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The map label for this gene is dhmA [H]

Identifier: 118581505

GI number: 118581505

Start: 3404821

End: 3405711

Strand: Direct

Name: dhmA [H]

Synonym: Ppro_3104

Alternate gene names: 118581505

Gene position: 3404821-3405711 (Clockwise)

Preceding gene: 118581504

Following gene: 118581506

Centisome position: 84.95

GC content: 65.66

Gene sequence:

>891_bases
ATGGTGAGCGATCCCCTGAAGCGGCACTACCCCTTTCAGAGCCACCATCTGGACCTGGACGGCCTGGCCTACCACTACCT
GGACGAGGGGAGCGGTCCAGCGGTGGTCATGCTCCACGGCAACCCCTCCTGGTCGTTCTACTACCGCAACCTGGTCAGGG
AGCTTTCCGCCAGCTACCGCTGCATCGTTCCGGACCACATCGGCTGCGGCCTTTCCGACAAGCCGGGTGACGAGCGCTAC
GACTACACCCTGGCCCGGCGGGTGCAGGACCTTGAGCGGCTGCTGGACCACCTGGCCATCAGGGACAACATCACCCTGGT
GGTTCACGACTGGGGCGGCATGATCGGCATGGCCTACGCAGTGGCCCACCCCAGGGCCATCCGACGGCTGGTGGTGATGA
ACACTGCCGCCTTCCAGCTCCCCCCGGGGAAACCATTCCCCCTGGCGCTCAGGATCTGCCGCGACACCCGCCTGGGGAGC
CTGCTGGTGCGCGGGTTCAACGCCTTCAGCCTGGCCGCCTCCTTCGTGGGCTGCAAACGAAATCCCCTGTCCCGAGAGCT
GCGCCGGCTCTACCGCCTCCCCTACGGCTCCTGGAACGACCGCATCGCCACCCTGCGCTTCGTCCAGGACATTCCGCTCA
AGCCCGGGGACCGCGGCTTTGATCTGGTGAACAGTGTTGACCGGGGGCTGGACCAGTTCCGCGACCTGCCGCTGCTCTTG
GTCTGGGGCGAGCGGGACTTTGTCTTCGACCGCCACTTCCTGGCCGAATGGCGGCGCCGTTTTCCGCAGGCAGAGGTCCA
CAGCTATGCCGATGCCGGCCACTACATCCTGGAGGACATGAAGGACGAGGTGGTGCCGATCATCTCCGCGTTCCTCAAAC
GGACGGAGTGA

Upstream 100 bases:

>100_bases
CCGCTGCCCTGGCGGCCGAGCGGGACATTCTGCTCACCGGCGACCGGGTGGCTCTGCTGGGCATCGGCAGCGGCCTCAAC
TGCCTGATGCTGGGAGTGGA

Downstream 100 bases:

>100_bases
CCCGCGGCCAGGGCCCATTGCCCACGGCAGGCGGAGAGCAAACAAGCCATAGATACATATTGATTTCTAGCAAACAGGAG
ACACCGATCATGGCCAACAG

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MVSDPLKRHYPFQSHHLDLDGLAYHYLDEGSGPAVVMLHGNPSWSFYYRNLVRELSASYRCIVPDHIGCGLSDKPGDERY
DYTLARRVQDLERLLDHLAIRDNITLVVHDWGGMIGMAYAVAHPRAIRRLVVMNTAAFQLPPGKPFPLALRICRDTRLGS
LLVRGFNAFSLAASFVGCKRNPLSRELRRLYRLPYGSWNDRIATLRFVQDIPLKPGDRGFDLVNSVDRGLDQFRDLPLLL
VWGERDFVFDRHFLAEWRRRFPQAEVHSYADAGHYILEDMKDEVVPIISAFLKRTE

Sequences:

>Translated_296_residues
MVSDPLKRHYPFQSHHLDLDGLAYHYLDEGSGPAVVMLHGNPSWSFYYRNLVRELSASYRCIVPDHIGCGLSDKPGDERY
DYTLARRVQDLERLLDHLAIRDNITLVVHDWGGMIGMAYAVAHPRAIRRLVVMNTAAFQLPPGKPFPLALRICRDTRLGS
LLVRGFNAFSLAASFVGCKRNPLSRELRRLYRLPYGSWNDRIATLRFVQDIPLKPGDRGFDLVNSVDRGLDQFRDLPLLL
VWGERDFVFDRHFLAEWRRRFPQAEVHSYADAGHYILEDMKDEVVPIISAFLKRTE
>Mature_296_residues
MVSDPLKRHYPFQSHHLDLDGLAYHYLDEGSGPAVVMLHGNPSWSFYYRNLVRELSASYRCIVPDHIGCGLSDKPGDERY
DYTLARRVQDLERLLDHLAIRDNITLVVHDWGGMIGMAYAVAHPRAIRRLVVMNTAAFQLPPGKPFPLALRICRDTRLGS
LLVRGFNAFSLAASFVGCKRNPLSRELRRLYRLPYGSWNDRIATLRFVQDIPLKPGDRGFDLVNSVDRGLDQFRDLPLLL
VWGERDFVFDRHFLAEWRRRFPQAEVHSYADAGHYILEDMKDEVVPIISAFLKRTE

Specific function: Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. Has a broad substrate specificity, which includes mono- and di- chlorinated

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the haloalkane dehalogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI218777837, Length=303, Percent_Identity=25.4125412541254, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI218777840, Length=328, Percent_Identity=25.609756097561, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI13376164, Length=328, Percent_Identity=25.609756097561, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554012, Length=306, Percent_Identity=21.5686274509804, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562298, Length=121, Percent_Identity=30.5785123966942, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324392, Length=270, Percent_Identity=24.8148148148148, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.8.1.5 [H]

Molecular weight: Translated: 34120; Mature: 34120

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSDPLKRHYPFQSHHLDLDGLAYHYLDEGSGPAVVMLHGNPSWSFYYRNLVRELSASYR
CCCCCHHHCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCCE
CIVPDHIGCGLSDKPGDERYDYTLARRVQDLERLLDHLAIRDNITLVVHDWGGMIGMAYA
EECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
VAHPRAIRRLVVMNTAAFQLPPGKPFPLALRICRDTRLGSLLVRGFNAFSLAASFVGCKR
HHCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHCCCC
NPLSRELRRLYRLPYGSWNDRIATLRFVQDIPLKPGDRGFDLVNSVDRGLDQFRDLPLLL
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
VWGERDFVFDRHFLAEWRRRFPQAEVHSYADAGHYILEDMKDEVVPIISAFLKRTE
EECCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVSDPLKRHYPFQSHHLDLDGLAYHYLDEGSGPAVVMLHGNPSWSFYYRNLVRELSASYR
CCCCCHHHCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCCE
CIVPDHIGCGLSDKPGDERYDYTLARRVQDLERLLDHLAIRDNITLVVHDWGGMIGMAYA
EECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
VAHPRAIRRLVVMNTAAFQLPPGKPFPLALRICRDTRLGSLLVRGFNAFSLAASFVGCKR
HHCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHCCCC
NPLSRELRRLYRLPYGSWNDRIATLRFVQDIPLKPGDRGFDLVNSVDRGLDQFRDLPLLL
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
VWGERDFVFDRHFLAEWRRRFPQAEVHSYADAGHYILEDMKDEVVPIISAFLKRTE
EECCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12147465 [H]