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The map label for this gene is hpt [H]

Identifier: 118581409

GI number: 118581409

Start: 3277461

End: 3278012

Strand: Reverse

Name: hpt [H]

Synonym: Ppro_3004

Alternate gene names: 118581409

Gene position: 3278012-3277461 (Counterclockwise)

Preceding gene: 118581410

Following gene: 118581408

Centisome position: 81.79

GC content: 62.86

Gene sequence:

>552_bases
ATGACGTTTGACGAGGCACGGCGCGTTCTGGACGAGGCAGACCTGCTGATGGGTGAGGAAGAAATCCAGGGGGCCATCGG
TCGCATGGCGGGCGAGATCACGGGGCGGTTGGCCGGCTCCAACCCGGTGGTACTTTGCATCATGAACGGCGGCCTGATCT
TCAGTGGCCAGCTTTTGCCCCGGCTGCACTTTCCCCTGGAGTTGGATTACGTCCATGCCACCCGTTACGGACAGGCCACC
TGGGGTGACCGGCTGAACTGGCACCGTAGGCCGCACCTGAACCTGGTCGGCAGGACGGTGCTGCTTCTGGACGATATCCT
GGACGAGGGGATCACCCTGGCCGCCATCATCGAGTACTGCCGCGGGATGGGGGCGCTTGAGGTGCTGACGGCGGTGCTGG
TGGAGAAGCTGCACAGCCGCAAGGTGACTCCCGGCATACGGGCCGATTTCACCGGCCTGGAAATCGGCGATCGTTTCCTG
TTCGGATACGGCCTGGACTACAAGGGGTACTGGCGCAACGCGCCCGGAATTTTTGCGGTGAAAGGGATGTGA

Upstream 100 bases:

>100_bases
AGATGTTCCCCCTGGCTGACGGGTATGGCCAGGTCGTTAGCTCCCCCGATCCCGGGGGGATTGAGCGGGTGGTGGGAGCG
GCACGAAAGGTGGAATTGAC

Downstream 100 bases:

>100_bases
GGCAGTGAAACGGTTCTTCCGCTTCGAGCGCTACAATACCAGCTTTCGTCAGGAAACTCTGGCCGGGGTGACCACCTTCC
TGACCATGGCCTACATTATC

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MTFDEARRVLDEADLLMGEEEIQGAIGRMAGEITGRLAGSNPVVLCIMNGGLIFSGQLLPRLHFPLELDYVHATRYGQAT
WGDRLNWHRRPHLNLVGRTVLLLDDILDEGITLAAIIEYCRGMGALEVLTAVLVEKLHSRKVTPGIRADFTGLEIGDRFL
FGYGLDYKGYWRNAPGIFAVKGM

Sequences:

>Translated_183_residues
MTFDEARRVLDEADLLMGEEEIQGAIGRMAGEITGRLAGSNPVVLCIMNGGLIFSGQLLPRLHFPLELDYVHATRYGQAT
WGDRLNWHRRPHLNLVGRTVLLLDDILDEGITLAAIIEYCRGMGALEVLTAVLVEKLHSRKVTPGIRADFTGLEIGDRFL
FGYGLDYKGYWRNAPGIFAVKGM
>Mature_182_residues
TFDEARRVLDEADLLMGEEEIQGAIGRMAGEITGRLAGSNPVVLCIMNGGLIFSGQLLPRLHFPLELDYVHATRYGQATW
GDRLNWHRRPHLNLVGRTVLLLDDILDEGITLAAIIEYCRGMGALEVLTAVLVEKLHSRKVTPGIRADFTGLEIGDRFLF
GYGLDYKGYWRNAPGIFAVKGM

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=163, Percent_Identity=30.6748466257669, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI87081689, Length=168, Percent_Identity=27.3809523809524, Blast_Score=74, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17510817, Length=171, Percent_Identity=27.4853801169591, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20343; Mature: 20212

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFDEARRVLDEADLLMGEEEIQGAIGRMAGEITGRLAGSNPVVLCIMNGGLIFSGQLLP
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCEEEECCCCC
RLHFPLELDYVHATRYGQATWGDRLNWHRRPHLNLVGRTVLLLDDILDEGITLAAIIEYC
EECCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
RGMGALEVLTAVLVEKLHSRKVTPGIRADFTGLEIGDRFLFGYGLDYKGYWRNAPGIFAV
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEE
KGM
CCC
>Mature Secondary Structure 
TFDEARRVLDEADLLMGEEEIQGAIGRMAGEITGRLAGSNPVVLCIMNGGLIFSGQLLP
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCEEEECCCCC
RLHFPLELDYVHATRYGQATWGDRLNWHRRPHLNLVGRTVLLLDDILDEGITLAAIIEYC
EECCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
RGMGALEVLTAVLVEKLHSRKVTPGIRADFTGLEIGDRFLFGYGLDYKGYWRNAPGIFAV
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEE
KGM
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]