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The map label for this gene is polA [H]

Identifier: 118581241

GI number: 118581241

Start: 3100114

End: 3102795

Strand: Direct

Name: polA [H]

Synonym: Ppro_2835

Alternate gene names: 118581241

Gene position: 3100114-3102795 (Clockwise)

Preceding gene: 118581240

Following gene: 118581242

Centisome position: 77.35

GC content: 63.05

Gene sequence:

>2682_bases
ATGAGTCACGACGATACGCTCTACCTGGTCGACGGCTCGTCCTATATCTACCGGGCCTACTACGCCATCCGCCACCTCTC
CTCCCCCACGGGGCACCCCACCAACACCATCTATGGATTCACCCAGATGCTGCTGAAGCTCCTCAAGGAGCACCAGCCGA
GACATGTGGCAGTGGTTTTCGATGTGGGGAGAGAAACATTCCGCACCGAACTGTACCCCGACTACAAGGCCAACCGCGCC
GCATTGCCCGATGACCTGCGGGTTCAGATGGGGCCGATCCGCGACCTGGTGCGCGCCTTCAACATCCCGGCCCTGGAACT
GGCCGGCTTCGAGGCCGACGACATCATCGGCTGCCTGGCCGCCCGCTTCAGCGCCACCGGCGGCAGGGTGGTGATAGTCA
CCGGCGACAAGGATCTGATGCAGATCGTCACCGAAAGGGTGACCCTGCTGGACACCATGAAGGAGAAGCGCTCCGCCATC
ACCGACGTTATCGAGCGCTTCGGCGTGGAACCGCGCCTGGTAACGGACATCCTTGGCCTGGCCGGCGACGCGTCGGACAA
CATTCCCGGCGTGCCGGGCATCGGCGAGAAGACCGCCATGAAACTGATCAGAGAGTATGGTTCCCTGGACCAACTGCTTG
AACGCGCCTCCGAGGTCAAAGGAAAGAACGGCGAGAAGCTACGCGAGTTCCGCGACCAGGCCCTGCTGTCGCGCCGACTG
GCCACCATCAGATGCGACGTACCGATCCAGGTGGAACTGGAGGAGTTAGCCAGCCAGGAGCCGGACCGGGAGGCGCTGAA
CACCCTCTTCCGCCTGTACGGGTTCACCACCCTGATCAAGGAACTGACCGGTCGTTCCACCCTCTCCAGCGAAGGTTACT
GCACGGTCACAGCCCAGGAGGAGTTGGAGGAACTCGTCCATGCCCTGGAGAGGTCCGAAGAGTTCGCCATCGACCTGGAG
ACCACCAGCCTGGATCCCCGGGACGCGGAGATCGTCGGCCTCTCCTTCTCCTTCAGGGACCACCAGGCCTGGTATATCCC
GGTGGGGCACACAAGCGATGCCGGCCTCCAGCCGGGCCAACTCCCCCGCGACCTGGTGCTGGAGCGACTGCGCCCGCAGC
TGGAGAGCCCATCTCCCACCAAGATCGGCCAGAACATAAAGTTCGACATGCAGGTGCTGGCCACCAACGGCGTCTCACTG
AGCGGCATCCGCTTCGACACCATGCTGGCCTCCTATGTGCTCAACCCCTCCCGCCAGGGGCACGGACTTGACGCCCTGGC
CCTGGAGCACCTGGGCCACCGCATGATCAGCTACGCGGAAGTAACCGGCAGCGGCAAGACGCAGAAAAACTTCTCCCAGG
TGGAGATCGAAACAGCCTCGCGCTACGCCTGCGAGGATGCCGACGCAACCTGGCTCCTGCATCGAAAGTTCTCCCCGCTG
CTGGCCGAGAACGGGGTTGAGGAGTTGTTCCATCGCATCGAGATGCCGCTGGTACCCATCCTGGCCGGGATGGAGAACCA
TGGCGTGCTGCTGGACATTCGACTGCTGGCGGATCTTTCACGCGATTTTTCCAGCCGCATGGCAACACTGGAGGGGCGCA
TATTCCAGCTGGCGGGCACAACCTTCAACCTTAACTCCCCCAAGCAGCTGGGCGAAGTACTCTTCGAGCGCCTGCAGCTG
AAGACCGGCAAGAAGACCAAGGGCAAGACCGGCTGGTCCACGGACAACGAGGTGCTCAGTTCCCTGGCCGAGGAGCACGA
GATCGCCCGCCTGATCCTGGACTACCGCGGCCTGTCCAAACTGAAATCAACCTACAGCGACGCCCTGCCGCGCCTGGTGC
ATCCCCGCACCGGACGGGTACACACCTCCTACAACCAGACCGTCACCAGCACCGGCCGCCTCTCCTCATCAGACCCCAAC
CTGCAGAACATCCCCATCCGCAGCGACGAGGGGCGCATGATCCGGCACGCCTTCATCGCCCCGCCCGGGCATGTGATCAT
CTCTGCTGACTACTCCCAGATCGAGCTGCGCGTACTGGCCCACCTGTCCGGCGATCCGGTCTTCTGTCAGGCCTTCGAGC
ACGACGAGGACATCCACACCCGCACCGCCAGCGAGGTTTTCGGCCTGTTCCCCGAGATGGTCACAGCCGAGATGCGCCGC
CAGGCCAAGACCATCAACTTCGGCATCATCTACGGCCAGGGTTCCTTCAGCCTGGCCAGGCAGCTGGGCATCGCCCGCAA
AACCGCCGAAGAGTTCATCAGCGCCTACAAGGAGCGCCATGCAAAGGCGGTTGGCTTCCTGGACGACTGCATCCGCCAGG
CGGAGGAGCAGGGGTTCGTCACCACCATCCTGGGGCGGCGACTGCCCATTGCGGACATCACCAGCACGAACGGCAACATC
CGCGCCTTTGCCCAGCGCAACGCCATCAACTACCCGATCCAAGGTTCGGCGGCCGACATCATCAAGAGCGCCATGATCCG
GGTGGACGGCCGCATCCGCAGCGAGGGGCTCAAGAGCCGCCTGATCATGCAGGTTCACGACGAACTGGTCTTCGAGGTTC
GGGAAGATGAGCTGCTGGCCATGGAGCTCTTGGTGGAGGAGGAAATGTCACGGGCGGTGGAATTGCGCATCCCGCTCAAG
GTTGACATCAGCCACGGCGTTAACTGGAGCGAGGCGCACTGA

Upstream 100 bases:

>100_bases
ACTACGACGGTATGCAGTTCGCCATGCGCGACGCCAGCCGTCGCCCGGCAATGGCCTTCCTCCTCTTCACCCGCGACGAA
CCGGGCGAGAGTGACCCGTC

Downstream 100 bases:

>100_bases
CTCGTGCCCTGGCTGTATGCCCCGCCCTCCTACCTTCTTCCCGTCACCACATCCCACAAACAGCCGCCGGGGAATGGCCG
TACGGCCGTTTCCCGGCGGC

Product: DNA polymerase I

Products: NA

Alternate protein names: POL I [H]

Number of amino acids: Translated: 893; Mature: 892

Protein sequence:

>893_residues
MSHDDTLYLVDGSSYIYRAYYAIRHLSSPTGHPTNTIYGFTQMLLKLLKEHQPRHVAVVFDVGRETFRTELYPDYKANRA
ALPDDLRVQMGPIRDLVRAFNIPALELAGFEADDIIGCLAARFSATGGRVVIVTGDKDLMQIVTERVTLLDTMKEKRSAI
TDVIERFGVEPRLVTDILGLAGDASDNIPGVPGIGEKTAMKLIREYGSLDQLLERASEVKGKNGEKLREFRDQALLSRRL
ATIRCDVPIQVELEELASQEPDREALNTLFRLYGFTTLIKELTGRSTLSSEGYCTVTAQEELEELVHALERSEEFAIDLE
TTSLDPRDAEIVGLSFSFRDHQAWYIPVGHTSDAGLQPGQLPRDLVLERLRPQLESPSPTKIGQNIKFDMQVLATNGVSL
SGIRFDTMLASYVLNPSRQGHGLDALALEHLGHRMISYAEVTGSGKTQKNFSQVEIETASRYACEDADATWLLHRKFSPL
LAENGVEELFHRIEMPLVPILAGMENHGVLLDIRLLADLSRDFSSRMATLEGRIFQLAGTTFNLNSPKQLGEVLFERLQL
KTGKKTKGKTGWSTDNEVLSSLAEEHEIARLILDYRGLSKLKSTYSDALPRLVHPRTGRVHTSYNQTVTSTGRLSSSDPN
LQNIPIRSDEGRMIRHAFIAPPGHVIISADYSQIELRVLAHLSGDPVFCQAFEHDEDIHTRTASEVFGLFPEMVTAEMRR
QAKTINFGIIYGQGSFSLARQLGIARKTAEEFISAYKERHAKAVGFLDDCIRQAEEQGFVTTILGRRLPIADITSTNGNI
RAFAQRNAINYPIQGSAADIIKSAMIRVDGRIRSEGLKSRLIMQVHDELVFEVREDELLAMELLVEEEMSRAVELRIPLK
VDISHGVNWSEAH

Sequences:

>Translated_893_residues
MSHDDTLYLVDGSSYIYRAYYAIRHLSSPTGHPTNTIYGFTQMLLKLLKEHQPRHVAVVFDVGRETFRTELYPDYKANRA
ALPDDLRVQMGPIRDLVRAFNIPALELAGFEADDIIGCLAARFSATGGRVVIVTGDKDLMQIVTERVTLLDTMKEKRSAI
TDVIERFGVEPRLVTDILGLAGDASDNIPGVPGIGEKTAMKLIREYGSLDQLLERASEVKGKNGEKLREFRDQALLSRRL
ATIRCDVPIQVELEELASQEPDREALNTLFRLYGFTTLIKELTGRSTLSSEGYCTVTAQEELEELVHALERSEEFAIDLE
TTSLDPRDAEIVGLSFSFRDHQAWYIPVGHTSDAGLQPGQLPRDLVLERLRPQLESPSPTKIGQNIKFDMQVLATNGVSL
SGIRFDTMLASYVLNPSRQGHGLDALALEHLGHRMISYAEVTGSGKTQKNFSQVEIETASRYACEDADATWLLHRKFSPL
LAENGVEELFHRIEMPLVPILAGMENHGVLLDIRLLADLSRDFSSRMATLEGRIFQLAGTTFNLNSPKQLGEVLFERLQL
KTGKKTKGKTGWSTDNEVLSSLAEEHEIARLILDYRGLSKLKSTYSDALPRLVHPRTGRVHTSYNQTVTSTGRLSSSDPN
LQNIPIRSDEGRMIRHAFIAPPGHVIISADYSQIELRVLAHLSGDPVFCQAFEHDEDIHTRTASEVFGLFPEMVTAEMRR
QAKTINFGIIYGQGSFSLARQLGIARKTAEEFISAYKERHAKAVGFLDDCIRQAEEQGFVTTILGRRLPIADITSTNGNI
RAFAQRNAINYPIQGSAADIIKSAMIRVDGRIRSEGLKSRLIMQVHDELVFEVREDELLAMELLVEEEMSRAVELRIPLK
VDISHGVNWSEAH
>Mature_892_residues
SHDDTLYLVDGSSYIYRAYYAIRHLSSPTGHPTNTIYGFTQMLLKLLKEHQPRHVAVVFDVGRETFRTELYPDYKANRAA
LPDDLRVQMGPIRDLVRAFNIPALELAGFEADDIIGCLAARFSATGGRVVIVTGDKDLMQIVTERVTLLDTMKEKRSAIT
DVIERFGVEPRLVTDILGLAGDASDNIPGVPGIGEKTAMKLIREYGSLDQLLERASEVKGKNGEKLREFRDQALLSRRLA
TIRCDVPIQVELEELASQEPDREALNTLFRLYGFTTLIKELTGRSTLSSEGYCTVTAQEELEELVHALERSEEFAIDLET
TSLDPRDAEIVGLSFSFRDHQAWYIPVGHTSDAGLQPGQLPRDLVLERLRPQLESPSPTKIGQNIKFDMQVLATNGVSLS
GIRFDTMLASYVLNPSRQGHGLDALALEHLGHRMISYAEVTGSGKTQKNFSQVEIETASRYACEDADATWLLHRKFSPLL
AENGVEELFHRIEMPLVPILAGMENHGVLLDIRLLADLSRDFSSRMATLEGRIFQLAGTTFNLNSPKQLGEVLFERLQLK
TGKKTKGKTGWSTDNEVLSSLAEEHEIARLILDYRGLSKLKSTYSDALPRLVHPRTGRVHTSYNQTVTSTGRLSSSDPNL
QNIPIRSDEGRMIRHAFIAPPGHVIISADYSQIELRVLAHLSGDPVFCQAFEHDEDIHTRTASEVFGLFPEMVTAEMRRQ
AKTINFGIIYGQGSFSLARQLGIARKTAEEFISAYKERHAKAVGFLDDCIRQAEEQGFVTTILGRRLPIADITSTNGNIR
AFAQRNAINYPIQGSAADIIKSAMIRVDGRIRSEGLKSRLIMQVHDELVFEVREDELLAMELLVEEEMSRAVELRIPLKV
DISHGVNWSEAH

Specific function: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity. It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template [H]

COG id: COG0749

COG function: function code L; DNA polymerase I - 3'-5' exonuclease and polymerase domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 5'-3' exonuclease domain [H]

Homologues:

Organism=Homo sapiens, GI112420958, Length=518, Percent_Identity=32.2393822393822, Blast_Score=259, Evalue=7e-69,
Organism=Homo sapiens, GI139394648, Length=690, Percent_Identity=27.1014492753623, Blast_Score=216, Evalue=9e-56,
Organism=Escherichia coli, GI1790294, Length=925, Percent_Identity=46.1621621621622, Blast_Score=798, Evalue=0.0,
Organism=Escherichia coli, GI226510970, Length=243, Percent_Identity=30.8641975308642, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI86563272, Length=407, Percent_Identity=30.7125307125307, Blast_Score=177, Evalue=3e-44,
Organism=Drosophila melanogaster, GI17933644, Length=594, Percent_Identity=28.4511784511784, Blast_Score=189, Evalue=6e-48,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR020046
- InterPro:   IPR020045
- InterPro:   IPR002421
- InterPro:   IPR020047
- InterPro:   IPR019760
- InterPro:   IPR001098
- InterPro:   IPR018320
- InterPro:   IPR002298
- InterPro:   IPR008918
- InterPro:   IPR003583
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF01367 5_3_exonuc; PF02739 5_3_exonuc_N; PF00476 DNA_pol_A [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 99805; Mature: 99674

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00447 DNA_POLYMERASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHDDTLYLVDGSSYIYRAYYAIRHLSSPTGHPTNTIYGFTQMLLKLLKEHQPRHVAVVF
CCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEE
DVGRETFRTELYPDYKANRAALPDDLRVQMGPIRDLVRAFNIPALELAGFEADDIIGCLA
ECCCHHHHHHCCCCCCCCCCCCCCCHHEEHHHHHHHHHHHCCCCEEECCCCHHHHHHHHH
ARFSATGGRVVIVTGDKDLMQIVTERVTLLDTMKEKRSAITDVIERFGVEPRLVTDILGL
HHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AGDASDNIPGVPGIGEKTAMKLIREYGSLDQLLERASEVKGKNGEKLREFRDQALLSRRL
CCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ATIRCDVPIQVELEELASQEPDREALNTLFRLYGFTTLIKELTGRSTLSSEGYCTVTAQE
HEEECCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHH
ELEELVHALERSEEFAIDLETTSLDPRDAEIVGLSFSFRDHQAWYIPVGHTSDAGLQPGQ
HHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEECCCCEEEEECCCCCCCCCCCCC
LPRDLVLERLRPQLESPSPTKIGQNIKFDMQVLATNGVSLSGIRFDTMLASYVLNPSRQG
CCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCEECCCHHHHHHHHHHCCCCCCC
HGLDALALEHLGHRMISYAEVTGSGKTQKNFSQVEIETASRYACEDADATWLLHRKFSPL
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHCCCCCCCEEEEHHCCCHH
LAENGVEELFHRIEMPLVPILAGMENHGVLLDIRLLADLSRDFSSRMATLEGRIFQLAGT
HHHCCHHHHHHHHCCCHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCEEEEEECC
TFNLNSPKQLGEVLFERLQLKTGKKTKGKTGWSTDNEVLSSLAEEHEIARLILDYRGLSK
EECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LKSTYSDALPRLVHPRTGRVHTSYNQTVTSTGRLSSSDPNLQNIPIRSDEGRMIRHAFIA
HHHHHHHHHHHHCCCCCCCEEECCCCEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
PPGHVIISADYSQIELRVLAHLSGDPVFCQAFEHDEDIHTRTASEVFGLFPEMVTAEMRR
CCCCEEEECCCCCEEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QAKTINFGIIYGQGSFSLARQLGIARKTAEEFISAYKERHAKAVGFLDDCIRQAEEQGFV
HHCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
TTILGRRLPIADITSTNGNIRAFAQRNAINYPIQGSAADIIKSAMIRVDGRIRSEGLKSR
HHHHCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
LIMQVHDELVFEVREDELLAMELLVEEEMSRAVELRIPLKVDISHGVNWSEAH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
SHDDTLYLVDGSSYIYRAYYAIRHLSSPTGHPTNTIYGFTQMLLKLLKEHQPRHVAVVF
CCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEE
DVGRETFRTELYPDYKANRAALPDDLRVQMGPIRDLVRAFNIPALELAGFEADDIIGCLA
ECCCHHHHHHCCCCCCCCCCCCCCCHHEEHHHHHHHHHHHCCCCEEECCCCHHHHHHHHH
ARFSATGGRVVIVTGDKDLMQIVTERVTLLDTMKEKRSAITDVIERFGVEPRLVTDILGL
HHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AGDASDNIPGVPGIGEKTAMKLIREYGSLDQLLERASEVKGKNGEKLREFRDQALLSRRL
CCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
ATIRCDVPIQVELEELASQEPDREALNTLFRLYGFTTLIKELTGRSTLSSEGYCTVTAQE
HEEECCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHH
ELEELVHALERSEEFAIDLETTSLDPRDAEIVGLSFSFRDHQAWYIPVGHTSDAGLQPGQ
HHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEECCCCEEEEECCCCCCCCCCCCC
LPRDLVLERLRPQLESPSPTKIGQNIKFDMQVLATNGVSLSGIRFDTMLASYVLNPSRQG
CCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCEECCCHHHHHHHHHHCCCCCCC
HGLDALALEHLGHRMISYAEVTGSGKTQKNFSQVEIETASRYACEDADATWLLHRKFSPL
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHCCCCCCCEEEEHHCCCHH
LAENGVEELFHRIEMPLVPILAGMENHGVLLDIRLLADLSRDFSSRMATLEGRIFQLAGT
HHHCCHHHHHHHHCCCHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCEEEEEECC
TFNLNSPKQLGEVLFERLQLKTGKKTKGKTGWSTDNEVLSSLAEEHEIARLILDYRGLSK
EECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LKSTYSDALPRLVHPRTGRVHTSYNQTVTSTGRLSSSDPNLQNIPIRSDEGRMIRHAFIA
HHHHHHHHHHHHCCCCCCCEEECCCCEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
PPGHVIISADYSQIELRVLAHLSGDPVFCQAFEHDEDIHTRTASEVFGLFPEMVTAEMRR
CCCCEEEECCCCCEEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QAKTINFGIIYGQGSFSLARQLGIARKTAEEFISAYKERHAKAVGFLDDCIRQAEEQGFV
HHCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
TTILGRRLPIADITSTNGNIRAFAQRNAINYPIQGSAADIIKSAMIRVDGRIRSEGLKSR
HHHHCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
LIMQVHDELVFEVREDELLAMELLVEEEMSRAVELRIPLKVDISHGVNWSEAH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6276402; 8346018; 9278503; 6183253; 6302278; 7035456; 3883192; 1989886; 8469987; 8260491; 9514742; 9888810; 10588690; 8442659 [H]