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The map label for this gene is purC

Identifier: 118581469

GI number: 118581469

Start: 3356037

End: 3356927

Strand: Direct

Name: purC

Synonym: Ppro_3066

Alternate gene names: 118581469

Gene position: 3356037-3356927 (Clockwise)

Preceding gene: 118581468

Following gene: 118581470

Centisome position: 83.73

GC content: 61.84

Gene sequence:

>891_bases
ATGTCACACCCCGTCATGCACACCGATTTTCCCGGGCTGAAACTTTTGGCCCGCGGCAAGGTGCGAGACATCTACGACCT
GGGAGAAACGCTGCTGCTGGTCACCTCCGACCGGATCTCGGCTTTTGACGTCATCATGAACGAACCGATACCGGACAAGG
GCTTTGTCTTGACCGAGATATCGTCCTTCTGGTTCCGACAGATGGAAGACATCGTCAGCAACCACATCATATCCACCGAC
GTGGACGAATTCCCGGCCGCCTGCCGTCCCCATGCCGACCTGCTCAGGGGCCGCTCCATGCTGGTGAAAAAGGCGCGCCC
CCTGCCGGTGGAGTGCATCGTGCGCGGCTACGTCTCCGGTTCCGGCTGGAAAGAGTATCAGAGCAGCGGCAGCATCTGCG
GCATTTCGCTTCCCCCTGGCCTGAGGGAGTCGGACCGCCTGCCGGAGCCGATCTTCACCCCCTCCACCAAGGCCGAACTG
GGCACCCATGACGAGAACATCTCCTTCGAGCGGATGACTGAACTGTGCGGCCGCGAACTGGCCGAACAGGCCCGCGACTA
CACCCTGAAGATATACGGCCGCGCCCGCGAACTGGCCGACCAGAAGGGGATCATCATCGCCGACACCAAGTTCGAATTCG
GCGTCTTCGAGGGGGAGTTGATCATCATCGACGAATGCATGACCCCCGATTCCAGCCGTTTCTGGCTGAAGGACGACTAC
CGGCCGGGCGGGCCGCAGCCCAGCTTTGACAAGCAGTTCCTGCGCGATTATCTGGAGGGACTGGACTGGAACAAGACAGC
CCCGGCGCCGGCGCTCCCGGCGGAGATCATCGCCAAGACCGCCCAGATGTACCGCGAGGCGCTCTCCCGCATCACCGGCA
TCTCTCTGTAA

Upstream 100 bases:

>100_bases
AAACAGCAGGAGGCTCTCACAACCTGGGTGAAACAGTTGCGAGGCAAGGCAAAGATCGAAATCAATCAGGCACTCGTCGC
CGACTAAACAGGAGAAACAT

Downstream 100 bases:

>100_bases
GAGCGTGTTCATGCAGCAAAAAAAGGCGAATCCCCCTGGGGTTTCGCCTTTTTTTGTGCCTCGTTCCCTTCCTGGCCACA
CTGGCGCTTCACCAATCCTG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MSHPVMHTDFPGLKLLARGKVRDIYDLGETLLLVTSDRISAFDVIMNEPIPDKGFVLTEISSFWFRQMEDIVSNHIISTD
VDEFPAACRPHADLLRGRSMLVKKARPLPVECIVRGYVSGSGWKEYQSSGSICGISLPPGLRESDRLPEPIFTPSTKAEL
GTHDENISFERMTELCGRELAEQARDYTLKIYGRARELADQKGIIIADTKFEFGVFEGELIIIDECMTPDSSRFWLKDDY
RPGGPQPSFDKQFLRDYLEGLDWNKTAPAPALPAEIIAKTAQMYREALSRITGISL

Sequences:

>Translated_296_residues
MSHPVMHTDFPGLKLLARGKVRDIYDLGETLLLVTSDRISAFDVIMNEPIPDKGFVLTEISSFWFRQMEDIVSNHIISTD
VDEFPAACRPHADLLRGRSMLVKKARPLPVECIVRGYVSGSGWKEYQSSGSICGISLPPGLRESDRLPEPIFTPSTKAEL
GTHDENISFERMTELCGRELAEQARDYTLKIYGRARELADQKGIIIADTKFEFGVFEGELIIIDECMTPDSSRFWLKDDY
RPGGPQPSFDKQFLRDYLEGLDWNKTAPAPALPAEIIAKTAQMYREALSRITGISL
>Mature_295_residues
SHPVMHTDFPGLKLLARGKVRDIYDLGETLLLVTSDRISAFDVIMNEPIPDKGFVLTEISSFWFRQMEDIVSNHIISTDV
DEFPAACRPHADLLRGRSMLVKKARPLPVECIVRGYVSGSGWKEYQSSGSICGISLPPGLRESDRLPEPIFTPSTKAELG
THDENISFERMTELCGRELAEQARDYTLKIYGRARELADQKGIIIADTKFEFGVFEGELIIIDECMTPDSSRFWLKDDYR
PGGPQPSFDKQFLRDYLEGLDWNKTAPAPALPAEIIAKTAQMYREALSRITGISL

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Escherichia coli, GI1788820, Length=253, Percent_Identity=30.4347826086957, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319326, Length=300, Percent_Identity=47.3333333333333, Blast_Score=271, Evalue=8e-74,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_PELPD (A1ATJ1)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902719.1
- ProteinModelPortal:   A1ATJ1
- SMR:   A1ATJ1
- STRING:   A1ATJ1
- GeneID:   4574111
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_3066
- eggNOG:   COG0152
- HOGENOM:   HBG555040
- OMA:   LTLMDEV
- PhylomeDB:   A1ATJ1
- ProtClustDB:   PRK13961
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 33306; Mature: 33175

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHPVMHTDFPGLKLLARGKVRDIYDLGETLLLVTSDRISAFDVIMNEPIPDKGFVLTEI
CCCCCCCCCCCCCEEECCCCHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCEEHHHH
SSFWFRQMEDIVSNHIISTDVDEFPAACRPHADLLRGRSMLVKKARPLPVECIVRGYVSG
HHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
SGWKEYQSSGSICGISLPPGLRESDRLPEPIFTPSTKAELGTHDENISFERMTELCGREL
CCHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AEQARDYTLKIYGRARELADQKGIIIADTKFEFGVFEGELIIIDECMTPDSSRFWLKDDY
HHHHHCEEEEEEECHHHHHCCCCEEEEECCEECEEECCCEEEEECCCCCCCCCEEEECCC
RPGGPQPSFDKQFLRDYLEGLDWNKTAPAPALPAEIIAKTAQMYREALSRITGISL
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SHPVMHTDFPGLKLLARGKVRDIYDLGETLLLVTSDRISAFDVIMNEPIPDKGFVLTEI
CCCCCCCCCCCCEEECCCCHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCEEHHHH
SSFWFRQMEDIVSNHIISTDVDEFPAACRPHADLLRGRSMLVKKARPLPVECIVRGYVSG
HHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
SGWKEYQSSGSICGISLPPGLRESDRLPEPIFTPSTKAELGTHDENISFERMTELCGREL
CCHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AEQARDYTLKIYGRARELADQKGIIIADTKFEFGVFEGELIIIDECMTPDSSRFWLKDDY
HHHHHCEEEEEEECHHHHHCCCCEEEEECCEECEEECCCEEEEECCCCCCCCCEEEECCC
RPGGPQPSFDKQFLRDYLEGLDWNKTAPAPALPAEIIAKTAQMYREALSRITGISL
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA