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The map label for this gene is cobB

Identifier: 118581295

GI number: 118581295

Start: 3162243

End: 3163634

Strand: Reverse

Name: cobB

Synonym: Ppro_2890

Alternate gene names: 118581295

Gene position: 3163634-3162243 (Counterclockwise)

Preceding gene: 118581296

Following gene: 118581293

Centisome position: 78.93

GC content: 63.07

Gene sequence:

>1392_bases
ATGAGCATAAACGGCTTTCTGATAGCCGCTCCCCAGAGTGGCAGCGGCAAGACCACCATCTCCCTGGCCATCATGGCCGC
GCTCAGGCGGCGAGGGCTGGTGGTCGCGCCCTTCAAGTGCGGGCCGGATTTCATCGATCCCGGTTACCATCGCATGGCAA
GCGGCCGGGCTTCCATCAACCTGGATGGCTGGATGTGTCCGGAGTCGTTCGTGGCGGAAACCTTCCGTCTGCATGCGGAA
GCCGCCGACGTGGCTGTGATCGAGGCGGTCATGGGTCTCTTCGATGGGCTCGGGGCCTCCCCCCTGCAGGGAAGCAGCGC
CCAGATAGCCGCTATCTGCGGTGCTCCGGTGGTGCTGGTGGTCAATGCGCGCGGCATGGCGGCCAGTGCTGCGGCTCTTG
TCAAGGGGTTCGCCGAGTTCGATCCGGACGTCAGGTTGGCCGGGGTGATTTTCAATAACGTGGGTAGCGCTGGCCATGCC
GAATTGCTGGCCAGGGTCATGGCCAGCGCTCTGCCTGAAATCGCCCTGCTCGGCTGCATTCCGCGTGACGAGGCGCTGGC
GATTCCCTCCCGTCATCTGGGGCTGGTTACGGCGGAAGATAATCCTCTGCCGCCGGAATATCTGGATCGCCTGGCCGATC
TGGCTGAGAAGCACCTGGATCTGGCGGGACTGGCGGGCTTGAGGATTACCCCACGCTCGGTGGGGGCGTCTCTTTCTCGG
ACTAACGGGGGGGGGATGCTACCCGTGCGCATAGCCGTTGCCCGGGATGCGGCTTTCTGTTTTGTTTATCAGGACAATTT
GCGCCTGCTGCGGGAGGCCGGGGGAGAGTTGCTGTTCTTCTCCCCCCTGGCGGACGGCGCTCTTCCCGAGGGGATCAGTG
GCATCTACCTGCCGGGCGGCTATCCTGAGTTGTATGCCGAACGCCTGGCTGTCAACGTGCCTATGTTGGATGCCATACGC
GGCGCGGCGCGGGACGGTATGCCGTTGTATGCCGAATGCGGTGGTTTTATCTATCTGACCCGGGGGATGGAGGATTCCCA
GGGCGCTCCCCTTGCGGATTTTGCCGGCATTTTCCCGGTGCGGGCGCGCATGTTGCCGAAACGCAAGGCCCTGGGTTACC
GCCAGGTGGAGTGCCTGAGTGTCTCGATCCTGGGGCCTGCCGGTGAAACCGCCCGTGGCCACGAGTTCCACTACTCGGAG
ATCTGTGAAATGCCGGTGGATGTTACGCGCACCTACAGTGTGACGCGTCAGGGAGCTTTCCTTGGCCAGGAGGGGTACTG
TCTGTCCAACTGCCTGGCCTCCTACGTGCATCTGCATTTCGGCAGTAATCCCTGCCTTGCGCCATCCCTTGTGGCGGCAT
GCAGGAAGTTTGCTGCCACCCGCCGGTCGTAA

Upstream 100 bases:

>100_bases
AGCTGATCGGCCCGGTGGGCGGATTTCCTCGCGGGTATGACAAGGACGAGTTCCACCTGATAGCGTTCTTTCAGTATGGC
ATGACAAGGAGATCCCTGAG

Downstream 100 bases:

>100_bases
CGGCGGTCCGTCTGTTCTCGAACTGGCGTTATGTGCGACCCCTAATCGTACCCTCAATCAACTGAGCAGAAGGAGTAGTT
GTTACGTCTTTCATTCTGCC

Product: cobyrinic acid a,c-diamide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSINGFLIAAPQSGSGKTTISLAIMAALRRRGLVVAPFKCGPDFIDPGYHRMASGRASINLDGWMCPESFVAETFRLHAE
AADVAVIEAVMGLFDGLGASPLQGSSAQIAAICGAPVVLVVNARGMAASAAALVKGFAEFDPDVRLAGVIFNNVGSAGHA
ELLARVMASALPEIALLGCIPRDEALAIPSRHLGLVTAEDNPLPPEYLDRLADLAEKHLDLAGLAGLRITPRSVGASLSR
TNGGGMLPVRIAVARDAAFCFVYQDNLRLLREAGGELLFFSPLADGALPEGISGIYLPGGYPELYAERLAVNVPMLDAIR
GAARDGMPLYAECGGFIYLTRGMEDSQGAPLADFAGIFPVRARMLPKRKALGYRQVECLSVSILGPAGETARGHEFHYSE
ICEMPVDVTRTYSVTRQGAFLGQEGYCLSNCLASYVHLHFGSNPCLAPSLVAACRKFAATRRS

Sequences:

>Translated_463_residues
MSINGFLIAAPQSGSGKTTISLAIMAALRRRGLVVAPFKCGPDFIDPGYHRMASGRASINLDGWMCPESFVAETFRLHAE
AADVAVIEAVMGLFDGLGASPLQGSSAQIAAICGAPVVLVVNARGMAASAAALVKGFAEFDPDVRLAGVIFNNVGSAGHA
ELLARVMASALPEIALLGCIPRDEALAIPSRHLGLVTAEDNPLPPEYLDRLADLAEKHLDLAGLAGLRITPRSVGASLSR
TNGGGMLPVRIAVARDAAFCFVYQDNLRLLREAGGELLFFSPLADGALPEGISGIYLPGGYPELYAERLAVNVPMLDAIR
GAARDGMPLYAECGGFIYLTRGMEDSQGAPLADFAGIFPVRARMLPKRKALGYRQVECLSVSILGPAGETARGHEFHYSE
ICEMPVDVTRTYSVTRQGAFLGQEGYCLSNCLASYVHLHFGSNPCLAPSLVAACRKFAATRRS
>Mature_462_residues
SINGFLIAAPQSGSGKTTISLAIMAALRRRGLVVAPFKCGPDFIDPGYHRMASGRASINLDGWMCPESFVAETFRLHAEA
ADVAVIEAVMGLFDGLGASPLQGSSAQIAAICGAPVVLVVNARGMAASAAALVKGFAEFDPDVRLAGVIFNNVGSAGHAE
LLARVMASALPEIALLGCIPRDEALAIPSRHLGLVTAEDNPLPPEYLDRLADLAEKHLDLAGLAGLRITPRSVGASLSRT
NGGGMLPVRIAVARDAAFCFVYQDNLRLLREAGGELLFFSPLADGALPEGISGIYLPGGYPELYAERLAVNVPMLDAIRG
AARDGMPLYAECGGFIYLTRGMEDSQGAPLADFAGIFPVRARMLPKRKALGYRQVECLSVSILGPAGETARGHEFHYSEI
CEMPVDVTRTYSVTRQGAFLGQEGYCLSNCLASYVHLHFGSNPCLAPSLVAACRKFAATRRS

Specific function: Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1797

COG function: function code H; Cobyrinic acid a,c-diamide synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBB_PELPD (A1AT17)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902545.1
- ProteinModelPortal:   A1AT17
- STRING:   A1AT17
- GeneID:   4574770
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_2890
- eggNOG:   COG1797
- HOGENOM:   HBG634910
- OMA:   VFKCGPD
- ProtClustDB:   PRK01077
- HAMAP:   MF_00027
- InterPro:   IPR002586
- InterPro:   IPR004484
- InterPro:   IPR017929
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00379

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: NA

Molecular weight: Translated: 48880; Mature: 48749

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 333-333 ACT_SITE 437-437

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSINGFLIAAPQSGSGKTTISLAIMAALRRRGLVVAPFKCGPDFIDPGYHRMASGRASIN
CCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHCCCCEEE
LDGWMCPESFVAETFRLHAEAADVAVIEAVMGLFDGLGASPLQGSSAQIAAICGAPVVLV
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEEE
VNARGMAASAAALVKGFAEFDPDVRLAGVIFNNVGSAGHAELLARVMASALPEIALLGCI
EECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEHCCC
PRDEALAIPSRHLGLVTAEDNPLPPEYLDRLADLAEKHLDLAGLAGLRITPRSVGASLSR
CCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHCCCCEECHHHHCCCCCC
TNGGGMLPVRIAVARDAAFCFVYQDNLRLLREAGGELLFFSPLADGALPEGISGIYLPGG
CCCCCEEEEEEEEECCCEEEEEEECHHHHHHHCCCCEEEECCCCCCCCCCCCCEEECCCC
YPELYAERLAVNVPMLDAIRGAARDGMPLYAECGGFIYLTRGMEDSQGAPLADFAGIFPV
CHHHHHHHHHCCCCHHHHHHHHHCCCCCEEECCCCEEEEECCCCCCCCCCHHHHHHHHHH
RARMLPKRKALGYRQVECLSVSILGPAGETARGHEFHYSEICEMPVDVTRTYSVTRQGAF
HHHHCCHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCHHHHHCCCCCCHHEEHHHHCCCE
LGQEGYCLSNCLASYVHLHFGSNPCLAPSLVAACRKFAATRRS
ECCCCCHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SINGFLIAAPQSGSGKTTISLAIMAALRRRGLVVAPFKCGPDFIDPGYHRMASGRASIN
CCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHCCCCEEE
LDGWMCPESFVAETFRLHAEAADVAVIEAVMGLFDGLGASPLQGSSAQIAAICGAPVVLV
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEEE
VNARGMAASAAALVKGFAEFDPDVRLAGVIFNNVGSAGHAELLARVMASALPEIALLGCI
EECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEHCCC
PRDEALAIPSRHLGLVTAEDNPLPPEYLDRLADLAEKHLDLAGLAGLRITPRSVGASLSR
CCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHCCCCEECHHHHCCCCCC
TNGGGMLPVRIAVARDAAFCFVYQDNLRLLREAGGELLFFSPLADGALPEGISGIYLPGG
CCCCCEEEEEEEEECCCEEEEEEECHHHHHHHCCCCEEEECCCCCCCCCCCCCEEECCCC
YPELYAERLAVNVPMLDAIRGAARDGMPLYAECGGFIYLTRGMEDSQGAPLADFAGIFPV
CHHHHHHHHHCCCCHHHHHHHHHCCCCCEEECCCCEEEEECCCCCCCCCCHHHHHHHHHH
RARMLPKRKALGYRQVECLSVSILGPAGETARGHEFHYSEICEMPVDVTRTYSVTRQGAF
HHHHCCHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCHHHHHCCCCCCHHEEHHHHCCCE
LGQEGYCLSNCLASYVHLHFGSNPCLAPSLVAACRKFAATRRS
ECCCCCHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA