Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 118581234

GI number: 118581234

Start: 3094649

End: 3095461

Strand: Direct

Name: proC [H]

Synonym: Ppro_2828

Alternate gene names: 118581234

Gene position: 3094649-3095461 (Clockwise)

Preceding gene: 118581233

Following gene: 118581235

Centisome position: 77.21

GC content: 62.36

Gene sequence:

>813_bases
ATGCTGATAAACAAAAAAATCGGTTTCATCGGCGGCGGCAACATGGCCGAAGCCATCATAAAGGGACTCCTCGCCGATTC
TTTCCGGGCGGACGCCATCATGGTTGCCGAGCCACAGGAACAGCGCAGAAAATCCCTCTCCTCCACCTACGGCATCGGGA
CCAGTGACAGCGGATCCGCCGTGGCCGGCCAAGCCGATATCGTCATCCTGGCCATAAAACCCCAGATGGCCGCCGGGGTG
CTGAGCGATCTGGAACCGGCAATCCCGGCGGACAAACTGGTCATCTCCATCATGGCCGGAATCCCCACTACCTACATTGA
GGAATCACTTGCCAGCGGCGTGCGGGTGGTTCGGGTCATGCCCAACACGGCGGCACTGATCCAGGCGGCAGCCAGCGCCA
TCTGCCCGGGGAGAAAAGCGGACGACAGCGATCTTGCCACCGCGACCGAGATTTTCTCCCGCGTCGGAGCGGTGGTCACC
ACCACGGAAAAACTTATGGACGCGGTCACCGGGTTGTCCGGCAGTGGGCCGGCCTATGTTTTCAGTTTTATCGAGGCACT
CTCCGATGCCGGCGTCAAGAACGGTCTGGCGCGGGACGTGTCGCTGAAACTGGCCGTACAGACCGTGCTGGGGGCCGCAC
GCATGGTGGACGAGACCGGAGATCACCCGGCCCTGCTGAGGGAAAAGGTAACCTCGCCCGGCGGCACGACCATCGCAGGC
CTGCACACCCTGGAAAACGGCCGCTTCCACGGCCTGGTCATGGATGCCGTGGACAGCGCCTGCGCCAAATCCCGGGAACT
GGCCGGAAAGTAG

Upstream 100 bases:

>100_bases
CGGCGTCATGCTGATCACCTCTTCCAGTACCAGCGAAGAGCGGCAGAACAAGGCTAACATCGAGGTTCCCCAGACGGATT
CTACTCACGGAGGCTGAAAC

Downstream 100 bases:

>100_bases
CTCCGACACCATTTGACCTGATTCGCAGATGTTGCTGTCGTTTCAAGACAGTATCTACCCTGGTCCGTCGTTGTTCCCAG
CGTGATAACGCTGAATGCAG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MLINKKIGFIGGGNMAEAIIKGLLADSFRADAIMVAEPQEQRRKSLSSTYGIGTSDSGSAVAGQADIVILAIKPQMAAGV
LSDLEPAIPADKLVISIMAGIPTTYIEESLASGVRVVRVMPNTAALIQAAASAICPGRKADDSDLATATEIFSRVGAVVT
TTEKLMDAVTGLSGSGPAYVFSFIEALSDAGVKNGLARDVSLKLAVQTVLGAARMVDETGDHPALLREKVTSPGGTTIAG
LHTLENGRFHGLVMDAVDSACAKSRELAGK

Sequences:

>Translated_270_residues
MLINKKIGFIGGGNMAEAIIKGLLADSFRADAIMVAEPQEQRRKSLSSTYGIGTSDSGSAVAGQADIVILAIKPQMAAGV
LSDLEPAIPADKLVISIMAGIPTTYIEESLASGVRVVRVMPNTAALIQAAASAICPGRKADDSDLATATEIFSRVGAVVT
TTEKLMDAVTGLSGSGPAYVFSFIEALSDAGVKNGLARDVSLKLAVQTVLGAARMVDETGDHPALLREKVTSPGGTTIAG
LHTLENGRFHGLVMDAVDSACAKSRELAGK
>Mature_270_residues
MLINKKIGFIGGGNMAEAIIKGLLADSFRADAIMVAEPQEQRRKSLSSTYGIGTSDSGSAVAGQADIVILAIKPQMAAGV
LSDLEPAIPADKLVISIMAGIPTTYIEESLASGVRVVRVMPNTAALIQAAASAICPGRKADDSDLATATEIFSRVGAVVT
TTEKLMDAVTGLSGSGPAYVFSFIEALSDAGVKNGLARDVSLKLAVQTVLGAARMVDETGDHPALLREKVTSPGGTTIAG
LHTLENGRFHGLVMDAVDSACAKSRELAGK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=266, Percent_Identity=35.7142857142857, Blast_Score=174, Evalue=8e-44,
Organism=Homo sapiens, GI198041662, Length=267, Percent_Identity=35.9550561797753, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI24797097, Length=266, Percent_Identity=36.8421052631579, Blast_Score=171, Evalue=4e-43,
Organism=Homo sapiens, GI24797095, Length=266, Percent_Identity=36.8421052631579, Blast_Score=171, Evalue=4e-43,
Organism=Escherichia coli, GI1786585, Length=267, Percent_Identity=39.3258426966292, Blast_Score=190, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17569021, Length=262, Percent_Identity=45.0381679389313, Blast_Score=214, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17540664, Length=279, Percent_Identity=35.1254480286738, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320861, Length=284, Percent_Identity=30.2816901408451, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=41.9475655430712, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24648116, Length=281, Percent_Identity=38.0782918149466, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=45.0292397660819, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27738; Mature: 27738

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLINKKIGFIGGGNMAEAIIKGLLADSFRADAIMVAEPQEQRRKSLSSTYGIGTSDSGSA
CCCCCCCCEECCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCE
VAGQADIVILAIKPQMAAGVLSDLEPAIPADKLVISIMAGIPTTYIEESLASGVRVVRVM
EECCCCEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCEEEEEEC
PNTAALIQAAASAICPGRKADDSDLATATEIFSRVGAVVTTTEKLMDAVTGLSGSGPAYV
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
FSFIEALSDAGVKNGLARDVSLKLAVQTVLGAARMVDETGDHPALLREKVTSPGGTTIAG
HHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEE
LHTLENGRFHGLVMDAVDSACAKSRELAGK
EEECCCCCEEEHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLINKKIGFIGGGNMAEAIIKGLLADSFRADAIMVAEPQEQRRKSLSSTYGIGTSDSGSA
CCCCCCCCEECCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCE
VAGQADIVILAIKPQMAAGVLSDLEPAIPADKLVISIMAGIPTTYIEESLASGVRVVRVM
EECCCCEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCEEEEEEC
PNTAALIQAAASAICPGRKADDSDLATATEIFSRVGAVVTTTEKLMDAVTGLSGSGPAYV
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
FSFIEALSDAGVKNGLARDVSLKLAVQTVLGAARMVDETGDHPALLREKVTSPGGTTIAG
HHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEE
LHTLENGRFHGLVMDAVDSACAKSRELAGK
EEECCCCCEEEHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11844777; 11932238 [H]