCGGTGGGGGATTTCTTTCGACTCGCCTGCGAAGAGCATGG
CGCGGCGATGCTCCTGGTCGATCCGGCACATGGCGCCATCGTCAGAGCCAACCAGCAAGCCTGTGTCCTCCTGGGAGAGA
CCGGTTCAGAGTTGGAGGGAAAGGGAATCACGGATATTTTCCTGCCGAATGGGGATATCAGTCCCCCCCGTGACCTCGAA
ACCAATCGCACCGGCCTGCGCAGAGACACAAACGGCGAGGAGCGACCGATTGAGATCCTGCCCCGACGCCTGCCACTGCG
GGAGGGAGACATCCTCTTCTGCGTGCTGCGCGACATGACGGAGCCGACCGGGTTTCGGCATGAACGGGCGGAGCAGGATA
ACGTCAGGCGCCAGCTGGAAATCGTCGTGGAGGAGAGGACAGGGCAGCTGAACGAAACCATGGAGGCACTCAGGCAGGAA
ACAGCCAGACGCCAGCAGATCGAAACCAATGTGACCACCATGCGGGAAAACCTGGAAAACCAGGAACGCGCGAGGGTGGC
CCGCGATATCCACGACGGCATCGGCCAGACCCTGCAGGCGATAAAACTGCAGCTCAAGATACGTCAGGCCCGCTGCAGGG
AAGGAGAGCCGTGCGGCGGTCAGGCACTGAACGAGATTATCGGGGAGCTGACGTCGGCCGCCACGGAACTGCGTGAAATT
ATTTTGGCTCTACGGCCGCTGTTCCTGGAGGACACCGACCTGGACCTGGCGGTCAGGTCACTGTGCGAGCGGAGCGCGAA
ACGGACCGGCCTTGACGTGCGGGCGGAGTGTCAGGGCTCATTCCGCGGTCTCGGTTCCTCCTTCAAACTCTCTATCTTCC
GCATCTGCCAGGAGGCACTCACCAACATCGTCAAGCATTCCGGTTGCCGTTCGGCACTCATCCGCCTGGAACGCGAGCCG
CATACCATGCGCATCACCATCCGTGACGACGGCAGAGGAGGGGTCTCCTGCCCGACCATCATCAGCCAGGAAGGATCGGG
ACTGGCTATCATGCGCGAACGGGCCGAACTTCTGGGCGGCGCTTTATCCGTCATCTCGCCACCCGGCATGGGCACCGCCA
TCACCGTGGAGGTACCGTTGCAATGA

Upstream 100 bases:

>100_bases
CGGATACCCAACAGGGAAAAACCATGGTATGTATCCAGCGCTGAGTTCATCGCGCCACAGGGGCGCGCCACGGTTCACAC
AACTTCCATCAGGTGAAGGC

Downstream 100 bases:

>100_bases
TCCGGGTTCTCATCGCCGACGACCACGTCATGTTCCGCCAGGGACTCATCAACCTGCTGACAACCGCTGAAGACATCCAT
ATCGCCGCCGAATGCGGCGA

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MGEKKQTAGRSSCSVGDFFRLACEEHGAAMLLVDPAHGAIVRANQQACVLLGETGSELEGKGITDIFLPNGDISPPRDLE
TNRTGLRRDTNGEERPIEILPRRLPLREGDILFCVLRDMTEPTGFRHERAEQDNVRRQLEIVVEERTGQLNETMEALRQE
TARRQQIETNVTTMRENLENQERARVARDIHDGIGQTLQAIKLQLKIRQARCREGEPCGGQALNEIIGELTSAATELREI
ILALRPLFLEDTDLDLAVRSLCERSAKRTGLDVRAECQGSFRGLGSSFKLSIFRICQEALTNIVKHSGCRSALIRLEREP
HTMRITIRDDGRGGVSCPTIISQEGSGLAIMRERAELLGGALSVISPPGMGTAITVEVPLQ

Sequences:

>Translated_381_residues
MGEKKQTAGRSSCSVGDFFRLACEEHGAAMLLVDPAHGAIVRANQQACVLLGETGSELEGKGITDIFLPNGDISPPRDLE
TNRTGLRRDTNGEERPIEILPRRLPLREGDILFCVLRDMTEPTGFRHERAEQDNVRRQLEIVVEERTGQLNETMEALRQE
TARRQQIETNVTTMRENLENQERARVARDIHDGIGQTLQAIKLQLKIRQARCREGEPCGGQALNEIIGELTSAATELREI
ILALRPLFLEDTDLDLAVRSLCERSAKRTGLDVRAECQGSFRGLGSSFKLSIFRICQEALTNIVKHSGCRSALIRLEREP
HTMRITIRDDGRGGVSCPTIISQEGSGLAIMRERAELLGGALSVISPPGMGTAITVEVPLQ
>Mature_380_residues
GEKKQTAGRSSCSVGDFFRLACEEHGAAMLLVDPAHGAIVRANQQACVLLGETGSELEGKGITDIFLPNGDISPPRDLET
NRTGLRRDTNGEERPIEILPRRLPLREGDILFCVLRDMTEPTGFRHERAEQDNVRRQLEIVVEERTGQLNETMEALRQET
ARRQQIETNVTTMRENLENQERARVARDIHDGIGQTLQAIKLQLKIRQARCREGEPCGGQALNEIIGELTSAATELREII
LALRPLFLEDTDLDLAVRSLCERSAKRTGLDVRAECQGSFRGLGSSFKLSIFRICQEALTNIVKHSGCRSALIRLEREPH
TMRITIRDDGRGGVSCPTIISQEGSGLAIMRERAELLGGALSVISPPGMGTAITVEVPLQ

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=200, Percent_Identity=30.5, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787474, Length=258, Percent_Identity=28.2945736434109, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87082311, Length=235, Percent_Identity=31.063829787234, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 42135; Mature: 42004

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEKKQTAGRSSCSVGDFFRLACEEHGAAMLLVDPAHGAIVRANQQACVLLGETGSELEG
CCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCEEEEECCCCCCCCC
KGITDIFLPNGDISPPRDLETNRTGLRRDTNGEERPIEILPRRLPLREGDILFCVLRDMT
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEEHHCC
EPTGFRHERAEQDNVRRQLEIVVEERTGQLNETMEALRQETARRQQIETNVTTMRENLEN
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QERARVARDIHDGIGQTLQAIKLQLKIRQARCREGEPCGGQALNEIIGELTSAATELREI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ILALRPLFLEDTDLDLAVRSLCERSAKRTGLDVRAECQGSFRGLGSSFKLSIFRICQEAL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCHHHHHHHHHHHHHH
TNIVKHSGCRSALIRLEREPHTMRITIRDDGRGGVSCPTIISQEGSGLAIMRERAELLGG
HHHHHCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCEECCCCCCHHHHHHHHHHHHH
ALSVISPPGMGTAITVEVPLQ
HHHHCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
GEKKQTAGRSSCSVGDFFRLACEEHGAAMLLVDPAHGAIVRANQQACVLLGETGSELEG
CCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCEEEEECCCCCCCCC
KGITDIFLPNGDISPPRDLETNRTGLRRDTNGEERPIEILPRRLPLREGDILFCVLRDMT
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEEHHCC
EPTGFRHERAEQDNVRRQLEIVVEERTGQLNETMEALRQETARRQQIETNVTTMRENLEN
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QERARVARDIHDGIGQTLQAIKLQLKIRQARCREGEPCGGQALNEIIGELTSAATELREI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ILALRPLFLEDTDLDLAVRSLCERSAKRTGLDVRAECQGSFRGLGSSFKLSIFRICQEAL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCHHHHHHHHHHHHHH
TNIVKHSGCRSALIRLEREPHTMRITIRDDGRGGVSCPTIISQEGSGLAIMRERAELLGG
HHHHHCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCEECCCCCCHHHHHHHHHHHHH
ALSVISPPGMGTAITVEVPLQ
HHHHCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]