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The map label for this gene is ilvI [H]

Identifier: 118581220

GI number: 118581220

Start: 3082918

End: 3084615

Strand: Direct

Name: ilvI [H]

Synonym: Ppro_2814

Alternate gene names: 118581220

Gene position: 3082918-3084615 (Clockwise)

Preceding gene: 118581218

Following gene: 118581221

Centisome position: 76.92

GC content: 62.84

Gene sequence:

>1698_bases
ATGGTCAAGAGCCTGGAGGACCTGGGGGTCAGCCGCATCTTCGGGTACACGGGCGCCGCCATCCTTCCGGTTTTCCACGC
CATGGGCAAGAGTTCCCTGGCCATCAACGTCAATGCCAATGAGCAGTCCTGCGCCTTCAGCGCAGCCGGTTATTCGCGTG
CCAGCGACAAGGTGGGAGTAGCGGTGGTCACCTCGGGGCCGGCCATCACCAACACCCTCACGGCCGTGGCCGACTCCTTC
GCCGATTCCATCCCGCTCCTGGTCTTCGCCGGCCAGGTGCAGCAGAGCCGGCTGGACACCGACGAGTTCCAGCATATCAA
CGTCAAGGACGTATTCGCCAGGGCAGCCAAGAAGGTCATCCAGATCACCGACATCAGCGACATCGAGGAGACGGTCAAGG
ACGCCTACTTCTTCGCCAAGACGGGCAAGCCGGGACCGGTGGTGATCGACTTCCCCCTGGACTCCCAGCGCAGGACCGGA
GTCTACCGCGGCATCGACATCGACCTATTCCGCTACAAGTACGACCAGGAGTCCCACCTGGGCATCAACCAGTGCCAGCA
GTTCTTCGACCTGCTGCAGCGCTCCCAACGGCCGCTGCTCTACATCGGCGGCGGGCTCAACTCCCGGGCCGCCAGCGACA
GGATCCGCGAATTCAACCGCATGTTCAACATCCCCTCCATCAACAGCCTGATGGGCAAGGGGATCCTGGACGAGTCCCTG
GACACCTCCCTGGGCATGCTCGGCATGTACGGCACCCCCTATGCCAATATGGCCATCCAGCGCACCGACCTGTTCGTCGC
TTTCGGTGTGCGCTGGAACGACCGGGTGGTGCAGAAAGTGGGAGAATCGGGGCTAACCGCAGAGATCGCCTACATCGACA
TCAACGCAAAGAAGATGCAGGAGGTCAGGGTCACCCGCAACCCCAAGTTCTCATTCATCGGCGATGCCCGCACGGTGCTG
GAGGATCTGGTGGAGTACGCCCGTGATCACCAGGTGACCCTGGACATCGCCCCCTGGCAGGAAGAGGCGGCCAAGCTGAA
GCGCAGCTATCCCCTCACCTGCAACCGCGAGGCCCGCATGATCCAGGCCGCCGAGGTCATGGACCTGCTGTCGCAGCGAC
TGACCGACACGACCATCATCACCACCGGCGTGGGCAACCACCAGATGCTTGCGGCCCAGTACCTCAAGACCGCCCAGCCG
CGATCATTTCTGACCTCCGGCGCCTTCGGCACCATGGGCTTTTCCCTGCCGGTCTCCATCGGTGCGCACTTCGCCAACCC
GGAAGCGCGGGTCATCGCCATCGACGGCGACAGCAGCATCAAGATGAACATGGGGGAGTTGCACACCATCGGCTCCCTGG
ATATCCCGATCAAGGTGCTCCTGATCAACAACCACGCCGACGGCATGGTCAGGTCCATCCAGGACGCGCTCTACGACGGC
CAGCACACCGCCTCGGAGCGTGACTTCGACGCCAACTTCGCCCACATCGCCCGGGAATGCGGCTTCGGCTGGTGCCGAAA
GGTTCTCAGCCGTCCCTACCTGGAGGATGCCCTGGATGAGTTTCTGGCCGCCGACGGCCCCTGCTTCCTGGAGATCGTCA
CCGACCGGGAGGAGACCATCTATCCGCTGATCCCCCAGGGCAAGGGGTACAAGGACATGATCCTGGGACCCTACATAAGC
AAACGGGAGGAAGCGTGA

Upstream 100 bases:

>100_bases
GCGACTGAAAAATATGCTAAGACTGGGTTTTCGAAATTCCAGTCATCCCAACAGACACGAGGAGTAACCCACGGTGCAGA
CAATGACGGGTGCAGAAATA

Downstream 100 bases:

>100_bases
CCTCCACCACCCGCGTGCACCTCATCCGCCACGGCCAGGTGGTAGGGCATGATCAGCCGCGCTACAACGGCCAGACCGAC
GTGGCCCTGACCGAACTGGG

Product: thiamine pyrophosphate binding domain-containing protein

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MVKSLEDLGVSRIFGYTGAAILPVFHAMGKSSLAINVNANEQSCAFSAAGYSRASDKVGVAVVTSGPAITNTLTAVADSF
ADSIPLLVFAGQVQQSRLDTDEFQHINVKDVFARAAKKVIQITDISDIEETVKDAYFFAKTGKPGPVVIDFPLDSQRRTG
VYRGIDIDLFRYKYDQESHLGINQCQQFFDLLQRSQRPLLYIGGGLNSRAASDRIREFNRMFNIPSINSLMGKGILDESL
DTSLGMLGMYGTPYANMAIQRTDLFVAFGVRWNDRVVQKVGESGLTAEIAYIDINAKKMQEVRVTRNPKFSFIGDARTVL
EDLVEYARDHQVTLDIAPWQEEAAKLKRSYPLTCNREARMIQAAEVMDLLSQRLTDTTIITTGVGNHQMLAAQYLKTAQP
RSFLTSGAFGTMGFSLPVSIGAHFANPEARVIAIDGDSSIKMNMGELHTIGSLDIPIKVLLINNHADGMVRSIQDALYDG
QHTASERDFDANFAHIARECGFGWCRKVLSRPYLEDALDEFLAADGPCFLEIVTDREETIYPLIPQGKGYKDMILGPYIS
KREEA

Sequences:

>Translated_565_residues
MVKSLEDLGVSRIFGYTGAAILPVFHAMGKSSLAINVNANEQSCAFSAAGYSRASDKVGVAVVTSGPAITNTLTAVADSF
ADSIPLLVFAGQVQQSRLDTDEFQHINVKDVFARAAKKVIQITDISDIEETVKDAYFFAKTGKPGPVVIDFPLDSQRRTG
VYRGIDIDLFRYKYDQESHLGINQCQQFFDLLQRSQRPLLYIGGGLNSRAASDRIREFNRMFNIPSINSLMGKGILDESL
DTSLGMLGMYGTPYANMAIQRTDLFVAFGVRWNDRVVQKVGESGLTAEIAYIDINAKKMQEVRVTRNPKFSFIGDARTVL
EDLVEYARDHQVTLDIAPWQEEAAKLKRSYPLTCNREARMIQAAEVMDLLSQRLTDTTIITTGVGNHQMLAAQYLKTAQP
RSFLTSGAFGTMGFSLPVSIGAHFANPEARVIAIDGDSSIKMNMGELHTIGSLDIPIKVLLINNHADGMVRSIQDALYDG
QHTASERDFDANFAHIARECGFGWCRKVLSRPYLEDALDEFLAADGPCFLEIVTDREETIYPLIPQGKGYKDMILGPYIS
KREEA
>Mature_565_residues
MVKSLEDLGVSRIFGYTGAAILPVFHAMGKSSLAINVNANEQSCAFSAAGYSRASDKVGVAVVTSGPAITNTLTAVADSF
ADSIPLLVFAGQVQQSRLDTDEFQHINVKDVFARAAKKVIQITDISDIEETVKDAYFFAKTGKPGPVVIDFPLDSQRRTG
VYRGIDIDLFRYKYDQESHLGINQCQQFFDLLQRSQRPLLYIGGGLNSRAASDRIREFNRMFNIPSINSLMGKGILDESL
DTSLGMLGMYGTPYANMAIQRTDLFVAFGVRWNDRVVQKVGESGLTAEIAYIDINAKKMQEVRVTRNPKFSFIGDARTVL
EDLVEYARDHQVTLDIAPWQEEAAKLKRSYPLTCNREARMIQAAEVMDLLSQRLTDTTIITTGVGNHQMLAAQYLKTAQP
RSFLTSGAFGTMGFSLPVSIGAHFANPEARVIAIDGDSSIKMNMGELHTIGSLDIPIKVLLINNHADGMVRSIQDALYDG
QHTASERDFDANFAHIARECGFGWCRKVLSRPYLEDALDEFLAADGPCFLEIVTDREETIYPLIPQGKGYKDMILGPYIS
KREEA

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=494, Percent_Identity=24.0890688259109, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI93004078, Length=487, Percent_Identity=21.9712525667351, Blast_Score=114, Evalue=4e-25,
Organism=Escherichia coli, GI87081685, Length=574, Percent_Identity=32.2299651567944, Blast_Score=311, Evalue=1e-85,
Organism=Escherichia coli, GI1790104, Length=555, Percent_Identity=31.7117117117117, Blast_Score=298, Evalue=5e-82,
Organism=Escherichia coli, GI1786717, Length=479, Percent_Identity=26.7223382045929, Blast_Score=198, Evalue=8e-52,
Organism=Escherichia coli, GI1787096, Length=573, Percent_Identity=24.0837696335079, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1788716, Length=479, Percent_Identity=22.964509394572, Blast_Score=99, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17542570, Length=504, Percent_Identity=24.2063492063492, Blast_Score=99, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17531299, Length=560, Percent_Identity=21.9642857142857, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17531301, Length=560, Percent_Identity=21.9642857142857, Blast_Score=92, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6323755, Length=577, Percent_Identity=32.5823223570191, Blast_Score=303, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6320816, Length=481, Percent_Identity=23.4927234927235, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI19922626, Length=480, Percent_Identity=23.5416666666667, Blast_Score=125, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 62455; Mature: 62455

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKSLEDLGVSRIFGYTGAAILPVFHAMGKSSLAINVNANEQSCAFSAAGYSRASDKVGV
CCCCHHHCCHHHHHCCCCHHHHHHHHHCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCE
AVVTSGPAITNTLTAVADSFADSIPLLVFAGQVQQSRLDTDEFQHINVKDVFARAAKKVI
EEEECCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHCCCHHHHCCCCHHHHHHHHHHHHE
QITDISDIEETVKDAYFFAKTGKPGPVVIDFPLDSQRRTGVYRGIDIDLFRYKYDQESHL
EECCHHHHHHHHHHHEEEEECCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEECCCCCCC
GINQCQQFFDLLQRSQRPLLYIGGGLNSRAASDRIREFNRMFNIPSINSLMGKGILDESL
CHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHH
DTSLGMLGMYGTPYANMAIQRTDLFVAFGVRWNDRVVQKVGESGLTAEIAYIDINAKKMQ
HHCCCHHCCCCCCCCCEEEEEEEEEEEECCCCCHHHHHHHCCCCCEEEEEEEECCHHHHH
EVRVTRNPKFSFIGDARTVLEDLVEYARDHQVTLDIAPWQEEAAKLKRSYPLTCNREARM
HHHHCCCCCEEEECCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCHHHH
IQAAEVMDLLSQRLTDTTIITTGVGNHQMLAAQYLKTAQPRSFLTSGAFGTMGFSLPVSI
HHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCEECCHHH
GAHFANPEARVIAIDGDSSIKMNMGELHTIGSLDIPIKVLLINNHADGMVRSIQDALYDG
CCEECCCCEEEEEEECCCCEEEECCCEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHCC
QHTASERDFDANFAHIARECGFGWCRKVLSRPYLEDALDEFLAADGPCFLEIVTDREETI
CCCCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCEE
YPLIPQGKGYKDMILGPYISKREEA
EEECCCCCCCCCCEECCCCCCCCCC
>Mature Secondary Structure
MVKSLEDLGVSRIFGYTGAAILPVFHAMGKSSLAINVNANEQSCAFSAAGYSRASDKVGV
CCCCHHHCCHHHHHCCCCHHHHHHHHHCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCE
AVVTSGPAITNTLTAVADSFADSIPLLVFAGQVQQSRLDTDEFQHINVKDVFARAAKKVI
EEEECCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHCCCHHHHCCCCHHHHHHHHHHHHE
QITDISDIEETVKDAYFFAKTGKPGPVVIDFPLDSQRRTGVYRGIDIDLFRYKYDQESHL
EECCHHHHHHHHHHHEEEEECCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEECCCCCCC
GINQCQQFFDLLQRSQRPLLYIGGGLNSRAASDRIREFNRMFNIPSINSLMGKGILDESL
CHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHH
DTSLGMLGMYGTPYANMAIQRTDLFVAFGVRWNDRVVQKVGESGLTAEIAYIDINAKKMQ
HHCCCHHCCCCCCCCCEEEEEEEEEEEECCCCCHHHHHHHCCCCCEEEEEEEECCHHHHH
EVRVTRNPKFSFIGDARTVLEDLVEYARDHQVTLDIAPWQEEAAKLKRSYPLTCNREARM
HHHHCCCCCEEEECCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCHHHH
IQAAEVMDLLSQRLTDTTIITTGVGNHQMLAAQYLKTAQPRSFLTSGAFGTMGFSLPVSI
HHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCEECCHHH
GAHFANPEARVIAIDGDSSIKMNMGELHTIGSLDIPIKVLLINNHADGMVRSIQDALYDG
CCEECCCCEEEEEEECCCCEEEECCCEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHCC
QHTASERDFDANFAHIARECGFGWCRKVLSRPYLEDALDEFLAADGPCFLEIVTDREETI
CCCCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCEE
YPLIPQGKGYKDMILGPYISKREEA
EEECCCCCCCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9688822; 12089438 [H]